Ribonucleotide reductase association with mammalian liver mitochondria

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 13145-13155

  Chimploy, Korakod ^a,b   Song, Shiwei ^a,c   Wheeler, Linda J ^a   Mathews, Christopher K ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF OREGON   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGICAL ACTIVITY; MAMMALIAN LIVER; MAMMALIAN TISSUES; MITOCHONDRIAL GENOMES; NUCLEAR GENOMES; RAT LIVER MITOCHONDRIA; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDES;

GENES; LAKES; MASS SPECTROMETRY; RATS; TISSUE;

MITOCHONDRIA;

CYTIDINE DIPHOSPHATE; DEOXYCYTIDINE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; GUANOSINE DIPHOSPHATE; RIBONUCLEOTIDE REDUCTASE; THYMIDINE;

ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL NUCLEUS; CELL ORGANELLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SYNTHESIS; IMMUNOPRECIPITATION; ISOTOPE LABELING; LIVER MITOCHONDRION; MAMMAL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT; REDUCTION KINETICS; SIGNAL TRANSDUCTION;

DNA PRECURSORS; DNTP SYNTHESIS; MITOCHONDRIA; MITOCHONDRIAL DNA; NUCLEOSIDE NUCLEOTIDE METABOLISM; NUCLEOTIDE; RIBONUCLEOTIDE REDUCTASE;

ANIMALS; CATALYTIC DOMAIN; DEOXYRIBONUCLEOTIDES; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; RATS; RIBONUCLEOTIDE REDUCTASES;

MAMMALIA; RATTUS;

EID: 84877122947     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.461111     Document Type: Article

References (41)

1. Schaaper, R. M., and Mathews, C. K. (2013) Mutational consequences of dNTP pool imbalance in. E. coli. DNA Repair 12, 73-79
2. Kumar, D., Abdulovic, A. L., Viberg, J., Nilsson, A. K., Kunkel, T. A., and Chabes, A. (2011) Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools. Nucleic Acids Res. 39, 1360-1371
3. Mathews, C. K., and Ji, J. (1992) DNA precursor asymmetries, replication fidelity, and variable genome evolution. BioEssays 14, 295-301
4. Martomo, S. A., and Mathews, C. K. (2002) Effects of biological DNA precursor pool asymmetry upon accuracy of DNA replication in vitro. Mutat. Res. 499, 197-211 (Pubitemid 34119396)
5. Song, S., Pursell, Z. F., Copeland, W. C., Longley, M. J., Kunkel, T. A., and Mathews, C. K. (2005) DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity. Proc. Natl. Acad. Sci. U.S.A. 102, 4990-4995
6. Wheeler, L. J., and Mathews, C. K. (2011) Nucleoside triphosphate pool asymmetry in mammalian mitochondria. J. Biol. Chem. 286, 16992-16996
7. Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., and Loeb, L. A. (2007) Mitochondrial point mutations do not limit the natural lifespan of mice. Nat. Genet. 39, 540-543 (Pubitemid 46514771)
8. Rotskaya, U. N., Rogozin, I. B., Vasyunina, E. A., Malyarchuk, B. A., Nevinsky, G. A., and Sinitsyna, O. I. (2010) High frequency of somatic mutations in rat liver mitochondrial DNA. Mutat. Res. 685, 97-102
9. Arnér, E. S., and Eriksson, S. (1995) Mammalian deoxyribonucleoside kinases. Pharmacol. Ther. 67, 155-186
10. Pontarin, G., Gallinaro, L., Ferraro, P., Reichard, P., and Bianchi, V. (2003) Origins of mitochondrial thymidine triphosphate. Dynamic relations to cytosolic pools. Proc. Natl. Acad. Sci. U.S.A. 100, 12159-12164 (Pubitemid 37271531)
11. Rampazzo, C., Fabris, S., Franzolin, E., Crovatto, K., Frangini, M., and Bianchi, V. (2007) Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells. J. Biol. Chem. 282, 34758-34769 (Pubitemid 350232408)
12. Pontarin, G., Ferraro, P., Håkansson, P., Thelander, L., Reichard, P., and Bianchi, V. (2007) p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of DNA damage. J. Biol. Chem. 282, 16820-16828 (Pubitemid 47093192)
13. Pontarin, G., Ferraro, P., Bee, L., Reichard, P., and Bianchi, V. (2012) Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells. Proc. Natl. Acad. Sci. U.S.A. 109, 13302-13307
14. Copeland, W. C. (2012) Defects in mitochondrial DNA replication and human disease. Crit. Rev. Biochem. Mol. Biol. 47, 64-74
15. Bourdon, A., Minai, L., Serre, V., Jais, J.-P., Sarzi, E., Aubert, S., Chrétien, D., de Lonlay, P., Paquis-Flucklinger, V., Arakawa, H., Nakamura, Y., Munnich, A., and Rötig, A. (2007) Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat. Genet. 39, 776-780 (Pubitemid 46848590)
16. Young, P., Leeds, J. M., Slabaugh, M. B., and Mathews, C. K. (1994) Ribonucleotide reductase. Evidence for specific association with HeLa cell mitochondria. Biochem. Biophys. Res. Commun. 203, 46-52
17. Anderson, D. D., Quintero, C. M., and Stover, P. J. (2011) Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc. Natl. Acad. Sci. U.S.A. 108, 15163-15168
18. Song, S., Wheeler, L. J., and Mathews, C. K. (2003) Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA. J. Biol. Chem. 278, 43893-43896 (Pubitemid 37377127)
19. Slabaugh, M. B., Johnson, T. L., and Mathews, C. K. (1984) Vaccinia virus induces ribonucleotide reductase in primate cells. J. Virol. 52, 507-514 (Pubitemid 15202487)
20. Wroblewski, F., and Ladue, J. S. (1955) Lactic dehydrogenase activity in blood. Proc. Soc. Exp. Biol. Med. 9, 210-213
21. Robinson, J. B. Jr. (1987) An enzymatic approach to the study of the Krebs tricarboxylic acid cycle. In Mitochondria: A Practical Approach Series (Darley-Usmar, V. M., Rickwood, D., and Wilson, T. M., eds) pp. 153-170, IRL Press, Washington, D. C.
22. Schnaitman, C., and Greenawalt, J. W. (1968) Enzymatic properties of the inner and outer membranes of rat liver mitochondria. J. Cell Biol. 38, 158-175
23. Darley-Usmar, V. M., Capaldi, R. A., Takamiya, S., Millett, F., Wilson, M. T., Malatesta, F., and Sarti, P. (1987) Reconstitution and molecular analysis of the respiratory chain. In Mitochondria: A Practical Approach Series (Darley-Usmar, V. M., Rickwood, D., and Wilson, T. M., eds) pp. 113-152, IRL Press, Washington, D. C.
24. Wang, Y., and Bogenhagen, D. F. (2006) Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane. J. Biol. Chem. 281, 25791-25802 (Pubitemid 44401967)
25. Ferraro, P., Nicolosi, L., Bernardi, P., Reichard, P., and Bianchi, V. (2006) Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate. Proc. Natl. Acad. Sci. U.S.A. 103, 18586-18591 (Pubitemid 44913454)
26. Ferraro, P., Franzolin, E., Pontarin, G., Reichard, P., and Bianchi, V. (2010) Quantitation of cellular deoxynucleoside triphosphates. Nucleic Acids Res. 38, e85
27. Sherman, P. A., and Fyfe, J. A. (1989) Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers. Anal. Biochem. 180, 222-226 (Pubitemid 19198050)
28. Mathews, C. K., and Wheeler, L. J. (2009) Measuring DNA precursor pools in mitochondria. Methods Mol. Biol. 554, 371-381
29. Shewach, D. S. (1992) Quantitation of deoxyribonucleoside 5′-triphosphates by a sequential boronate and anion-exchange high-pressure liquid chromatographic procedure. Anal. Biochem. 206, 178-182
30. Turner, M. K., Abrams, R., and Lieberman, I. (1968) Levels of ribonucleotide reductase activity during the division cycle of the L cell. J. Biol. Chem. 243, 3725-3728
31. Elford, H. L., Freese, M., Passamani, E., and Morris, H. P. (1970) Ribonucleotide reductase and cell proliferation. J. Biol. Chem. 245, 5228-5233
32. Kang, D., Nishida, J., Iyama, A., Nakabeppu, Y., Furiuchi, M., Fujiwara, T., Sekiguchi, M., and Takeshiga, K. (1995) Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. J. Biol. Chem. 270, 14659-14665
33. Ragan, C. I., Wilson, M. T., Darley-Usmar, V. M., Lowe, P. N. (1987) Sub-fractionation of mitochondria and isolation of the proteins of oxidative phosphorylation. In Mitochondria: A Practical Approach Series (Darley-Usmar, V. M., Rickwood, D., and Wilson, T. M., eds) pp. 113-152, IRL Press, Washington, D. C.
34. Kukat, C., Wurm, C. A., Spåhr, H., Falkenberg, M., Larsson, N.-G., and Jakobs, S. (2011) Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA. Proc. Natl. Acad. Sci. U.S.A. 108, 13534-13539
35. Song, S. (2005) Precursors for mitochondrial DNA replication: Metabolic sources and relations to mutagenesis and human diseases, Ph.D. Thesis, Oregon State University
36. Rampazzo, C., Gallinaro, L., Milanesi, E.,Frigimelica, E., Reichard, P., and Bianchi, V. (2000) A deoxyribonucleotidase in mitochondria. Involvement in regulation of dNTP pools and possible link to genetic disease. Proc. Natl. Acad. Sci. U.S.A. 97, 8239-8244 (Pubitemid 30639656)
37. Rampazzo, C., Miazzi, C., Franzolin, E., Pontarin, G., Ferraro, P., Frangini, M., Reichard, P., and Bianchi, V. (2010) Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances. Mutat. Res. 703, 2-10
38. Becker, T., Böttinger, L., and Pfanner, N. (2012) Mitochondrial protein import. From transport pathways to an integrated network. Trends Biochem. Sci. 37, 85-91
39. Dudek, J., Rehling, P., and van der Laan, M. (2013) Mitochondrial protein import. Common principles and physiological networks. Biochim. Biophys. Acta 1833, 274-285
40. Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., Hill, D. E., Vidal, M., Evans, J. G., Thorburn, D. R., Carr, S. A., and Mootha, V. K. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134, 112-123 (Pubitemid 351916708)
41. Morris, G. W., Iams, T. A., Slepchenko, K. G., and McKee, E. E. (2009) Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart. Implications for 3′-azido-3′-deoxythymidine-dependent cardiotoxicity. Biochem. J. 422, 513-520