Circulating levels of persistent organic pollutants (POPs) are associated with left ventricular systolic and diastolic dysfunction in the elderly

Environmental Research

Volumn 123, Issue , 2013, Pages 39-45

  Sjöberg Lind, Ylva ^a   Lind, P Monica ^b   Salihovic, Samira ^c   Van Bavel, Bert ^c   Lind, Lars ^b  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c ÖREBRO UNIVERSITY   (Sweden)

Author keywords

Diastolic dysfunction; Environmental contaminants; Heart failure; PCBs; Persistent organic pollutants; Systolic dysfunction

Indexed keywords

2,2 BIS(4 CHLOROPHENYL) 1,1 DICHLOROETHENE; BROMODIPHENYL ETHER; HEXACHLOROBENZENE; NONACHLOR; OCTACHLORODIBENZO 4 DIOXIN; ORGANIC COMPOUND; ORGANOCHLORINE PESTICIDE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; UNCLASSIFIED DRUG; VINYLIDENE CHLORIDE;

CARDIOVASCULAR DISEASE; DIABETES; GENDER; HEALTH RISK; HYPERTENSION; MASS SPECTROMETRY; OBESITY; ORGANIC POLLUTANT; PCB; SERUM; SMOKING;

AGED; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR RISK; CHROMATOGRAPHY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; PERSISTENT ORGANIC POLLUTANT; POLLUTANT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RELAXATION TIME; VASCULARIZATION;

AGED; CROSS-SECTIONAL STUDIES; DIASTOLE; ECHOCARDIOGRAPHY; FEMALE; HUMANS; MALE; POLYCHLORINATED BIPHENYLS; SYSTOLE; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84877095606     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2013.02.007     Document Type: Article

References (47)

1. Andren B., et al. Left ventricular systolic function in a population sample of elderly men. Echocardiography 1998, 15:315-324.
2. Aragon A.C., et al. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicol. Sci. 2008, 101:321-330.
3. Arnold D.L., et al. Two-generation chronic toxicity study with hexachlorobenzene in the rat. IARC Sci. Publ. 1986, 405-410.
4. Barac A., et al. Markers of inflammation, metabolic risk factors, and incident heart failure in american indians: the strong heart study. J. Clin Hypertens (Greenwich) 2012, 14:13-19.
5. Covaci A., et al. Distribution of organobrominated and organochlorinated contaminants in belgian human adipose tissue. Environ. Res. 2002, 88:210-218.
6. Dalton T.P., et al. Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovasc Toxicol. 2001, 1:285-298.
7. Dong W., et al. TCDD induced pericardial edema and relative COX-2 expression in medaka (Oryzias Latipes) embryos. Toxicol. Sci. 2010, 118:213-223.
8. Eriksson H., et al. Risk factors for heart failure in the general population: the study of men born in 1913. Eur. Heart J. 1989, 10:647-656.
9. Everett C.J., et al. Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension. J. Environ. Monit. 2011, 13:241-251.
10. Flesch-Janys D., et al. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. Am. J. Epidemiol. 1995, 142:1165-1175.
11. Guggilam A., et al. TNF-alpha blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H599-H609.
12. Ha M.H., et al. Association between serum concentrations of persistent organic pollutants and self-reported cardiovascular disease prevalence: results from the National Health and Nutrition Examination Survey, 1999-2002. Environ. Health Perspect. 2007, 115:1204-1209.
13. Ho K.K., et al. The epidemiology of heart failure: the Framingham Study. J. Am. Coll. Cardiol. 1993, 22:6A-13A.
14. Ingelsson E., et al. Inflammation, as measured by the erythrocyte sedimentation rate, is an independent predictor for the development of heart failure. J. Am. Coll. Cardiol. 2005, 45:1802-1806.
15. Kopf P.G., et al. Hypertension, cardiac hypertrophy, and impaired vascular relaxation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are associated with increased superoxide. Cardiovasc Toxicol. 2008, 8:181-193.
16. Koppen G., et al. Persistent organochlorine pollutants in human serum of 50-65 years old women in the Flanders Environmental and Health Study (FLEHS). Part 1: Concentrations and regional differences. Chemosphere 2002, 48:811-825.
17. Lampa E., et al. An investigation of the co-variation in circulating levels of a large number of environmental contaminants. J. Expo. Sci. Environ. Epidemiol. 2012, 22:476-482.
18. Lee D.H., et al. Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetologia 2007, 50:1841-1851.
19. Lee D.H., et al. Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study. Diabetes Care 2011, 34:1778-1784.
20. Lee D.H., et al. Associations of persistent organic pollutants with abdominal obesity in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study. Environ. Int. 2012, 40:170-178.
21. Lesmana R., et al. Lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor. Environ. Toxicol. 2012.
22. Levy D., et al. The progression from hypertension to congestive heart failure. JAMA 1996, 275:1557-1562.
23. Li X., et al. Molecular docking, molecular dynamics simulation, and structure-based 3D-QSAR studies on estrogenic activity of hydroxylated polychlorinated biphenyls. Sci. Total Environ. 2012, 441:230-238.
24. Lind L., et al. A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study. Arterioscler Thromb. Vasc. Biol. 2005, 25:2368-2375.
25. Lind P.M., et al. The dioxin-like pollutant PCB 126 (3,3',4,4',5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats. Toxicol. Lett. 2004, 150:293-299.
26. Maisel W.H., Stevenson L.W. Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am. J. Cardiol. 2003, 91:2D-8D.
27. Majkova Z., et al. Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicol. Appl. Pharmacol. 2009, 237:1-7.
28. Mellin V., et al. Transient reduction in myocardial free oxygen radical levels is involved in the improved cardiac function and structure after long-term allopurinol treatment initiated in established chronic heart failure. Eur. Heart J. 2005, 26:1544-1550.
29. Mureddu G.F., et al. Appropriate or inappropriate left ventricular mass in the presence or absence of prognostically adverse left ventricular hypertrophy. J. Hypertens. 2001, 19:1113-1119.
30. Neri T., et al. The differentiation of cardiomyocytes from mouse embryonic stem cells is altered by dioxin. Toxicol. Lett. 2011, 202:226-236.
31. Neubauer S. The failing heart-an engine out of fuel. N. Engl. J. Med. 2007, 356:1140-1151.
32. Park J.Y., et al. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage. Proc. Nat. Acad. Sci. U S A 1996, 93:2322-2327.
33. Puga A. Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease. Toxicol. Sci. 2011, 120:256-261.
34. Ronn M., et al. Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans. Chemosphere. 2011, 85:335-343.
35. Ruzzin J., et al. Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ. Health Perspect. 2010, 118:465-471.
36. Rylander L., et al. A simplified precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids. Chemosphere. 2006, 62:333-336.
37. Salihovic, S., et al., 2012. A Rapid Method for Screening of the Stockholm Convention POPs in Small amounts of Human Plasma Using SPE and HRGC/HRMS. Chemosphere. 86, 747-753.
38. Sergeev A.V., Carpenter D.O. Hospitalization rates for coronary heart disease in relation to residence near areas contaminated with persistent organic pollutants and other pollutants. Environ. Health Perspect. 2005, 113:756-761.
39. Shertzer H.G., et al. Dioxin causes a sustained oxidative stress response in the mouse. Biochem. Biophys. Res. Commun. 1998, 253:44-48.
40. Thackaberry E.A., et al. Toxicogenomic profile of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes. Toxicol. Sci. 2005, 88:231-241.
41. Tian X., et al. Polychlorinated biphenyls and their different level metabolites as inhibitors of glutathione S-transferase isoenzymes. Chem. Biol. Interact. 2012, 198:1-8.
42. Van den Berg M., et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 1998, 106:775-792.
43. Van den Berg M., et al. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol. Sci. 2006, 93:223-241.
44. Vogel C.F., et al. Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. Arch. Biochem. Biophys. 2007, 461:169-175.
45. Wayman G.A., et al. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ. Health Perspect. 2012, 120:997-1002.
46. Weiss J., et al. Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with Bone Density. Environ. Sci. Technol. 2006, 40:6282-6289.
47. Wu C.K., et al. The relationship among central obesity, systemic inflammation, and left ventricular diastolic dysfunction as determined by structural equation modeling. Obesity (Silver Spring) 2012, 20:730-737.