Expression of MUC17 is regulated by HIF1α -mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Kitamoto, Sho ^a   Yokoyama, Seiya ^a   Higashi, Michiyo ^a   Yamada, Norishige ^a   Matsubara, Shyuichiro ^b   Takao, Sonshin ^b   Batra, Surinder K ^c   Yonezawa, Suguru ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MUC17 PROTEIN; MUCIN; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN; MUC17 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CANCER GROWTH; CANCER RISK; CELL HYPOXIA; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DISEASE ASSOCIATION; DNA METHYLATION; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PANCREAS ADENOCARCINOMA; PANCREATIC CANCER CELL LINE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR MICROENVIRONMENT; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PANCREAS TUMOR; PATHOLOGY; PROTEIN BINDING; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

BASE SEQUENCE; CELL HYPOXIA; CELL LINE, TUMOR; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MOLECULAR SEQUENCE DATA; MUCINS; PANCREATIC NEOPLASMS; PROTEIN BINDING; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84877145991     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044108     Document Type: Article

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