Polysubstance and alcohol dependence: Unique abnormalities of magnetic resonance-derived brain metabolite levels

Drug and Alcohol Dependence

Volumn 130, Issue 1-3, 2013, Pages 30-37

  Abé, Christoph ^a   Mon, Anderson ^a   Durazzo, Timothy C ^a   Pennington, David L ^a   Schmidt, Thomas P ^a   Meyerhoff, Dieter J ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol dependence; Brain metabolite concentrations; Dorsolateral prefrontal cortex; Magnetic resonance spectroscopy; Neurocognition; Substance use comorbidity

Indexed keywords

4 AMINOBUTYRIC ACID; COCAINE;

ADULT; ALCOHOL ABSTINENCE; ALCOHOLISM; ANTERIOR CINGULATE; ARTICLE; BRAIN LEVEL; BRAIN METABOLISM; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; HUMAN; MALE; METABOLITE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL CORTEX; PARIETAL CORTEX; PARIETO-OCCIPITAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; SUBSTANCE ABUSE;

ADULT; ALCOHOLISM; BRAIN; COHORT STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SUBSTANCE ABUSE TREATMENT CENTERS; SUBSTANCE-RELATED DISORDERS;

EID: 84877017738     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2012.10.004     Document Type: Article

References (79)

1. Abi-Saab D., Beauvais J., Mehm J., Brody M., Gottschalk C., Kosten T.R. The effect of alcohol on the neuropsychological functioning of recently abstinent cocaine-dependent subjects. Am. J. Addict. 2005, 14:166-178.
2. Baler R.D., Volkow N.D. Drug addiction: the neurobiology of disrupted self-control. Trends Mol. Med. 2006, 12:559-566.
3. Beck A.T. Depression Inventory. 1978, Center for Cognitive Therapy, Philadelphia.
4. Benedict R. Brief Visuospatial Memory Test - Revised: Professional Manual 1997, Psychological Assessment Resources, Inc., Odessa, FL.
5. Bjork J.M., Grant S.J., Hommer D.W. Cross-sectional volumetric analysis of brain atrophy in alcohol dependence: effects of drinking history and comorbid substance use disorder. Am. J. Psychiatry 2003, 160:2038-2045.
6. Buhler M., Mann K. Alcohol and the human brain: a systematic review of different neuroimaging methods. Alcohol. Clin. Exp. Res. 2011, 35:1771-1793.
7. Buttner A. Review: the neuropathology of drug abuse. Neuropathol. Appl. Neurobiol. 2011, 37:118-134.
8. Cardona P.S., Chaturvedi A.K., Soper J.W., Canfield D.V. Simultaneous analyses of cocaine, cocaethylene, and their possible metabolic and pyrolytic products. Forensic Sci. Int. 2006, 157:46-56.
9. 31P MR spectroscopy study. Magn. Reson. Med. 1996, 35:658-663.
10. Cohen J. Statistical Power Analysis for the Behavioral Sciences 1988, Lawrence Erlbaum Associates, Hillsdale, NJ.
11. Coupland N.J., Ogilvie C.J., Hegadoren K.M., Seres P., Hanstock C.C., Allen P.S. Decreased prefrontal myo-inositol in major depressive disorder. Biol. Psychiatry 2005, 57:1526-1534.
12. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. California Verbal Learning Test 2000, The Psychological Corporation, San Antonio, TX. 2nd edition.
13. Di Sclafani V., Tolou-Shams M., Price L.J., Fein G. Neuropsychological performance of individuals dependent on crack-cocaine, or crack-cocaine and alcohol, at 6 weeks and 6 months of abstinence. Drug Alcohol Depend. 2002, 66:161-171.
14. Durazzo T.C., Gazdzinski S., Banys P., Meyerhoff D.J. Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study. Alcohol. Clin. Exp. Res. 2004, 28:1849-1860.
15. Durazzo T.C., Gazdzinski S., Banys P., Meyerhoff D.J. Brain metabolite concentrations and neurocognition during short-term recovery from alcohol dependence: preliminary evidence of the effects of concurrent chronic cigarette smoking. Alcohol. Clin. Exp. Res. 2006, 30:539-551.
16. Durazzo T.C., Gazdzinski S., Yeh P.H., Meyerhoff D.J. Combined neuroimaging, neurocognitive and psychiatric factors to predict alcohol consumption following treatment for alcohol dependence. Alcohol Alcohol. 2008, 43:683-691.
17. Durazzo T.C., Meyerhoff D.J. Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism. Front. Biosci. 2007, 12:4079-4100.
18. Durazzo T.C., Pathak V., Gazdzinski S., Mon A., Meyerhoff D.J. Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence. J. Stud. Alcohol Drugs 2010, 71:278-289.
19. Durazzo T.C., Rothlind J.C., Gazdzinski S., Banys P., Meyerhoff D.J. Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation. Alcohol. Clin. Exp. Res. 2007, 31:1114-1127.
20. Ersche K.D., Barnes A., Jones P.S., Morein-Zamir S., Robbins T.W., Bullmore E.T. Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence. Brain 2011, 134:2013-2024.
21. Ersche K.D., Jones P.S., Williams G.B., Robbins T.W., Bullmore E.T. Cocaine dependence: a fast-track for brain ageing?. Mol. Psychiatry 2012, (Epub ahead of print).
22. Fagerstrom K.O., Heatherton T.F., Kozlowski L.T. Nicotine addiction and its assessment. Ear Nose Throat J. 1991, 69:763-765.
23. Farooq M.U., Bhatt A., Patel M. Neurotoxic and cardiotoxic effects of cocaine and ethanol. J. Med. Toxicol. 2009, 5:134-138.
24. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders - Patient Edition (SCID-I/P, Version 2.0, 8/98 revision) 1998, Biometrics Research Department, New York, NY.
25. Frahm J., Merboldt K.D., H"nicke W. Localized proton spectroscopy using stimulated echoes. J. Magn. Reson. 1987, 72:502-508.
26. Goldstein R.Z., Craig A.D., Bechara A., Garavan H., Childress A.R., Paulus M.P., Volkow N.D. The neurocircuitry of impaired insight in drug addiction. Trends Cogn. Sci. 2009, 13:372-380.
27. Goldstein R.Z., Volkow N.D. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat. Rev. Neurosci. 2011, 12:652-669.
28. Griffin J.L., Bollard M., Nicholson J.K., Bhakoo K. Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy. NMR Biomed. 2002, 15:375-384.
29. Grober E., Sliwinski M. Development and validation of a model for estimating premorbid verbal intelligence in the elderly. J. Clin. Exp. Neuropsychol. 1991, 13:933-949.
30. Hasin D.S., Stinson F.S., Ogburn E., Grant B.F. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch. Gen. Psychiatry 2007, 64:830-842.
31. Heatherton T.F., Wagner D.D. Cognitive neuroscience of self-regulation failure. Trends Cogn. Sci. 2011, 15:132-139.
32. Hester R., Garavan H. Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity. J. Neurosci. 2004, 24:11017-11022.
33. Horner M.D. Cognitive functioning in alcoholic patients with and without cocaine dependence. Arch. Clin. Neuropsychol. 1997, 12:667-676.
34. Jansen J.F., Backes W.H., Nicolay K., Kooi M.E. 1H MR spectroscopy of the brain: absolute quantification of metabolites. Radiology 2006, 240:318-332.
35. Johnson B.A. Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function. CNS Drugs 2005, 19:873-896.
36. Kaiser L.G., Young K., Meyerhoff D.J., Mueller S.G., Matson G.B. A detailed analysis of localized J-difference GABA editing: theoretical and experimental study at 4 T. NMR Biomed. 2008, 21:22-32.
37. Ke Y., Streeter C.C., Nassar L.E., Sarid-Segal O., Hennen J., Yurgelun-Todd D.A., Awad L.A., Rendall M.J., Gruber S.A., Nason A., Mudrick M.J., Blank S.R., Meyer A.A., Knapp C., Ciraulo D.A., Renshaw P.F. Frontal lobe GABA levels in cocaine dependence: a two-dimensional. J-resolved magnetic resonance spectroscopy study. Psychiatry Res. 2004, 130:283-293.
38. Kedia S., Sell M.A., Relyea G. Mono- versus polydrug abuse patterns among publicly funded clients. Subst. Abuse Treat. Prev. Policy 2007, 2:33.
39. Licata S.C., Renshaw P.F. Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction. Ann. N.Y. Acad. Sci. 2010, 1187:148-171.
40. Liu X., Matochik J.A., Cadet J.L., London E.D. Smaller volume of prefrontal lobe in polysubstance abusers: a magnetic resonance imaging study. Neuropsychopharmacology 1998, 18:243-252.
41. Lundqvist T. Cognitive consequences of cannabis use: comparison with abuse of stimulants and heroin with regard to attention, memory and executive functions. Pharmacol. Biochem. Behav. 2005, 81:319-330.
42. McLellan A.T., Kushner H., Metzger D., Peters R., Smith I., Grissom G., Pettinati H., Argeriou M. The Fifth Edition of the Addiction Severity Index. J. Subst. Abuse Treat. 1992, 9:199-213.
43. McLellan A.T., Lewis D.C., O'Brien C.P., Kleber H.D. Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. JAMA 2000, 284:1689-1695.
44. Medina K.L., Shear P.K., Schafer J., Armstrong T.G., Dyer P. Cognitive functioning and length of abstinence in polysubstance dependent men. Arch. Clin. Neuropsychol. 2004, 19:245-258.
45. Mertens J.R., Lu Y.W., Parthasarathy S., Moore C., Weisner C.M. Medical and psychiatric conditions of alcohol and drug treatment patients in an HMO: comparison with matched controls. Arch. Intern. Med. 2003, 163:2511-2517.
46. Mertens J.R., Weisner C., Ray G.T., Fireman B., Walsh K. Hazardous drinkers and drug users in HMO primary care: prevalence, medical conditions, and costs. Alcohol. Clin. Exp. Res. 2005, 29:989-998.
47. Meyerhoff D.J., Bloomer C., Salas G., Schuff N., Norman.D., Weiner M.W., Fein G. Cortical metabolite in abstinent cocaine and cocaine/alcohol dependent subjects: an in-vivo proton magnetic resonance spectroscopic imaging study. Addict. Biol. 1999, 4:405-419.
48. Meyerhoff D.J., Durazzo T.C. Proton magnetic resonance spectroscopy in alcohol use disorders: a potential new endophenotype?. Alcohol. Clin. Exp. Res. 2008, 32:1146-1158.
49. Meyerhoff D.J., Durazzo T.C., Ende G. Chronic alcohol consumption, abstinence and relapse: brain proton magnetic resonance spectroscopy studies in animals and humans. Curr. Top. Behav. Neurosci. 2011, 2013:511-540.
50. Moeller F.G., Hasan K.M., Steinberg J.L., Kramer L.A., Dougherty D.M., Santos R.M., Valdes I., Swann A.C., Barratt E.S., Narayana P.A. Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging. Neuropsychopharmacology 2005, 30:610-617.
51. Mon A., Durazzo T., Meyerhoff D.J. Glutamate, GABA, and other cortical metabolite concentrations during early abstinence from alcohol and their associations with neurocognitive changes. Drug Alcohol Depend. 2012, 125:27-36.
52. Moore G.J., Bebchuk J.M., Parrish J.K., Faulk M.W., Arfken C.L., Strahl-Bevacqua J., Manji H.K. Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. Am. J. Psychiatry 1999, 156:1902-1908.
53. O'Neill J., Cardenas V.A., Meyerhoff D.J. Separate and interactive effects of cocaine and alcohol dependence on brain structures and metabolites: quantitative MRI and proton MR spectroscopic imaging. Addict. Biol. 2001, 6:347-361.
54. Oscar-Berman, M., 2000. Neuropsychological vulnerabilites in chronic alcoholism. Review of NIAAA's Neuroscience and Behavioral Research Portfolio. NIAAA Research Monograph No. 34. NIAAA, Bethesda, MD. pp. 437-472.
55. Parekh R.S., Klag M.J. Alcohol: role in the development of hypertension and end-stage renal disease. Curr. Opin. Nephrol. Hypertens. 2001, 10:385-390.
56. Petrides M. Lateral prefrontal cortex: architectonic and functional organization. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2005, 360:781-795.
57. Salo R., Nordahl T.E., Possin K., Leamon M., Gibson D.R., Galloway G.P., Flynn N.M., Henik A., Pfefferbaum A., Sullivan E.V. Preliminary evidence of reduced cognitive inhibition in methamphetamine-dependent individuals. Psychiatry Res. 2002, 111:65-74.
58. Sankoh A.J., Huque M.F., Dubey S.D. Some comments on frequently used multiple endpoint adjustment methods in clinical trials. Stat. Med. 1997, 16:2529-2542.
59. Schuff N., Ezekiel F., Gamst A.C., Amend D.L., Capizzano A.A., Maudsley A.A., Weiner M.W. Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging. Magn. Reson. Med. 2001, 45:899-907.
60. Schweinsburg B.C., Taylor M.J., Alhassoon O.M., Videen J.S., Brown G.G., Patterson T.L., Berger F., Grant I. Chemical pathology in brain white matter of recently detoxified alcoholics: a 1H magnetic resonance spectroscopy investigation of alcohol-associated frontal lobe injury. Alcohol. Clin. Exp. Res. 2001, 25:924-934.
61. Selby M.J., Azrin R.L. Neuropsychological functioning in drug abusers. Drug Alcohol Depend. 1998, 50:39-45.
62. Simon S.L., Domier C., Carnell J., Brethen P., Rawson R., Ling W. Cognitive impairment in individuals currently using methamphetamine. Am. J. Addict. 2000, 9:222-231.
63. Skinner H.A., Sheu W.J. Reliability of alcohol use indices. The Lifetime Drinking History and the MAST. J. Stud. Alcohol. 1982, 43:1157-1170.
64. Smith S.S. Addictive Drug Survey Manual 1991, NIDA Addiction Research Center, Baltimore, MD.
65. Sobell L.C., Sobell M.B. Self-reports issues in alcohol abuse: state of the art and future directions. Behav. Assess. 1990, 12:77-90.
66. Sobell L.C., Sobell M.B., Riley D.M., Schuller R., Pavan D.S., Cancilla A., Klajner F., Leo G.I. The reliability of alcohol abusers' self-reports of drinking and life events that occurred in the distant past. J. Stud. Alcohol. 1988, 49:225-232.
67. Spielberger C.D., Gorsuch R.L., Lushene R., Vagg P.R., Jacobs G.A. Self-Evaluation Questionaire 1977, Consulting Psychologist Press, Palo Alto, CA.
68. Stapleton J.M., Morgan M.J., Phillips R.L., Wong D.F., Yung B.C., Shaya E.K., Dannals R.F., Liu X., Grayson R.L., London E.D. Cerebral glucose utilization in polysubstance abuse. Neuropsychopharmacology 1995, 13:21-31.
69. Stinson F.S., Grant B.F., Dawson D.A., Ruan W.J., Huang B., Saha T. Comorbidity between DSM-IV alcohol and specific drug use disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depend. 2005, 80:105-116.
70. Sullivan E.V., Rosenbloom M.J., Pfefferbaum A. Brain Vulnerability to Alcoholism: Evidence from Neuroimaging Studies 2000, NIAAA, Bethesda.
71. Toennes S.W., Thiel M., Walther M., Kauert G.F. Studies on metabolic pathways of cocaine and its metabolites using microsome preparations from rat organs. Chem. Res. Toxicol. 2003, 16:375-381.
72. Van Leemput K., Maes F., Vandermeulen D., Suetens P. Automated model-based tissue classification of MR images of the brain. IEEE Trans. Med. Imaging 1999, 18:897-908.
73. Verdejo-Garcia A., Betanzos-Espinosa P., Lozano O.M., Vergara-Moragues E., Gonzalez-Saiz F., Fernandez-Calderon F., Bilbao-Acedos I., Perez-Garcia M. Self-regulation and treatment retention in cocaine dependent individuals: a longitudinal study. Drug Alcohol Depend. 2011, 122:142-148.
74. Verdejo-Garcia A., Lopez-Torrecillas F., Gimenez C.O., Perez-Garcia M. Clinical implications and methodological challenges in the study of the neuropsychological correlates of cannabis, stimulant, and opioid abuse. Neuropsychol. Rev. 2004, 14:1-41.
75. Verdejo-Garcia A., Rivas-Perez C., Vilar-Lopez R., Perez-Garcia M. Strategic self-regulation, decision-making and emotion processing in poly-substance abusers in their first year of abstinence. Drug Alcohol Depend. 2007, 86:139-146.
76. Volkow N.D., Chang L., Wang G.J., Fowler J.S., Leonido-Yee M., Franceschi D., Sedler M.J., Gatley S.J., Hitzemann R., Ding Y.S., Logan J., Wong C., Miller E.N. Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am. J. Psychiatry 2001, 158:377-382.
77. Volkow N.D., Wang G.-J., Fowler J.S., Tomasi D., Telang F. Addiction: Beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences 2011, 108:15037-15042.
78. Voytek B., Berman S.M., Hassid B.D., Simon S.L., Mandelkern M.A., Brody A.L., Monterosso J., Ling W., London E.D. Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers. Synapse 2005, 57:113-115.
79. Wechsler D. Wechsler Memory Scale-III (WMS-III) 1997, The Psychological Corporation, San Antonio, TX.