Lysophosphatidylcholine acyltransferase 3 is the key enzyme for incorporating arachidonic acid into glycerophospholipids during adipocyte differentiation

International Journal of Molecular Sciences

Volumn 13, Issue 12, 2012, Pages 16267-16280

  Eto, Miki ^a,b   Shindou, Hideo ^a   Koeberle, Andreas ^b,c   Harayama, Takeshi ^a   Yanagida, Keisuke ^b   Shimizu, Takao ^a,b  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Adipocyte; Arachidonic acid; C3H10T1 2; Glycerophospholipid; Lands' cycle; LPCAT3; Lysophospholipid acyltransferase

Indexed keywords

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE; ACYL COENZYME A; ARACHIDONIC ACID; GLYCEROPHOSPHOLIPID; LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 3; LYSOPHOSPHATIDYLETHANOLAMINE ACYLTRANSFERASE; LYSOPHOSPHATIDYLSERINE; LYSOPHOSPHATIDYLSERINE ACYLTRANSFERASE; MESSENGER RNA; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG; FATTY ACID; LPCAT3 PROTEIN, MOUSE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME REGULATION; ENZYME SYNTHESIS; IN VITRO STUDY; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; CELL CULTURE; GENETICS; LIPID METABOLISM; METABOLISM; MOUSE; PHYSIOLOGY;

1-ACYLGLYCEROPHOSPHOCHOLINE O-ACYLTRANSFERASE; ADIPOCYTES; ADIPOGENESIS; ANIMALS; ARACHIDONIC ACID; CELL DIFFERENTIATION; CELLS, CULTURED; FATTY ACIDS; GLYCEROPHOSPHOLIPIDS; LIPID METABOLISM; MICE;

EID: 84871703879     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131216267     Document Type: Article

References (36)

1. MacDonald, J.I.; Sprecher, H. Phospholipid fatty acid remodeling in mammalian cells. Biochim. Biophys. Acta 1991, 1084, 105-121.
2. Wood, R.; Harlow, R.D. Structural analyses of rat liver phosphoglycerides. Arch. Biochem. Biophys. 1969, 135, 272-281.
3. Schlame, M.; Brody, S.; Hostetler, K.Y. Mitochondrial cardiolipin in diverse eukaryotes. Comparison of biosynthetic reactions and molecular acyl species. Eur. J. Biochem. 1993, 212, 727-735.
4. Yamashita, A.; Sugiura, T.; Waku, K. Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells. J. Biochem. 1997, 122, 1-16.
5. Kennedy, E.P.; Weiss, S.B. The function of cytidine coenzymes in the biosynthesis of phospholipides. J. Biol. Chem. 1956, 222, 193-214.
6. Van Meer, G.; Voelker, D.R.; Feigenson, G.W. Membrane lipids: Where they are and how they behave. Nat. Rev. Mol. Cell Biol. 2008, 9, 112-124.
7. Coleman, R.A.; Lee, D.P. Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 2004, 43, 134-176.
8. Lands, W.E. Stories about acyl chains. Biochim. Biophys. Acta 2000, 1483, 1-14.
9. Waku, K.; Nakazawa, Y. Acyltransferase activity to 1-acyl-, 1-O-alkenyl-, and 1-O-alkyl-glycero-3-phosphorylcholine in ehrlich ascites tumor cells. J. Biochem. 1972, 72, 495-497.
10. Shimizu, T. Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 2009, 49, 123-150.
11. Lands, W.E. Metabolism of glycerolipides: A comparison of lecithin and triglyceride synthesis. J. Biol. Chem. 1958, 231, 883-888.
12. Shindou, H.; Hishikawa, D.; Harayama, T.; Yuki, K.; Shimizu, T. Recent progress on acyl CoA: Lysophospholipid acyltransferase research. J. Lipid Res. 2009, 50, S46-S51.
13. Shindou, H.; Shimizu, T. Acyl-CoA:Lysophospholipid acyltransferases. J. Biol. Chem. 2009, 284, 1-5.
14. Lewin, T.M.; Wang, P.; Coleman, R.A. Analysis of amino acid motifs diagnostic for the sn-glycerol-3-phosphate acyltransferase reaction. Biochemistry 1999, 38, 5764-5771.
15. Yamashita, A.; Nakanishi, H.; Suzuki, H.; Kamata, R.; Tanaka, K.; Waku, K.; Sugiura, T. Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1. Biochim. Biophys. Acta 2007, 1771, 1202-1215.
16. Harayama, T.; Shindou, H.; Ogasawara, R.; Suwabe, A.; Shimizu, T. Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. J. Biol. Chem. 2008, 283, 11097-11106.
17. Shindou, H.; Eto, M.; Morimoto, R.; Shimizu, T. Identification of membrane O-acyltransferase family motifs. Biochem. Biophys. Res. Commun. 2009, 383, 320-325.
18. Hishikawa, D.; Shindou, H.; Kobayashi, S.; Nakanishi, H.; Taguchi, R.; Shimizu, T. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. USA 2008, 105, 2830-2835.
19. Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. 2008, 283, 8258-8265.
20. Gijon, M.A.; Riekhof, W.R.; Zarini, S.; Murphy, R.C.; Voelker, D.R. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. J. Biol. Chem. 2008, 283, 30235-30245.
21. Matsuda, S.; Inoue, T.; Lee, H.C.; Kono, N.; Tanaka, F.; Gengyo-Ando, K.; Mitani, S.; Arai, H. Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity. Genes Cells 2008, 13, 879-888.
22. Kadowaki, T.; Yamauchi, T.; Kubota, N.; Hara, K.; Ueki, K.; Tobe, K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 2006, 116, 1784-1792.
23. Gale, S.E.; Frolov, A.; Han, X.; Bickel, P.E.; Cao, L.; Bowcock, A.; Schaffer, J.E.; Ory, D.S. A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation. J. Biol. Chem. 2006, 281, 11082-11089.
24. Cortes, V.A.; Curtis, D.E.; Sukumaran, S.; Shao, X.; Parameswara, V.; Rashid, S.; Smith, A.R.; Ren, J.; Esser, V.; Hammer, R.E.; et al. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 2009, 9, 165-176.
25. Agarwal, A.K.; Arioglu, E.; De Almeida, S.; Akkoc, N.; Taylor, S.I.; Bowcock, A.M.; Barnes, R.I.; Garg, A. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat. Genet. 2002, 31, 21-23.
26. Krahmer, N.; Guo, Y.; Wilfling, F.; Hilger, M.; Lingrell, S.; Heger, K.; Newman, H.W.; Schmidt-Supprian, M.; Vance, D.E.; Mann, M.; et al. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:Phosphocholine cytidylyltransferase. Cell Metab. 2011, 14, 504-515.
27. Horl, G.; Wagner, A.; Cole, L.K.; Malli, R.; Reicher, H.; Kotzbeck, P.; Kofeler, H.; Hofler, G.; Frank, S.; Bogner-Strauss, J.G.; et al. Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J. Biol. Chem. 2011, 286, 17338-17350.
28. Reznikoff, C.A.; Brankow, D.W.; Heidelberger, C. Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res. 1973, 33, 3231-3238.
29. Feldman, B.J.; Streeper, R.S.; Farese, R.V., Jr.; Yamamoto, K.R. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc. Natl. Acad. Sci. USA 2006, 103, 15675-15680.
30. Ntambi, J.M.; Buhrow, S.A.; Kaestner, K.H.; Christy, R.J.; Sibley, E.; Kelly, T.J., Jr.; Lane, M.D. Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 1988, 263, 17291-17300.
31. Harmon, G.S.; Lam, M.T.; Glass, C.K. PPARs and lipid ligands in inflammation and metabolism. Chem. Rev. 2011, 111, 6321-6340.
32. Massiera, F.; Saint-Marc, P.; Seydoux, J.; Murata, T.; Kobayashi, T.; Narumiya, S.; Guesnet, P.; Amri, E.Z.; Negrel, R.; Ailhaud, G. Arachidonic acid and prostacyclin signaling promote adipose tissue development: A human health concern? J. Lipid Res. 2003, 44, 271-279.
33. Savva, S.C.; Chadjigeorgiou, C.; Hatzis, C.; Kyriakakis, M.; Tsimbinos, G.; Tornaritis, M.; Kafatos, A. Association of adipose tissue arachidonic acid content with BMI and overweight status in children from Cyprus and Crete. Br. J. Nutr. 2004, 91, 643-649.
34. Williams, E.S.; Baylin, A.; Campos, H. Adipose tissue arachidonic acid and the metabolic syndrome in Costa Rican adults. Clin. Nutr. 2007, 26, 474-482.
35. Koeberle, A.; Shindou, H.; Harayama, T.; Yuki, K.; Shimizu, T. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2011, 26, 169-180.
36. Bligh, E.G.; Dyer, W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37, 911-917.