Molecular identification of a novel mammalian brain isoform of acyl-CoA:Lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 19049-19057

  Cao, Jingsong ^a   Shan, Dandan ^a   Revett, Tracy ^a   Li, Dongmei ^a   Wu, Leeying ^a   Liu, Wei ^a   Tobin, James F ^a   Gimeno, Ruth E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; CALCIUM; ENCODING (SYMBOLS); ENZYME ACTIVITY; ENZYMES; GENE ENCODING; GENES; GLYCEROL; LIPIDS; MAMMALS; PHOSPHOLIPIDS; PLANTS (BOTANY);

ACYL TRANSFERASES; ALKENYL; DIACYLGLYCEROL; ECTOPIC EXPRESSIONS; EMPTY VECTORS; ENDOPLASMIC RETICULUM; ENZYMATIC ACTIVITIES; ETHANOLAMINE; GENES ENCODING; ISOFORM; LONG CHAINS; LYSOPHOSPHATIDIC ACIDS; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHATIDYLETHANOLAMINE; LYSOPHOSPHOLIPIDS; MAMMALIAN BRAINS; MAMMALIAN CELLS; MOLECULAR IDENTIFICATIONS; MOLECULAR SPECIES; MULTIPLE GENES; PHOSPHATIDYLETHANOL AMINES;

BRAIN;

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE; 1 O ALKENYLLYSOPHOSPHATIDYLETHANOLAMINE; 1 O ALKYLLYSOPHOSPHATIDYLCHOLINE; CALCIUM; DIACYLGLYCEROL; ETHANOLAMINE; GENE PRODUCT; GLYCEROPHOSPHATE; ISOENZYME; LONG CHAIN FATTY ACID COENZYME A LIGASE; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHATIDYLGLYCEROL; LYSOPHOSPHATIDYLINOSITOL; LYSOPHOSPHATIDYLSERINE; LYSOPHOSPHOLIPID; PHOSPHOLIPID; PROTEIN LPEAT2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; AGPAT7 PROTEIN, HUMAN; NERVE PROTEIN;

ACYLATION; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LPEAT2 GENE; MAMMAL CELL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; ANTIBODY SPECIFICITY; BIOSYNTHESIS; BRAIN; CELL LINE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY;

MAMMALIA;

1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; BRAIN; CELL LINE; ENDOPLASMIC RETICULUM; HUMANS; ISOENZYMES; LYSOPHOSPHOLIPIDS; NERVE TISSUE PROTEINS; ORGAN SPECIFICITY; SUBSTRATE SPECIFICITY;

EID: 49649090149     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800364200     Document Type: Article

References (32)

1. Dowhan, W. (1997) Annu. Rev. Biochem. 66, 199-232
2. Yamashita, A., Sugiura, T., and Waku, K. (1997) J. Biochem. (Tokyo) 122, 1-16
3. Kent, C. (1995) Annu. Rev. Biochem. 64, 315-343
4. Vance, D. E., Li, Z., and Jacobs, R. L. (2007) J. Biol. Chem. 282, 33237-33241
5. Lands, W. E., and Merkl, I. (1963) J. Biol. Chem. 238, 898-904
6. Merkl, I., and Lands, W. E. (1963) J. Biol. Chem. 238, 905-906
7. Lands, W. E. (1960) J. Biol. Chem. 235, 2233-2237
8. Lewin, T. M., Wang, P., and Coleman, R. A. (1999) Biochemistry 38, 5764-5771
9. Beigneux, A. P., Vergnes, L., Qiao, X., Quatela, S., Davis, R., Watkins, S. M., Coleman, R. A., Walzem, R. L., Philips, M., Reue, K., and Young, S. G. (2006) J. Lipid Res. 47, 734-744
10. Coleman, R. A., and Lee, D. P. (2004) Prog. Lipid Res. 43, 134-176
11. Cao, J., Liu, Y., Lockwood, J., Burn, P., and Shi, Y. (2004) J. Biol. Chem. 279, 31727-31734
12. Chen, X., Hyatt, B. A., Mucenski, M. L., Mason, R. J., and Shannon, J. M. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 11724-11729
13. Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R., and Shimizu, T. (2006) J. Biol. Chem. 281, 20140-20147
14. Shindou, H., Hishikawa, D., Nakanishi, H., Harayama, T., Ishii, S., Taguchi, R., and Shimizu, T. (2007) J. Biol. Chem. 282, 6532-6539
15. Yang, Y., Cao, J., and Shi, Y. (2004) J. Biol. Chem. 279, 55866-55874
16. Cao, J., Li, J. L., Li, D., Tobin, J. F., and Gimeno, R. E. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 19695-19700
17. Ye, G. M., Chen, C., Huang, S., Han, D. D., Guo, J. H., Wan, B., and Yu, L. (2005) DNA Seq. 16, 386-390
18. Cao, J., Lockwood, J., Burn, P., and Shi, Y. (2003) J. Biol. Chem. 278, 13860-13866
19. Finn, R. D., Mistry, J., Schuster-Bockler, B., Griffiths-Jones, S., Hollich, V., Lassmann, T., Moxon, S., Marshall, M., Khanna, A., Durbin, R., Eddy, S. R., Sonnhammer, E. L., and Bateman, A. (2006) Nucleic Acids Res. 34, 247-251
20. Cheng, D., Nelson, T. C., Chen, J., Walker, S. G., Wardwell-Swanson, J., Meegalla, R., Taub, R., Billheimer, J. T., Ramaker, M., and Feder, J. N. (2003) J. Biol. Chem. 278, 13611-13614
21. Cheng, J. B., and Russell, D. W. (2004) J. Biol. Chem. 279, 37798-37807
22. Soupene, E., Fyrst, H., and Kuypers, F. A. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 88-93
23. Cao, J., Cheng, L., and Shi, Y. (2007) J. Lipid Res. 48, 583-591
24. Guan, Z., Grunler, J., Piao, S., and Sindelar, P. J. (2001) Anal. Biochem. 297, 137-143
25. Guan, Z., Wang, Y., Cairns, N. J., Lantos, P. L., Dallner, G., and Sindelar, P. J. (1999) J. Neuropathol. Exp. Neurol. 58, 740-747
26. Hishikawa, D., Shindou, H., Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 2830-2835
27. Yen, C. L., Monetti, M., Burri, B. J., and Farese, R. V., Jr. (2005) J. Lipid Res. 46, 1502-1511
28. Turkish, A. R., Henneberry, A. L., Cromley, D., Padamsee, M., Oelkers, P., Bazzi, H., Christiano, A. M., Billheimer, J. T., and Sturley, S. L. (2005) J. Biol. Chem. 280, 14755-14764
29. Zhao, Y., Chen, Y. Q., Bonacci, T. M., Bredt, D. S., Li, S., Bensch, W. R., Moller, D. E., Kowala, M., Konrad, R. J., and Cao, G. (2008) J. Biol. Chem. 283, 8258-8265
30. Nitsch, R., Pittas, A., Blusztajn, J. K., Slack, B. E., Growdon, J. H., and Wurtman, R. J. (1991) Ann. N. Y. Acad. Sci. 640, 110-113
31. Nitsch, R. M., Blusztajn, J. K., Pittas, A. G., Slack, B. E., Growdon, J. H., and Wurtman, R. J. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 1671-1675
32. Soderberg, M., Edlund, C., Kristensson, K., and Dallner, G. (1990) J. Neurochem. 54, 415-423