Influence of (S)-ketamine on human motor cortex excitability

Experimental Brain Research

Volumn 225, Issue 1, 2013, Pages 47-53

  Höffken, Oliver ^a   Haussleiter, Ida S ^b   Westermann, Andrea ^a   Lötsch, Jörn ^c   Maier, Christoph ^a   Tegenthoff, Martin ^a   Schwenkreis, Peter ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

(S) ketamine; Excitability; Motor cortex; TMS

Indexed keywords

KETAMINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLACEBO;

ADULT; ARTICLE; BEHAVIOR CHANGE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG MEGADOSE; EVOKED RESPONSE; EXCITABILITY; FACILITATION; FEMALE; HUMAN; MALE; MOTOR CORTEX; NEUROTRANSMISSION; NORMAL HUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; ANALYSIS OF VARIANCE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTROMYOGRAPHY; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; KETAMINE; MALE; MOTOR CORTEX; STEREOISOMERISM; TRANSCRANIAL MAGNETIC STIMULATION; YOUNG ADULT;

EID: 84877077070     PISSN: 00144819     EISSN: 14321106     Source Type: Journal    
DOI: 10.1007/s00221-012-3347-6     Document Type: Article

References (34)

1. Adams HA, Werner C (1997) From the racemate to the eutomer: (S)-ketamine. Renaissance of a substance? Anaesthesist 46:1026-1042
2. Badawy RA, Tarletti R, Mula M, Varrasi C, Cantello R (2011) The routine circular coil is reliable in paired-TMS studies. Clin Neurophysiol 122:784-788
3. Bouillon T, Bruhn J, Radu-Radulescu L, Andresen C, Cohane C, Shafer SL (2003) A model of the ventilatory depressant potency of remifentanil in the non-steady state. Anesthesiology 99:779-787
4. Bruhn J, Bouillon TW, Shafer SL (2000) Bispectral index (BIS) and burst suppression: revealing a part of the BIS algorithm. J Clin Monit Comput 16:593-596
5. Bustos G, Abarca J, Forray MI, Gysling K, Bradberry CW, Roth RH (1992) Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies. Brain Res 585:105-115
6. Chizh BA (2007) Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways. J Psychopharmacol 21:259-271
7. Deakin JF, Lees J, McKie S, Hallak JE, Williams SR, Dursun SM (2008) Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study. Arch Gen Psychiatry 65:154-164
8. Di Lazzaro V, Oliviero A, Profice P, Pennisi MA, Pilato F, Zito G, Dileone M, Nicoletti R, Pasqualetti P, Tonali PA (2003) Ketamine increases human motor cortex excitability to transcranial magnetic stimulation. J Physiol 547:485-496
9. Fleming MK, Sorinola IO, Newham DJ, Roberts-Lewis SF, Bergmann JH (2012) The effect of coil type and navigation on the reliability of transcranial magnetic stimulation. IEEE Trans Neural Syst Rehabil Eng 20:617-625
10. Gilbert DL, Ridel KR, Sallee FR, Zhang J, Lipps TD, Wassermann EM (2006) Comparison of the inhibitory and excitatory effects of ADHD medications methylphenidate and atomoxetine on motor cortex. Neuropsychopharmacology 31:442-449
11. Hallett M, Chen R, Ziemann U, Cohen LG (1999) Reorganization in motor cortex in amputees and in normal volunteers after ischemic limb deafferentation. Electroencephalogr Clin Neurophysiol Suppl 51:183-187
12. Harrison NL, Simmonds MA (1985) Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex. Br J Pharmacol 84:381-391
13. Ihmsen H, Geisslinger G, Schuttler J (2001) Stereoselective pharmacokinetics of ketamine: R(-)-ketamine inhibits the elimination of S(+)-ketamine. Clin Pharmacol Ther 70:431-438
14. Ikoma K, Samii A, Mercuri B, Wassermann EM, Hallett M (1996) Abnormal cortical motor excitability in dystonia. Neurology 46:1371-1376
15. Irifune M, Shimizu T, Nomoto M, Fukuda T (1992) Ketamine-induced anesthesia involves the N-methyl-D-aspartate receptor-channel complex in mice. Brain Res 596:1-9
16. Kobayashi M, Pascual-Leone A (2003) Transcranial magnetic stimulation in neurology. Lancet Neurol 2:145-156
17. Kohrs R, Durieux ME (1998) Ketamine: teaching an old drug new tricks. Anesth Analg 87:1186-1193
18. Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, Wroe S, Asselman P, Marsden CD (1993) Corticocortical inhibition in human motor cortex. J Physiol 471:501-519
19. Liu J, Moghaddam B (1995) Regulation of glutamate efflux by excitatory amino acid receptors: evidence for tonic inhibitory and phasic excitatory regulation. J Pharmacol Exp Ther 274:1209-1215
20. Lotsch J, Skarke C, Schmidt H, Rohrbacher M, Hofmann U, Schwab M, Geisslinger G (2006) Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites. Clin Pharmacol Ther 79:35-48
21. Moghaddam B, Adams B, Verma A, Daly D (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17:2921-2927
22. Oertel BG, Felden L, Tran PV, Bradshaw MH, Angst MS, Schmidt H, Johnson S, Greer JJ, Geisslinger G, Varney MA, Lotsch J (2010) Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia. Clin Pharmacol Ther 87:204-211
23. Overall JE, Gorham DR (1962) Brief psychiatric rating scale. Psychol Rep 10:799-812
24. Roick H, von Giesen HJ, Benecke R (1993) On the origin of the postexcitatory inhibition seen after transcranial magnetic brain stimulation in awake human subjects. Exp Brain Res 94:489-498
25. Schuhfried G (2009) Daueraufmerksamkeit (DAUF) aus dem Wiener Testsystem (WTS). In: Schellig D, Drechsler R, Heinemann D, Sturm W (eds) Handbuch neuropsychologischer Testverfahren. Hogrefe, Aufmerksamkeit, Gedächtnis und exekutive Funktionen, pp 67-72
26. Schwenkreis P, Witscher K, Janssen F, Addo A, Dertwinkel R, Zenz M, Malin JP, Tegenthoff M (1999) Influence of the N-methyl-D-aspartate antagonist memantine on human motor cortex excitability. Neurosci Lett 270:137-140
27. Shafer SL, Siegel LC, Cooke JE, Scott JC (1988) Testing computer-controlled infusion pumps by simulation. Anesthesiology 68:261-266
28. Shafer SL, Varvel JR, Aziz N, Scott JC (1990) Pharmacokinetics of fentanyl administered by computer-controlled infusion pump. Anesthesiology 73:1091-1102
29. Storustovu S, Sanchez C, Porzgen P, Brennum LT, Larsen AK, Pulis M, Ebert B (2004) R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter. Br J Pharmacol 142:172-180
30. van Berckel BN, Oranje B, van Ree JM, Verbaten MN, Kahn RS (1998) The effects of low dose ketamine on sensory gating, neuroendocrine secretion and behavior in healthy human subjects. Psychopharmacology 137:271-281
31. Ziemann U, Lonnecker S, Steinhoff BJ, Paulus W (1996a) The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res 109:127-135
32. Ziemann U, Lonnecker S, Steinhoff BJ, Paulus W (1996b) Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Ann Neurol 40:367-378
33. Ziemann U, Rothwell JC, Ridding MC (1996c) Interaction between intracortical inhibition and facilitation in human motor cortex. J Physiol 496(Pt 3):873-881
34. Ziemann U, Chen R, Cohen LG, Hallett M (1998) Dextromethorphan decreases the excitability of the human motor cortex. Neurology 51:1320-1324