Edaravone alleviates hypoxia-acidosis/reoxygenation-induced neuronal injury by activating ERK1/2

Neuroscience Letters

Volumn 543, Issue , 2013, Pages 72-77

  Wang, Guibin ^a,b   Su, Jingjing ^c   Li, Lingjuan ^a   Feng, Jie ^a   Shi, Lei ^b   He, Wei ^b   Liu, Yunhai ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b 163rd Hospital of the Chinese People's Liberation Army   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Edaravone; ERK1 2; Hypoxia acidosis reoxygenation; Neuronal injury

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACID SENSING ION CHANNEL; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NORPHENAZONE; PROTEIN BCL 2;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPOXIA; NERVE INJURY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REOXYGENATION;

ACIDOSIS; ANIMALS; ANTIPYRINE; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CELL HYPOXIA; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME ACTIVATION; GLUCOSE; HYDROGEN-ION CONCENTRATION; L-LACTATE DEHYDROGENASE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NEUROPROTECTIVE AGENTS; OXYGEN; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS;

EID: 84877151920     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.02.067     Document Type: Article

References (18)

1. Aemiya S., Kamiya T., Nito C., Inaba T., Kato K., Ueda M., Shimazaki K., Katayama Y. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur. J. Pharmacol. 2005, 516:125-130.
2. Arumugam S., Thandavarayan R.A., Veeraveedu P.T., Giridharan V.V., Soetikno V., Harima M., Suzuki K., Nagata M., Tagaki R., Kodama M., Watanabe K. Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant. Exp. Mol. Pathol. 2012, 93:183-189.
3. Choi D.W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 1988, 11:465-469.
4. Edaravone Acute Infarction Study Group Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc. Dis. 2003, 15:222-229.
5. Hayashi H., Tsuchiya Y., Nakayama K., Satoh T., Nishida E. Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling. Genes Cells 2008, 13:941-947.
6. Ishikawa A., Yoshida H., Metoki N., Toki T., Imaizumi T., Matsumiya T., Yamashita K., Taima K., Satoh K. Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia. Neurosci. Res. 2007, 59:406-412.
7. Kawasaki T., Kitao T., Nakagawa K., Fujisaki H., Takegawa Y., Koda K., Ago Y., Baba A., Matsuda T. Nitric oxide-induced apoptosis in cultured rat astrocytes: protection by edaravone, a radical scavenger. Glia 2007, 55:1325-1333.
8. Lee B.J., Egi Y., van Leyen K., Lo E.H., Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010, 1307:22-27.
9. Lee J.M., Zipfel G.J., Choi D.W. The changing landscape of ischaemic brain injury mechanisms. Nature 1999, 399:A7-A14.
10. Liu X.Y., Yao L.L., Chen Y.J., Tao B.B., Yu Y.C., Bian W.H., Yu J., Wang Y.G. Survivin is involved in the anti-apoptotic effect of edaravone in PC12 cells. Mol. Cell. Biochem. 2009, 327:21-28.
11. Liu L., Zhang R., Liu K., Zhou H., Yang X., Liu X., Tang M., Su J., Dong Q. Tissue kallikrein protects cortical neurons against in vitro ischemia-acidosis/reperfusion-induced injury through the ERK1/2 pathway. Exp. Neurol. 2009, 219:453-465.
12. Nemoto E.M., Frinak S. Brain tissue pH after global brain ischemia and barbiturate loading in rats. Stroke 1981, 12:77-82.
13. Pignataro G., Simon R.P., Xiong Z.G. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 2007, 130:151-158.
14. Siesjö B.K., Katsura K., Kristián T. Acidosis-related damage. Adv. Neurol. 1996, 71:209-233. discussion 234-236.
15. Xiong Z.G., Zhu X.M., Chu X.P., Minami M., Hey J., Wei W.L., MacDonald J.F., Wemmie J.A., Price M.P., Welsh M.J., Simon R.P. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell 2004, 118:687-698.
16. Yamashita T., Deguchi K., Nagotani S., Abe K. Vascular protection and restorative therapy in ischemic stroke. Cell Transplant. 2011, 20:95-97.
17. Yan Y., Gong K., Ma T., Zhang L., Zhao N., Zhang X., Tang P., Gong Y. Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells. Neurosci. Lett. 2012, 531:160-165.
18. Zhang W., Sato K., Hayashi T., Omori N., Nagano I., Kato S., Horiuchi S., Abe K. Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain. Neurol. Res. 2004, 26:342-348.