Endocannabinoid metabolism in the prefrontal cortex in schizophrenia

Schizophrenia Research

Volumn 147, Issue 1, 2013, Pages 53-57

  Volk, David W ^a   Siegel, Benjamin I ^a   Verrico, Christopher D ^a,b   Lewis, David A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Hydrolase domain 6; 2 Arachidonylglycerol; ABHD6; Cannabinoid receptor; Cannabis

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ALPHA BETA HYDROLASE; CANNABIS; HALOPERIDOL; HYDROLASE; MESSENGER RNA; OLANZAPINE; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

ABHD6 GENE; ADULT; AGE; ARTICLE; BRAIN METABOLISM; CANNABIS ADDICTION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; FEMALE; GENE; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN TISSUE; MACACA FASCICULARIS; MALE; MEMORY DISORDER; NEUROTOXICITY; NONHUMAN; POLYMERASE CHAIN REACTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; SCHIZOPHRENIA; TREATMENT DURATION;

ADOLESCENT; ADULT; AGE FACTORS; ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BERBERINE; CALCIUM CHANNEL BLOCKERS; ENDOCANNABINOIDS; FEMALE; GENE EXPRESSION REGULATION; HALOPERIDOL; HUMANS; MACACA FASCICULARIS; MALE; MIDDLE AGED; MONOACYLGLYCEROL LIPASES; PREFRONTAL CORTEX; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84877144492     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2013.02.038     Document Type: Article

References (35)

1. Akbarian S., Kim J.J., Potkin S.G., Hagman J.O., Tafazzoli A., Bunney W.E., Jones E.G. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch. Gen. Psychiatry 1995, 52:258-266.
2. Bellon A. New genes associated with schizophrenia in neurite formation: a review of cell culture experiments. Mol. Psychiatry 2007, 12:620-629.
3. Bellon A., Krebs M.O., Jay T.M. Factoring neurotrophins into a neurite-based pathophysiological model of schizophrenia. Prog. Neurobiol. 2011, 94:77-90.
4. Berghuis P., Dobszay M.B., Wang X., Spano S., Ledda F., Sousa K.M., Schulte G., Ernfors P., Mackie K., Paratcha G., Hurd Y.L., Harkany T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:19115-19120.
5. Berghuis P., Rajnicek A.M., Morozov Y.M., Ross R.A., Mulder J., Urban G.M., Monory K., Marsicano G., Matteoli M., Canty A., Irving A.J., Katona I., Yanagawa Y., Rakic P., Lutz B., Mackie K., Harkany T. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science 2007, 316:1212-1216.
6. Casadio P., Fernandes C., Murray R.M., Di Forti M. Cannabis use in young people: the risk for schizophrenia. Neurosci. Biobehav. Rev. 2011, 35:1779-1787.
7. Compton M.T., Kelley M.E., Ramsay C.E., Pringle M., Goulding S.M., Esterberg M.L., Stewart T., Walker E.F. Association of pre-onset cannabis, alcohol, and tobacco use with age at onset of prodrome and age at onset of psychosis in first-episode patients. Am. J. Psychiatry 2009, 166:1251-1257.
8. Curley A.A., Arion D., Volk D.W., Asafu-Adjei J.K., Sampson A.R., Fish K.N., Lewis D.A. Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features. Am. J. Psychiatry 2011, 168:921-929.
9. Dorph-Petersen K.A., Pierri J.N., Perel J.M., Sun Z., Sampson A.R., Lewis D.A. The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 2005, 30:1649-1661.
10. D'Souza D.C., Abi-Saab W.M., Madonick S., Forselius-Bielen K., Doersch A., Braley G., Gueorguieva R., Cooper T.B., Krystal J.H. Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biol. Psychiatry 2005, 57:594-608.
11. Eggan S.M., Hashimoto T., Lewis D.A. Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch. Gen. Psychiatry 2008, 65:772-784.
12. Eggan S.M., Melchitzky D.S., Sesack S.R., Fish K.N., Lewis D.A. Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex. Neuroscience 2010, 169:1651-1661.
13. Foti D.J., Kotov R., Guey L.T., Bromet E.J. Cannabis use and the course of schizophrenia: 10-year follow-up after first hospitalization. Am. J. Psychiatry 2010, 167:987-993.
14. Fung S.J., Webster M.J., Sivagnanasundaram S., Duncan C., Elashoff M., Weickert C.S. Expression of interneuron markers in the dorsolateral prefrontal cortex of the developing human and in schizophrenia. Am. J. Psychiatry 2010, 167:1479-1488.
15. Galvez-Buccollini J.A., Proal A.C., Tomaselli V., Trachtenberg M., Coconcea C., Chun J., Manschreck T., Fleming J., DeLisi L.E. Association between age at onset of psychosis and age at onset of cannabis use in non-affective psychosis. Schizophr. Res. 2012, 139:157-160.
16. 67) expression in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry 2000, 57:1061-1069.
17. Hashimoto T., Bazmi H.H., Mirnics K., Wu Q., Sampson A.R., Lewis D.A. Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am. J. Psychiatry 2008, 165:479-489.
18. Keimpema E., Barabas K., Morozov Y.M., Tortoriello G., Torii M., Cameron G., Yanagawa Y., Watanabe M., Mackie K., Harkany T. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. J. Neurosci. 2010, 30:13992-14007.
19. Ludanyi A., Hu S.S., Yamazaki M., Tanimura A., Piomelli D., Watanabe M., Kano M., Sakimura K., Magloczky Z., Mackie K., Freund T.F., Katona I. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience 2011, 174:50-63.
20. Manrique-Garcia E., Zammit S., Dalman C., Hemmingsson T., Andreasson S., Allebeck P. Cannabis, schizophrenia and other non-affective psychoses: 35years of follow-up of a population-based cohort. Psychol. Med. 2012, 42:1321-1328.
21. Marrs W.R., Blankman J.L., Horne E.A., Thomazeau A., Lin Y.H., Coy J., Bodor A.L., Muccioli G.G., Hu S.S., Woodruff G., Fung S., Lafourcade M., Alexander J.P., Long J.Z., Li W., Xu C., Moller T., Mackie K., Manzoni O.J., Cravatt B.F., Stella N. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat. Neurosci. 2010, 13:951-957.
22. Marrs W.R., Horne E.A., Ortega-Gutierrez S., Cisneros J.A., Xu C., Lin Y.H., Muccioli G.G., Lopez-Rodriguez M.L., Stella N. Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. J. Biol. Chem. 2011, 286:28723-28728.
23. Navia-Paldanius D., Savinainen J.R., Laitinen J.T. Biochemical and pharmacological characterization of human alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J. Lipid Res. 2012, 53:2413-2424.
24. Palkovits M., Harvey-White J., Liu J., Kovacs Z.S., Bobest M., Lovas G., Bago A.G., Kunos G. Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. Neuroscience 2008, 152:1032-1039.
25. Straub R.E., Lipska B.K., Egan M.F., Goldberg T.E., Callicott J.H., Mayhew M.B., Vakkalanka R.K., Kolachana B.S., Kleinman J.E., Weinberger D.R. Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression. Mol. Psychiatry 2007, 12:854-869.
26. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3:34.1-34.11.
27. Verrico C.D., Lewis D.A. Long-term exposure of adolescent monkeys to delta 9-tetrahydrocannabinol selectively and persistently impairs spatial working memory. Soc Neurosci Abstr 2011, 911.08. 11-16-2011.
28. Verrico C.D., Liu S., Bitler E.J., Gu H., Sampson A.R., Bradberry C.W., Lewis D.A. Delay- and dose-dependent effects of delta(9)-tetrahydrocannabinol administration on spatial and object working memory tasks in adolescent rhesus monkeys. Neuropsychopharmacology 2012, 37:1357-1366.
29. Volk D.W., Austin M.C., Pierri J.N., Sampson A.R., Lewis D.A. Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch. Gen. Psychiatry 2000, 57:237-245.
30. Volk D.W., Eggan S.M., Lewis D.A. Alterations in metabotropic glutamate receptor 1alpha and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia. Am. J. Psychiatry 2010, 167:1489-1498.
31. Volk D.W., Radchenkova P.V., Walker E.M., Sengupta E.J., Lewis D.A. Cortical opioid markers in schizophrenia and across postnatal development. Cereb. Cortex 2011, 22:1215-1223.
32. Volk D.W., Matsubara T., Li S., Sengupta E.J., Georgiev D., Minabe Y., Sampson A., Hashimoto T., Lewis D.A. Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia. Am. J. Psychiatry 2012, 169:1082-1091.
33. Yoshida T., Fukaya M., Uchigashima M., Miura E., Kamiya H., Kano M., Watanabe M. Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. J. Neurosci. 2006, 26:4740-4751.
34. Yoshino H., Miyamae T., Hansen G., Zambrowicz B., Flynn M., Pedicord D., Blat Y., Westphal R.S., Zaczek R., Lewis D.A., Gonzalez-Burgos G. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. J. Physiol. 2011, 589:4857-4884.
35. Zorina Y., Iyengar R., Bromberg K.D. Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J. Biol. Chem. 2010, 285:1358-1370.