메뉴 건너뛰기




Volumn 27, Issue 3, 2013, Pages 133-142

Management of older adults with multiple myeloma

Author keywords

Bortezomib; Elderly patients; Fit; Lenalidomide; Multiple myeloma; Thalidomide; Unfit

Indexed keywords

ACETYLSALICYLIC ACID; ACICLOVIR; ANTIANEMIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CARFILZOMIB; CLODRONIC ACID; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; ELOTUZUMAB; GRANULOCYTE COLONY STIMULATING FACTOR; LENALIDOMIDE; LOW MOLECULAR WEIGHT HEPARIN; MELPHALAN; PAMIDRONIC ACID; PLACEBO; POMALIDOMIDE; PREDNISONE; THALIDOMIDE; ZOLEDRONIC ACID;

EID: 84877111787     PISSN: 0268960X     EISSN: 15321681     Source Type: Journal    
DOI: 10.1016/j.blre.2013.04.001     Document Type: Article
Times cited : (41)

References (89)
  • 1
    • 79952781038 scopus 로고    scopus 로고
    • Multiple myeloma
    • Palumbo A., Anderson K. Multiple myeloma. N Engl J Med 2011, 364(11):1046-1060.
    • (2011) N Engl J Med , vol.364 , Issue.11 , pp. 1046-1060
    • Palumbo, A.1    Anderson, K.2
  • 2
    • 41949114641 scopus 로고    scopus 로고
    • Recent major improvement in long-term survival of younger patients with multiple myeloma
    • Brenner H., Gondos A., Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood 2008, 111(5):2521-2526.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2521-2526
    • Brenner, H.1    Gondos, A.2    Pulte, D.3
  • 3
    • 84861532638 scopus 로고    scopus 로고
    • Clonal competition with alternating dominance in multiple myeloma
    • Keats J.J., Chesi M., Egan J.B., Garbitt V.M., Palmer S.E., Braggio E., et al. Clonal competition with alternating dominance in multiple myeloma. Blood 2012, 120(5):1067-1076.
    • (2012) Blood , vol.120 , Issue.5 , pp. 1067-1076
    • Keats, J.J.1    Chesi, M.2    Egan, J.B.3    Garbitt, V.M.4    Palmer, S.E.5    Braggio, E.6
  • 4
    • 84864561961 scopus 로고    scopus 로고
    • Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides
    • Egan J.B., Shi C.-X., Tembe W., Christoforides A., Kurdoglu A., Sinari S., et al. Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides. Blood 2012, 120(5):1060-1066.
    • (2012) Blood , vol.120 , Issue.5 , pp. 1060-1066
    • Egan, J.B.1    Shi, C.-X.2    Tembe, W.3    Christoforides, A.4    Kurdoglu, A.5    Sinari, S.6
  • 5
  • 6
    • 84873566331 scopus 로고    scopus 로고
    • Improvement in long-term outcomes with successive total therapy trials for multiple myeloma: are patients now being cured?
    • Usmani S.Z., Crowley J., Hoering A., Mitchell A., Waheed S., Nair B., et al. Improvement in long-term outcomes with successive total therapy trials for multiple myeloma: are patients now being cured?. Leukemia 2013, 27(1):226-232.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 226-232
    • Usmani, S.Z.1    Crowley, J.2    Hoering, A.3    Mitchell, A.4    Waheed, S.5    Nair, B.6
  • 7
    • 84856719479 scopus 로고    scopus 로고
    • Risk of progression and survival in multiple myeloma relapsing after therapy with imids and bortezomib: a multicenter international myeloma working group study
    • Kumar S.K., Lee J.H., Lahuerta J.J., Morgan G., Richardson P.G., Crowley J., et al. Risk of progression and survival in multiple myeloma relapsing after therapy with imids and bortezomib: a multicenter international myeloma working group study. Leukemia 2012, 26(1):149-157.
    • (2012) Leukemia , vol.26 , Issue.1 , pp. 149-157
    • Kumar, S.K.1    Lee, J.H.2    Lahuerta, J.J.3    Morgan, G.4    Richardson, P.G.5    Crowley, J.6
  • 8
    • 36349031205 scopus 로고    scopus 로고
    • Complete response correlates with long-term survival and progression-free survival in high-dose therapy in multiple myeloma
    • Van de Velde H.J.K., Liu X., Chen G., Deraedt W., Bayssas M. Complete response correlates with long-term survival and progression-free survival in high-dose therapy in multiple myeloma. Haematologica 2007, 92(10):1399-1406.
    • (2007) Haematologica , vol.92 , Issue.10 , pp. 1399-1406
    • Van de Velde, H.J.K.1    Liu, X.2    Chen, G.3    Deraedt, W.4    Bayssas, M.5
  • 9
    • 79953078844 scopus 로고    scopus 로고
    • Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patients
    • Gay F., Larocca A., Wijermans P., Cavallo F., Rossi D., Schaafsma R., et al. Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patients. Blood 2011, 117(11):3025-3031.
    • (2011) Blood , vol.117 , Issue.11 , pp. 3025-3031
    • Gay, F.1    Larocca, A.2    Wijermans, P.3    Cavallo, F.4    Rossi, D.5    Schaafsma, R.6
  • 10
    • 78650993336 scopus 로고    scopus 로고
    • Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trial
    • Palumbo A., Bringhen S., Rossi D., Cavalli M., Larocca A., Ria R., et al. Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trial. J Clin Oncol 2010, 28(34):5101-5109.
    • (2010) J Clin Oncol , vol.28 , Issue.34 , pp. 5101-5109
    • Palumbo, A.1    Bringhen, S.2    Rossi, D.3    Cavalli, M.4    Larocca, A.5    Ria, R.6
  • 11
    • 84862937267 scopus 로고    scopus 로고
    • The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis
    • Morgan G.J., Gregory W.M., Davies F.E., Bell S.E., Szubert A.J., Brown J.M., et al. The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis. Blood 2012, 119(1):7-15.
    • (2012) Blood , vol.119 , Issue.1 , pp. 7-15
    • Morgan, G.J.1    Gregory, W.M.2    Davies, F.E.3    Bell, S.E.4    Szubert, A.J.5    Brown, J.M.6
  • 12
    • 79953246757 scopus 로고    scopus 로고
    • Bortezomib, melphalan, prednisone and thalidomide followed by maintenance with bortezomib and thalidomide (VMPT-VT) for initial treatment of elderly multiple myeloma patients: updated follow-up and impact of prognostic factors
    • Palumbo A., Bringhen S., Cavalli M., Ria R., Offidani M., Patriarca F., et al. Bortezomib, melphalan, prednisone and thalidomide followed by maintenance with bortezomib and thalidomide (VMPT-VT) for initial treatment of elderly multiple myeloma patients: updated follow-up and impact of prognostic factors. ASH Annual Meeting Abstracts 2010, 116(21):620.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 620
    • Palumbo, A.1    Bringhen, S.2    Cavalli, M.3    Ria, R.4    Offidani, M.5    Patriarca, F.6
  • 13
    • 84874311612 scopus 로고    scopus 로고
    • Overall survival benefit for bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in newly diagnosed multiple myeloma patients
    • Palumbo A., Bringhen S., Rossi D., Cavalli M., Ria R., Gentilini S., et al. Overall survival benefit for bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in newly diagnosed multiple myeloma patients. ASH Annual Meeting Abstracts 2012, 120(21):200.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 200
    • Palumbo, A.1    Bringhen, S.2    Rossi, D.3    Cavalli, M.4    Ria, R.5    Gentilini, S.6
  • 14
    • 84860744403 scopus 로고    scopus 로고
    • Continuous lenalidomide treatment for newly diagnosed multiple myeloma
    • Palumbo A., Hajek R., Delforge M., Kropff M., Petrucci M.T., Catalano J., et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N Engl J Med 2012, 366(19):1759-1769.
    • (2012) N Engl J Med , vol.366 , Issue.19 , pp. 1759-1769
    • Palumbo, A.1    Hajek, R.2    Delforge, M.3    Kropff, M.4    Petrucci, M.T.5    Catalano, J.6
  • 15
    • 80051570906 scopus 로고    scopus 로고
    • Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials
    • Fayers P.M., Palumbo A., Hulin C., Waage A., Wijermans P., Beksaç M., et al. Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials. Blood 2011, 118(5):1239-1247.
    • (2011) Blood , vol.118 , Issue.5 , pp. 1239-1247
    • Fayers, P.M.1    Palumbo, A.2    Hulin, C.3    Waage, A.4    Wijermans, P.5    Beksaç, M.6
  • 17
    • 84866851061 scopus 로고    scopus 로고
    • Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial
    • Mateos M.-V., Oriol A., Martínez-López J., Gutiérrez N., Teruel A.I., López de la Guía A., et al. Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65 trial. Blood 2012, 120(13):2581-2588.
    • (2012) Blood , vol.120 , Issue.13 , pp. 2581-2588
    • Mateos, M.-V.1    Oriol, A.2    Martínez-López, J.3    Gutiérrez, N.4    Teruel, A.I.5    López de la Guía, A.6
  • 18
    • 80055066620 scopus 로고    scopus 로고
    • Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN)
    • Palumbo A., Bringhen S., Ludwig H., Dimopoulos M.A., Bladé J., Mateos M.V., et al. Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN). Blood 2011, 118(17):4519-4529.
    • (2011) Blood , vol.118 , Issue.17 , pp. 4519-4529
    • Palumbo, A.1    Bringhen, S.2    Ludwig, H.3    Dimopoulos, M.A.4    Bladé, J.5    Mateos, M.V.6
  • 19
    • 84888432028 scopus 로고    scopus 로고
    • Phase 3b upfront study: interim results from a community-based prospective randomized trial evaluating three bortezomib-based regimens in elderly, newly diagnosed multiple myeloma patients
    • Niesvizky R., Reeves J., Flinn I. Phase 3b upfront study: interim results from a community-based prospective randomized trial evaluating three bortezomib-based regimens in elderly, newly diagnosed multiple myeloma patients. EHA Annual Meeting 2010, 95(2):0358.
    • (2010) EHA Annual Meeting , vol.95 , Issue.2 , pp. 0358
    • Niesvizky, R.1    Reeves, J.2    Flinn, I.3
  • 21
    • 34249945940 scopus 로고    scopus 로고
    • Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003
    • Kristinsson S.Y., Landgren O., Dickman P.W., Derolf A.R., Björkholm M. Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003. J Clin Oncol 2007, 25(15):1993-1999.
    • (2007) J Clin Oncol , vol.25 , Issue.15 , pp. 1993-1999
    • Kristinsson, S.Y.1    Landgren, O.2    Dickman, P.W.3    Derolf, A.R.4    Björkholm, M.5
  • 22
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of patients 65years of age or older in cancer-treatment trials
    • Hutchins L.F., Unger J.M., Crowley J.J., Coltman C.A., Albain K.S. Underrepresentation of patients 65years of age or older in cancer-treatment trials. N Engl J Med 1999, 341(27):2061-2067.
    • (1999) N Engl J Med , vol.341 , Issue.27 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3    Coltman, C.A.4    Albain, K.S.5
  • 25
    • 8644260170 scopus 로고    scopus 로고
    • Intermediate-dose melphalan improves survival of myeloma patients aged 50 to 70: results of a randomized controlled trial
    • Palumbo A., Bringhen S., Petrucci M.T., Musto P., Rossini F., Nunzi M., et al. Intermediate-dose melphalan improves survival of myeloma patients aged 50 to 70: results of a randomized controlled trial. Blood 2004, 104(10):3052-3057.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3052-3057
    • Palumbo, A.1    Bringhen, S.2    Petrucci, M.T.3    Musto, P.4    Rossini, F.5    Nunzi, M.6
  • 26
    • 34848833957 scopus 로고    scopus 로고
    • Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial
    • Facon T., Mary J.Y., Hulin C., Benboubker L., Attal M., Pegourie B., et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial. Lancet 2007, 370(9594):1209-1218.
    • (2007) Lancet , vol.370 , Issue.9594 , pp. 1209-1218
    • Facon, T.1    Mary, J.Y.2    Hulin, C.3    Benboubker, L.4    Attal, M.5    Pegourie, B.6
  • 27
    • 84888438949 scopus 로고    scopus 로고
    • Prospective randomized trial of Len/Dex induction followed by tandem mel140 with autologous blood stem cell transplantation and Len maintenance versus continued therapy with Len/Dex in myeloma patients age 60-75years: protocol-defined safety analysis after 100 patients
    • Straka C., Schafer-Eckart K., Bassermann F., Hertenstein B., Engelhardt M., Salwender H., et al. Prospective randomized trial of Len/Dex induction followed by tandem mel140 with autologous blood stem cell transplantation and Len maintenance versus continued therapy with Len/Dex in myeloma patients age 60-75years: protocol-defined safety analysis after 100 patients. ASH Annual Meeting Abstracts 2012, 120(21):2012.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 2012
    • Straka, C.1    Schafer-Eckart, K.2    Bassermann, F.3    Hertenstein, B.4    Engelhardt, M.5    Salwender, H.6
  • 28
    • 44649149612 scopus 로고    scopus 로고
    • Velcade/dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma (MM): updated results of the IFM 2005/01 trial
    • Harousseau J.L., Mathiot C., Attal M., Marit G., Caillot D., Mohty M.M.M., et al. Velcade/dexamethasone (Vel/D) versus VAD as induction treatment prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma (MM): updated results of the IFM 2005/01 trial. ASH Annual Meeting Abstracts 2007, 110(11):450.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 450
    • Harousseau, J.L.1    Mathiot, C.2    Attal, M.3    Marit, G.4    Caillot, D.5    Mohty, M.M.M.6
  • 29
    • 36349010285 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America
    • Weber D.M., Chen C., Niesvizky R., Wang M., Belch A., Stadtmauer E.A., et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 2007, 357(21):2133-2142.
    • (2007) N Engl J Med , vol.357 , Issue.21 , pp. 2133-2142
    • Weber, D.M.1    Chen, C.2    Niesvizky, R.3    Wang, M.4    Belch, A.5    Stadtmauer, E.A.6
  • 30
    • 77649215631 scopus 로고    scopus 로고
    • Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients
    • Palumbo A., Gay F., Falco P., Crippa C., Montefusco V., Patriarca F., et al. Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients. J Clin Oncol 2010, 28(5):800-807.
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 800-807
    • Palumbo, A.1    Gay, F.2    Falco, P.3    Crippa, C.4    Montefusco, V.5    Patriarca, F.6
  • 31
    • 84858791955 scopus 로고    scopus 로고
    • Melphalan/prednisone/lenalidomide (MPR) versus high-dose melphalan and autologous transplantation (MEL200) in newly diagnosed multiple myeloma (MM) patients <65years: results of a randomized phase iii study
    • Palumbo A., Cavallo F., Hardan I., Lupo B., Redoglia V., Levin M., et al. Melphalan/prednisone/lenalidomide (MPR) versus high-dose melphalan and autologous transplantation (MEL200) in newly diagnosed multiple myeloma (MM) patients <65years: results of a randomized phase iii study. ASH Annual Meeting Abstracts 2011, 118(21):3069.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 3069
    • Palumbo, A.1    Cavallo, F.2    Hardan, I.3    Lupo, B.4    Redoglia, V.5    Levin, M.6
  • 32
    • 65349142006 scopus 로고    scopus 로고
    • Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma
    • Ludwig H., Hajek R., Tóthová E., Drach J., Adam Z., Labar B., et al. Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma. Blood 2009, 113(15):3435-3442.
    • (2009) Blood , vol.113 , Issue.15 , pp. 3435-3442
    • Ludwig, H.1    Hajek, R.2    Tóthová, E.3    Drach, J.4    Adam, Z.5    Labar, B.6
  • 33
    • 68949137225 scopus 로고    scopus 로고
    • Efficacy of melphalan and prednisone plus thalidomide in patients older than 75years with newly diagnosed multiple myeloma: IFM 01/01 trial
    • Hulin C., Facon T., Rodon P., Pegourie B., Benboubker L., Doyen C., et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75years with newly diagnosed multiple myeloma: IFM 01/01 trial. J Clin Oncol 2009, 27(22):3664-3670.
    • (2009) J Clin Oncol , vol.27 , Issue.22 , pp. 3664-3670
    • Hulin, C.1    Facon, T.2    Rodon, P.3    Pegourie, B.4    Benboubker, L.5    Doyen, C.6
  • 34
    • 33644843725 scopus 로고    scopus 로고
    • Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial
    • Palumbo A., Bringhen S., Caravita T., Merla E., Capparella V., Callea V., et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial. Lancet 2006, 367(9513):825-831.
    • (2006) Lancet , vol.367 , Issue.9513 , pp. 825-831
    • Palumbo, A.1    Bringhen, S.2    Caravita, T.3    Merla, E.4    Capparella, V.5    Callea, V.6
  • 35
    • 77955495783 scopus 로고    scopus 로고
    • Phase III study of the value of thalidomide added to melphalan plus prednisone in elderly patients with newly diagnosed multiple myeloma: the HOVON 49 study
    • Wijermans P., Schaafsma M., Termorshuizen F., et al. Phase III study of the value of thalidomide added to melphalan plus prednisone in elderly patients with newly diagnosed multiple myeloma: the HOVON 49 study. J Clin Oncol 2010, 28(19):3160-3166.
    • (2010) J Clin Oncol , vol.28 , Issue.19 , pp. 3160-3166
    • Wijermans, P.1    Schaafsma, M.2    Termorshuizen, F.3
  • 36
    • 77956599686 scopus 로고    scopus 로고
    • Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma
    • Waage A., Gimsing P., Fayers P., et al. Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma. Blood 2010, 116(9):1405-1412.
    • (2010) Blood , vol.116 , Issue.9 , pp. 1405-1412
    • Waage, A.1    Gimsing, P.2    Fayers, P.3
  • 37
    • 78650159700 scopus 로고    scopus 로고
    • Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: results of a randomized trial from the Turkish Myeloma Study Group
    • Beksac M., Haznedar R., Firatli-Tuglular T., Ozdogu H., Aydogdu I., Konuk N., et al. Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: results of a randomized trial from the Turkish Myeloma Study Group. Eur J Haematol 2011, 86(1):16-22.
    • (2011) Eur J Haematol , vol.86 , Issue.1 , pp. 16-22
    • Beksac, M.1    Haznedar, R.2    Firatli-Tuglular, T.3    Ozdogu, H.4    Aydogdu, I.5    Konuk, N.6
  • 38
    • 84872055497 scopus 로고    scopus 로고
    • Safety of thalidomide in newly diagnosed elderly myeloma patients: a meta-analysis of data from individual patients in six randomized trials
    • Palumbo A., Waage A., Hulin C., Beksac M., Zweegman S., Gay F., et al. Safety of thalidomide in newly diagnosed elderly myeloma patients: a meta-analysis of data from individual patients in six randomized trials. Haematologica 2013, 98(1):87-94.
    • (2013) Haematologica , vol.98 , Issue.1 , pp. 87-94
    • Palumbo, A.1    Waage, A.2    Hulin, C.3    Beksac, M.4    Zweegman, S.5    Gay, F.6
  • 39
    • 80051557449 scopus 로고    scopus 로고
    • Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation
    • Morgan G.J., Davies F.E., Gregory W.M., Russell N.H., Bell S.E., Szubert A.J., et al. Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation. Blood 2011, 118(5):1231-1238.
    • (2011) Blood , vol.118 , Issue.5 , pp. 1231-1238
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3    Russell, N.H.4    Bell, S.E.5    Szubert, A.J.6
  • 41
    • 41349122600 scopus 로고    scopus 로고
    • Superiority of lenalidomide (Len) plus high-dose dexamethasone (HD) compared to HD alone as treatment of newly-diagnosed multiple myeloma (NDMM): results of the randomized, double-blinded, placebo-controlled SWOG trial S0232
    • Zonder J.A., Crowley J., Hussein M.A., Bolejack V., Moore D.F., Whittenberger B.F., et al. Superiority of lenalidomide (Len) plus high-dose dexamethasone (HD) compared to HD alone as treatment of newly-diagnosed multiple myeloma (NDMM): results of the randomized, double-blinded, placebo-controlled SWOG trial S0232. ASH Annual Meeting Abstracts 2007, 110(11):77.
    • (2007) ASH Annual Meeting Abstracts , vol.110 , Issue.11 , pp. 77
    • Zonder, J.A.1    Crowley, J.2    Hussein, M.A.3    Bolejack, V.4    Moore, D.F.5    Whittenberger, B.F.6
  • 42
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial
    • Rajkumar S.V., Jacobus S., Callander N.S., Fonseca R., Vesole D.H., Williams M.E., et al. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial. Lancet Oncol 2010, 11(1):29-37.
    • (2010) Lancet Oncol , vol.11 , Issue.1 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3    Fonseca, R.4    Vesole, D.H.5    Williams, M.E.6
  • 43
    • 84858791957 scopus 로고    scopus 로고
    • Continued overall survival benefit after 5years' follow-up with bortezomib-melphalan-prednisone (VMP) versus melphalan-prednisone (MP) in patients with previously untreated multiple myeloma, and no increased risk of second primary malignancies: final results of the phase 3 vista trial
    • San Miguel J.F., Schlag R., Khuageva N.K., Dimopoulos M.A., Shpilberg O., Kropff M., et al. Continued overall survival benefit after 5years' follow-up with bortezomib-melphalan-prednisone (VMP) versus melphalan-prednisone (MP) in patients with previously untreated multiple myeloma, and no increased risk of second primary malignancies: final results of the phase 3 vista trial. ASH Annual Meeting Abstracts 2011, 118(21):476.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 476
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3    Dimopoulos, M.A.4    Shpilberg, O.5    Kropff, M.6
  • 44
    • 77957344540 scopus 로고    scopus 로고
    • Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma: a randomised trial
    • Mateos M.-V., Oriol A., Martínez-López J., Gutiérrez N., Teruel A.I., de Paz R., et al. Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple myeloma: a randomised trial. Lancet Oncol 2010, 11(10):934-941.
    • (2010) Lancet Oncol , vol.11 , Issue.10 , pp. 934-941
    • Mateos, M.-V.1    Oriol, A.2    Martínez-López, J.3    Gutiérrez, N.4    Teruel, A.I.5    de Paz, R.6
  • 45
    • 84862696861 scopus 로고    scopus 로고
    • Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: results from all randomized patients in the community-based, phase 3b UPFRONT study
    • Niesvizky R., Flinn I.W., Rifkin R., Gabrail N., Charu V., Clowney B., et al. Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: results from all randomized patients in the community-based, phase 3b UPFRONT study. ASH Annual Meeting Abstracts 2011, 118(21):478.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 478
    • Niesvizky, R.1    Flinn, I.W.2    Rifkin, R.3    Gabrail, N.4    Charu, V.5    Clowney, B.6
  • 46
    • 67650882695 scopus 로고    scopus 로고
    • Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial
    • Reeder C.B., Reece D.E., Kukreti V., Chen C., Trudel S., Hentz J., et al. Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial. Leukemia 2009, 23(7):1337-1341.
    • (2009) Leukemia , vol.23 , Issue.7 , pp. 1337-1341
    • Reeder, C.B.1    Reece, D.E.2    Kukreti, V.3    Chen, C.4    Trudel, S.5    Hentz, J.6
  • 47
    • 77951453409 scopus 로고    scopus 로고
    • Once- versus twice-weekly bortezomib induction therapy with cybord in newly diagnosed multiple myeloma
    • Reeder C.B., Reece D.E., Kukreti V., Chen C., Trudel S., Laumann K., et al. Once- versus twice-weekly bortezomib induction therapy with cybord in newly diagnosed multiple myeloma. Blood 2010, 115(16):3416-3417.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3416-3417
    • Reeder, C.B.1    Reece, D.E.2    Kukreti, V.3    Chen, C.4    Trudel, S.5    Laumann, K.6
  • 48
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson P.G., Weller E., Lonial S., Jakubowiak A.J., Jagannath S., Raje N.S., et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010, 116(5):679-686.
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3    Jakubowiak, A.J.4    Jagannath, S.5    Raje, N.S.6
  • 49
    • 84860907057 scopus 로고    scopus 로고
    • Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma
    • Kumar S., Flinn I., Richardson P.G., Hari P., Callander N., Noga S.J., et al. Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma. Blood 2012, 119(19):4375-4382.
    • (2012) Blood , vol.119 , Issue.19 , pp. 4375-4382
    • Kumar, S.1    Flinn, I.2    Richardson, P.G.3    Hari, P.4    Callander, N.5    Noga, S.J.6
  • 50
    • 78649681350 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
    • Bringhen S., Larocca A., Rossi D., Cavalli M., Genuardi M., Ria R., et al. Efficacy and safety of once-weekly bortezomib in multiple myeloma patients. Blood 2010, 116(23):4745-4753.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4745-4753
    • Bringhen, S.1    Larocca, A.2    Rossi, D.3    Cavalli, M.4    Genuardi, M.5    Ria, R.6
  • 51
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study
    • Moreau P., Pylypenko H., Grosicki S., Karamanesht I., Leleu X., Grishunina M., et al. Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 2011, 12(5):431-440.
    • (2011) Lancet Oncol , vol.12 , Issue.5 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3    Karamanesht, I.4    Leleu, X.5    Grishunina, M.6
  • 52
    • 84875218691 scopus 로고    scopus 로고
    • Lenalidomide-prednisone induction followed by lenalidomide-melphalan-prednisone consolidation and lenalidomide-prednisone maintenance in newly diagnosed elderly unfit myeloma patients
    • Falco P., Cavallo F., Larocca A., Rossi D., Guglielmelli T., Rocci A., et al. Lenalidomide-prednisone induction followed by lenalidomide-melphalan-prednisone consolidation and lenalidomide-prednisone maintenance in newly diagnosed elderly unfit myeloma patients. Leukemia 2013, 27(3):695-701.
    • (2013) Leukemia , vol.27 , Issue.3 , pp. 695-701
    • Falco, P.1    Cavallo, F.2    Larocca, A.3    Rossi, D.4    Guglielmelli, T.5    Rocci, A.6
  • 54
    • 64749113465 scopus 로고    scopus 로고
    • Treatment of relapsed/refractory multiple myeloma
    • Kastritis E., Palumbo A., Dimopoulos M.A. Treatment of relapsed/refractory multiple myeloma. Semin Hematol 2009, 46(2):143-157.
    • (2009) Semin Hematol , vol.46 , Issue.2 , pp. 143-157
    • Kastritis, E.1    Palumbo, A.2    Dimopoulos, M.A.3
  • 55
    • 33745801771 scopus 로고    scopus 로고
    • Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone
    • Jagannath S., Richardson P.G., Barlogie B., Berenson J.R., Singhal S., Irwin D., et al. Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone. Haematologica 2006, 91(7):929-934.
    • (2006) Haematologica , vol.91 , Issue.7 , pp. 929-934
    • Jagannath, S.1    Richardson, P.G.2    Barlogie, B.3    Berenson, J.R.4    Singhal, S.5    Irwin, D.6
  • 56
    • 54849413402 scopus 로고    scopus 로고
    • Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma
    • Jagannath S., Barlogie B., Berenson J.R., Siegel D.S., Irwin D., Richardson P.G., et al. Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma. Br J Haematol 2008, 143(4):537-540.
    • (2008) Br J Haematol , vol.143 , Issue.4 , pp. 537-540
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.R.3    Siegel, D.S.4    Irwin, D.5    Richardson, P.G.6
  • 57
    • 84862639087 scopus 로고    scopus 로고
    • Efficacy of lenalidomide plus dexamethasone in patients older than 75years with relapsed multiple myeloma
    • Touzeau C., Blin N., Clavert A., Roland V., Loirat M., Tessoulin B., et al. Efficacy of lenalidomide plus dexamethasone in patients older than 75years with relapsed multiple myeloma. Leuk Lymphoma 2012, 53(7):1318-1320.
    • (2012) Leuk Lymphoma , vol.53 , Issue.7 , pp. 1318-1320
    • Touzeau, C.1    Blin, N.2    Clavert, A.3    Roland, V.4    Loirat, M.5    Tessoulin, B.6
  • 59
    • 35148825003 scopus 로고    scopus 로고
    • Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the apex trial
    • Richardson P.G., Sonneveld P., Schuster M., Irwin D., Stadtmauer E.A., Facon T., et al. Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time-to-event results of the apex trial. Blood 2007, 110(10):3557-3560.
    • (2007) Blood , vol.110 , Issue.10 , pp. 3557-3560
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.3    Irwin, D.4    Stadtmauer, E.A.5    Facon, T.6
  • 60
    • 70350094381 scopus 로고    scopus 로고
    • International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation
    • Palumbo A., Sezer O., Kyle R., Miguel J.S., Orlowski R.Z., Moreau P., et al. International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation. Leukemia 2009, 23(10):1716-1730.
    • (2009) Leukemia , vol.23 , Issue.10 , pp. 1716-1730
    • Palumbo, A.1    Sezer, O.2    Kyle, R.3    Miguel, J.S.4    Orlowski, R.Z.5    Moreau, P.6
  • 61
    • 58149384555 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure
    • Wang M., Dimopoulos M.A., Chen C., Cibeira M.T., Attal M., Spencer A., et al. Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure. Blood 2008, 112(12):4445-4451.
    • (2008) Blood , vol.112 , Issue.12 , pp. 4445-4451
    • Wang, M.1    Dimopoulos, M.A.2    Chen, C.3    Cibeira, M.T.4    Attal, M.5    Spencer, A.6
  • 62
    • 84859760906 scopus 로고    scopus 로고
    • Integrated safety from phase 2 studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): an updated analysis
    • Singhal S., Siegel D.S., Martin T., Vij R., Wang L., Jakubowiak A.J., et al. Integrated safety from phase 2 studies of monotherapy carfilzomib in patients with relapsed and refractory multiple myeloma (MM): an updated analysis. ASH Annual Meeting Abstracts 2011, 118(21):1876.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , Issue.21 , pp. 1876
    • Singhal, S.1    Siegel, D.S.2    Martin, T.3    Vij, R.4    Wang, L.5    Jakubowiak, A.J.6
  • 63
    • 70349643684 scopus 로고    scopus 로고
    • Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
    • [abstr 8504]
    • Jagannath S., Vij R., Stewart K., Somlo G., Jakubowiak A., Trudel S., et al. Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J Clin Oncol 2009, 27(Suppl. 15s). [abstr 8504].
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15S
    • Jagannath, S.1    Vij, R.2    Stewart, K.3    Somlo, G.4    Jakubowiak, A.5    Trudel, S.6
  • 64
    • 79955511317 scopus 로고    scopus 로고
    • Results of PX-171-003-A1, an open-label, single-arm, phase 2 (Ph 2) study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM)
    • diCapua Siegel D.S., Martin T., Wang M., Vij R., Jakubowiak A.J., Jagannath S., et al. Results of PX-171-003-A1, an open-label, single-arm, phase 2 (Ph 2) study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). ASH Annual Meeting Abstracts 2010, 116(21):985.
    • (2010) ASH Annual Meeting Abstracts , vol.116 , Issue.21 , pp. 985
    • DiCapua Siegel, D.S.1    Martin, T.2    Wang, M.3    Vij, R.4    Jakubowiak, A.J.5    Jagannath, S.6
  • 65
    • 84862507585 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naïve patients with relapsed and/or refractory multiple myeloma
    • Vij R., Wang M., Kaufman J.L., Lonial S., Jakubowiak A.J., Stewart A.K., et al. An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naïve patients with relapsed and/or refractory multiple myeloma. Blood 2012, 119(24):5661-5670.
    • (2012) Blood , vol.119 , Issue.24 , pp. 5661-5670
    • Vij, R.1    Wang, M.2    Kaufman, J.L.3    Lonial, S.4    Jakubowiak, A.J.5    Stewart, A.K.6
  • 66
    • 84869021235 scopus 로고    scopus 로고
    • Dose-escalation study of carfilzomib (CFZ) plus lenalidomide (LEN) plus low-dose dexamethasone (DEX) (CRd) in relapsed/refractory multiple myeloma (R/R MM)
    • Bensinger W., Wang M., Orlowski R.Z., Alsina M., Martin T., Singhal S., et al. Dose-escalation study of carfilzomib (CFZ) plus lenalidomide (LEN) plus low-dose dexamethasone (DEX) (CRd) in relapsed/refractory multiple myeloma (R/R MM). J Clin Oncol 2010, 28(15):8029.
    • (2010) J Clin Oncol , vol.28 , Issue.15 , pp. 8029
    • Bensinger, W.1    Wang, M.2    Orlowski, R.Z.3    Alsina, M.4    Martin, T.5    Singhal, S.6
  • 67
    • 84877147624 scopus 로고    scopus 로고
    • Pomalidomide cyclophosphamide and prednisone (PCP) treatment for relapsed/refractory multiple myeloma
    • Palumbo A., Larocca A., Montefusco V., Rossi D., Carella A.M., Mina R., et al. Pomalidomide cyclophosphamide and prednisone (PCP) treatment for relapsed/refractory multiple myeloma. ASH Annual Meeting Abstracts 2012, 120(21):446.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 446
    • Palumbo, A.1    Larocca, A.2    Montefusco, V.3    Rossi, D.4    Carella, A.M.5    Mina, R.6
  • 68
    • 84877136004 scopus 로고    scopus 로고
    • CLAPD (clarithromycin, pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma
    • Mark T.M., Boyer A., Rossi A.C., Shah M., Pearse R.N., Zafar F., et al. CLAPD (clarithromycin, pomalidomide, dexamethasone) therapy in relapsed or refractory multiple myeloma. ASH Annual Meeting Abstracts 2012, 120(21):77.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , Issue.21 , pp. 77
    • Mark, T.M.1    Boyer, A.2    Rossi, A.C.3    Shah, M.4    Pearse, R.N.5    Zafar, F.6
  • 69
    • 33749237119 scopus 로고    scopus 로고
    • Evaluation of anaemia in patients with multiple myeloma and lymphoma: findings of the European Cancer Anaemia Survey
    • Birgegård G., Gascón P., Ludwig H. Evaluation of anaemia in patients with multiple myeloma and lymphoma: findings of the European Cancer Anaemia Survey. Eur J Haematol 2006, 77(5):378-386.
    • (2006) Eur J Haematol , vol.77 , Issue.5 , pp. 378-386
    • Birgegård, G.1    Gascón, P.2    Ludwig, H.3
  • 72
    • 79951509269 scopus 로고    scopus 로고
    • Management of older patients with multiple myeloma
    • Gay F., Palumbo A. Management of older patients with multiple myeloma. Blood Rev 2011, 25(2):65-73.
    • (2011) Blood Rev , vol.25 , Issue.2 , pp. 65-73
    • Gay, F.1    Palumbo, A.2
  • 73
    • 33746010219 scopus 로고    scopus 로고
    • Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib
    • Richardson P.G., Briemberg H., Jagannath S., Wen P.Y., Barlogie B., Berenson J., et al. Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. J Clin Oncol 2006, 24(19):3113-3120.
    • (2006) J Clin Oncol , vol.24 , Issue.19 , pp. 3113-3120
    • Richardson, P.G.1    Briemberg, H.2    Jagannath, S.3    Wen, P.Y.4    Barlogie, B.5    Berenson, J.6
  • 74
    • 78049528177 scopus 로고    scopus 로고
    • Treatment-related peripheral neuropathy in multiple myeloma: the challenge continues
    • Delforge M., Bladé J., Dimopoulos M.A., Facon T., Kropff M., Ludwig H., et al. Treatment-related peripheral neuropathy in multiple myeloma: the challenge continues. Lancet Oncol 2010, 11(11):1086-1095.
    • (2010) Lancet Oncol , vol.11 , Issue.11 , pp. 1086-1095
    • Delforge, M.1    Bladé, J.2    Dimopoulos, M.A.3    Facon, T.4    Kropff, M.5    Ludwig, H.6
  • 75
    • 43249097561 scopus 로고    scopus 로고
    • Thalidomide for treatment of multiple myeloma: 10years later
    • Palumbo A., Facon T., Sonneveld P., Bladè J., Offidani M., Gay F., et al. Thalidomide for treatment of multiple myeloma: 10years later. Blood 2008, 111(8):3968-3977.
    • (2008) Blood , vol.111 , Issue.8 , pp. 3968-3977
    • Palumbo, A.1    Facon, T.2    Sonneveld, P.3    Bladè, J.4    Offidani, M.5    Gay, F.6
  • 76
    • 0035880229 scopus 로고    scopus 로고
    • Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients
    • Barlogie B., Desikan R., Eddlemon P., Spencer T., Zeldis J., Munshi N., et al. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. Blood 2001, 98(2):492-494.
    • (2001) Blood , vol.98 , Issue.2 , pp. 492-494
    • Barlogie, B.1    Desikan, R.2    Eddlemon, P.3    Spencer, T.4    Zeldis, J.5    Munshi, N.6
  • 77
    • 0036839013 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
    • Richardson P.G., Schlossman R.L., Weller E., Hideshima T., Mitsiades C., Davies F., et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 2002, 100(9):3063-3067.
    • (2002) Blood , vol.100 , Issue.9 , pp. 3063-3067
    • Richardson, P.G.1    Schlossman, R.L.2    Weller, E.3    Hideshima, T.4    Mitsiades, C.5    Davies, F.6
  • 79
    • 0026656725 scopus 로고
    • Primary dexamethasone treatment of multiple myeloma
    • Alexanian R., Dimopoulos M.A., Delasalle K., Barlogie B. Primary dexamethasone treatment of multiple myeloma. Blood 1992, 80(4):887-890.
    • (1992) Blood , vol.80 , Issue.4 , pp. 887-890
    • Alexanian, R.1    Dimopoulos, M.A.2    Delasalle, K.3    Barlogie, B.4
  • 80
    • 74949121208 scopus 로고    scopus 로고
    • VMP (bortezomib, melphalan, and prednisone) is active and well tolerated in newly diagnosed patients with multiple myeloma with moderately impaired renal function, and results in reversal of renal impairment: cohort analysis of the phase III VISTA study
    • Dimopoulos M.A., Richardson P.G., Schlag R., Khuageva N.K., Shpilberg O., Kastritis E., et al. VMP (bortezomib, melphalan, and prednisone) is active and well tolerated in newly diagnosed patients with multiple myeloma with moderately impaired renal function, and results in reversal of renal impairment: cohort analysis of the phase III VISTA study. J Clin Oncol 2009, 27(36):6086-6093.
    • (2009) J Clin Oncol , vol.27 , Issue.36 , pp. 6086-6093
    • Dimopoulos, M.A.1    Richardson, P.G.2    Schlag, R.3    Khuageva, N.K.4    Shpilberg, O.5    Kastritis, E.6
  • 81
    • 79951891171 scopus 로고    scopus 로고
    • Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the International Myeloma Working Group
    • Dimopoulos M.A., Terpos E., Chanan-Khan A., Khuageva N.K., Shpilberg O., Kastritis E., et al. Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the International Myeloma Working Group. J Clin Oncol 2010, 28(33):4976-4984.
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4976-4984
    • Dimopoulos, M.A.1    Terpos, E.2    Chanan-Khan, A.3    Khuageva, N.K.4    Shpilberg, O.5    Kastritis, E.6
  • 82
    • 84877110457 scopus 로고    scopus 로고
    • Celgene corporation
    • available at:, [accessed July 2012]
    • Celgene corporation Revlimid package insert. Summit, NJ available at:, [accessed July 2012]. http://www.revlimid.com/pdf/revlimid_pi.pdf.
    • Revlimid package insert. Summit, NJ
  • 83
    • 77949482895 scopus 로고    scopus 로고
    • How to treat elderly patients with multiple myeloma: combination of therapy or sequencing
    • Palumbo A., Gay F. How to treat elderly patients with multiple myeloma: combination of therapy or sequencing. Hematology Am Soc Hematol Educ Program 2009, 566-577.
    • (2009) Hematology Am Soc Hematol Educ Program , pp. 566-577
    • Palumbo, A.1    Gay, F.2
  • 84
    • 54249089458 scopus 로고    scopus 로고
    • Analysis of herpes zoster events among bortezomib-treated patients in the phase III APEX study
    • Chanan-Khan A., Sonneveld P., Schuster M.W., Stadtmauer E.A., Facon T., Harousseau J.L., et al. Analysis of herpes zoster events among bortezomib-treated patients in the phase III APEX study. J Clin Oncol 2008, 26(29):4784-4790.
    • (2008) J Clin Oncol , vol.26 , Issue.29 , pp. 4784-4790
    • Chanan-Khan, A.1    Sonneveld, P.2    Schuster, M.W.3    Stadtmauer, E.A.4    Facon, T.5    Harousseau, J.L.6
  • 85
    • 78650174738 scopus 로고    scopus 로고
    • First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial
    • Morgan G.J., Davies F.E., Gregory W.M., Cocks K., Bell S.E., Szubert A.J., et al. First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. Lancet 2010, 376(9757):1989-1999.
    • (2010) Lancet , vol.376 , Issue.9757 , pp. 1989-1999
    • Morgan, G.J.1    Davies, F.E.2    Gregory, W.M.3    Cocks, K.4    Bell, S.E.5    Szubert, A.J.6
  • 86
    • 79960891058 scopus 로고    scopus 로고
    • Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC myeloma IX): secondary outcomes from a randomised controlled trial
    • Morgan G.J., Child J.A., Gregory W.M., Szubert A.J., Cocks K., Bell S.E., et al. Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC myeloma IX): secondary outcomes from a randomised controlled trial. Lancet Oncol 2011, 12(8):743-752.
    • (2011) Lancet Oncol , vol.12 , Issue.8 , pp. 743-752
    • Morgan, G.J.1    Child, J.A.2    Gregory, W.M.3    Szubert, A.J.4    Cocks, K.5    Bell, S.E.6
  • 87
    • 10744233021 scopus 로고    scopus 로고
    • Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial
    • Rosen L.S., Gordon D., Kaminski M., Howell A., Belch A., Mackey J., et al. Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial. Cancer 2003, 98(8):1735-1744.
    • (2003) Cancer , vol.98 , Issue.8 , pp. 1735-1744
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3    Howell, A.4    Belch, A.5    Mackey, J.6
  • 88
    • 34347260332 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma
    • Kyle R.A., Yee G.C., Somerfield M.R., Flynn P.J., Halabi S., Jagannath S., et al. American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma. J Clin Oncol 2007, 25(17):2464-2472.
    • (2007) J Clin Oncol , vol.25 , Issue.17 , pp. 2464-2472
    • Kyle, R.A.1    Yee, G.C.2    Somerfield, M.R.3    Flynn, P.J.4    Halabi, S.5    Jagannath, S.6
  • 89
    • 69449108135 scopus 로고    scopus 로고
    • The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network
    • Terpos E., Sezer O., Croucher P.I., García-Sanz R., Boccadoro M., San Miguel J., et al. The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009, 20(8):1303-1317.
    • (2009) Ann Oncol , vol.20 , Issue.8 , pp. 1303-1317
    • Terpos, E.1    Sezer, O.2    Croucher, P.I.3    García-Sanz, R.4    Boccadoro, M.5    San Miguel, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.