Human umbilical cord blood stem cells for spinal cord injury: Early transplantation results in better local angiogenesis

Regenerative Medicine

Volumn 8, Issue 3, 2013, Pages 271-281

  Ning, Guangzhi ^a   Tang, Liang ^b   Wu, Qiang ^a   Li, Yulin ^a   Li, Yan ^a   Zhang, Chao ^a   Feng, Shiqing ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN HAIHE HOSPITAL   (China)

Author keywords

angiogenesis; BBB scores; CD34+ cell; human umbilical cord blood; rat; regeneration; spinal cord injury; transplantation

Indexed keywords

CD34 ANTIGEN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASSO BEATTIE AND BRESNAHAN SCORE; BLOOD VESSEL DENSITY; BLOOD VESSEL PARAMETERS; CELL SURVIVAL; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; HUMAN; HUMAN CELL; MOTOR PERFORMANCE; NERVE CELL DIFFERENTIATION; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SPINAL CORD INJURY;

ANIMALS; BLOOD VESSELS; BLOOD-BRAIN BARRIER; CELL DIFFERENTIATION; CELL SURVIVAL; FEMALE; FETAL BLOOD; HUMANS; MOTOR ACTIVITY; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, WISTAR; SPINAL CORD; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 84876933089     PISSN: 17460751     EISSN: 1746076X     Source Type: Journal    
DOI: 10.2217/rme.13.26     Document Type: Article

References (41)

1. Sobani ZA, Quadri SA, Enam SA. Stem cells for spinal cord regeneration: current status. Surg. Neurol. Int. 1, 93 (2010).
2. Garbossa D, Boido M, Fontanella M, Fronda C, Ducati A, Vercelli A. Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells. Neurosurg. Rev. 35, 293-311 (2012).
3. Gurudutta GU, Satija NK, Singh VK, Verma YK, Gupta P, Tripathi RP. Stem cell therapy: a novel & futuristic treatment modality for disaster injuries. Indian J. Med. Res. 135, 15-25 (2012).
4. Ruff CA, Wilcox JT, Fehlings MG. Cell-based transplantation strategies to promote plasticity following spinal cord injury. Exp. Neurol. 235, 78-90 (2012).
5. Sandner B, Prang P, Rivera FJ, Aigner L, Blesch A, Weidner N. Neural stem cells for spinal cord repair. Cell Tissue Res. 349, 349-362 (2012).
6. Liu S, Qu Y, Stewart TJ et al. Embryonic stem cells differentiate into oligodendrocytes and myelinate in cultureand after spinal cord transplantation. Proc. Natl Acad. Sci. USA 97, 6126-6131 (2000).
7. Rodrigues LP, Iglesias D, Nicola FC et al. Transplantation of mononuclear cells from human umbilical cord blood promotes functional recovery after traumatic spinal cord injury in Wistar rats. Braz. J. Med. Biol. Res. 45, 49-57 (2012).
8. Zhou XH, Ning GZ, Feng SQ et al. Transplantation of autologous activated schwann cells in the treatment of spinal cord injury, six cases, more than five years' follow-up. Cell Transplant. 21, S39-S47 (2012).
9. Yazdani SO, Pedram M, Hafizi M et al. A comparison between neurally induced bone marrow derived mesenchymal stem cells and olfactory ensheathing glial cells to repair spinal cord injuries in rat. Tissue Cell 44, 205-213 (2012).
10. Kao CH, Chen SH, Chio CC Lin MT. Human umbilical cord blood-derived CD34+ cells may attenuate spinal cord injuryby stimulating vascular endothelial and neurotrophic factors. Shock 29, 49-55 (2008).
11. Urdzíková L, Jendelová P, Glogarová K, Burian M, Hájek M, Syková E. Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats. J. Neurotrauma 23, 1379-1391 (2006).
12. Chen J, Sanberg PR, Li Y et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32, 2682-2688 (2001).
13. Lu D, Sanberg PR, Mahmood A et al. Intravenous administration of human umbilical cord blood reduces neurologicaldeficit in the rat after traumatic brain injury. Cell Transplant. 11, 275-281 (2002).
14. Liu HY, Zhang QJ, Li HJ, Han ZC. Effect of intracranial transplantation of CD34+ cells derived from human umbilical cord blood in rats with cerebral ischemia. Chin. Med. J. 119, 1744-1748 (2006).
15. Zhao ZM, Li HJ, Liu HY et al. Intraspinal transplantation of CD34+ human umbilical cord blood cells afterspinal cord hemisection injury improves functional recovery in adult rats. Cell Transplant. 13, 113-122 (2004).
16. Kaner T, Karadag T, Cirak B et al. The effects of human umbilical cord blood transplantation in rats with experimentally induced spinal cord injury. J. Neurosurg. Spine 13, 543-551 (2010).
17. Dasari VR, Veeravalli KK, Tsung AJ et al. Neuronal apoptosis is inhibited by cord blood stem cells after spinal cordinjury. J. Neurotrauma 26, 2057-2069 (2009).
18. Chua SJ, Bielecki R, Yamanaka N, Fehlings MG, Rogers IM Casper RF. The effect of umbilical cord blood cells on outcomes after experimental traumaticspinal cord injury. Spine 35, 1520-1526 (2010).
19. Park DH, Lee JH, Borlongan CV, Sanberg PR, Chung YG, Cho TH. Transplantation of umbilical cord blood stem cells for treating spinal cordinjury. Stem Cell Rev. 7, 181-194 (2011).
20. Park SS, Byeon YE, Ryu HH et al. Comparison of canine umbilical cord blood-derived mesenchymal stem cell transplantation times: involvement of astrogliosis, inflammation, intracellular actin cytoskeleton pathways, and neurotrophin. Cell Transplant. 20(11-12), 1867-1880 (2011).
21. Chen CT, Foo NH, Liu WS, Chen SH. Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction inexperimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms. Pediatr. Neonatol. 49, 77-83 (2008).
22. Nandoe Tewarie RD, Hurtado A, Ritfeld GJ et al. Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord. J. Neurotrauma 26, 2313-2322 (2009).
23. Tetzlaff W, Okon EB, Karimi-Abdolrezaee S et al. A systematic review of cellular transplantation therapies for spinal cord injury. J. Neurotrauma 28, 1611-1682 (2011).
24. NIH. Guide for the Care and Use of Laboratory Animals. National Academy Press, MA, USA (1996).
25. Boido M, Rupa R, Garbossa D, Fontanella M, Ducati A, Vercelli A. Embryonic and adult stem cells promote raphespinal axon outgrowth and improvefunctional outcome following spinal hemisection in mice. Eur. J. Neurosci. 30, 833-846 (2009).
26. Wang G, Ao Q, Gong K, Zuo H, Gong Y, Zhang X. Synergistic effect of neural stem cells and olfactory ensheathing cells on repair of adult rat spinal cord injury. Cell Transplant. 19, 1325-1337 (2010).
27. Saporta S, Kim JJ, Willing AE, Fu ES, Davis CD, Sanberg PR. Human umbilical cord blood stem cells infusion in spinal cord injury: engraftmentand beneficial influence on behavior. J. Hematother. Stem Cell Res. 12, 271-278 (2003).
28. McMahon SS, Albermann S, Rooney GE et al. Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury. Cytotherapy 12, 313-325 (2010).
29. Karaoz E, Kabatas S, Duruksu G et al. Reduction of lesion in injured rat spinal cord and partial functional recovery of motility after bone marrow derived mesenchymal stem cell transplantation. Turk. Neurosurg. 22, 207-217 (2012).
30. Sakai K, Yamamoto A, Matsubara K et al. Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. J. Clin. Invest. 122, 80-90 (2012).
31. Oudega M. Molecular and cellular mechanisms underlying the role of blood vessels in spinal cord injury and repair. Cell Tissue Res. 349, 269-288 (2012).
32. Nishio Y, Koda M, Kamada T et al. The use of hemopoietic stem cells derived from human umbilical cord blood topromote restoration of spinal cord tissue and recovery of hindlimb function inadult rats. J. Neurosurg. Spine 5, 424-433 (2006).
33. Kim HM, Hwang DH, Lee JE, Kim SU, Kim BG. Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury. PLoS ONE 4, e4987 (2009).
34. Herrera JJ, Sundberg LM, Zentilin L, Giacca M, Narayana PA. Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury. J. Neurotrauma 27, 2067-2076 (2010).
35. De Laporte L, des Rieux A, Tuinstra HM et al. Vascular endothelial growth factor and fibroblast growth factor 2 delivery from spinal cord bridges to enhance angiogenesis following injury. J. Biomed. Mater. Res. A 98, 372-382 (2011).
36. Newman MB, Davis CD, Kuzmin-Nichols N, Sanberg PR. Human umbilical cord blood (HUCB) cells for central nervous system repair. Neurotox. Res. 5, 355-368 (2003).
37. Lutton C, Young YW, Williams R, Meedeniya AC, Mackay-Sim A, Goss B. Combined VEGF and PDGF treatment reduces secondary degeneration after spinal cord injury. J. Neurotrauma 29, 957-970 (2012).
38. Loy DN, Crawford CH, Darnall JB, Burke DA, Onifer SM, Whittemore SR. Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat. J. Comp. Neurol. 445, 308-324 (2002).
39. Graumann U, Ritz MF, Hausmann O. Necessity for re-vascularization after spinal cord injury and the search for potential therapeutic options. Curr. Neurovasc. Res. 8, 334-341 (2011).
40. Taguchi A, Soma T, Tanaka H. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J. Clin. Invest. 114, 330-338 (2004).
41. Dray C, Rougon G, Debarbieux F. Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord. Proc. Natl Acad. Sci. USA 106, 9459-9464 (2009).