Sex differences in familiality effects on neurocognitive performance in schizophrenia

Biological Psychiatry

Volumn 73, Issue 10, 2013, Pages 976-984

  Calkins, Monica E ^a   Ray, Amrita ^b   Gur, Ruben C ^a   Freedman, Robert ^c   Green, Michael F ^d,n   Greenwood, Tiffany A ^e,f   Light, Gregory A ^e,f   Nuechterlein, Keith H ^d   Olincy, Ann ^c   Radant, Allen D ^g,h   Seidman, Larry J ^i,j   Siever, Larry J ^k,l,m   Silverman, Jeremy M ^k,l,m   Stone, William S ^i,j   Sugar, Catherine ⁿ   Swerdlow, Neal R ^e,f   Tsuang, Debby W ^b   Tsuang, Ming T ^e,f   Turetsky, Bruce I ^a   Braff, David L ^e,f   Lazzeroni, Laura C ^a,b   Gur, Raquel E ^a   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^h 20 Mental Illness Research Education and Clinical Center ^*  (United States)

ⁱ HARVARD UNIVERSITY   (United States)

^j HARVARD MEDICAL SCHOOL   (United States)

^k State University of New York Upstate Medical University: College of Medicine   (United States)

^l MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^m James J Peters Veterans Affairs   (United States)

ⁿ VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

Endophenotype; genetics; heritability; neurocognition; schizophrenia; sex differences

Indexed keywords

ADULT; ARTICLE; COGNITION; COGNITIVE DEFECT; FACE MEMORY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; MENTAL PERFORMANCE; NEUROCOGNITIVE PERFORMANCE; PRIORITY JOURNAL; RELATIVE; SCHIZOPHRENIA; SEX DIFFERENCE; SIBLING; SPATIAL MEMORY;

ADOLESCENT; ADULT; AGED; DIAGNOSIS, COMPUTER-ASSISTED; FAMILY; FEMALE; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS; PSYCHIATRIC STATUS RATING SCALES; RECOGNITION (PSYCHOLOGY); SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEX DIFFERENTIATION; YOUNG ADULT;

EID: 84876930361     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.12.021     Document Type: Article

References (33)

1. R.W. Heinrichs, and K.K. Zakzanis Neurocognitive deficit in schizophrenia: A quantitative review of the evidence Neuropsychology 12 1998 426 445
2. J.A. Husted, S. Lim, E.W. Chow, C. Greenwood, and A.S. Bassett Heritability of neurocognitive traits in familial schizophrenia Am J Med Genet B Neuropsychiatr Genet 150B 2009 845 853
3. Q. Wang, E. Vassos, W. Deng, X. Ma, X. Hu, and R.M. Murray Factor structures of the neurocognitive assessments and familial analysis in first-episode schizophrenia patients, their relatives and controls Aust N Z J Psychiatry 44 2010 109 119
4. T. Toulopoulou, M. Picchioni, F. Rijsdijk, M. Hua-Hall, U. Ettinger, P. Sham, and R. Murray Substantial genetic overlap between neurocognition and schizophrenia: Genetic modeling in twin samples Arch Gen Psychiatry 64 2007 1348 1355
5. L.S. Chen, T.K. Rice, P.A. Thompson, D.M. Barch, and J.G. Csernansky Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia Schizophr Res 111 2009 159 166
6. A. Tuulio-Henriksson, J. Haukka, T. Partonen, T. Varilo, T. Paunio, and J. Ekelund Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia Am J Med Genet 114 2002 483 490
7. S.F. Owens, F. Rijsdijk, M.M. Picchioni, D. Stahl, I. Nenadic, R.M. Murray, and T. Toulopoulou Genetic overlap between schizophrenia and selective components of executive function Schizophr Res 127 2011 181 187
8. D.C. Glahn, L. Almasy, J. Blangero, G.M. Burk, J. Estrada, and J.M. Peralta Adjudicating neurocognitive endophenotypes for schizophrenia Am J Med Genet B Neuropsychiatr Genet 144B 2007 242 249
9. H. Bertisch, D. Li, M.J. Hoptman, and L.E. Delisi Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia Am J Med Genet B Neuropsychiatr Genet 153B 2010 885 894
10. M.F. Aukes, B.Z. Alizadeh, M.M. Sitskoorn, J.P. Selten, R.J. Sinke, and C. Kemner Finding suitable phenotypes for genetic studies of schizophrenia: Heritability and segregation analysis Biol Psychiatry 64 2008 128 136
11. R.C. Gur, J. Richard, P. Hughett, M.E. Calkins, L. Macy, and W.B. Bilker A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: Standardization and initial construct validation J Neurosci Methods 187 2010 254 262
12. R. Gur, J. Ragland, P. Moberg, T. Turner, W. Bilker, and C. Kohler Computerized neurocognitive scanning: I. Methodology and validation in healthy people Neuropsychopharmacology 25 2001 766 788
13. R.C. Gur, J.D. Ragland, P.J. Moberg, W.B. Bilker, C Kohler, S.J Siegel, and R.E. Gur Computerized neurocognitive scanning: II. The profile of schizophrenia Neuropsychopharmacology 25 2001 777 788
14. R.E. Gur, V.L. Nimgaonkar, L. Almasy, M.E. Calkins, J.D. Ragland, and M.F. Pogue-Geile Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia Am J Psychiatry 164 2007 813 819
15. M.E. Calkins, P. Tepper, R.C. Gur, J.D. Ragland, L. Klei, and H.W. Wiener Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Evidence for impairment and heritability of neurocognitive functioning in families of schizophrenia patients Am J Psychiatry 167 2010 459 472
16. T.A. Greenwood, D.L. Braff, G.A. Light, K.S. Cadenhead, M.E. Calkins, and D.J. Dobie Initial heritability analyses of endophenotypic measures for schizophrenia: The consortium on the genetics of schizophrenia Arch Gen Psychiatry 64 2007 1242 1250
17. I.I. Gottesman, and T.D. Gould The endophenotype concept in psychiatry: Etymology and strategic intentions Am J Psychiatry 160 2003 636 645
18. B.E. Snitz, A.W. Macdonald 3rd, and C.S. Carter Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes Schizophr Bull 32 2006 179 194
19. M.M. Sitskoorn, A. Aleman, S.J. Ebisch, M.C. Appels, and R.S. Kahn Cognitive deficits in relatives of patients with schizophrenia: A meta-analysis Schizophr Res 71 2004 285 295
20. X. Ma, Q. Wang, P.C. Sham, X. Liu, S. Rabe-Hesketh, and X. Sun Neurocognitive deficits in first-episode schizophrenic patients and their first-degree relatives Am J Med Genet B Neuropsychiatr Genet 144B 2007 407 416
21. M.F. Egan, T.E. Goldberg, T. Gscheidle, M. Weirich, R. Rawlings, and T.M. Hyde Relative risk for cognitive impairments in siblings of patients with schizophrenia Biol Psychiatry 50 2001 98 107
22. M.F. Egan, T.E. Goldberg, T. Gscheidle, M. Weirich, L.B. Bigelow, and D.R. Weinberger Relative risk of attention deficits in siblings of patients with schizophrenia Am J Psychiatry 157 2000 1309 1316
23. D.F. Halpern, C.P. Benbow, D.C. Geary, R.C. Gur, J.S. Hyde, and M.A. Gernsbacher The science of sex differences in science and mathematics Psychol Sci Public Interest 8 2007 1 51
24. A. Leung, and P. Chue Sex differences in schizophrenia, a review of the literature Acta Psychiatr Scand Suppl 401 2000 3 38
25. J.A. Jimenez, A. Mancini-Marie, N. Lakis, M. Rinaldi, and A. Mendrek Disturbed sexual dimorphism of brain activation during mental rotation in schizophrenia Schizophr Res 122 2010 53 62
26. K.M. Abel, R. Drake, and J.M. Goldstein Sex differences in schizophrenia Int Rev Psychiatry 22 2010 417 428
27. M.E. Calkins, D.J. Dobie, K.S. Cadenhead, A. Olincy, R. Freedman, and M.F. Green The Consortium on the Genetics of Endophenotypes in Schizophrenia: Model recruitment, assessment, and endophenotyping methods for a multisite collaboration Schizophr Bull 33 2007 33 48
28. T.A. Greenwood, L.C. Lazzeroni, S.S. Murray, K.S. Cadenhead, M.E. Calkins, and D.J. Dobie Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia Am J Psychiatry 168 2011 930 946
29. L. Almasy, and J. Blangero Multipoint quantitative-trait linkage analysis in general pedigrees Am J Hum Genet 62 1998 1198 1211
30. R.E. Gur, M.E. Calkins, R.C. Gur, W.P. Horan, K.H. Nuechterlein, L.J. Seidman, and W.S. Stone The Consortium on the Genetics of Schizophrenia: Neurocognitive endophenotypes Schizophr Bull 33 2007 49 68
31. W.S. Stone, A.J. Giuliano, M.T. Tsuang, D.L. Braff, K.S. Cadenhead, and M.E. Calkins Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS) Schizophr Res 128 2011 102 110
32. W.P. Horan, D.L. Braff, K.H. Nuechterlein, C.A. Sugar, K.S. Cadenhead, and M.E. Calkins Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia Schizophr Res 103 2008 218 228
33. A. Vaskinn, K. Sundet, C. Simonsen, T. Hellvin, I. Melle, and O.A. Andreassen Sex differences in neuropsychological performance and social functioning in schizophrenia and bipolar disorder Neuropsychology 25 2011 499 510