Transplantation of mononuclear cells from human umbilical cord blood promotes functional recovery after traumatic spinal cord injury in Wistar rats

Brazilian Journal of Medical and Biological Research

Volumn 45, Issue 1, 2012, Pages 49-57

  Rodrigues, L P ^a   Iglesias, D ^a   Nicola, F C ^a   Steffens, D ^a   Valentim, L ^a   Witczak, A ^a   Zanatta, G ^a   Achaval, M ^a   Pranke, P ^a   Netto, C A ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cell therapy; Functional recovery; Human umbilical cord blood; MASCIS impactor; Mononuclear cells; Spinal cord injury

Indexed keywords

CYCLOSPORIN A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL TRANSPLANTATION; CISTERNA MAGNA; CLINICAL EFFECTIVENESS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CONTUSION; FEMALE; HUMAN; IMMUNOFLUORESCENCE; IMMUNOSUPPRESSIVE TREATMENT; MONONUCLEAR CELL; NERVE CELL; NEWBORN; NONHUMAN; OLIGODENDROGLIA; RAT; SPINAL CORD INJURY; UMBILICAL CORD BLOOD;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84855908073     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2011007500162     Document Type: Article

References (31)

1. Becker D, Sadowsky CL, McDonald JW. Restoring function after spinal cord injury. Neurologist 2003; 9: 1-15.
2. National Spinal Cord Injury Database (NSCID). http://www. spinalcord.uab.edu. Accessed September 12, 2010.
3. Brazilian Institute of Geography and Statistics (IBGE). Census of 2000. Rio de Janeiro [Internet document]. http:// www.ibge.gov.br/censo/text_censodemog.shtm. Accessed September 12, 2010.
4. Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 1991; 75: 15-26.
5. McDonald JW, Howard MJ. Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination. Prog Brain Res 2002; 137: 299-309.
6. Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996; 139: 244-256.
7. Gruner JA. A monitored contusion model of spinal cord injury in the rat. J Neurotrauma 1992; 9: 123-126.
8. Coutts M, Keirstead HS. Stem cells for the treatment of spinal cord injury. Exp Neurol 2008; 209: 368-377.
9. Horner PJ, Gage FH. Regenerating the damaged central nervous system. Nature 2000; 407: 963-970.
10. Osaka M, Honmou O, Murakami T, Nonaka T, Houkin K, Hamada H, et al. Intravenous administration of mesenchymal stem cells derived from bone marrow after contusive spinal cord injury improves functional outcome. Brain Res 2010; 1343: 226-235.
11. McDonald JW, Becker D, Holekamp TF, Howard M, Liu S, Lu A, et al. Repair of the injured spinal cord and the potential of embryonic stem cell transplantation. J Neurotrauma 2004; 21: 383-393.
12. Secco M, Zucconi E, Vieira NM, Fogaca LL, Cerqueira A, Carvalho MD, et al. Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells 2008; 26: 146-150.
13. Harris DT. Cord blood stem cells: a review of potential neurological applications. Stem Cell Rev 2008; 4: 269-274.
14. van de Ven C, Collins D, Bradley MB, Morris E, Cairo MS. The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regeneration. Exp Hematol 2007; 35: 1753-1765.
15. Saporta S, Kim JJ, Willing AE, Fu ES, Davis CD, Sanberg PR. Human umbilical cord blood stem cells infusion in spinal cord injury: engraftment and beneficial influence on behavior. J Hematother Stem Cell Res 2003; 12: 271-278.
16. Kao CH, Chen SH, Chio CC, Lin MT. Human umbilical cord blood-derived CD34+ cells may attenuate spinal cord injury by stimulating vascular endothelial and neurotrophic factors. Shock 2008; 29: 49-55.
17. Dasari VR, Spomar DG, Li L, Gujrati M, Rao JS, Dinh DH. Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Neurochem Res 2008; 33: 134-149.
18. Weeks J, Hart RP. SCI-Base: an open-source spinal cord injury animal experimentation database. Lab Anim 2004; 33: 35-41.
19. Canabarro R, Sporleder H, Gomes T, Zanatta G, Scribel L, Freitas F, et al. Immunophenotypic evaluation, and physiological and laboratory corelations of hematopoietic stem cells from umbilical cord blood. Biocell 2007; 31: 397-403.
20. Pranke P, Hendrikx J, Debnath G, Alespeiti G, Rubinstein P, Nardi N, et al. Immunophenotype of hematopoietic stem cells from placental/umbilical cord blood after culture. Braz J Med Biol Res 2005; 38: 1775-1789.
21. Andrews MR, Stelzner DJ. Evaluation of olfactory ensheathing and Schwann cells after implantation into a dorsal injury of adult rat spinal cord. J Neurotrauma 2007; 24: 1773-1792.
22. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21.
23. Arteni NS, Pereira LO, Rodrigues AL, Lavinsky D, Achaval ME, Netto CA. Lateralized and sex-dependent behavioral and morphological effects of unilateral neonatal cerebral hypoxia-ischemia in the rat. Behav Brain Res 2010; 210: 92-98.
24. Mestriner RG, Pagnussat AS, Boisserand LS, Valentim L, Netto CA. Skilled reaching training promotes astroglial changes and facilitated sensorimotor recovery after collagenase-induced intracerebral hemorrhage. Exp Neurol 2011; 227: 53-61.
25. Chopp M, Zhang XH, Li Y, Wang L, Chen J, Lu D, et al. Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport 2000; 11: 3001-3005.
26. Vaquero J, Zurita M, Oya S, Santos M. Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration? Neurosci Lett 2006; 398: 129-134.
27. Lee KH, Suh-Kim H, Choi JS, Jeun SS, Kim EJ, Kim SS, et al. Human mesenchymal stem cell transplantation promotes functional recovery following acute spinal cord injury in rats. Acta Neurobiol Exp 2007; 67: 13-22.
28. Nandoe Tewarie RD, Hurtado A, Ritfeld GJ, Rahiem ST, Wendell DF, Barroso MM, et al. Bone marrow stromal cells elicit tissue sparing after acute but not delayed transplantation into the contused adult rat thoracic spinal cord. J Neurotrauma 2009; 26: 2313-2322.
29. Urdzikova L, Jendelova P, Glogarova K, Burian M, Hajek M, Sykova E. Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats. J Neurotrauma 2006; 23: 1379-1391.
30. Park WB, Kim SY, Lee SH, Kim HW, Park JS, Hyun JK. The effect of mesenchymal stem cell transplantation on the recovery of bladder and hindlimb function after spinal cord contusion in rats. BMC Neurosci 2010; 11: 119.
31. Rossi SL, Nistor G, Wyatt T, Yin HZ, Poole AJ, Weiss JH, et al. Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord. PLoS One 2010; 5: e11852.