-
1
-
-
72949093335
-
From pathogenesis to treatment of chronic lymphocytic leukaemia
-
Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S. From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 2010, 10:37-50.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 37-50
-
-
Zenz, T.1
Mertens, D.2
Kuppers, R.3
Dohner, H.4
Stilgenbauer, S.5
-
2
-
-
84867154468
-
Molecular pathogenesis of chronic lymphocytic leukemia
-
10.1172/JCI64101, 3461921, 23023714
-
Gaidano G, Foa R, Dalla-Favera R. Molecular pathogenesis of chronic lymphocytic leukemia. J Clin Invest 2012, 122:3432-3438. 10.1172/JCI64101, 3461921, 23023714.
-
(2012)
J Clin Invest
, vol.122
, pp. 3432-3438
-
-
Gaidano, G.1
Foa, R.2
Dalla-Favera, R.3
-
3
-
-
37549015263
-
Germinal centres: role in B-cell physiology and malignancy
-
10.1038/nri2217, 18097447
-
Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol 2008, 8:22-33. 10.1038/nri2217, 18097447.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 22-33
-
-
Klein, U.1
Dalla-Favera, R.2
-
4
-
-
0033567907
-
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
-
Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999, 94:1848-1854.
-
(1999)
Blood
, vol.94
, pp. 1848-1854
-
-
Hamblin, T.J.1
Davis, Z.2
Gardiner, A.3
Oscier, D.G.4
Stevenson, F.K.5
-
5
-
-
54049141334
-
Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up
-
10.1182/blood-2008-04-154070, 18689542
-
Zenz T, Kröber A, Scherer K, Häbe S, Buhler A, Benner A, Denzel T, Winkler D, Edelmann J, Schwänen C, Döhner H, Stilgenbauer S. Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up. Blood 2008, 112:3322-3329. 10.1182/blood-2008-04-154070, 18689542.
-
(2008)
Blood
, vol.112
, pp. 3322-3329
-
-
Zenz, T.1
Kröber, A.2
Scherer, K.3
Häbe, S.4
Buhler, A.5
Benner, A.6
Denzel, T.7
Winkler, D.8
Edelmann, J.9
Schwänen, C.10
Döhner, H.11
Stilgenbauer, S.12
-
6
-
-
27644450586
-
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
-
10.1182/blood-2004-11-4516, 16014569
-
Austen B, Powell JE, Alvi A, Edwards I, Hooper L, Starczynski J, Taylor AM, Fegan C, Moss P, Stankovic T. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood 2005, 106:3175-3182. 10.1182/blood-2004-11-4516, 16014569.
-
(2005)
Blood
, vol.106
, pp. 3175-3182
-
-
Austen, B.1
Powell, J.E.2
Alvi, A.3
Edwards, I.4
Hooper, L.5
Starczynski, J.6
Taylor, A.M.7
Fegan, C.8
Moss, P.9
Stankovic, T.10
-
7
-
-
0037406968
-
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
-
10.1056/NEJMoa023143, 12724482
-
Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, Marce S, Lopez-Guillermo A, Campo E, Montserrat E. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003, 348:1764-1775. 10.1056/NEJMoa023143, 12724482.
-
(2003)
N Engl J Med
, vol.348
, pp. 1764-1775
-
-
Crespo, M.1
Bosch, F.2
Villamor, N.3
Bellosillo, B.4
Colomer, D.5
Rozman, M.6
Marce, S.7
Lopez-Guillermo, A.8
Campo, E.9
Montserrat, E.10
-
8
-
-
36148992239
-
CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
-
10.1182/blood-2007-04-083832, 2200908, 17684154
-
Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C, Allen SL, Rai KR, Chiorazzi N. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 2007, 110:3352-3359. 10.1182/blood-2007-04-083832, 2200908, 17684154.
-
(2007)
Blood
, vol.110
, pp. 3352-3359
-
-
Damle, R.N.1
Temburni, S.2
Calissano, C.3
Yancopoulos, S.4
Banapour, T.5
Sison, C.6
Allen, S.L.7
Rai, K.R.8
Chiorazzi, N.9
-
9
-
-
80052936981
-
Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia
-
10.1182/blood-2010-12-327858, 3175782, 21795749
-
Ouillette P, Collins R, Shakhan S, Li J, Peres E, Kujawski L, Talpaz M, Kaminski M, Li C, Shedden K, Malek SN. Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia. Blood 2011, 118:3051-3061. 10.1182/blood-2010-12-327858, 3175782, 21795749.
-
(2011)
Blood
, vol.118
, pp. 3051-3061
-
-
Ouillette, P.1
Collins, R.2
Shakhan, S.3
Li, J.4
Peres, E.5
Kujawski, L.6
Talpaz, M.7
Kaminski, M.8
Li, C.9
Shedden, K.10
Malek, S.N.11
-
10
-
-
18744396337
-
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
-
10.1073/pnas.242606799, 137750, 12434020
-
Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99:15524-15529. 10.1073/pnas.242606799, 137750, 12434020.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15524-15529
-
-
Calin, G.A.1
Dumitru, C.D.2
Shimizu, M.3
Bichi, R.4
Zupo, S.5
Noch, E.6
Aldler, H.7
Rattan, S.8
Keating, M.9
Rai, K.10
Rassenti, L.11
Kipps, T.12
Negrini, M.13
Bullrich, F.14
Croce, C.M.15
-
11
-
-
73649116987
-
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia
-
10.1016/j.ccr.2009.11.019, 20060366
-
Klein U, Lia M, Crespo M, Siegel R, Shen Q, Mo T, Ambesi-Impiombato A, Califano A, Migliazza A, Bhagat G, Dalla-Favera R. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010, 17:28-40. 10.1016/j.ccr.2009.11.019, 20060366.
-
(2010)
Cancer Cell
, vol.17
, pp. 28-40
-
-
Klein, U.1
Lia, M.2
Crespo, M.3
Siegel, R.4
Shen, Q.5
Mo, T.6
Ambesi-Impiombato, A.7
Califano, A.8
Migliazza, A.9
Bhagat, G.10
Dalla-Favera, R.11
-
12
-
-
72849144434
-
Sequencing technologies - the next generation
-
10.1038/nrg2626, 19997069
-
Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet 2010, 11:31-46. 10.1038/nrg2626, 19997069.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 31-46
-
-
Metzker, M.L.1
-
13
-
-
64749094310
-
The cancer genome
-
10.1038/nature07943, 2821689, 19360079
-
Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature 2009, 458:719-724. 10.1038/nature07943, 2821689, 19360079.
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
-
14
-
-
77956838065
-
Advances in understanding cancer genomes through second-generation sequencing
-
10.1038/nrg2841, 20847746
-
Meyerson M, Gabriel S, Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet 2010, 11:685-696. 10.1038/nrg2841, 20847746.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 685-696
-
-
Meyerson, M.1
Gabriel, S.2
Getz, G.3
-
15
-
-
77957932941
-
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
-
10.1038/nbt.1682, 2955169, 20852635
-
Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL, Johnson BE, Fouse SD, Delaney A, Zhao Y, Olshen A, Ballinger T, Zhou X, Forsberg KJ, Gu J, Echipare L, O'Geen H, Lister R, Pelizzola M, Xi Y, Epstein CB, Bernstein BE, Hawkins RD, Ren B, Chung WY, Gu H, Bock C, Gnirke A, Zhang MQ, Haussler D. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol 2010, 28:1097-1105. 10.1038/nbt.1682, 2955169, 20852635.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1097-1105
-
-
Harris, R.A.1
Wang, T.2
Coarfa, C.3
Nagarajan, R.P.4
Hong, C.5
Downey, S.L.6
Johnson, B.E.7
Fouse, S.D.8
Delaney, A.9
Zhao, Y.10
Olshen, A.11
Ballinger, T.12
Zhou, X.13
Forsberg, K.J.14
Gu, J.15
Echipare, L.16
O'Geen, H.17
Lister, R.18
Pelizzola, M.19
Xi, Y.20
Epstein, C.B.21
Bernstein, B.E.22
Hawkins, R.D.23
Ren, B.24
Chung, W.Y.25
Gu, H.26
Bock, C.27
Gnirke, A.28
Zhang, M.Q.29
Haussler, D.30
more..
-
16
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
10.1038/nature05610, 2712719, 17344846
-
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D. Patterns of somatic mutation in human cancer genomes. Nature 2007, 446:153-158. 10.1038/nature05610, 2712719, 17344846.
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
Davies, H.7
Teague, J.8
Butler, A.9
Stevens, C.10
Edkins, S.11
O'Meara, S.12
Vastrik, I.13
Schmidt, E.E.14
Avis, T.15
Barthorpe, S.16
Bhamra, G.17
Buck, G.18
Choudhury, B.19
Clements, J.20
Cole, J.21
Dicks, E.22
Forbes, S.23
Gray, K.24
Halliday, K.25
Harrison, R.26
Hills, K.27
Hinton, J.28
Jenkinson, A.29
Jones, D.30
more..
-
17
-
-
77951115122
-
International network of cancer genome projects
-
10.1038/nature08987, 2902243, 20393554, International Cancer Genome Consortium
-
Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabe RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, . International Cancer Genome Consortium International network of cancer genome projects. Nature 2010, 464:993-998. 10.1038/nature08987, 2902243, 20393554, International Cancer Genome Consortium.
-
(2010)
Nature
, vol.464
, pp. 993-998
-
-
Hudson, T.J.1
Anderson, W.2
Artez, A.3
Barker, A.D.4
Bell, C.5
Bernabe, R.R.6
Bhan, M.K.7
Calvo, F.8
Eerola, I.9
Gerhard, D.S.10
Guttmacher, A.11
Guyer, M.12
Hemsley, F.M.13
Jennings, J.L.14
Kerr, D.15
Klatt, P.16
Kolar, P.17
Kusada, J.18
Lane, D.P.19
Laplace, F.20
Youyong, L.21
Nettekoven, G.22
Ozenberger, B.23
Peterson, J.24
Rao, T.S.25
Remacle, J.26
Schafer, A.J.27
Shibata, T.28
Stratton, M.R.29
Vockley, J.G.30
more..
-
18
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
10.1038/nature10113, 3322590, 21642962
-
Puente XS, Pinyol M, Quesada V, Conde L, Ordonez GR, Villamor N, Escaramis G, Jares P, Bea S, Gonzalez-Diaz M, Bassaganyas L, Baumann T, Juan M, López-Guerra M, Colomer D, Tubío JM, López C, Navarro A, Tornador C, Aymerich M, Rozman M, Hernández JM, Puente DA, Freije JM, Velasco G, Gutiérrez-Fernández A, Costa D, Carrió A, Guijarro S, Enjuanes A. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011, 475:101-105. 10.1038/nature10113, 3322590, 21642962.
-
(2011)
Nature
, vol.475
, pp. 101-105
-
-
Puente, X.S.1
Pinyol, M.2
Quesada, V.3
Conde, L.4
Ordonez, G.R.5
Villamor, N.6
Escaramis, G.7
Jares, P.8
Bea, S.9
Gonzalez-Diaz, M.10
Bassaganyas, L.11
Baumann, T.12
Juan, M.13
López-Guerra, M.14
Colomer, D.15
Tubío, J.M.16
López, C.17
Navarro, A.18
Tornador, C.19
Aymerich, M.20
Rozman, M.21
Hernández, J.M.22
Puente, D.A.23
Freije, J.M.24
Velasco, G.25
Gutiérrez-Fernández, A.26
Costa, D.27
Carrió, A.28
Guijarro, S.29
Enjuanes, A.30
more..
-
19
-
-
77958567414
-
NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL
-
10.1111/j.1365-2141.2010.08368.x, 20813007
-
Sportoletti P, Baldoni S, Cavalli L, Del Papa B, Bonifacio E, Ciurnelli R, Bell AS, Di Tommaso A, Rosati E, Crescenzi B, Mecucci C, Screpanti I, Marconi P, Martelli MF, Di Ianni M, Falzetti F. NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL. Br J Haematol 2010, 151:404-406. 10.1111/j.1365-2141.2010.08368.x, 20813007.
-
(2010)
Br J Haematol
, vol.151
, pp. 404-406
-
-
Sportoletti, P.1
Baldoni, S.2
Cavalli, L.3
Del Papa, B.4
Bonifacio, E.5
Ciurnelli, R.6
Bell, A.S.7
Di Tommaso, A.8
Rosati, E.9
Crescenzi, B.10
Mecucci, C.11
Screpanti, I.12
Marconi, P.13
Martelli, M.F.14
Di Ianni, M.15
Falzetti, F.16
-
20
-
-
79960353160
-
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
-
10.1084/jem.20110921, 3135373, 21670202
-
Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J, Grunn A, Fangazio M, Capello D, Monti S, Cresta S, Gargiulo E, Forconi F, Guarini A, Arcaini L, Paulli M, Laurenti L, Larocca LM, Marasca R, Gattei V, Oscier D, Bertoni F, Mullighan CG, Foá R, Pasqualucci L, Rabadan R, Dalla-Favera R, Gaidano G. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 2011, 208:1389-1401. 10.1084/jem.20110921, 3135373, 21670202.
-
(2011)
J Exp Med
, vol.208
, pp. 1389-1401
-
-
Fabbri, G.1
Rasi, S.2
Rossi, D.3
Trifonov, V.4
Khiabanian, H.5
Ma, J.6
Grunn, A.7
Fangazio, M.8
Capello, D.9
Monti, S.10
Cresta, S.11
Gargiulo, E.12
Forconi, F.13
Guarini, A.14
Arcaini, L.15
Paulli, M.16
Laurenti, L.17
Larocca, L.M.18
Marasca, R.19
Gattei, V.20
Oscier, D.21
Bertoni, F.22
Mullighan, C.G.23
Foá, R.24
Pasqualucci, L.25
Rabadan, R.26
Dalla-Favera, R.27
Gaidano, G.28
more..
-
21
-
-
84855854025
-
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
-
10.1182/blood-2011-09-379966, 3257017, 22077063
-
Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F, Marasca R, Laurenti L, Bruscaggin A, Cerri M, Monti S, Cresta S, Famà R, De Paoli L, Bulian P, Gattei V, Guarini A, Deaglio S, Capello D, Rabadan R, Pasqualucci L, Dalla-Favera R, Foà R, Gaidano G. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 2012, 119:521-529. 10.1182/blood-2011-09-379966, 3257017, 22077063.
-
(2012)
Blood
, vol.119
, pp. 521-529
-
-
Rossi, D.1
Rasi, S.2
Fabbri, G.3
Spina, V.4
Fangazio, M.5
Forconi, F.6
Marasca, R.7
Laurenti, L.8
Bruscaggin, A.9
Cerri, M.10
Monti, S.11
Cresta, S.12
Famà, R.13
De Paoli, L.14
Bulian, P.15
Gattei, V.16
Guarini, A.17
Deaglio, S.18
Capello, D.19
Rabadan, R.20
Pasqualucci, L.21
Dalla-Favera, R.22
Foà, R.23
Gaidano, G.24
more..
-
22
-
-
84877637121
-
NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome
-
Villamor N, Conde L, Martinez-Trillos A, Cazorla M, Navarro A, Bea S, Lopez C, Colomer D, Pinyol M, Aymerich M, Rozman M, Abrisqueta P, Baumann T, Delgado J, Giné E, González-Díaz M, Hernández JM, Colado E, Payer AR, Rayon C, Navarro B, José Terol M, Bosch F, Quesada V, Puente XS, López-Otín C, Jares P, Pereira A, Campo E, López-Guillermo A. NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia 2012,
-
(2012)
Leukemia
-
-
Villamor, N.1
Conde, L.2
Martinez-Trillos, A.3
Cazorla, M.4
Navarro, A.5
Bea, S.6
Lopez, C.7
Colomer, D.8
Pinyol, M.9
Aymerich, M.10
Rozman, M.11
Abrisqueta, P.12
Baumann, T.13
Delgado, J.14
Giné, E.15
González-Díaz, M.16
Hernández, J.M.17
Colado, E.18
Payer, A.R.19
Rayon, C.20
Navarro, B.21
José Terol, M.22
Bosch, F.23
Quesada, V.24
Puente, X.S.25
López-Otín, C.26
Jares, P.27
Pereira, A.28
Campo, E.29
López-Guillermo, A.30
more..
-
23
-
-
84873986676
-
Gamma-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation
-
Rosati E, Sabatini R, De Falco F, Del Papa B, Falzetti F, Di Ianni M, Cavalli L, Fettucciari K, Bartoli A, Screpanti I, Marconi P. gamma-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation. Int J Cancer 2012, 132:1940-1953.
-
(2012)
Int J Cancer
, vol.132
, pp. 1940-1953
-
-
Rosati, E.1
Sabatini, R.2
De Falco, F.3
Del Papa, B.4
Falzetti, F.5
Di Ianni, M.6
Cavalli, L.7
Fettucciari, K.8
Bartoli, A.9
Screpanti, I.10
Marconi, P.11
-
24
-
-
84555171449
-
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
-
10.1038/ng.1032, 22158541
-
Quesada V, Conde L, Villamor N, Ordonez GR, Jares P, Bassaganyas L, Ramsay AJ, Bea S, Pinyol M, Martinez-Trillos A, López-Guerra M, Colomer D, Navarro A, Baumann T, Aymerich M, Rozman M, Delgado J, Giné E, Hernández JM, González-Díaz M, Puente DA, Velasco G, Freije JM, Tubío JM, Royo R, Gelpí JL, Orozco M, Pisano DG, Zamora J, Vázquez M. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2011, 44:47-52. 10.1038/ng.1032, 22158541.
-
(2011)
Nat Genet
, vol.44
, pp. 47-52
-
-
Quesada, V.1
Conde, L.2
Villamor, N.3
Ordonez, G.R.4
Jares, P.5
Bassaganyas, L.6
Ramsay, A.J.7
Bea, S.8
Pinyol, M.9
Martinez-Trillos, A.10
López-Guerra, M.11
Colomer, D.12
Navarro, A.13
Baumann, T.14
Aymerich, M.15
Rozman, M.16
Delgado, J.17
Giné, E.18
Hernández, J.M.19
González-Díaz, M.20
Puente, D.A.21
Velasco, G.22
Freije, J.M.23
Tubío, J.M.24
Royo, R.25
Gelpí, J.L.26
Orozco, M.27
Pisano, D.G.28
Zamora, J.29
Vázquez, M.30
more..
-
25
-
-
84855370035
-
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
-
10.1056/NEJMoa1109016, 22150006
-
Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, DeLuca DS, Zhang L, Zhang W, Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, Cibulskis K, Tesar B, Sievers QL, Shefler E, Gabriel S, Hacohen N, Reed R, Meyerson M, Golub TR, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011, 365:2497-2506. 10.1056/NEJMoa1109016, 22150006.
-
(2011)
N Engl J Med
, vol.365
, pp. 2497-2506
-
-
Wang, L.1
Lawrence, M.S.2
Wan, Y.3
Stojanov, P.4
Sougnez, C.5
Stevenson, K.6
Werner, L.7
Sivachenko, A.8
DeLuca, D.S.9
Zhang, L.10
Zhang, W.11
Vartanov, A.R.12
Fernandes, S.M.13
Goldstein, N.R.14
Folco, E.G.15
Cibulskis, K.16
Tesar, B.17
Sievers, Q.L.18
Shefler, E.19
Gabriel, S.20
Hacohen, N.21
Reed, R.22
Meyerson, M.23
Golub, T.R.24
Lander, E.S.25
Neuberg, D.26
Brown, J.R.27
Getz, G.28
Wu, C.J.29
more..
-
26
-
-
34548095157
-
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
-
10.1038/nchembio.2007.18, 17643111
-
Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S, Yoshida M. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol 2007, 3:576-583. 10.1038/nchembio.2007.18, 17643111.
-
(2007)
Nat Chem Biol
, vol.3
, pp. 576-583
-
-
Kaida, D.1
Motoyoshi, H.2
Tashiro, E.3
Nojima, T.4
Hagiwara, M.5
Ishigami, K.6
Watanabe, H.7
Kitahara, T.8
Yoshida, T.9
Nakajima, H.10
Tani, T.11
Horinouchi, S.12
Yoshida, M.13
-
27
-
-
79952220808
-
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A
-
10.1101/gad.2014311, 3049286, 21363963
-
Corrionero A, Minana B, Valcarcel J. Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes Dev 2011, 25:445-459. 10.1101/gad.2014311, 3049286, 21363963.
-
(2011)
Genes Dev
, vol.25
, pp. 445-459
-
-
Corrionero, A.1
Minana, B.2
Valcarcel, J.3
-
28
-
-
80053900941
-
Frequent pathway mutations of splicing machinery in myelodysplasia
-
10.1038/nature10496, 21909114
-
Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 2011, 478:64-69. 10.1038/nature10496, 21909114.
-
(2011)
Nature
, vol.478
, pp. 64-69
-
-
Yoshida, K.1
Sanada, M.2
Shiraishi, Y.3
Nowak, D.4
Nagata, Y.5
Yamamoto, R.6
Sato, Y.7
Sato-Otsubo, A.8
Kon, A.9
Nagasaki, M.10
Chalkidis, G.11
Suzuki, Y.12
Shiosaka, M.13
Kawahata, R.14
Yamaguchi, T.15
Otsu, M.16
Obara, N.17
Sakata-Yanagimoto, M.18
Ishiyama, K.19
Mori, H.20
Nolte, F.21
Hofmann, W.K.22
Miyawaki, S.23
Sugano, S.24
Haferlach, C.25
Koeffler, H.P.26
Shih, L.Y.27
Haferlach, T.28
Chiba, S.29
Nakauchi, H.30
more..
-
29
-
-
80054010617
-
Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
-
10.1056/NEJMoa1103283, 3322589, 21995386
-
Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P, Bowen D, Pellagatti A, Wainscoat JS, Hellstrom-Lindberg E, Gambacorti-Passerini C, Godfrey AL, Rapado I, Cvejic A, Rance R, McGee C, Ellis P, Mudie LJ, Stephens PJ, McLaren S, Massie CE, Tarpey PS, Varela I, Nik-Zainal S, Davies HR, Shlien A, Jones D, Raine K, Hinton J, Butler AP, Teague JW. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011, 365:1384-1395. 10.1056/NEJMoa1103283, 3322589, 21995386.
-
(2011)
N Engl J Med
, vol.365
, pp. 1384-1395
-
-
Papaemmanuil, E.1
Cazzola, M.2
Boultwood, J.3
Malcovati, L.4
Vyas, P.5
Bowen, D.6
Pellagatti, A.7
Wainscoat, J.S.8
Hellstrom-Lindberg, E.9
Gambacorti-Passerini, C.10
Godfrey, A.L.11
Rapado, I.12
Cvejic, A.13
Rance, R.14
McGee, C.15
Ellis, P.16
Mudie, L.J.17
Stephens, P.J.18
McLaren, S.19
Massie, C.E.20
Tarpey, P.S.21
Varela, I.22
Nik-Zainal, S.23
Davies, H.R.24
Shlien, A.25
Jones, D.26
Raine, K.27
Hinton, J.28
Butler, A.P.29
Teague, J.W.30
more..
-
30
-
-
84859597590
-
Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
-
10.1182/blood-2011-12-399774, 3321850, 22323480
-
Makishima H, Visconte V, Sakaguchi H, Jankowska AM, Abu Kar S, Jerez A, Przychodzen B, Bupathi M, Guinta K, Afable MG, Sekeres MA, Padgett RA, Tiu RV, Maciejewski JP. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Blood 2012, 119:3203-3210. 10.1182/blood-2011-12-399774, 3321850, 22323480.
-
(2012)
Blood
, vol.119
, pp. 3203-3210
-
-
Makishima, H.1
Visconte, V.2
Sakaguchi, H.3
Jankowska, A.M.4
Abu Kar, S.5
Jerez, A.6
Przychodzen, B.7
Bupathi, M.8
Guinta, K.9
Afable, M.G.10
Sekeres, M.A.11
Padgett, R.A.12
Tiu, R.V.13
Maciejewski, J.P.14
-
31
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
10.1038/nature11547, 3530898, 23103869
-
Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Manning S, Wani S, Gongora M, Pajic M, Scarlett CJ, Gill AJ, Pinho AV, Rooman I, Anderson M, Holmes O, Leonard C, Taylor D. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012, 491:399-405. 10.1038/nature11547, 3530898, 23103869.
-
(2012)
Nature
, vol.491
, pp. 399-405
-
-
Biankin, A.V.1
Waddell, N.2
Kassahn, K.S.3
Gingras, M.C.4
Muthuswamy, L.B.5
Johns, A.L.6
Miller, D.K.7
Wilson, P.J.8
Patch, A.M.9
Wu, J.10
Chang, D.K.11
Cowley, M.J.12
Gardiner, B.B.13
Song, S.14
Harliwong, I.15
Idrisoglu, S.16
Nourse, C.17
Nourbakhsh, E.18
Manning, S.19
Wani, S.20
Gongora, M.21
Pajic, M.22
Scarlett, C.J.23
Gill, A.J.24
Pinho, A.V.25
Rooman, I.26
Anderson, M.27
Holmes, O.28
Leonard, C.29
Taylor, D.30
more..
-
32
-
-
84873086305
-
Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
-
10.1038/ng.2523, 23313955
-
Harbour JW, Roberson ED, Anbunathan H, Onken MD, Worley LA, Bowcock AM. Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma. Nat Genet 2013, 45:133-135. 10.1038/ng.2523, 23313955.
-
(2013)
Nat Genet
, vol.45
, pp. 133-135
-
-
Harbour, J.W.1
Roberson, E.D.2
Anbunathan, H.3
Onken, M.D.4
Worley, L.A.5
Bowcock, A.M.6
-
33
-
-
84862584058
-
Whole-genome analysis informs breast cancer response to aromatase inhibition
-
3383766, 22722193
-
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 2012, 486:353-360. 3383766, 22722193.
-
(2012)
Nature
, vol.486
, pp. 353-360
-
-
Ellis, M.J.1
Ding, L.2
Shen, D.3
Luo, J.4
Suman, V.J.5
Wallis, J.W.6
Van Tine, B.A.7
Hoog, J.8
Goiffon, R.J.9
Goldstein, T.C.10
Ng, S.11
Lin, L.12
Crowder, R.13
Snider, J.14
Ballman, K.15
Weber, J.16
Chen, K.17
Koboldt, D.C.18
Kandoth, C.19
Schierding, W.S.20
McMichael, J.F.21
Miller, C.A.22
Lu, C.23
Harris, C.C.24
McLellan, M.D.25
Wendl, M.C.26
DeSchryver, K.27
Allred, D.C.28
Esserman, L.29
Unzeitig, G.30
more..
-
34
-
-
84880322359
-
Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia
-
Ramsay AJ, Rodriguez D, Villamor N, Kwarciak A, Tejedor JR, Valcarcel J, Lopez-Guillermo A, Martinez-Trillos A, Puente XS, Campo E, López-Otín C, Quesada V. Frequent somatic mutations in components of the RNA processing machinery in chronic lymphocytic leukemia. Leukemia 2012,
-
(2012)
Leukemia
-
-
Ramsay, A.J.1
Rodriguez, D.2
Villamor, N.3
Kwarciak, A.4
Tejedor, J.R.5
Valcarcel, J.6
Lopez-Guillermo, A.7
Martinez-Trillos, A.8
Puente, X.S.9
Campo, E.10
López-Otín, C.11
Quesada, V.12
-
35
-
-
84871236747
-
Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders
-
10.1038/leu.2012.130, 22678168
-
Visconte V, Makishima H, Maciejewski JP, Tiu RV. Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders. Leukemia 2012, 26:2447-2454. 10.1038/leu.2012.130, 22678168.
-
(2012)
Leukemia
, vol.26
, pp. 2447-2454
-
-
Visconte, V.1
Makishima, H.2
Maciejewski, J.P.3
Tiu, R.V.4
-
36
-
-
14644431836
-
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
-
10.1101/gad.1284605, 551574, 15741318
-
Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H. Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev 2005, 19:536-541. 10.1101/gad.1284605, 551574, 15741318.
-
(2005)
Genes Dev
, vol.19
, pp. 536-541
-
-
Isono, K.1
Mizutani-Koseki, Y.2
Komori, T.3
Schmidt-Zachmann, M.S.4
Koseki, H.5
-
37
-
-
84255160977
-
Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
-
10.1182/blood-2011-08-373159, 3245210, 22039264
-
Rossi D, Bruscaggin A, Spina V, Rasi S, Khiabanian H, Messina M, Fangazio M, Vaisitti T, Monti S, Chiaretti S, Guarini A, Del Giudice I, Cerri M, Cresta S, Deambrogi C, Gargiulo E, Gattei V, Forconi F, Bertoni F, Deaglio S, Rabadan R, Pasqualucci L, Foà R, Dalla-Favera R, Gaidano G. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood 2011, 118:6904-6908. 10.1182/blood-2011-08-373159, 3245210, 22039264.
-
(2011)
Blood
, vol.118
, pp. 6904-6908
-
-
Rossi, D.1
Bruscaggin, A.2
Spina, V.3
Rasi, S.4
Khiabanian, H.5
Messina, M.6
Fangazio, M.7
Vaisitti, T.8
Monti, S.9
Chiaretti, S.10
Guarini, A.11
Del Giudice, I.12
Cerri, M.13
Cresta, S.14
Deambrogi, C.15
Gargiulo, E.16
Gattei, V.17
Forconi, F.18
Bertoni, F.19
Deaglio, S.20
Rabadan, R.21
Pasqualucci, L.22
Foà, R.23
Dalla-Favera, R.24
Gaidano, G.25
more..
-
38
-
-
84872388894
-
Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome
-
10.1007/s12094-012-0922-z, 22911550
-
Ramsay AJ, Martinez-Trillos A, Jares P, Rodriguez D, Kwarciak A, Quesada V. Next-generation sequencing reveals the secrets of the chronic lymphocytic leukemia genome. Clin Transl Oncol 2013, 15:3-8. 10.1007/s12094-012-0922-z, 22911550.
-
(2013)
Clin Transl Oncol
, vol.15
, pp. 3-8
-
-
Ramsay, A.J.1
Martinez-Trillos, A.2
Jares, P.3
Rodriguez, D.4
Kwarciak, A.5
Quesada, V.6
-
39
-
-
84858859064
-
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
-
10.1182/blood-2011-12-395673, 22308293
-
Rossi D, Fangazio M, Rasi S, Vaisitti T, Monti S, Cresta S, Chiaretti S, Del Giudice I, Fabbri G, Bruscaggin A, Spina V, Deambrogi C, Marinelli M, Famà R, Greco M, Daniele G, Forconi F, Gattei V, Bertoni F, Deaglio S, Pasqualucci L, Guarini A, Dalla-Favera R, Foà R, Gaidano G. Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 2012, 119:2854-2862. 10.1182/blood-2011-12-395673, 22308293.
-
(2012)
Blood
, vol.119
, pp. 2854-2862
-
-
Rossi, D.1
Fangazio, M.2
Rasi, S.3
Vaisitti, T.4
Monti, S.5
Cresta, S.6
Chiaretti, S.7
Del Giudice, I.8
Fabbri, G.9
Bruscaggin, A.10
Spina, V.11
Deambrogi, C.12
Marinelli, M.13
Famà, R.14
Greco, M.15
Daniele, G.16
Forconi, F.17
Gattei, V.18
Bertoni, F.19
Deaglio, S.20
Pasqualucci, L.21
Guarini, A.22
Dalla-Favera, R.23
Foà, R.24
Gaidano, G.25
more..
-
40
-
-
79957949229
-
Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial
-
10.1200/JCO.2010.32.0838, 21483000
-
Gonzalez D, Martinez P, Wade R, Hockley S, Oscier D, Matutes E, Dearden CE, Richards SM, Catovsky D, Morgan GJ. Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial. J Clin Oncol 2011, 29:2223-2229. 10.1200/JCO.2010.32.0838, 21483000.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2223-2229
-
-
Gonzalez, D.1
Martinez, P.2
Wade, R.3
Hockley, S.4
Oscier, D.5
Matutes, E.6
Dearden, C.E.7
Richards, S.M.8
Catovsky, D.9
Morgan, G.J.10
-
41
-
-
84858190503
-
SF3B1 in chronic lymphocytic leukemia
-
author reply 10571058
-
Mori J, Takahashi Y, Tanimoto T. SF3B1 in chronic lymphocytic leukemia. N Engl J Med 2012, 366:1057. author reply 10571058.
-
(2012)
N Engl J Med
, vol.366
, pp. 1057
-
-
Mori, J.1
Takahashi, Y.2
Tanimoto, T.3
-
42
-
-
84862854953
-
Chronic lymphocytic leukemia with SF3B1 mutation
-
10.1056/NEJMc1204033, 22738114
-
Quesada V, Ramsay AJ, Lopez-Otin C. Chronic lymphocytic leukemia with SF3B1 mutation. N Engl J Med 2012, 366:2530. 10.1056/NEJMc1204033, 22738114.
-
(2012)
N Engl J Med
, vol.366
, pp. 2530
-
-
Quesada, V.1
Ramsay, A.J.2
Lopez-Otin, C.3
-
43
-
-
84868198427
-
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
-
10.1038/ng.2443, 23064414
-
Kulis M, Heath S, Bibikova M, Queiros AC, Navarro A, Clot G, Martinez-Trillos A, Castellano G, Brun-Heath I, Pinyol M, Barberán-Soler S, Papasaikas P, Jares P, Beà S, Rico D, Ecker S, Rubio M, Royo R, Ho V, Klotzle B, Hernández L, Conde L, López-Guerra M, Colomer D, Villamor N, Aymerich M, Rozman M, Bayes M, Gut M, Gelpí JL. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet 2012, 44:1236-1242. 10.1038/ng.2443, 23064414.
-
(2012)
Nat Genet
, vol.44
, pp. 1236-1242
-
-
Kulis, M.1
Heath, S.2
Bibikova, M.3
Queiros, A.C.4
Navarro, A.5
Clot, G.6
Martinez-Trillos, A.7
Castellano, G.8
Brun-Heath, I.9
Pinyol, M.10
Barberán-Soler, S.11
Papasaikas, P.12
Jares, P.13
Beà, S.14
Rico, D.15
Ecker, S.16
Rubio, M.17
Royo, R.18
Ho, V.19
Klotzle, B.20
Hernández, L.21
Conde, L.22
López-Guerra, M.23
Colomer, D.24
Villamor, N.25
Aymerich, M.26
Rozman, M.27
Bayes, M.28
Gut, M.29
Gelpí, J.L.30
more..
-
44
-
-
78650791604
-
Analysis of next-generation genomic data in cancer: accomplishments and challenges
-
10.1093/hmg/ddq391, 2953747, 20843826
-
Ding L, Wendl MC, Koboldt DC, Mardis ER. Analysis of next-generation genomic data in cancer: accomplishments and challenges. Hum Mol Genet 2010, 19:R188-196. 10.1093/hmg/ddq391, 2953747, 20843826.
-
(2010)
Hum Mol Genet
, vol.19
-
-
Ding, L.1
Wendl, M.C.2
Koboldt, D.C.3
Mardis, E.R.4
-
45
-
-
84874428346
-
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
-
10.1182/blood-2012-09-458265, 23243274
-
Rossi D, Rasi S, Spina V, Bruscaggin A, Monti S, Ciardullo C, Deambrogi C, Khiabanian H, Serra R, Bertoni F, Forconi F, Laurenti L, Marasca R, Dal-Bo M, Rossi FM, Bulian P, Nomdedeu J, Del Poeta G, Gattei V, Pasqualucci L, Rabadan R, Foà R, Dalla-Favera R, Gaidano G. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 2013, 121:1403-1412. 10.1182/blood-2012-09-458265, 23243274.
-
(2013)
Blood
, vol.121
, pp. 1403-1412
-
-
Rossi, D.1
Rasi, S.2
Spina, V.3
Bruscaggin, A.4
Monti, S.5
Ciardullo, C.6
Deambrogi, C.7
Khiabanian, H.8
Serra, R.9
Bertoni, F.10
Forconi, F.11
Laurenti, L.12
Marasca, R.13
Dal-Bo, M.14
Rossi, F.M.15
Bulian, P.16
Nomdedeu, J.17
Del Poeta, G.18
Gattei, V.19
Pasqualucci, L.20
Rabadan, R.21
Foà, R.22
Dalla-Favera, R.23
Gaidano, G.24
more..
-
46
-
-
84877608629
-
Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia
-
Schwaederlé M, Ghia E, Rassenti L, Obara M, Dell'aquila ML, Fecteau-Farah J, Kipps TJ. Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia. Leukemia 2013,
-
(2013)
Leukemia
-
-
Schwaederlé, M.1
Ghia, E.2
Rassenti, L.3
Obara, M.4
Dell'aquila, M.L.5
Fecteau-Farah, J.6
Kipps, T.J.7
-
47
-
-
84859896966
-
Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis
-
10.1002/ijc.26322, 21796624
-
Rossi D, Spina V, Forconi F, Capello D, Fangazio M, Rasi S, Martini M, Gattei V, Ramponi A, Larocca LM, Bertoni F, Gaidano G. Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis. Int J Cancer 2012, 130:3006-3010. 10.1002/ijc.26322, 21796624.
-
(2012)
Int J Cancer
, vol.130
, pp. 3006-3010
-
-
Rossi, D.1
Spina, V.2
Forconi, F.3
Capello, D.4
Fangazio, M.5
Rasi, S.6
Martini, M.7
Gattei, V.8
Ramponi, A.9
Larocca, L.M.10
Bertoni, F.11
Gaidano, G.12
-
48
-
-
84877926927
-
The evolution and impact of subclonal mutations in chronic lymphocytic leukemia
-
Atlanta, GA, abstract 5
-
Landau D-A, Carter S, Stojanov P, Stevenson KE, Mckenna A, Lawrence M, Sougnez C, Sivachenko A, Wang L, Zhang W, Sachet S, Vartanov AR, Fernandes SM, Cibulskis K, Tesar B, Gabriel S, Meyerson M, Lander ES, Neuberg DS, Brown JR, Getz G, Wu CJ. The evolution and impact of subclonal mutations in chronic lymphocytic leukemia. 54th ASH Annual Meeting and Exposition: December 8-11, 2012 2012, Atlanta, GA, abstract 5.
-
(2012)
54th ASH Annual Meeting and Exposition: December 8-11, 2012
-
-
Landau, D.-A.1
Carter, S.2
Stojanov, P.3
Stevenson, K.E.4
Mckenna, A.5
Lawrence, M.6
Sougnez, C.7
Sivachenko, A.8
Wang, L.9
Zhang, W.10
Sachet, S.11
Vartanov, A.R.12
Fernandes, S.M.13
Cibulskis, K.14
Tesar, B.15
Gabriel, S.16
Meyerson, M.17
Lander, E.S.18
Neuberg, D.S.19
Brown, J.R.20
Getz, G.21
Wu, C.J.22
more..
-
49
-
-
84874102335
-
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
-
10.1016/j.cell.2013.01.019, 23415222
-
Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS, Sougnez C, Stewart C, Sivachenko A, Wang L, Wan Y, Zhang W, Shukla SA, Vartanov A, Fernandes SM, Saksena G, Cibulskis K, Tesar B, Gabriel S, Hacohen N, Meyerson M, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013, 152:714-726. 10.1016/j.cell.2013.01.019, 23415222.
-
(2013)
Cell
, vol.152
, pp. 714-726
-
-
Landau, D.A.1
Carter, S.L.2
Stojanov, P.3
McKenna, A.4
Stevenson, K.5
Lawrence, M.S.6
Sougnez, C.7
Stewart, C.8
Sivachenko, A.9
Wang, L.10
Wan, Y.11
Zhang, W.12
Shukla, S.A.13
Vartanov, A.14
Fernandes, S.M.15
Saksena, G.16
Cibulskis, K.17
Tesar, B.18
Gabriel, S.19
Hacohen, N.20
Meyerson, M.21
Lander, E.S.22
Neuberg, D.23
Brown, J.R.24
Getz, G.25
Wu, C.J.26
more..
-
50
-
-
84874652133
-
The evolutionary biography of chronic lymphocytic leukemia
-
10.1038/ng.2556, 23435090
-
Puente XS, Lopez-Otin C. The evolutionary biography of chronic lymphocytic leukemia. Nat Genet 2013, 45:229-231. 10.1038/ng.2556, 23435090.
-
(2013)
Nat Genet
, vol.45
, pp. 229-231
-
-
Puente, X.S.1
Lopez-Otin, C.2
-
51
-
-
79959293462
-
BRAF mutations in hairy-cell leukemia
-
10.1056/NEJMoa1014209, 21663470
-
Tiacci E, Trifonov V, Schiavoni G, Holmes A, Kern W, Martelli MP, Pucciarini A, Bigerna B, Pacini R, Wells VA, Sportoletti P, Pettirossi V, Mannucci R, Elliott O, Liso A, Ambrosetti A, Pulsoni A, Forconi F, Trentin L, Semenzato G, Inghirami G, Capponi M, Di Raimondo F, Patti C, Arcaini L, Musto P, Pileri S, Haferlach C, Schnittger S, Pizzolo G. BRAF mutations in hairy-cell leukemia. N Engl J Med 2011, 364:2305-2315. 10.1056/NEJMoa1014209, 21663470.
-
(2011)
N Engl J Med
, vol.364
, pp. 2305-2315
-
-
Tiacci, E.1
Trifonov, V.2
Schiavoni, G.3
Holmes, A.4
Kern, W.5
Martelli, M.P.6
Pucciarini, A.7
Bigerna, B.8
Pacini, R.9
Wells, V.A.10
Sportoletti, P.11
Pettirossi, V.12
Mannucci, R.13
Elliott, O.14
Liso, A.15
Ambrosetti, A.16
Pulsoni, A.17
Forconi, F.18
Trentin, L.19
Semenzato, G.20
Inghirami, G.21
Capponi, M.22
Di Raimondo, F.23
Patti, C.24
Arcaini, L.25
Musto, P.26
Pileri, S.27
Haferlach, C.28
Schnittger, S.29
Pizzolo, G.30
more..
-
52
-
-
80053189298
-
Predicting the functional impact of protein mutations: application to cancer genomics
-
10.1093/nar/gkr407, 3177186, 21727090
-
Reva B, Antipin Y, Sander C. Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res 2011, 39:e118. 10.1093/nar/gkr407, 3177186, 21727090.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Reva, B.1
Antipin, Y.2
Sander, C.3
-
53
-
-
84870599966
-
Functional impact bias reveals cancer drivers
-
10.1093/nar/gks743, 3505979, 22904074
-
Gonzalez-Perez A, Lopez-Bigas N. Functional impact bias reveals cancer drivers. Nucleic Acids Res 2012, 40:e169. 10.1093/nar/gks743, 3505979, 22904074.
-
(2012)
Nucleic Acids Res
, vol.40
-
-
Gonzalez-Perez, A.1
Lopez-Bigas, N.2
-
54
-
-
84868010133
-
Domain landscapes of somatic mutations in cancer
-
3521244, 23281853
-
Nehrt NL, Peterson TA, Park D, Kann MG. Domain landscapes of somatic mutations in cancer. BMC Genomics 2012, 13:S9. 3521244, 23281853.
-
(2012)
BMC Genomics
, vol.13
-
-
Nehrt, N.L.1
Peterson, T.A.2
Park, D.3
Kann, M.G.4
-
55
-
-
84877926730
-
The significance of spliceosome mutations in chronic lymphocytic leukemia
-
[Epub ahead of print.]
-
Rozovski U, Keating M, Estrov Z. The significance of spliceosome mutations in chronic lymphocytic leukemia. Leuk Lymphoma 2013, [Epub ahead of print.].
-
(2013)
Leuk Lymphoma
-
-
Rozovski, U.1
Keating, M.2
Estrov, Z.3
-
56
-
-
84878551940
-
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia
-
10.1038/ng.2584, 23502782
-
Ramsay AJ, Quesada V, Foronda M, Conde L, Martinez-Trillos A, Villamor N, Rodriguez D, Kwarciak A, Garabaya C, Gallardo M, López-Guerra M, López-Guillermo A, Puente XS, Blasco MA, Campo E, López-Otín C. POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet 2013, 45:526-530. 10.1038/ng.2584, 23502782.
-
(2013)
Nat Genet
, vol.45
, pp. 526-530
-
-
Ramsay, A.J.1
Quesada, V.2
Foronda, M.3
Conde, L.4
Martinez-Trillos, A.5
Villamor, N.6
Rodriguez, D.7
Kwarciak, A.8
Garabaya, C.9
Gallardo, M.10
López-Guerra, M.11
López-Guillermo, A.12
Puente, X.S.13
Blasco, M.A.14
Campo, E.15
López-Otín, C.16
-
57
-
-
84877894013
-
Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients
-
10.1093/hmg/ddt078, 23418305
-
Rodriguez D, Ramsay AJ, Quesada V, Garabaya C, Campo E, Freije JM, Lopez-Otin C. Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients. Hum Mol Genet 2013, 22:2273-2282. 10.1093/hmg/ddt078, 23418305.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 2273-2282
-
-
Rodriguez, D.1
Ramsay, A.J.2
Quesada, V.3
Garabaya, C.4
Campo, E.5
Freije, J.M.6
Lopez-Otin, C.7
-
58
-
-
33947608617
-
Animal models for chronic lymphocytic leukemia
-
10.1002/jcb.21147, 17131382
-
Pekarsky Y, Zanesi N, Aqeilan RI, Croce CM. Animal models for chronic lymphocytic leukemia. J Cell Biochem 2007, 100:1109-1118. 10.1002/jcb.21147, 17131382.
-
(2007)
J Cell Biochem
, vol.100
, pp. 1109-1118
-
-
Pekarsky, Y.1
Zanesi, N.2
Aqeilan, R.I.3
Croce, C.M.4
-
59
-
-
67651037334
-
A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen
-
10.1182/blood-2009-01-198937, 19332766
-
ter Brugge PJ, Ta VB, de Bruijn MJ, Keijzers G, Maas A, van Gent DC, Hendriks RW. A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigen. Blood 2009, 114:119-127. 10.1182/blood-2009-01-198937, 19332766.
-
(2009)
Blood
, vol.114
, pp. 119-127
-
-
ter Brugge, P.J.1
Ta, V.B.2
de Bruijn, M.J.3
Keijzers, G.4
Maas, A.5
van Gent, D.C.6
Hendriks, R.W.7
-
60
-
-
84875212754
-
Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions
-
Bertilaccio MT, Scielzo C, Simonetti G, Hacken ET, Apollonio B, Ghia P, Caligaris-Cappio F. Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions. Leukemia 2012, 27:534-540.
-
(2012)
Leukemia
, vol.27
, pp. 534-540
-
-
Bertilaccio, M.T.1
Scielzo, C.2
Simonetti, G.3
Hacken, E.T.4
Apollonio, B.5
Ghia, P.6
Caligaris-Cappio, F.7
-
61
-
-
84868355027
-
The spliceosome as a target of novel antitumour drugs
-
10.1038/nrd3823, 23123942
-
Bonnal S, Vigevani L, Valcarcel J. The spliceosome as a target of novel antitumour drugs. Nat Rev Drug Discov 2012, 11:847-859. 10.1038/nrd3823, 23123942.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 847-859
-
-
Bonnal, S.1
Vigevani, L.2
Valcarcel, J.3
-
62
-
-
84873567287
-
NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia
-
Mansouri L, Cahill N, Gunnarsson R, Smedby KE, Tjonnfjord E, Hjalgrim H, Juliusson G, Geisler C, Rosenquist R. NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia. Leukemia 2012, 27:512-514.
-
(2012)
Leukemia
, vol.27
, pp. 512-514
-
-
Mansouri, L.1
Cahill, N.2
Gunnarsson, R.3
Smedby, K.E.4
Tjonnfjord, E.5
Hjalgrim, H.6
Juliusson, G.7
Geisler, C.8
Rosenquist, R.9
-
63
-
-
84877920734
-
SF3B1 mutations have adverse impact on time to treatment especially in patients with 13q deletions: a study on 1,124 chronic lymphocytic leukemia (CLL) patients
-
Atlanta, GA, abstract 709
-
Jeromin S, Haferlach C, Bayer K, Dicker F, Weissmann S, Grossmann V, Alpermann T, Kohlmann A, Haferlach T, Kern W, Schnittger S. SF3B1 mutations have adverse impact on time to treatment especially in patients with 13q deletions: a study on 1,124 chronic lymphocytic leukemia (CLL) patients. In 54th ASH Annual Meeting and Exposition: December 8-11, 2012. 2012, Atlanta, GA, abstract 709.
-
(2012)
In 54th ASH Annual Meeting and Exposition: December 8-11, 2012
-
-
Jeromin, S.1
Haferlach, C.2
Bayer, K.3
Dicker, F.4
Weissmann, S.5
Grossmann, V.6
Alpermann, T.7
Kohlmann, A.8
Haferlach, T.9
Kern, W.10
Schnittger, S.11
-
64
-
-
84904614197
-
Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial
-
Atlanta, GA, abstract 433
-
Stilgenbauer S, Busch R, Schnaiter A, Paschka P, Rossi M, Döhner K, Zenz T, Bühler A, Winkler D, Edelmann J, Mertens D, Bullinger L, Kless S, Mack S, Böttcher S, Ritgen M, Kneba M, Jäger U, Lichter P, Patten N, Wenger MK, Mendila M, Fingerle-Rowson G, Cazzola M, Wendtner C, Fink AM, Fischer K, Hallek M, Döhner H. Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. 54th ASH Annual Meeting and Exposition: December 8-11, 2012. 2012, Atlanta, GA, abstract 433.
-
(2012)
54th ASH Annual Meeting and Exposition: December 8-11, 2012.
-
-
Stilgenbauer, S.1
Busch, R.2
Schnaiter, A.3
Paschka, P.4
Rossi, M.5
Döhner, K.6
Zenz, T.7
Bühler, A.8
Winkler, D.9
Edelmann, J.10
Mertens, D.11
Bullinger, L.12
Kless, S.13
Mack, S.14
Böttcher, S.15
Ritgen, M.16
Kneba, M.17
Jäger, U.18
Lichter, P.19
Patten, N.20
Wenger, M.K.21
Mendila, M.22
Fingerle-Rowson, G.23
Cazzola, M.24
Wendtner, C.25
Fink, A.M.26
Fischer, K.27
Hallek, M.28
Döhner, H.29
more..
-
65
-
-
84872469222
-
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
-
10.1182/blood-2012-05-429282, 23086750
-
Oscier DG, Rose-Zerilli MJ, Winkelmann N, Gonzalez De Castro D, Gomez B, Forster J, Parker H, Parker A, Gardiner A, Collins A, Else M, Cross NC, Catovsky D, Strefford JC. The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial. Blood 2013, 121:468-475. 10.1182/blood-2012-05-429282, 23086750.
-
(2013)
Blood
, vol.121
, pp. 468-475
-
-
Oscier, D.G.1
Rose-Zerilli, M.J.2
Winkelmann, N.3
Gonzalez De Castro, D.4
Gomez, B.5
Forster, J.6
Parker, H.7
Parker, A.8
Gardiner, A.9
Collins, A.10
Else, M.11
Cross, N.C.12
Catovsky, D.13
Strefford, J.C.14
-
66
-
-
84858440807
-
Screens, maps & networks: from genome sequences to personalized medicine
-
10.1016/j.gde.2012.02.001, 22366531
-
Sandmann T, Boutros M. Screens, maps & networks: from genome sequences to personalized medicine. Curr Opin Genet Dev 2012, 22:36-44. 10.1016/j.gde.2012.02.001, 22366531.
-
(2012)
Curr Opin Genet Dev
, vol.22
, pp. 36-44
-
-
Sandmann, T.1
Boutros, M.2
-
67
-
-
84865973305
-
Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer
-
10.1073/pnas.1203559109, 3437850, 22891318
-
Beckman RA, Schemmann GS, Yeang CH. Impact of genetic dynamics and single-cell heterogeneity on development of nonstandard personalized medicine strategies for cancer. Proc Natl Acad Sci U S A 2012, 109:14586-14591. 10.1073/pnas.1203559109, 3437850, 22891318.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 14586-14591
-
-
Beckman, R.A.1
Schemmann, G.S.2
Yeang, C.H.3
|