Expression and regulation of α-transducin in the pig gastrointestinal tract

Journal of Cellular and Molecular Medicine

Volumn 17, Issue 4, 2013, Pages 466-474

  Mazzoni, Maurizio ^a   De Giorgio, Roberto ^a   Latorre, Rocco ^a   Vallorani, Claudia ^a   Bosi, Paolo ^a   Trevisi, Paolo ^a   Barbara, Giovanni ^a   Stanghellini, Vincenzo ^a   Corinaldesi, Roberto ^a   Forni, Monica ^a   Faussone Pellegrini, Maria S ^b   Sternini, Catia ^c,d   Clavenzani, Paolo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

gustducin; Chemosensing; Enteroendocrine cells; Taste receptors

Indexed keywords

TRANSDUCIN;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; CYTOLOGY; DUODENUM; ENTEROENDOCRINE CELL; FLUORESCENT ANTIBODY TECHNIQUE; FOOD DEPRIVATION; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; JEJUNUM; MALE; METABOLISM; STOMACH; STOMACH MUCOSA; SWINE;

ANIMALS; DUODENUM; ENTEROENDOCRINE CELLS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FOOD DEPRIVATION; GASTRIC MUCOSA; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENE EXPRESSION REGULATION; JEJUNUM; MALE; ORGAN SPECIFICITY; STOMACH; SUS SCROFA; TRANSDUCIN;

SUIDAE;

EID: 84877017074     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12026     Document Type: Article

References (33)

1. Dockray GJ. Luminal sensing in the gut: an overview. J Physiol Pharmacol. 2003; 54: 9-17.
2. Furness JB, Kunze WA, Clerc N. Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses. Am J Physiol. 1999; 277: G922-8.
3. Sternini C, Anselmi L, Rozengurt E. Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes. 2008; 15: 73-8.
4. Sternini C. Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. Am J Physiol Gastrointest Liver Physiol. 2007; 292: G45761.
5. Chandrashekar J, Mueller KL, Hoon MA, et al. T2Rs function as bitter taste receptors. Cell. 2000; 100: 703-11.
6. Nelson G, Hoon MA, Chandrashekar J, et al. Mammalian sweet taste receptors. Cell. 2001; 106: 381-90.
7. Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem. 2002; 277: 1-4.
8. Höfer D, Puschel B, Drenckhahn D. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA. 1996; 93: 6631-4.
9. Wu SV, Rozengurt N, Yang M, et al. Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells. Proc Natl Acad Sci USA. 2002; 99: 2392-7.
10. Sutherland K, Young RL, Cooper NJ, et al. Phenotypic characterization of taste cells of the mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2007; 292: G1420-8.
11. Janssen S, Laermans J, Verhulst PJ, et al. Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc Natl Acad Sci USA. 2011; 108: 2094-9.
12. Clavenzani P, De Giorgio R, Mazzoni M, et al. Expression of α-transducin, a chemoreceptive molecule, in endocrine and non endocrine cells of the pig gastrointestinal tract. Vet Res Commun. 2009; 33: S85-7.
13. Moran AW, Al-Rammahi MA, Arora DK, et al. Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners. Br J Nutr. 2010; 104: 637-46.
14. Rozengurt N, Wu SV, Chen MC, et al. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol. 2006; 291: G792-802.
15. Höfer D, Drenckhahn D. Identification of the taste cell G-protein, alpha-gustducin, in brush cells of the rat pancreatic duct system. Histochem Cell Biol. 1998; 110: 303-9.
16. Lukinius A, Stridsberg M, Wilander E. Cellular expression and specific intragranular localization of chromogranin A, chromogranin B, and synaptophysin during ontogeny of pancreatic islet cells: an ultrastructural study. Pancreas. 2003; 27: 38-46.
17. Hass N, Schwarzenbacher K, Breer H. A cluster of gustducin-expressing cells in the mouse stomach associated with two distinct population of enteroendocrine cells. Histochem Cell Biol. 2007; 128: 457-71.
18. Ruiz-Avila L, McLaughlin SK, Wildman D, et al. Coupling of bitter receptor to phosphodiesterase through transducing in taste receptor cells. Nature. 1995; 376: 80-5.
19. He W, Danilova V, Zou S, et al. Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin. Chem Senses. 2002; 27: 719-27.
20. Chen MC, Wu SV, Reeve JR Jr, et al. Bitter stimuli induce Ca2 + signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2 + channels. Am J Physiol Cell Physiol. 2006; 291: C726-39.
21. Horvath TL, Diano S, Sotonyi P, et al. Minireview: ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology. 2001; 142: 4163-9.
22. Masuda Y, Tanaka T, Inomata N. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun. 2000; 276: 905-8.
23. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000; 141: 4325-8.
24. Salfen BE, Carroll JA, Keisler DH, et al. Effects of exogenous ghrelin on feed intake, weight gain, behavior, and endocrine responses in weanling pigs. J Anim Sci. 2004; 82: 1957-66.
25. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest. 2007; 17: 13-23.
26. Van Op den Bosch J, Adriaensen D, Van Nassauw L, et al. The role(s) of somatostatin, structurally related peptides and somatostatin receptors in the gastrointestinal tract: a review. Regul Pept. 2009; 156: 1-8.
27. Lallès JP, David JC. Fasting and refeeding modulate the expression of stress proteins along the gastrointestinal tract of weaned pigs. J Anim Physiol Anim Nutr(Berl). 2011; 95: 478-88.
28. Toshinai K, Mondal MS, Nakazato M, et al. Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun. 2001; 281: 1220-5.
29. Wu V, Sumii K, Tari A, et al. Regulation of rat antral gastrin and somatostatin gene expression during starvation and after refeeding. Gastroenterology. 1991; 101: 1552-8.
30. Salfen BE, Carroll JA, Keisler DH. Endocrine responses to short-term feed deprivation in weanling pigs. J Endocrinol. 2003; 178: 541-51.
31. Barb CR, Kraeling RR, Rampacek GB, et al. Metabolic changes during the transition from the fed to the acute feed-deprived state in prepuberal and mature gilts. J Anim Sci. 1997; 75: 781-9.
32. Kanayama S, Liddle RA. Influence of food deprivation on intestinal cholecystokinin and somatostatin. Gastroenterology. 1991; 100: 909-15.
33. Rojkittikhun T, Uvnäs-Moberg K, Einarsson S. Plasma oxytocin, prolactin, insulin and LH after 24 h of fasting and after refeeding in lactating sows. Acta Physiol Scand. 1993; 148: 413-9.