Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 304, Issue 6, 2013, Pages

  Takemura, Yoshizumi ^a,b   Helms, My N ^a   Eaton, Amity F ^a   Self, Julie ^a   Ramosevac, Semra ^a   Jain, Lucky ^a   Bao, Hui Fang ^a   Eaton, Douglas C ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Alveolar type 2 epithelial cell; Cholinergic receptor; Epithelial sodium channels; Single channel recording

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ATROPINE; CARBACHOL; EPITHELIAL SODIUM CHANNEL; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; NICOTINE; NICOTINIC RECEPTOR; OXOTREMORINE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; AMIDE; EPITHELIAL SODIUM CHANNEL STIMULATING AGENT; MUSCARINIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINIC AGENT; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG FLUID; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; LUNG ALVEOLUS CELL; MEMBRANE POTENTIAL; METABOLISM; MOUSE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMIDES; ANIMALS; ATROPINE; CARBACHOL; CELLS, CULTURED; ENZYME ACTIVATION; EPITHELIAL SODIUM CHANNEL AGONISTS; EPITHELIAL SODIUM CHANNELS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; NICOTINE; NICOTINIC AGONISTS; OXOTREMORINE; PATCH-CLAMP TECHNIQUES; PNEUMOCYTES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN;

MLCS; MLOWN;

EID: 84877146339     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00129.2012     Document Type: Article

References (32)

1. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405: 458-462, 2000.
2. Boucher RC. Molecular insights into the physiology of the "thin film" of airway surface liquid. J Physiol 516: 631-638, 1999.
3. Chen XJ, Eaton DC, Jain L. β-Adrenergic regulation of amiloridesensitive lung sodium channels. Am J Physiol Lung Cell Mol Physiol 282: L609-L6220, 2002.
4. Chen XJ, Seth S, Yue G, Kamat P, Compans RW, Guidot D, Brown LA, Eaton DC, Jain L. Influenza virus inhibits ENaC and lung fluid clearance. Am J Physiol Lung Cell Mol Physiol 287: L366-L373, 2004.
5. Downs CA, Kriener LH, Yu L, Eaton DC, Jain L, Helms MN. β-Adrenergic agonists differentially regulate highly selective and nonselective epithelial sodium channels to promote alveolar fluid clearance in vivo. Am J Physiol Lung Cell Mol Physiol 302: L1167-L1178, 2012.
6. + channels in lung alveolar type II epithelial cells. Proc Am Thorac Soc 1: 10-16, 2004.
7. Eaton DC, Helms MN, Koval M, Bao HF, Jain L. The contribution of epithelial sodium channels to alveolar function in health and disease. Annu Rev Physiol 71: 403-423, 2009.
8. Engelhardt JF, Yankaskas JR, Ernst SA, Yang Y, Marino CR, Boucher RC, Cohn JA, Wilson JM. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat Genet 2: 240-248, 1992.
9. Gosens R, Zaagsma J, Meurs H, Halayko AJ. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 7: 73, 2006.
10. Gross NJ, Skorodin MS. Role of the parasympathetic system in airway obstruction due to emphysema. N Engl J Med 311: 421-425, 1984.
11. Helms MN, Chen XJ, Ramosevac S, Eaton DC, Jain L. Dopamine regulation of amiloride-sensitive sodium channels in lung cells. Am J Physiol Lung Cell Mol Physiol 290: L710-L722, 2006.
12. Helms MN, Self J, Bao HF, Job LC, Jain L, Eaton DC. Dopamine activates amiloride-sensitive sodium channels in alveolar type I cells in lung slice preparations. Am J Physiol Lung Cell Mol Physiol 291: L610-L618, 2006.
13. Jain L, Chen XJ, Malik B, Al-Khalili OK, Eaton DC. Antisense oligonucleotides against the α-subunit of ENaC decrease lung epithelial cation-channel activity. Am J Physiol Lung Cell Mol Physiol 276: L1046-L1051, 1999.
14. Jain L, Chen XJ, Ramosevac S, Brown LA, Eaton DC. Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions. Am J Physiol Lung Cell Mol Physiol 280: L646-L658, 2001.
15. Keller J, Schmidt M, Hussein B, Rumenapp U, Jakobs KH. Muscarinic receptor-stimulated cytosol-membrane translocation of RhoA. FEBS Lett 403: 299-302, 1997.
16. Knowles M, Murray G, Shallal J, Askin F, Ranga V, Gatzy J, Boucher R. Bioelectric properties and ion flow across excised human bronchi. J Appl Physiol 56: 868-877, 1984.
17. Marunaka Y, Eaton DC. Effects of vasopressin and cAMP on single amiloride-blockable Na channels. Am J Physiol Cell Physiol 260: C1071-C1084, 1991.
18. Matalon S, Lazrak A, Jain L, Eaton DC. Biophysical properties of sodium channels in lung alveolar epithelial cells. J Appl Physiol 93: 1852-1859, 2002.
19. Pochynyuk O, Bugaj V, Stockand JD. Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens 17: 533-540, 2008.
20. + channel in response to RhoA signaling. J Biol Chem 281: 26520-26527, 2006.
21. + channel toward the plasma membrane with total internal reflection fluorescencefluorescence recovery after photobleaching. J Biol Chem 282: 14576-14585, 2007.
22. + channel (ENaC) by phosphatidylinositides. J Physiol 580: 365-372, 2007.
23. Racke K, Juergens UR, Matthiesen S. Control by cholinergic mechanisms. Eur J Pharmacol 533: 57-68, 2006.
24. Roffel AF, Elzinga CR, Van Amsterdam RG, De Zeeuw RA, Zaagsma J. Muscarinic M2 receptors in bovine tracheal smooth muscle: discrepancies between binding and function. Eur J Pharmacol 153: 73-82, 1988.
25. Seasholtz TM, Majumdar M, Brown JH. Rho as a mediator of G protein-coupled receptor signaling. Mol Pharmacol 55: 949-956, 1999.
26. + channel. J Biol Chem 279: 49989-49994, 2004.
27. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol 37: 186-192, 2007.
28. Takeyama K, Tamaoki J, Nakata J, Konno K. Effect of oxitropium bromide on histamine-induced airway goblet cell secretion. Am J Respir Crit Care Med 154: 231-236, 1996.
29. Tamaoki J, Chiyotani A, Tagaya E, Takemura H, Konno K. Cholinergic control of rabbit tracheal transepithelial potential difference in vivo. Eur Respir J 9: 1632-1636, 1996.
30. Tokuyama K, Kuo HP, Rohde JA, Barnes PJ, Rogers DF. Neural control of goblet cell secretion in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 259: L108-L115, 1990.
31. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421: 384-388, 2003.
32. Woods BA, Ng W, Thakorlal D, Liu AL, Perks AM. Effects of acetylcholine on lung liquid production by in vitro lungs from fetal guinea pigs. Can J Physiol Pharmacol 74: 918-927, 1996.