Pharmacogenetics of resistance to cisplatin and other anticancer drugs and the role of sphingolipid metabolism

Methods in Molecular Biology

Volumn 983, Issue , 2013, Pages 185-204

  Alexander, Stephen ^a   Swatson, William S ^a   Alexander, Hannah ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Ceramide; Chemotherapy; Sphingosine kinase; Sphingosine 1 phosphate; Sphingosine 1 phosphate lyase

Indexed keywords

CISPLATIN; SPHINGOLIPID;

ARTICLE; DICTYOSTELIUM DISCOIDEUM; DRUG SENSITIVITY; GENE EXPRESSION; HOMOLOGOUS RECOMBINATION; HUMAN; PHARMACOGENETICS; PRIORITY JOURNAL;

EID: 84877132059     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-302-2_10     Document Type: Article

References (41)

1. AmericanCancerSociety (2010) Cancer facts and fi gures (2010) http://www.cancer.org/Research/CancerFactsFigures/index\
2. Siddik ZH (2003) Cisplatin: Mode of cytotoxic action and molecular basis of resistance. Oncogene 22:7265-7279
3. Rabik CA, Dolan ME (2007) Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 33:9-23
4. Wernyj RP, Morin PJ (2004) Molecular mechanisms of platinum resistance: Still searching for the Achilles' heel. Drug Resist Updat 7:227-232
5. Williams JG (2010) Dictyostelium finds new roles to model. Genetics 185:717-726
6. Williams RS, Boeckeler K, Gräf R, Müller-Taubenberger A, Li Z, Isberg RR, Wessels D, Soll DR, Alexander H, Alexander S (2006) Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol Med 12:415-424
7. Glöckner G, Eichinger L, Szafranski K, Pachebat JA, Bankier AT, Dear PH, Lehmann D, Baumgart C, Parra G, Abril JF, Guigo R, Kumpf K, Tunggal B, Cox E, Quail MA, Platzer M, Rosenthal A, Noegel AA (2002) Sequence and analysis of chromosome 2 of Dictyostelium discoideum. Nature 418:79-85
8. Eichinger L, Pachebat JA, Glöckner G, Rajandream MA, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov BA, Rivero F, Bankier AT, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, (2005) The genome of the social amoeba Dictyostelium discoideum. Nature 435:43-57
9. Kessin RH (2001) Dictyostelium - evolution, cell biology, and the development of multicellularity. Cambridge Univ. Press, Cambridge
10. Kuspa A, Loomis WF (1992) Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA. Proc Natl Acad Sci U S A 89:8803-8807
11. Loomis WF (1987) Genetic tools for Dictyostelium discoideum. Methods Cell Biol 28:31-65
12. Newell PC (1982) Genetics. In: Loomis WF (ed) The development of Dictyostelium discoideum. Academic, New York
13. Garcia MXU, Roberts C, Alexander H, Stewart AM, Harwood A, Alexander S, Insall RH (2002) Methanol and acri fl avine resistance in Dictyostelium are caused by loss of catalase. Microbiology 148:333-340
14. Li GC, Alexander H, Schneider N, Alexander S (2000) Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium. Microbiology 146:2219-2227
15. Alexander S, Min J, Alexander H (2006) Dictyostelium discoideum to human cells: Pharmacogenetic studies demonstrate a role for sphingolipids in chemoresistance. Biochim Biophys Acta 1760:301-309
16. Min J, Stegner A, Alexander H, Alexander S (2004) Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum based chemotherapy drugs. Eukaryot Cell 3:795-805
17. Min J, Traynor D, Stegner AL, Zhang L, Hanigan MH, Alexander H, Alexander S (2005) Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. Eukaryot Cell 4:178-189
18. Min J, Van Veldhoven PP, Zhang L, Hanigan MH, Alexander H, Alexander S (2005) Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner. Mol Cancer Res 3:287-296
19. Min J, Mesika A, Sivaguru M, Van Veldhoven PP, Alexander H, Futerman AH, Alexander S (2007) (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. Mol Cancer Res 5:801-812
20. Sridevi P, Alexander H, Laviad EL, Min J, Mesika A, Hannink M, Futerman AH, Alexander S (2010) Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Exp Cell Res 316:78-91
21. Sridevi P, Alexander H, Laviad EL, Pewzner-Jung Y, Hannink M, Futerman AH, Alexander S (2009) Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochim Biophys Acta 1793:1218-1227
22. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (2006) Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A 103: 17384-17389
23. Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH Jr, Saba JD (2004) Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem 279:1281-1290
24. Alexander S, Alexander H (2011) Lead genetic studies in Dictyostelium discoideum and translational studies in human cells demonstrate that sphingolipids are key regulators of sensitivity to cisplatin and other anticancer drugs. Semin Cell Dev Biol 22:97-104
25. Van Driessche N, Alexander H, Min J, Kuspa A, Alexander S, Shaulsky G (2007) Global transcriptional responses to cisplatin in Dictyostelium discoideum identify potential drug targets. Proc Natl Acad Sci U S A 104:15406-15411
26. Sussman M (1987) Cultivation and synchronous morphogenesis of Dictyostelium under controlled experimental conditions. Methods Cell Biol 28:9-29
27. Manstein DJ, Schuster HP, Morandini P, Hunt DM (1995) Cloning vectors for the production of proteins in Dictyostelium discoideum. Gene 162:129-134
28. Loomis WF, Kuspa A (eds) (2005) Dictyostelium genomics. Horizon Bioscience, Norfolk
29. Adley KE, Keim M, Williams RS (2006) Pharmacogenetics: De fi ning the genetic basis of drug action and inositol trisphosphate analysis. Methods Mol Biol 346:517-534
30. Keim M, Williams RS, Harwood AJ (2004) An inverse PCR technique to rapidly isolate the fl anking DNA of Dictyostelium insertion mutants. Mol Biotechnol 26:221-224
31. Faix J, Kreppel L, Shaulsky G, Schleicher M, Kimmel AR (2004) A rapid and ef fi cient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res 32:e143
32. Dubin M, Nellen W (2010) A versatile set of tagged expression vectors to monitor protein localisation and function in Dictyostelium. Gene 465:1-8
33. Li G, Foote C, Alexander S, Alexander H (2001) Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. Development 128:3473-3483
34. Williams RS (2005) Pharmacogenetics in model systems: De fi ning a common mechanism of action for mood stabilisers. Prog Neuropsychopharmacol Biol Psychiatry 29:1029-1037
35. Alexander H, Vomund AN, Alexander S (2003) Viability assay for Dictyostelium for use in drug studies. Biotechniques 35:464-470
36. Min J, Sridevi P, Alexander S, Alexander H (2006) Sensitive cell viability assay for use in drug screens and for studying the mechanism of action of drugs in Dictyostelium discoideum. Biotechniques 41:591-595
37. Veldhoven V (1999) Sphingosine-1-phosphate lyase. Methods Enzymol 311:244-254
38. Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben-David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH (2010) A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem 285:10911-10923
39. Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brugger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH Jr, Futerman AH (2010) A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem 285:10902-10910
40. King J, Insall R (2006) Parasexual genetics using axenic cells. Methods Mol Biol 346: 125-135
41. King J, Insall RH (2003) Parasexual genetics of Dictyostelium gene disruptions: Identification of a ras pathway using diploids. BMC Genet 4:12