Identification, by gene expression profiling analysis, of novel gene targets in Staphylococcus aureus treated with betulinaldehyde

Research in Microbiology

Volumn 164, Issue 4, 2013, Pages 319-326

  Chung, Pooi Yin ^a   Chung, Lip Yong ^b   Navaratnam, Parasakthi ^a  

^a MONASH UNIVERSITY MALAYSIA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Betulinaldehyde; Staphylococcus aureus; Transcriptional analysis

Indexed keywords

ABC TRANSPORTER; ALDEHYDE DERIVATIVE; AMINO ACID TRANSFER RNA LIGASE; ANTIINFECTIVE AGENT; PEPTIDOGLYCAN;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CELL DIVISION; CONTROLLED STUDY; DEFENSE MECHANISM; DNA MICROARRAY; FATTY ACID SYNTHESIS; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE TARGETING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; RNA ANALYSIS; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; GENE EXPRESSION; GENE EXPRESSION PROFILING; METABOLIC NETWORKS AND PATHWAYS; MICROARRAY ANALYSIS; PENTACYCLIC TRITERPENES; STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS AUREUS;

EID: 84876964599     PISSN: 09232508     EISSN: 17697123     Source Type: Journal    
DOI: 10.1016/j.resmic.2013.01.005     Document Type: Article

References (29)

1. BioRad Laboratories Real-time PCR Applications Guide 2006.
2. Cassels R., Olivia B., Knowles D. Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci. J. Bacteriol. 1995, 177:5161-5165.
3. Chandramu C., Manohar R.D., Krupadanam D.G., Dashavantha R.V. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother. Res. 2003, 17:129-134.
4. Chung P.Y., Chung L.Y., Ngeow Y.F., Goh S.H., Imiyabir Z. Antimicrobial activities of Malaysian plant species. Pharm. Biol. 2004, 42:292-300.
5. Chung P.Y., Navaratnam P., Chung L.Y. Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains. Ann. Clin. Microb. Antimicrob. 2011, 10:25.
6. Feng H., Xiang H., Zhang J., Liu G., Guo N., Wang X., Wu X., Deng X., Yu L. Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cryptotanshione. J. Biomed. Biotechnol 2009, http://dx.doi.org/10.1155/2009/617509.
7. Gibbons S. Anti-staphylococcal plant natural products. Nat. Prod. Rep. 2004, 21:263-277.
8. Giraudo A.T., Calzolari A.A., Cataldi A.A., Bogni C., Nagel R. The sae locus of Staphylococcus aureus encodes a two-component regulatory system. FEMS Microbiol. Lett. 1999, 177:15-22.
9. Hutter B., Schaab C., Albrecht S., Borgmann M., Brunner N.A., Freiberg C., Ziegelbauer K., Rock C.O., Ivanov I., Loferer H. Prediction of mechanisms of action of antibacterial compounds by gene expression profiling. Antimicrob. Agents Chemother. 2004, 48:2838-2844.
10. Kuroda M., Kuroda H., Oshima T., Takeuchi F., Mori H., Hiramatsu K. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Mol. Microbiol. 2003, 49:807-821.
11. Lange R.P., Locher H.H., Wyss P.C., Then R.L. The targets of currently used antibacterial agents: lessons for drug discovery. Curr. Pharm. Des. 2007, 13:3140-3154.
12. Lock R.L., Harry E.J. Cell-division inhibitors: new insights for future antibiotics. Nat. Rev. Drug Disc. 2008, 7:324-338.
13. Macheboeuf P., Contretas-Martel C., Job V., Diderberg O., Dessen A. Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes. FEMS Microbiol. Rev. 2006, 30:673-691.
14. Mallavadhani U.V., Mahapatra A., Jamil K., Reddy P.S. Antimicrobial activity of some pentacyclic triterpenes and their synthesized 3-O-lipophilic chain. Biol. Pharm. Bull. 2004, 27:1576-1579.
15. Margalit D.N., Romberg I., Mets R.B., Hebert A.M., Mitchison T.J., Kirschner M.W., Ray-Chaudhuri D. Targeting cell division: small molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:11821-11826.
16. Novick R.P., Geisinger E. Quorum sensing in staphylococci. Annu. Rev. Genet. 2008, 42:541-564.
17. Ohlsen K., Lorenz U. Novel targets for antibiotics in Staphylococcus aureus. Future Microbiol. 2007, 2:655-666.
18. Rohrer S., Ehlert K., Tschierske M., Labischinski H., Berger-Bachi B. The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:9351-9356.
19. Roux A., Payne S.M., Gilmore M.S. Microbial telesensing: probing the environment for friends, foes and food. Cell Host Microbe 2009, 6:115-124.
20. Schneider T., Sahl H. An oldie but goodie - cell wall biosynthesis as antibiotic target pathway. Int. J. Med. Microbiol. 2010, 300:161-169.
21. Silver L.L. Multi-targeting by monotherapeutic antibacterials. Nat. Rev. Drug Disc. 2007, 6:41-55.
22. Singh B., Singh S. Antimicrobial activity of terpenoids from Trichodesma amplexicaule Roth. Phytother. Res. 2003, 17:814-816.
23. Tao J., Schimmel P. Inhibitors of amino-acyl tRNA synthetase as novel anti-infectives. Exp. Opin. Investig. Drugs 2000, 9:1767-1775.
24. Vollmer W. Targeting the bacterial Z-ring. Chem. Biol. 2008, 15:93-94.
25. Wang D., Yu L., Xiang H., Fan J., He L., Guo N., Feng H., Deng X. Global transcriptional profiles of Staphylococcus aureus treated with berberine chloride. FEMS Microbiol. Lett. 2008, 279:217-225.
26. White S.W., Zheng J., Zhang Y.M., Rock C.O. The structural biology of type II fatty acid biosynthesis. Annu. Rev. Biochem. 2005, 74:791-831.
27. + sensing and Agr signaling to infection programming. Infect. Immun. 2011, 79:2154-2167.
28. Yu L., Xiang H., Fan J., Wang D., Yang F., Guo N., Jin Q., Deng X. Global transcriptional response of Staphylococcus aureus to rhein, a natural plant product. J. Biotech. 2008, 135:304-308.
29. Zhang Y., Rock C.O. Membrane lipid homeostasis in bacteria. Nat. Rev. Microb. 2008, 6:222-233.