A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid

Journal of Biochemistry

Volumn 153, Issue 5, 2013, Pages 421-429

  Ago, Hideo ^a,d   Okimoto, Noriaki ^b   Kanaoka, Yoshihide ^c   Morimoto, Gentaro ^b   Ukita, Yoko ^a   Saino, Hiromichi ^a   Taiji, Makoto ^b   Miyano, Masashi ^a  

^a Harima Institute ^*  (Japan)

^b RIKEN   (Japan)

^c HARVARD MEDICAL SCHOOL   (United States)

^d AOYAMA GAKUIN UNIVERSITY   (Japan)

Author keywords

enzyme inhibitor; in silico screening; inflammation; leukotriene; membrane protein

Indexed keywords

5 (5 METHYLENE 4 OXO 4,5 DIHYDROTHIAZOL 2 YLAMINO) ISOPHTHALIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ISOPHTHALIC ACID; LEUKOTRIENE C4 SYNTHASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE; ISOPHTHALATE; LEUKOTRIENE-C4 SYNTHASE; PHTHALIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CERVICAL SPINE; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG INHIBITION; ENZYME ASSAY; GLUTATHIONE METABOLISM; IC 50; MOUSE; NONHUMAN; WHOLE CELL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM;

ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; MOLECULAR STRUCTURE; PHTHALIC ACIDS;

EID: 84877258351     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvt007     Document Type: Article

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