Age-specific reference ranges for serum testosterone and androstenedione concentrations in women measured by liquid chromatography-tandem mass spectrometry

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 2, 2012, Pages 408-415

  Haring, Robin ^a   Hannemann, Anke ^a   John, Ulrich ^a   Radke, Dor̈te ^a   Nauck, Matthias ^a   Wallaschofski, Henri ^a   Owen, Laura ^b   Adaway, Jo ^b   Keevil, Brian G ^b   Brabant, Georg ^b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; TESTOSTERONE;

ADULT; AGE; AGED; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CLINICAL ASSESSMENT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HORMONE DETERMINATION; HUMAN; LIQUID CHROMATOGRAPHY; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL;

ADULT; AGE DISTRIBUTION; AGE FACTORS; AGED; AGED, 80 AND OVER; ANDROSTENEDIONE; CHROMATOGRAPHY, LIQUID; DIAGNOSTIC TECHNIQUES, ENDOCRINE; FEMALE; HUMANS; MIDDLE AGED; OSMOLAR CONCENTRATION; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TESTOSTERONE; YOUNG ADULT;

EID: 84856782567     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-2134     Document Type: Article

References (41)

1. Guay A, Davis SR 2002 Testosterone insufficiency in women: fact or fiction? World J Urol 20:106-110
2. Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH, van der Schouw YT 2011 Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies. Int J Epidemiol 40:189-207
3. Ding EL, Song Y, Malik VS, Liu S 2006 Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 295:1288-1299
4. Sievers C, Klotsche J, Pieper L, Schneider HJ, März W, Wittchen HU, Stalla GK, Mantzoros C 2010 Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients. Eur J Endocrinol/Eur Fed Endocr Soc 163:699-708
5. Steinberger E, Ayala C, Hsi B, Smith KD, Rodriguez-Rigau LJ, Weidman ER, Reimondo GG 1998 Utilization of commercial laboratory results in management of hyperandrogenism in women. Endocr Pract 4:1-10
6. Demers LM 2010 Androgen deficiency in women; role of accurate testosterone measurements. Maturitas 67:39-45
7. Anttila L, Koskinen P, Irjala K, Kaihola HL 1991 Reference intervals for serum sex steroids and gonadotropins in regularly menstruating women. Acta Obstet Gynecol Scand 70:475-481
8. Ayala C, Steinberger E, Smith KD, Rodriguez-Rigau LJ, Petak SM 1999 Serum testosterone levels and reference ranges in reproductive-age women. Endocr Pract 5:322-329
9. Barth JH, Field HP, Yasmin E, Balen AH 2010 Defining hyperandrogenism in polycystic ovary syndrome: measurement of testosterone and androstenedione by liquid chromatography-tandem mass spectrometry and analysis by receiver operator characteristic plots. Eur J Endocrinol/Eur Fed Endocr Soc 162:611-615
10. Elmlinger MW, Kühnel W, Wormstall H, Döller PC 2005 Reference intervals for testosterone, androstenedione and SHBG levels in healthy females and males from birth until old age. Clin Lab 51: 625-632 (Pubitemid 41763079)
11. Kushnir MM, Blamires T, Rockwood AL, Roberts WL, Yue B, Erdogan E, Bunker AM, Meikle AW 2010 Liquid chromatography-tandem mass spectrometry assay for androstenedione, dehydroepiandrosterone, and testosterone with pediatric and adult reference intervals. Clin Chem 56:1138-1147
12. Shiraishi S, Lee PW, Leung A, Goh VH, Swerdloff RS, Wang C 2008 Simultaneous measurement of serum testosterone and dihydrotes-tosterone by liquid chromatography-tandem mass spectrometry. Clin Chem 54:1855-1863
13. Turpeinen U, Linko S, Itkonen O, Hämäläinen E 2008 Determination of testosterone in serum by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest 68:50-57 (Pubitemid 351161507)
14. Vesper HW, Botelho JC 2010 Standardization of testosterone measurements in humans. J Steroid Biochem Mol Biol 121:513-519
15. Taieb J, Mathian B, Millot F, Patricot MC, Mathieu E, Queyrel N, Lacroix I, Somma-Delpero C, Boudou P 2003 Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography- mass spectrometry in sera from 116 men, women, and children. Clin Chem 49:1381-1395 (Pubitemid 36900626)
16. Moal V, Mathieu E, Reynier P, Malthièry Y, Gallois Y 2007 Low serum testosterone assayed by liquid chromatography-tandem mass spectrometry. Comparison with five immunoassay techniques. Clin Chim Acta 386:12-19 (Pubitemid 47417956)
17. Friedrich N, Alte D, Völzke H, Spilcke-Liss E, Lüdemann J, Lerch MM, Kohlmann T, Nauck M, Wallaschofski H 2008 Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: results of the Study of Health in Pomerania (SHIP). Growth Horm IGF Res 18:228-237 (Pubitemid 351479927)
18. Friedrich N, Krebs A, Nauck M, Wallaschofski H 2010 Age- and gender-specific reference ranges for serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 concentrations on the Immulite 2500: results of the Study of Health in Pomerania (SHIP). Clin Chem Lab Med 48:115-120
19. Friedrich N, Völzke H, Rosskopf D, Steveling A, Krebs A, Nauck M, Wallaschofski H 2008 Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men. J Androl 29: 610-617
20. Völzke H, Alte D, Schmidt CO, Radke D, Lorbeer R, Friedrich N, Aumann N, Lau K, Piontek M, Born G, Havemann C, Ittermann T, Schipf S, Haring R, Baumeister SE, Wallaschofski H, Nauck M, Frick S, Arnold A, Jünger M, Mayerle J, Kraft M, Lerch MM, Dörr M, Reffelmann T, Empen K, Felix SB, Obst A, Koch B, Gläser S, Ewert R, Fietze I, Penzel T, Dören M, Rathmann W, et al. 2011 Cohort profile: the study of health in pomerania. Int J Epidemiol 40:294-307
21. Haring R, Alte D, Völzke H, Sauer S, Wallaschofski H, John U, Schmidt CO 2009 Extended recruitment efforts minimize attrition but not necessarily bias. J Clin Epidemiol 62:252-260
22. Thienpont LM, Van Uytfanghe K, Blincko S, Ramsay CS, Xie H, Doss RC, Keevil BG, Owen LJ, Rockwood AL, Kushnir MM, Chun KY, Chandler DW, Field HP, Sluss PM 2008 State-of-the-art of serum testosterone measurement by isotope dilution-liquid chromatography- tandem mass spectrometry. Clin Chem 54:1290-1297
23. Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672 (Pubitemid 30645223)
24. Miller KK, Rosner W, Lee H, Hier J, Sesmilo G, Schoenfeld D, Neubauer G, Klibanski A 2004 Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods. J Clin Endocrinol Metab 89:525-533 (Pubitemid 38269853)
25. Rinaldi S, Geay A, Déchaud H, Biessy C, Zeleniuch-Jacquotte A, Akhmedkhanov A, Shore RE, Riboli E, Toniolo P, Kaaks R 2002 Validity of free testosterone and free estradiol determinations in serum samples from postmenopausal women by theoretical calculations. Cancer Epidemiol Biomarkers Prev 11:1065-1071 (Pubitemid 35192658)
26. Alte D, Luedemann J, Rose HJ, John U 2004 Laboratory markers carbohydrate-deficient transferrin, γ-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the Study of Health in Pomerania (SHIP). Alcohol Clin Exp Res 28:931-940 (Pubitemid 38780570)
27. Schwarz S, Völzke H, Alte D, Schwahn C, Grabe HJ, Hoffmann W, John U, Dören M 2007 Menopause and determinants of quality of life in women at midlife and beyond: the study of health in pomerania (SHIP). Menopause (New York, NY) 14:123-134 (Pubitemid 46072013)
28. Völzke H, Schwarz S, Baumeister SE, Wallaschofski H, Schwahn C, Grabe HJ, Kohlmann T, John U, Dören M 2007 Menopausal status and hepatic steatosis in a general female population. Gut 56:594-595 (Pubitemid 46580520)
29. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D 1999 A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461-470 (Pubitemid 29135798)
30. Friedrich N, Schneider HJ, Spielhagen C, Markus MR, Haring R, Grabe HJ, Buchfelder M, Wallaschofski H, Nauck M 2011 The association of serum prolactin concentration with inflammatory biomarkers-cross-sectional findings from the population-based Study of Health in Pomerania. Clin Endocrinol (Oxf) 75:561-566
31. Völzke H, Alte D, Kohlmann T, Lüdemann J, Nauck M, John U, Meng W 2005 Reference intervals of serum thyroid function tests in a previously iodine-deficient area. Thyroid 15:279-285 (Pubitemid 40424602)
32. Torkler S, Wallaschofski H, Baumeister SE, Völzke H, Dörr M, Felix S, Rettig R, Nauck M, Haring R 2011 Inverse association between total testosterone concentrations, incident hypertension and blood pressure. Aging Male 14:176-182
33. Koenker R 2005 Quantile regression. New York: Cambridge University Press
34. Statistisches Bundesamt Deutschland (Federal Statistics Germany). Fachserie 1 Reihe 1.3. Bevölkerungsfortschreibung. Bevölkerung und Erwerbstätigkeit 2008. Available at: http:// www.destatis.de/jetspeed/ portal/cms/Sites/destatis/Internet/DE/ Content/Publikationen/ Fachveroeffentlichungen/Bevoelkerung/ Bevoelkerungsstand/ Bevoelkerungsfortschreibung2010130087004, property=file.pdf. Accessed 22 November 2011
35. Cawood ML, Field HP, Ford CG, Gillingwater S, Kicman A, Cowan D, Barth JH 2005 Testosterone measurement by isotope-dilution liquid chromatography-tandem mass spectrometry: validation of a method for routine clinical practice. Clin Chem 51:1472-1479 (Pubitemid 41060880)
36. Thienpont LM, Van Nieuwenhove B, Stöckl D, Reinauer H, De Leenheer AP 1996 Determination of reference method values by isotope dilution-gas chromatography/mass spectrometry: a five years' experience of two European reference laboratories. Eur J Clin Chem Clin Biochem 34:853-860 (Pubitemid 26383887)
37. Elliott KJ, Cable NT, Reilly T, Diver MJ 2003 Effect of menstrual cycle phase on the concentration of bioavailable 17-β oestradiol and testosterone and muscle strength. Clin Sci (Lond) 105:663-669 (Pubitemid 38002356)
38. Oka K, Hirano T, Noguchi M 1988 Changes in the concentration of testosterone in serum during the menstrual cycle, as determined by liquid chromatography. Clin Chem 34:557-560
39. Rothman MS, Carlson NE, Xu M, Wang C, Swerdloff R, Lee P, Goh VH, Ridgway EC, Wierman ME 2011 Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry. Steroids 76:177-182
40. Salonia A, Pontillo M, Nappi RE, Zanni G, Fabbri F, Scavini M, Daverio R, Gallina A, Rigatti P, Bosi E, Bonini PA, Montorsi F 2008 Menstrual cycle-related changes in circulating androgens in healthy women with self-reported normal sexual function. J Sex Med 5:854-863 (Pubitemid 351472195)
41. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group 2004 Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 9:41-48