Simultaneous imaging of temporal changes of NF-κB activity and viable tumor cells in Huh7/NF-κB-tk-luc2/rfp tumor-bearing mice

In Vivo

Volumn 27, Issue 3, 2013, Pages 339-350

  Wang, Wei Hsun ^a,b   Chiang, I Tsang ^a   Liu, Yu Chang ^a   Hsu, Fei Ting ^a   Chen, Hong Wen ^c   Chen, Chuan Lin ^a   Lee, Yi Jang ^a   Lin, Wuu Jyh ^d   Hwang, Jeng Jong ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^c MACKAY MEMORIAL HOSPITAL   (Taiwan)

^d INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

Author keywords

Human hepatocellular carcinoma; Imaging; RFP; Sorafenib; Temporal NF B monitoring

Indexed keywords

FIREFLY LUCIFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RED FLUORESCENT PROTEIN; SORAFENIB; THYMIDINE KINASE;

ARTICLE; BIOLUMINESCENCE; CANCER GROWTH; CELL VIABILITY; DNA BINDING; HUMAN; IN VIVO STUDY; LIVER CELL CARCINOMA; MOLECULAR IMAGING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR CELL; WESTERN BLOTTING; WHOLE BODY AUTORADIOGRAPHY;

EID: 84876941159     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. Ver.1.2. http://globocan.iarc.fr. Last accessed 29th, January, 2012.
2. El-Serag HB: Hepatocellular carcinoma. N Engl J Med 365: 1118-1127, 2011.
3. Feng M and Ben-Josef E: Radiation therapy for hepatocellular carcinoma. Semin Radiat Oncol 21: 271-277, 2011.
4. Koehler BC, Urbanik T, Vick B, Boger RJ, Heeger S, Galle PR, Schuchmann M and Schulze-Bergkamen H: TRAILinduced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies. World J Gastroenterol 15: 5924-5935, 2009.
5. Li F and Sethi G: Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta 1805: 167-180, 2010.
6. Wu JM, Sheng H, Saxena R, Skill NJ, Bhat-Nakshatri P, Yu M, Nakshatri H and Maluccio MA: NF-κB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy. Cancer Lett 278: 145-155, 2009.
7. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E and Ben-Neriah Y: NF-κB functions as a tumour promoter in inflammationassociated cancer. Nature 431: 461-466, 2004.
8. Ozaki I, Zhang H, Mizuta T, Ide Y, Eguchi Y, Yasutake T, Sakamaki T, Pestell RG and Yamamoto K: Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation. Clin Cancer Res 13: 2236-2245, 2007.
9. Kang YH, Park MY, Yoon DY, Han SR, Lee CI, Ji NY, Myung PK, Lee HG, Kim JW, Yeom YI, Jang YJ, Ahn DK and Song EY: Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and BCL-2. Cancer Lett 318: 226-233, 2012.
10. Shyu MH, Kao TC and Yen GC: Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. J Agric Food Chem 58: 6110-6118, 2010.
11. Xiang Z, Zeng Z, Tang Z, Fan J, Sun H, Wu W and Tan Y: Increased expression of vascular endothelial growth factor-C and nuclear CXCR4 in hepatocellular carcinoma is correlated with lymph node metastasis and poor outcome. Cancer J 15: 519-525, 2009.
12. Claudio PP, Russo G, Kumar CA, Minimo C, Farina A, Tutton S, Nuzzo G, Giuliante F, Angeloni G, Maria V, Vecchio FM, Campli CD and Giordano A: pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: Their clinical significance. Clin Cancer Res 10: 3509-3517, 2004.
13. Meng F, Henson R and Patel T: Chemotherapeutic stress selectively activates NF-κB-dependent AKT and VEGF expression in liver cancer-derived endothelial cells. Am J Physiol Cell Physiol 293: C749-760, 2007.
14. Hsiang CY, Wu SL, Chen JC, Lo HY, Li CC, Chiang SY, Wu HC and Ho TY: Acetaldehyde induces matrix metalloproteinase-9 gene expression via nuclear factor-κB and activator protein 1 signaling pathways in human hepatocellular carcinoma cells: Association with the invasive potential. Toxicol Lett 171: 78-86, 2007.
15. Cheng JC, Chou CH, Kuo ML and Hsieh CY: Radiationenhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/AKT/NF-κB signal transduction pathway. Oncogene 25: 7009-7018, 2006.
16. Lee KW, Kang NJ, Kim JH, Lee KM, Lee DE, Hur HJ and Lee HJ: Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B. Genes Nutr 2: 319-322, 2008.
17. Liu YC, Chiang IT, Hsu FT and Hwang JJ: Using NF-κB as a molecular target for theranostics in radiation oncology research. Expert Rev Mol Diagn 12: 139-146, 2012.
18. Liu Z, Cheng M and Cao M: Potential targets for molecular imaging of apoptosis resistance in hepatocellular carcinoma. Biomed Imaging Interv J 7: e5, 2011.
19. Chang TJ, Chang YJ, Ho TY, Hsiang CY, Yu CY, Lee TW, Lin WJ and Chang CH: Noninvasive bioluminescent and microPET imaging for the regulation of NF-κB in human hepatoma-bearing mice. Anticancer Res 29: 987-994, 2009.
20. Calvisi DF, Ladu S, Gorden A, Farina M, Conner EA, Lee JS, Factor VM and Thorgeirsson SS: Ubiquitous activation of RAS and JAK/STAT pathways in human HCC. Gastroenterology 130: 1117-1128, 2006.
21. Arsura M, Mercurio F, Oliver AL, Thorgeirsson SS and Sonenshein GE: Role of the IkappaB kinase complex in oncogenic Ras-and Raf-mediated transformation of rat liver epithelial cells. Mol Cell Biol 20: 5381-5391, 2000.
22. Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, Schwartz B, Simantov R and Kelley S: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug discov 5: 835-844, 2006.
23. Chiang IT, Liu YC, Wang WH, Hsu FT, Chen HW, Lin WJ, Chang WY and Hwang JJ: Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-κB pathway in hepatocellular carcinoma cells. In Vivo 26: 671-681, 2012.
24. Urbanik T, Kohler BC, Boger RJ, Worns MA, Heeger S, Otto G, Hovelmeyer N, Galle PR, Schuchmann M, Waisman A and Schulze-Bergkamen H: Down-regulation of CYLD as a trigger for NF-κB activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol 38: 121-131, 2011.
25. Chang YF, Lin YY, Wang HE, Liu RS, Pang F and Hwang JJ: Monitoring of tumor growth and metastasis potential in MDAMB-435s/tk-luc human breast cancer xenografts. Nucl Instr Meth Phys Res A 571: 155-159, 2007.
26. Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G and Hwang JJ: Biodistribution study of [(123)I] ADAM in mice: Correlation with whole body autoradiography. Nucl Med Biol 29: 643-650, 2002.
27. Kuo YC, Lin WC, Chiang IT, Chang YF, Chen CW, Su SH, Chen CL and Hwang JJ: Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-κB expression in vitro and in vivo. Biomed Pharmacother 66: 12-20, 2012.
28. Kim R, Emi M and Tanabe K: Cancer immunoediting from immune surveillance to immune escape. Immunology 121: 1-14, 2007.
29. Magne N, Toillon RA, Bottero V, Didelot C, Houtte PV, Gerard JP and Peyron JF: NF-κB modulation and ionizing radiation: Mechanisms and future directions for cancer treatment. Cancer Lett 231: 158-168, 2006.