Ligand-independent Tie2 dimers mediate kinase activity stimulated by high dose angiopoietin-1

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 12469-12477

  Yamakawa, Daishi ^a   Kidoya, Hiroyasu ^a   Sakimoto, Susumu ^a   Jia, Weizhen ^a   Naito, Hisamichi ^a   Takakura, Nobuyuki ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; BIOLOGICAL SIGNIFICANCE; COMPLEMENTATION; DIMERIZATION DOMAIN; INTRACELLULAR DOMAIN; KINASE ACTIVITY; RECEPTOR TYROSINE KINASE; VASCULAR ENDOTHELIAL CELLS;

AMINO ACIDS; BLOOD VESSELS; DIMERIZATION; ENDOTHELIAL CELLS; ENZYMES; OLIGOMERS; PHOSPHORYLATION;

LIGANDS;

ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; TIE 1 RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BIMOLECULAR FLUORESCENCE COMPLEMENTATION ASSAY; CELL SURFACE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLUORESCENCE ANALYSIS; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANGIOGENESIS; ANGIOPOIETIN; ENDOTHELIAL CELL; IMAGING; TYROSINE PROTEIN KINASE (TYROSINE KINASE); VASCULAR BIOLOGY;

AMINO ACID MOTIFS; ANGIOPOIETIN-1; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; MICE; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, TIE-1; RECEPTOR, TIE-2;

EID: 84877154358     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.433979     Document Type: Article

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