Mild dystrophic damage in the androgen-sensitive levator ani muscle of the mdx mouse

Neuromuscular Disorders

Volumn 15, Issue 1, 2005, Pages 48-56

  Souccar, Caden ^a   Gonçalo, Maria Do Carmo ^a   Buck, Hudson De Sousa ^b   Lima Landman, Maria Teresa R ^a   Lapa, Antonio José ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

Author keywords

Caffeine contractures; Contraction properties; Levator ani muscle; mdx mouse; Muscle dystrophy; Testosterone

Indexed keywords

ANDROGEN; CAFFEINE; CENTRAL STIMULANT AGENT;

AGING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DIAPHRAGM MUSCLE; GONADECTOMY; HISTOLOGY; LEVATOR ANI MUSCLE; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE GROWTH; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRENGTH; MUSCLE TETANIC CONTRACTION; MUSCULAR DYSTROPHY; NONHUMAN; PRIORITY JOURNAL; RELAXATION TIME; SARCOPLASMIC RETICULUM; AGE; ANIMAL; ANIMAL MUSCULAR DYSTROPHY; BODY WEIGHT; C57BL MOUSE; COMPARATIVE STUDY; DIAPHRAGM; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; METHODOLOGY; NEWBORN; ORGAN SIZE; PATHOPHYSIOLOGY; PHYSIOLOGY; REACTION TIME; STAINING; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

AGE FACTORS; ANDROGENS; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; DIAPHRAGM; ISOMETRIC CONTRACTION; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MUSCULAR DYSTROPHY, ANIMAL; ORGAN SIZE; REACTION TIME; STAINING AND LABELING;

EID: 15044351089     PISSN: 09608966     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nmd.2004.10.010     Document Type: Article

References (45)

1. Hoffman EP, Brown RHJ, Kunkel LM. Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 1987;51: 919-28.
2. Sicinski P, Geng Y, Ryder-Cook AS, Barnard EA, Darlison MG, Barnard PJ. The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science 1989;244:1578-80 .
3. Watcko JF, O'Day TL, Hoffman EP. Functional characteristics of dystrophic skeletal muscle: insights from animal models. J Appl Physiol 2002;931:407-17 .
4. O'Brien KF, Kunkel LM. Dystrophin and muscular dystrophy: past, present, and future. MoI Genet Metab 2001;74:75-88.
5. Blake DJ, Weir A, Newey SE, Davies KE. Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev 2002;82:291-329 .
6. Rybakova IN, Patel JR, Ervasti JM. The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin. J Cell Biol 2000;150:1209-14.
7. Petrof BJ, Shrager JB, Stedman HH, Kelly AM, Sweeney HL. Dystrophin protects the sarcolemma from stresses developed during muscle contraction. Proc Natl Acad Sci USA 1993;90:3710-4 .
8. Pasternak C, Wong S, Elson EL. Mechanical function of dystrophin in muscle cells. J Cell Biol 1995;128:355-61.
9. Carnwath JW, Shotton DM. Muscular dystrophy in the mdx mouse: histopathology of the soleus and extensor digitorum longus muscles. J Neurol Sci 1987;80:39-54.
10. Dangain J, Vrbova G. Muscle development in mdx mutant mice. Muscle Nerve 1984;7:700-4 .
11. Stedman HH, Sweeney HL, Shrager JB, et al. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature 1991;352:536-9.
12. Lefaucheur JP, Pastoret C, Sebille A. Phenotype of dystrophinopathy in old mdx mice. Anat Rec 1995;242:70-6.
13. Pastoret C, Sebille A. mdx mice show progressive weakness and muscle deterioration with age. J Neurol Sci 1995;129:97-105.
14. Lynch GS, Hinkle RT, Chamberlain JS, Brooks SV, Faulkner JA. Force and power output of fast and slow skeletal muscles from mdx mice 6-28 months old. J Physiol 2001;535.2:591-600.
15. Torres LF, Duchen LW. The mutant mdx: inherited myopathy in the mouse. Morphological studies of nerves, muscles and end-plates. Brain 1987;110:269-99 .
16. Di Mario JX, Uzman A, Strohman RC. Fiber regeneration is not persistent in dystrophic (mdx) mouse skeletal muscle. Dev Biol 1991; 148:314-21.
17. Jean-Faucher C, Berger M, de TM, Veyssiere G, Jean C. Testosterone and dihydrotestosterone levels in the epididymis, vas deferens and preputial gland of mice during sexual maturation. Int J Androl 1985;8: 44-57 .
18. Krahn MJ, Anderson JE. Anabolic steroid treatment increases myofiber damage in mdx mouse muscular dystrophy. J Neurol Sci 1994;125:138-46.
19. Tingus SJ, Carlsen RC. Effect of continuous infusion of an anabolic steroid on murine skeletal muscle. Med Sci Sports Exerc 1993;25: 485-94 .
20. Cihák R, Gutmann E, Hanzliková V. Involution and hormone induced persistance of the M. Sphincter (levator) ani in female rats. J Anat 1970;106:93-110.
21. Venable JH. Morphology of the cells of normal, testosterone-deprived and testosterone-stimulated levator ani muscles. Am J Anat 1966;119: 271-301.
22. Wee BEF, Clemens LG. Characteristics of the spinal nucleus of the bulbocavernosus are influenced by genotype in the house mouse. Brain Res 1987;424:305-10.
23. Holmes GM, Sachs BD. Physiology and mechanics of rat levator ani muscle: evidence for a sexual function. Physiol Behav 1994;55: 255-66.
24. Krieg M, Dennis M, Voigt KD. Comparison between the binding of 19-nortestosterone 5alpha-dihydrotestosterone and testosterone in rat prostate and bulbocavernosus/levator ani muscle. J Endocrinol 1976; 70:379-87.
25. Breedlove SM, Arnold AP. Hormonal accumulation in a sexually dimorphic motor nucleus in the rat spinal cord. Science 1980;210: 564-6.
26. Gobinet J, Poujol N, Sultan Ch. Molecular action of androgens. Mol Cell Endocrinol 2002;198:15-24.
27. Souccar C, Lapa AJ, Valle JR. Influence of castration on the electrical excitability and contraction properties of the rat levator ani muscle. Exp Neurol 1982;75:576-88.
28. Souccar C, Gonçalo MC, Lapa AJ, Troncone LR, Lebrun I, Magnoli F. Blockade of acetylcholine release at the motor endplate by a polypeptide from the venom of Phoneutria nigriventer. Br J Pharmacol 1995;116:2817-23.
29. Sokal RR, Rohlf FJ. In: Biometry: the principle and pratice of statistics in biological research. 2nd ed. New York: W.H. Freeman; 1981.
30. Tokarz SA, Duncan NM, Rash SM, Sadeghi A, Dewan AK, Pillers DA. Redefinition of dystrophin isoform distribution in mouse tissue by RT-PCR implies role in nonmuscle manifestations of duchenne muscular dystrophy. Mol Genet Metab 1998;65:272-81.
31. Hirota M, Furukawa Y, Shinoda I, et al. Changes in nerve growth factor content of the submaxillary gland in the genetically dystrophic (mdx) mouse. J Neurol Sci 1994;121:176-82.
32. Hawke TJ, Garry DJ. Myogenic satellite cells: physiology to molecular biology. J Appl Physiol 2001;91:534-51
33. . [33] Karpati G, Carpenter S, Prescott S. Small-caliber skeletal muscle fibers do not suffer necrosis in mdx mouse dystrophy. Muscle Nerve 1988;11:795-803.
34. Joubert Y, Tobin C. Testosterone treatment results in quiescent satellite cells being activated and recruited into cell cycle in rat levator ani muscle. Dev Biol 1995;169:286-94.
35. Coquelin A, Desjardins C. Luteinizing hormone and testosterone secretion in young and old male mice. Am J Physiol 1982;243: E257-E63.
36. Fenichel GM, Griggs RC, Kissel J, et al. A randomized efficacy and safety trial of oxandrolone in the treatment of Duchenne dystrophy. Neurology 2001;56:1075-9.
37. Alderton JM, Steinhardt RA. How calcium influx through calcium leak channels is responsible for the elevated levels of calcium-dependent proteolysis in dystrophic myotubes. Trends Cardiovasc Med 2000;10:268-72.
38. + channels. Proc Natl Acad Sci USA 2000;97:4950-5.
39. Gailly P. New aspects of calcium signaling in skeletal muscle cells: implications in Duchenne muscular dystrophy. Biochim Biophys Acta 2002;1600:38-44.
40. Divet A, Huchet-Cadiou C. Sarcoplasmic reticulum function in slow-and fast-twitch skeletal muscles from mdx mice. Pflugers Arch 2002; 444:634-43.
41. Weber A, Herz R. The relationship between caffeine contracture of intact muscle and the effect of caffeine on reticulum. J Gen Physiol 1968;52:750-9.
42. Takagi A, Kojima S, Ida M, Araki M. Increased leakage of calcium ion from the sarcoplasmic reticulum of the mdx mouse. J Neurol Sci 1992;110:160-4.
43. Kargacin ME, Kargacin GJ. The sarcoplasmic reticulum calcium pump is functionally altered in dystrophic muscle. Biochim Biophys Acta 1996;1290:4-8.
44. 2+-sequestration by the sarcoplasmic reticulum of fast and slow muscles in normal and dystrophic mice. Eur J Biochem 1988;174:247-53.
45. Gori Z, Pellegrino C, Pollera M. The castration atrophy of the dorsal bulbocavernosus muscle of rat: an electron microscopic study. Exp Mol Pathol 1967;6:172-98.