Low molecular weight dual inhibitors of factor Xa and fibrinogen binding to GPIIb/IIIa with highly overlapped pharmacophores

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 302-313

  Trstenjak, Uroš ^a   Ilaš, Janez ^a   Kikelj, Danijel ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Antiaggregant; Anticoagulant; Designed multiple ligands; Factor Xa; GPIIb IIIa; Platelet fibrinogen receptor

Indexed keywords

1 [4 [2 OXO 5 [[4 (5 OXO 4,5 DIHYDRO 1,2,4 OXADIAZOL 3 YL)BENZAMIDO]METHYL]OXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLIC ACID; 1 [4 [2 OXO 5 [[[4 (5 OXO 4,5 DIHYDRO 1,2,4 OXADIAZOL 3 YL)BENZYL]AMINO]METHYL]OXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLIC ACID; 1 [4 [5 [(2 AMINOTHIAZOLE 5 CARBOXAMIDO)METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLIC ACID; 1 [4 [5 [(3 AMINO 4 CHLOROBENZAMIDO)METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLIC ACID; 1 [4 [5 [(4 CARBAMIMIDOYLBENZAMIDO)METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLIC ACID; 1 [4 [5 [[(4 CARBAMIMIDOYLBENZYL)AMINO]METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLIC ACID; 1 [4 [5 [[4 CHLORO 3 (5 OXO 4,5 DIHYDRO 1,2,4 OXADIAZOL 3 YL)BENZAMIDO]METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLIC ACID; ANTITHROMBOCYTIC AGENT; ARGINYLGLYCYLASPARTIC ACID; BLOOD CLOTTING FACTOR 10A INHIBITOR; DABIGATRAN; EPTIFIBATIDE; ETHYL 1 [4 [2 OX 5 [[[4 (5 OXO 4,5 DIHYDRO 1,2,4 OXADIAZOL 3 YL)BENZYL]AMINO]METHYL]OXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLATE; ETHYL 1 [4 [2 OXO 5 [[4 (5 OXO 4,5 DIHYDRO 1,2,4 OXADIAZOL 3 YL)BENZAMIDO]METHYL]OXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLATE; ETHYL 1 [4 [5 [(2 AMINOTHIAZOLE 5 CARBOXAMIDO)METHYL]OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLATE; ETHYL 1 [4 [5 [(3 AMINO 4 CHLOROBENZAMIDO)METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLATE; ETHYL 1 [4 [5 [(4 CARBAMIMIDOYLBENZAMIDO)METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLATE; ETHYL 1 [4 [5 [[(4 CARBAMIMIDOYLBENZYL)AMINO]METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLATE; ETHYL 1 [4 [5 [[4 CHLORO 3 (5 OXO 4,5 DIHYDRO 1,2,4 OXADIAZOL 3 YL)BENZAMIDO]METHYL] 2 OXOOXAZOLIDIN 3 YL]PHENYL]PIPERIDINE 4 CARBOXYLATE; FIBRINOGEN; FIBRINOGEN RECEPTOR ANTAGONIST; RIVAROXABAN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; TIROFIBAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR WEIGHT; PHARMACOPHORE; RECEPTOR BINDING;

DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; FIBRINOGEN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; OXADIAZOLES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; SERINE PROTEASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877010327     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.056     Document Type: Article

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