Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein

Genes to Cells

Volumn 18, Issue 5, 2013, Pages 397-409

  Hirata, Yusuke ^a   Yamamori, Natsumi ^a   Kono, Nozomu ^a   Lee, Hyeon Cheol ^a   Inoue, Takao ^a,c   Arai, Hiroyuki ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LONG CHAIN FATTY ACID COENZYME A LIGASE; SERINE PALMITOYLTRANSFERASE;

ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL CELL; MICROSOME; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL;

ACYLTRANSFERASES; ANIMALS; ARACHIDONIC ACID; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HELA CELLS; HUMANS; MICE; MITOCHONDRIAL MEMBRANES; PHOSPHATIDYLINOSITOLS; PROTEIN BINDING; PROTEIN SUBUNITS; PROTEIN TRANSPORT; SERINE C-PALMITOYLTRANSFERASE; SPHINGOLIPIDS; SUS SCROFA;

MAMMALIA; MUS;

EID: 84876987986     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/gtc.12046     Document Type: Article

References (54)

1. Akino, T. & Shimojo, T. (1970) On the metabolic heterogeneity of rat liver phosphatidylinositol. Biochim. Biophys. Acta 210, 343-346.
2. Bligh, E. & Dyer, W. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
3. de Brito, O.M. & Scorrano, L. (2010) An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. EMBO J. 29, 2715-2723.
4. Cao, J., Liu, Y., Lockwood, J., Burn, P. & Shi, Y. (2004) A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA: lysocardiolipin acyltransferase (ALCAT1) in mouse. J. Biol. Chem. 279, 31727-31734.
5. Cao, J., Shan, D., Revett, T., Li, D., Wu, L., Liu, W., Tobin, J.F. & Gimeno, R.E. (2008) Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. J. Biol. Chem. 283, 19049-19057.
6. Cui, Z., Vance, J.E., Chen, M.H., Voelker, D.R. & Vance, D.E. (1993) Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver. J. Biol. Chem. 268, 16655-16663.
7. Darnell, J.C., Osterman, D.G. & Saltiel, A.R. (1991a) Fatty acid remodelling of phosphatidylinositol under conditions of de novo synthesis in rat liver microsomes. Biochim. Biophys. Acta 1084, 279-291.
8. Darnell, J.C., Osterman, D.G. & Saltiel, A.R. (1991b) Synthesis of phosphatidylinositol in rat liver microsomes is accompanied by the rapid formation of lysophosphatidylinositol. Biochim. Biophys. Acta 1084, 269-278.
9. Demeure, O., Lecerf, F., Duby, C., Desert, C., Ducheix, S., Guillou, H. & Lagarrigue, S. (2011) Regulation of LPCAT3 by LXR. Gene 470, 7-11.
10. Der, O.M. & Sun, G.Y. (1983) Acylation of lysoglycerophospholipids by adrenal membranes. Int. J. Biochem. 15, 615-619.
11. Di Paolo, G. & De Camilli, P. (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657.
12. Eto, M., Shindou, H., Koeberle, A., Harayama, T., Yanagida, K. & Shimizu, T. (2012) Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation. Int. J. Mol. Sci. 13, 16267-16280.
13. Gable, K., Slife, H., Bacikova, D., Monaghan, E. & Dunn, T.M. (2000) Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. J. Biol. Chem. 275, 7597-7603.
14. Gijón, M.A., Riekhof, W.R., Zarini, S., Murphy, R.C. & Voelker, D.R. (2008) Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. J. Biol. Chem. 283, 30235-30245.
15. Han, G., Gupta, S.D., Gable, K., Niranjanakumari, S., Moitra, P., Eichler, F., Brown, R.H., Harmon, J.M. & Dunn, T.M. (2009) Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Proc. Natl Acad. Sci. USA 106, 8186-8191.
16. Hanada, K., Nishijima, M., Fujita, T. & Kobayashi, S. (2000) Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant. Biochem. Pharmacol. 59, 1211-1216.
17. Hayashi, T., Rizzuto, R., Hajnoczky, G. & Su, T.P. (2009) MAM: more than just a housekeeper. Trends Cell Biol. 19, 81-88.
18. He, Q., Johnson, V.J., Osuchowski, M.F. & Sharma, R.P. (2004) Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver. Mycopathologia 157, 339-347.
19. Hishikawa, D., Shindou, H., Kobayashi, S., Nakanishi, H., Taguchi, R. & Shimizu, T. (2008) Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl Acad. Sci. USA 105, 2830-2835.
20. Holub, B.J. & Kuksis, A. (1971) Differential distribution of orthophosphate- 32 P and glycerol- 14 C among molecular species of phosphatidylinositols of rat liver in vivo. J. Lipid Res. 12, 699-705.
21. Hörl, G., Wagner, A., Cole, L.K., Malli, R., Reicher, H., Kotzbeck, P., Köfeler, H., Höfler, G., Frank, S., Bogner- Strauss, J.G., Sattler, W., Vance, D.E. & Steyrer, E. (2011) Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J. Biol. Chem. 286, 17338-17350.
22. Imae, R., Inoue, T., Nakasaki, Y., Uchida, Y., Ohba, Y., Kono, N., Nakanishi, H., Sasaki, T., Mitani, S. & Arai, H. (2012) LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice. J. Lipid Res. 53, 335-347.
23. Kang, M.J., Fujino, T., Sasano, H., Minekura, H., Yabuki, N., Nagura, H., Iijima, H. & Yamamoto, T.T. (1997) A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis. Proc. Natl Acad. Sci. USA 94, 2880-2884.
24. Keenan, R.W. & Hokin, L.E. (1964) The enzymatic acylation of lysophosphatidylinositol. J. Biol. Chem. 239, 2123-2129. Kim, Y.J., Guzman-Hernandez, M.L. & Balla, T. (2011) A highly dynamic ER-derived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranes. Dev. Cell 21, 813-824.
25. Kim, Y.J., Guzman-Hernandez, M.L. & Balla, T. (2011) A highly dynamic ERderived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranes. Dev. Cell 21, 813-824.
26. Koeberle, A., Shindou, H., Harayama, T., Yuki, K. & Shimizu, T. (2012) Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 26, 169-180.
27. Lee, H.C., Inoue, T., Imae, R., Kono, N., Shirae, S., Matsuda, S., Gengyo-Ando, K., Mitani, S. & Arai, H. (2008) Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Mol. Biol. Cell 19, 1174-1184.
28. Lee, H.C., Inoue, T., Sasaki, J., et al. (2012a) LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol. Biol. Cell 23, 4689-4700.
29. Lee, H.C., Kubo, T., Kono, N., Kage-Nakadai, E., Gengyo-Ando, K., Mitani, S., Inoue, T. & Arai, H. (2012b) Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans. Genes Cells 17, 748-757.
30. Lewin, T.M., Kim, J.H., Granger, D.A., Vance, J.E. & Coleman, R.A. (2001) Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. J. Biol. Chem. 276, 24674-24679.
31. Li, J., Romestaing, C., Han, X., Li, Y., Hao, X., Wu, Y., Sun, C., Liu, X., Jefferson, L.S., Xiong, J., Lanoue, K.F., Chang, Z., Lynch, C.J., Wang, H. & Shi, Y. (2010) Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab. 12, 154-165.
32. Liu, X., Ye, B., Miller, S., Yuan, H., Zhang, H., Tian, L., Nie, J., Imae, R., Arai, H., Li, Y., Cheng, Z. & Shi, Y. (2012) Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy. Mol. Cell. Biol. 32, 4493-4504.
33. Luthra, M.G. & Sheltawy, A. (1976) The metabolic turnover of molecular species of phosphatidylinositol and its precursor phosphatidic acid in guinea-pig cerebral hemispheres. J. Neurochem. 27, 1501-1511.
34. Lynes, E.M., Bui, M., Yap, M.C., Benson, M.D., Schneider, B., Ellgaard, L., Berthiaume, L.G. & Simmen, T. (2012) Palmitoylated TMX and calnexin target to the mitochondria- associated membrane. EMBO J. 31, 457-470.
35. MacDonald, J.I. & Sprecher, H. (1991) Phospholipid fatty acid remodeling in mammalian cells. Biochim. Biophys. Acta 1084, 105-121.
36. Myhill, N., Lynes, E.M., Nanji, J.A., Blagoveshchenskaya, A.D., Fei, H., Carmine Simmen, K., Cooper, T.J., Thomas, G. & Simmen, T. (2008) The subcellular distribution of calnexin is mediated by PACS-2. Mol. Biol. Cell 19, 2777-2788.
37. Nakagawa, Y., Rüstow, B., Rabe, H., Kunze, D. & Waku, K. (1989) The de novo synthesis of molecular species of phosphatidylinositol from endogenously labeled CDP diacylglycerol in alveolar macrophage microsomes. Arch. Biochem. Biophys. 268, 559-566.
38. Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R. & Shimizu, T. (2006) Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. J. Biol. Chem. 281, 20140-20147.
39. Patton, G.M., Fasulo, J.M. & Robins, S.J. (1982) Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography. J. Lipid Res. 23, 190-196.
40. Prasad, S.S., Garg, A. & Agarwal, A.K. (2011) Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. J. Lipid Res. 52, 451-462.
41. Rusiñol, A.E., Cui, Z., Chen, M.H. & Vance, J.E. (1994) A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J. Biol. Chem. 269, 27494-27502.
42. Sasaki, T., Takasuga, S., Sasaki, J., Kofuji, S., Eguchi, S., Yamazaki, M. & Suzuki, A. (2009) Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res. 48, 307-343.
43. Shaner, N.C., Campbell, R.E., Steinbach, P.A., Giepmans, B.N., Palmer, A.E. & Tsien, R.Y. (2004) Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22, 1567-1572.
44. Shindou, H., Hishikawa, D., Nakanishi, H., Harayama, T., Ishii, S., Taguchi, R. & Shimizu, T. (2007) A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. J. Biol. Chem. 282, 6532-6539.
45. Shindou, H. & Shimizu, T. (2009) Acyl-CoA:lysophospholipid acyltransferases. J. Biol. Chem. 284, 1-5.
46. Stagljar, I., Korostensky, C., Johnsson, N. & te Heesen, S. (1998) A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo. Proc. Natl Acad. Sci. USA 95, 5187-5192.
47. Stone, S.J., Levin, M.C., Zhou, P., Han, J., Walther, T.C. & Farese, R.V. (2009) The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J. Biol. Chem. 284, 5352-5361.
48. Stone, S.J. & Vance, J.E. (2000) Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. J. Biol. Chem. 275, 34534-34540.
49. Tanaka, T., Iwawaki, D., Sakamoto, M., Takai, Y., Morishige, J., Murakami, K. & Satouchi, K. (2003) Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail. A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata. Eur. J. Biochem. 270, 1466-1473.
50. Taylor, W.A. & Hatch, G.M. (2009) Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1). J. Biol. Chem. 284, 30360-30371.
51. Wieckowski, M.R., Giorgi, C., Lebiedzinska, M., Duszynski, J. & Pinton, P. (2009) Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells. Nat. Protoc. 4, 1582-1590.
52. Yamazaki, T., Hirose, A., Sakamoto, T., Okazaki, M., Mitsumoto, A., Kudo, N. & Kawashima, Y. (2009) Peroxisome proliferators attenuate free arachidonic acid pool in the kidney through inducing lysophospholipid acyltransferases. J. Pharmacol. Sci. 111, 201-210.
53. Yang, Y., Cao, J. & Shi, Y. (2004) Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase. J. Biol. Chem. 279, 55866-55874.
54. Yuki, K., Shindou, H., Hishikawa, D. & Shimizu, T. (2009) Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. J. Lipid Res. 50, 860-869.