Drug dependence, a chronic medical illness implications for treatment, insurance, and outcomes evaluation

JAMA

Volumn 284, Issue 13, 2000, Pages 1689-1695

  McLellan, A Thomas ^a,b   Lewis, David C ^c   O'Brien, Charles P ^b   Kleber, Herbert D ^d  

^a TREATMENT RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BROWN UNIVERSITY   (United States)

^d Yale School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CANNABIS; NICOTINE; OPIATE;

ALCOHOLISM; ARTICLE; ASTHMA; CANNABIS ADDICTION; DRUG DEPENDENCE; HEALTH INSURANCE; HERITABILITY; HUMAN; HYPERTENSION; LONG TERM CARE; NON INSULIN DEPENDENT DIABETES MELLITUS; OPIATE ADDICTION; PRIORITY JOURNAL; TREATMENT INDICATION;

EID: 0034605531     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.284.13.1689     Document Type: Article

References (88)

1. Estimates of the economic costs of alcohol, and drug abuse and mental illness, 1985 and 1988
2. Does drug abuse treatment affect employment and earnings of clients?
3. The effectiveness of alcoholism screening in an ambulatory care setting
4. Alcohol and drug problems among diverse health and social service populations
5. The long-term course of treated alcoholism, II: Predictors and correlates of 10-year functioning and mortality
6. Overview of 1-year follow-up outcomes in the Drug Abuse Treatment Outcome Study (DATOS)
7. The treatment of addiction: What can research offer practice?
8. A comparison of DSM-III, DSM-IV and ICD-10 substance use disorders diagnoses in 1992 men and women subjects in the COGA study
9. Caffeine dependence: What are the implications?
10. Early detection of harmful alcohol consumption
11. Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure?
12. Heritability of conventional and ambulatory blood pressures: A study in twins
13. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
14. Concordance rates of insulin dependent diabetes mellitus
15. Genetics of asthma and hay fever in Australian twins
16. A population-based study of bronchial asthma in adult twin pairs
17. Genetic influences on DSM-III-R drug abuse and dependence: A study of 3,372 twin pairs
18. Cannabis use, abuse and dependence in a population-based sample of female twins
19. Genetic and environmental influences on drug use and abuse/dependence in male and female twins
20. Common genetic vulnerability for nicotine and alcohol dependence in men
21. Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans
22. Heritability of salt sensitivity in black Americans
23. Low level of response to alcohol as a predictor of future alcoholism
24. An 8-year follow-up of 450 sons of alcoholics and controls
25. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men
26. Association of the ADH2*2 allele with reduced alcohol consumption in Jewish men in Israel: A pilot study
27. Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients
28. Cellular and molecular mechanisms of drug dependence
29. Special issue
30. Series on addiction
31. Brain substrates for reinforcement and drug-self-administration
32. Changes in brain glucose metabolism in cocaine dependence and withdrawal
33. Cocaine-induced reduction of glucose utilization in human brain: A study of positron emission tomography and [flourine 18]-fluorodeoxyglucose
34. Drug dependence: Stress and dysregulation of brain reward pathways
35. Drug dependence: Stress and dysregulation of brain reward pathways
36. Neurochemical adaptation in brain reward systems during drug addiction
37. Long-term frontal brain metabolic changes in cocaine abusers
38. Limbic activation during cue-induced cocaine craving
39. Regional cerebral blood flow improves with treatment in chronic cocaine polydrug users
40. Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects
41. Experimental analysis of conditioning factors in human narcotic addiction
42. Is addiction treatment 'worth it'? public health expectations, policy-based comparisons
43. HIV seroconversion among intravenous drug users in and out of treatment
44. Substance abuse treatment entry, retention and effectiveness
45. Cost effectiveness of treatment for drug abusing pregnant women
46. Opiate withdrawal: Inpatient versus outpatient programmes and preferred versus random assignment to treatment
47. Are detoxification programmes effective?
48. National Consensus Development Panel on Effective Medical Treatment of Opiate Addiction. Effective medical treatment of opiate addiction
49. Buprenorphine treatment of opioid dependence
50. A randomized trial of buprenorphine maintenance for heroin dependence in a primary care clinic for substance users versus a methadone clinic
51. Pharmacologic treatment of heroin-dependent patients
52. Clinical experience with naltrexone
53. Naltrexone treatment for addicted health care professionals
54. Naltrexone pharmacotherapy for opioid dependent federal probationers
55. Naltrexone in the treatment of alcohol dependence
56. Naltrexone and coping skills therapy for alcohol dependence
57. Relapse prevention by acamprosate
58. Psychotherapy and pharmacotherapy for ambulatory cocaine abusers
59. One-year follow-up status of treatment-seeking cocaine abusers: Psychopathology and dependence severity as predictors of outcome
60. Effectiveness and costs of inpatient versus day hospital cocaine rehabilitation
61. A behavioral approach to achieving initial cocaine abstinence
62. Development of a therapeutic vaccine for the treatment of cocaine addiction
63. Myths about the treatment of addiction
64. Similarity of outcome predictors across opiate, cocaine and alcohol treatments
65. Dropout and relapse during diabetes care
66. Improving compliance and increasing control of hypertension: Needs of special hypertensive populations
67. Compliance with pulmonary medication in general practice
68. Adherence to diabetic regimens: Empirical status and clinical applications
69. Hospitalization of diabetes
70. Compliance to treatment
71. Influence of outpatient treatment and 12-step group involvement on one-year substance abuse treatment outcomes
72. A long-term follow-up of male alcohol abuse
73. The role of the generalist in the care of the substance abusing patient
74. Who teaches residents about the prevention and treatment of substance abuse disorders? A national survey