Effect of methacholine on peripheral lung mechanics and ventilation heterogeneity in asthma

Journal of Applied Physiology

Volumn 114, Issue 6, 2013, Pages 770-777

  Downie, Sue R ^a,b,c   Salome, Cheryl M ^a,b,c   Verbanck, Sylvia ^d   Thompson, Bruce R ^c,e   Berend, Norbert ^a,b,c,f   King, Gregory G ^a,b,c,f  

^a WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Cooperative Research Centre for Asthma Glebe ^*  (Australia)

^d UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^e MONASH UNIVERSITY   (Australia)

^f ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Forced oscillation technique; Lung impedance; Multiplebreath nitrogen washout; Ventilation heterogeneity

Indexed keywords

BRONCHOCONSTRICTING AGENT; DIAGNOSTIC AGENT; METHACHOLINE CHLORIDE;

ADOLESCENT; ADULT; AGED; AIRWAY RESISTANCE; ANALYSIS OF VARIANCE; ARTICLE; ASTHMA; BREATH ANALYSIS; BREATHING MECHANICS; FEMALE; FORCED EXPIRATORY VOLUME; FUNCTIONAL RESIDUAL CAPACITY; HUMAN; INHALATION TEST; INSPIRATORY CAPACITY; LUNG; LUNG VENTILATION; MALE; MAXIMAL MID EXPIRATORY FLOW; MIDDLE AGED; OSCILLOMETRY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; SPIROMETRY;

ADOLESCENT; ADULT; AGED; AIRWAY RESISTANCE; ANALYSIS OF VARIANCE; ASTHMA; BREATH TESTS; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; FEMALE; FORCED EXPIRATORY VOLUME; FUNCTIONAL RESIDUAL CAPACITY; HUMANS; INSPIRATORY CAPACITY; LUNG; MALE; MAXIMAL MIDEXPIRATORY FLOW RATE; METHACHOLINE CHLORIDE; MIDDLE AGED; OSCILLOMETRY; PREDICTIVE VALUE OF TESTS; PULMONARY VENTILATION; RESPIRATORY MECHANICS; SPIROMETRY; YOUNG ADULT;

EID: 84876900827     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01198.2012     Document Type: Article

References (56)

1. American Thoracic Society. Standardization of spirometry. 1994 Update. Am J Respir Crit Care Med 152: 1107-1136, 1995.
2. Bates JH, Shardonofsky F, Stewart DE, Bates JH, Shardonofsky F, Stewart DE. The low-frequency dependence of respiratory system resistance and elastance in normal dogs. Respir Physiol 78: 369-382, 1989.
3. Carroll N, Elliot J, Morton A, James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 147: 405-410, 1993.
4. Crawford AB, Makowska M, Kelly S, Engel LA. Effect of breath holding on ventilation maldistribution during tidal breathing in normal subjects. J Appl Physiol 61: 2108-2115, 1986.
5. Crawford AB, Makowska M, Paiva M, Engel LA. Convection-and diffusion-dependent ventilation maldistribution in normal subjects. J Appl Physiol 59: 838-846, 1985.
6. Dellaca RL, Andersson Olerud M, Zannin E, Kostic P, Pompilio PP, Hedenstierna G, Pedotti A, Frykholm P. Lung recruitment assessed by total respiratory system input reactance. Intensive Care Med 35: 2164-2172, 2009.
7. Diba C, Salome CM, Reddel HK, Thorpe CW, Toelle B, King GG. Short-term variability of airway caliber-a marker of asthma? J Appl Physiol 103: 296-304, 2007.
8. Downie SR, Salome CM, King G, Berend N. Increase in respiratory impedance post methacholine is driven by different mechanisms in normals and asthmatics. In: American Thoracic Society International Conference, 2010, New Orleans. New York: American Thoracic Society, 2010, p. A5017.
9. Downie SR, Salome CM, Verbanck S, Thompson B, Berend N, King GG. Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation. Thorax 62: 684-689, 2007.
10. Downie SR, Verbanck S, Salome CM, King GG. The relationship between ventilation heterogeneity, airway closure and respiratory system conductance in asthmatics before and after methacholine. Abstracts of the Thoracic Society of Australia and New Zealand and The Australian and New Zealand Society of Respiratory Science 2006 Annual Scientific Meetings. Canberra, Australia. March 24-29, 2006. Respirology 11, Suppl 2: A31, 2006.
11. Farah CS, King GG, Brown NJ, Downie SR, Kermode JA, Hardaker KM, Peters MJ, Berend N, Salome CM. The role of the small airways in the clinical expression of asthma in adults. J Allergy Clin Immunol 129: 381-387, 387.e1, 2012.
12. Farah CS, King GG, Brown NJ, Peters MJ, Berend N, Salome CM. Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration. J Allergy Clin Immunol 130: 61-68, 2012.
13. Fish JE, Rosenthal RR, Batra G, Menkes H, Summer W, Permutt S, Norman P. Airway responses to methacholine in allergic and nonallergic subjects. Am Rev Respir Dis 113: 579-586, 1976.
14. Gibbons WJ, Sharma A, Lougheed D, Macklem P. Detection of excessive bronchoconstriction in asthma. Am J Respir Crit Care Med 153: 582-589, 1996.
15. Grimby G, Takishima T, Graham W, Macklem P, Mead J. Frequency dependence of flow resistance in patients with obstructive lung disease. J Clin Invest 47: 1455-1465, 1968.
16. Gustafsson PM, Johansson HJ, Dahlback GO. Pneumotachographic nitrogen washout method for measurement of the volume of trapped gas in the lungs. Pediatr Pulmonol 17: 258-268, 1994.
17. Gustafsson PM, Ljungberg HK, Kjellman B. Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout. Eur Respir J 21: 1033-1039, 2003.
18. In't Veen JCCM, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 161: 1902-1906, 2000.
19. Kaminsky DA, Bates JH, Irvin CG. Effects of cool, dry air stimulation on peripheral lung mechanics in asthma. Am J Respir Crit Care Med 162: 179-186, 2000.
20. Kaminsky DA, Irvin CG, Lundblad L, Moriya HT, Lang S, Allen J, Viola T, Lynn M, Bates JH. Oscillation mechanics of the human lung periphery in asthma. J Appl Physiol 97: 1849-1858, 2004.
21. Kaminsky DA, Irvin CG, Lundblad LK, Thompson-Figueroa J, Klein J, Sullivan MJ, Flynn F, Lang S, Bourassa L, Burns S, Bates JH. Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine. J Appl Physiol 104: 10-19, 2008.
22. King GG, Carroll JD, Muller NL, Whittall KP, Gao M, Nakano Y, Pare PD. Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT. Eur Respir J 24: 211-218, 2004.
23. King GG, Downie SR, Verbanck S, Thorpe CW, Berend N, Salome CM, Thompson B. Effects of methacholine on small airway function measured by forced oscillation technique and multiple breath nitrogen washout in normal subjects. Respir Physiol Neurobiol 148: 165-177, 2005.
24. Levine G, Housley E, MacLeod P, Macklem PT. Gas exchange abnormalities in mild bronchitis and asymptomatic asthma. N Engl J Med 282: 1277-1282, 1970.
25. Lundblad LK, Thompson-Figueroa J, Allen GB, Rinaldi L, Norton RJ, Irvin CG, Bates JH. Airway hyperresponsiveness in allergically inflamed mice: the role of airway closure. Am J Respir Crit Care Med 175: 768-774, 2007.
26. Lutchen KR, Gillis H. Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance. J Appl Physiol 83: 1192-1201, 1997.
27. Lutchen KR, Greenstein JL, Suki B, Lutchen KR, Greenstein JL, Suki B. How inhomogeneities and airway walls affect frequency dependence and separation of airway and tissue properties. J Appl Physiol 80: 1696-1707, 1996.
28. Lutchen KR, Habib RH, Dorkin HL, Wall MA. Respiratory impedance and multibreath N2 washout in healthy, asthmatic, and cystic fibrosis subjects. J Appl Physiol 68: 2139-2149, 1990.
29. Lutchen KR, Hantos Z, Jackson AC. Importance of low-frequency impedance data for reliably quantifying parallel imhomogeneities of respiratory mechanics. IEEE Trans Biomed Eng 35: 472-481, 1988.
30. Lyons HA, McFadden ER Jr. Airways resistance, airflow and inhomogeneity of distribution of ventilation as independent abnormalities of bronchial asthma. Aspen Emphysema Conf 10: 267-273, 1967.
31. Martin R. Airways inflammation in nocturnal asthma. Am Rev Respir Dis 143: 351-357, 1991.
32. Michils A, Elkrim Y, Haccuria A, Van Muylem A. Adenosine 5=-monophosphate challenge elicits a more peripheral airway response than methacholine challenge. J Appl Physiol 110: 1241-1247, 2011.
33. Milanese M, Crimi E, Scordamaglia A, Riccio A, Pellegrino R, Canonica GW, Brusasco V. On the functional consequences of bronchial basement membrane thickening. J Appl Physiol 91: 1035-1040, 2001.
34. National Heart, Lung, and Blood Institute. Guidelines for the Diagnosis and Management of Asthma. Bethesda, MD: US Dept. of Health and Human Services, Public Health Service, National Heart, Lung, and Blood Institute, 1997.
35. Ohrui T, Sekizawa K, Yanai M, Morikawa M, Jin Y, Sasaki H, Takishima T. Partitioning of pulmonary responses to inhaled methacholine in subjects with asymptomatic asthma. Am Rev Respir Dis 146: 1501-1505, 1992.
36. Oppenheimer BW, Goldring RM, Berger KI. Distal airway function assessed by oscillometry at varying respiratory rate: comparison with dynamic compliance. COPD 6: 162-170, 2009.
37. Otis A, McKerrow C, Bartlett R, Mead J, McIlroy M, Selverstone N, Radford E. Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol 8: 427-443, 1956.
38. Paiva M, Engel LA. Model analysis of gas distribution within human lung acinus. J Appl Physiol 56: 418-425, 1984.
39. Salome CM, Schoeffel RE, Woolcock AJ. Comparison of bronchial reactivity to histamine and methacholine in asthmatics. Clin Allergy 10: 541-546, 1980.
40. Sekizawa K, Sasaki H, Shimizu Y, Takishima T. Dose-response effects of methacholine in normal and in asthmatic subjects. Relationship between the site of airway response and overall airway hyperresponsiveness. Am Rev Respir Dis 133: 593-599, 1986.
41. Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Wenzel SE. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 104: 394-403, 2008.
42. Sundblad BM, Larsson K. Effect of deep inhalations after a bronchial methacholine provocation in asthmatic and non-asthmatic subjects. Respir Med 96: 477-481, 2002.
43. Thorpe CW, Bates JHT. Effect of stochastic heterogeneity on lung impedance during acute bronchoconstriction: a model analysis. J Appl Physiol 82: 1616-1625, 1997.
44. Thorpe CW, Salome CM, Berend N, King G. Modeling airway resistance dynamics after tidal and deep inspirations. J Appl Physiol 97: 1643-1653, 2004.
45. Tzeng YS, Lutchen K, Albert M. The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI. J Appl Physiol 106: 813-822, 2009.
46. Verbanck S, Schuermans D, Meysman M, Paiva M, Vincken W. Noninvasive assessment of airway alterations in smokers. The small airways revisited. Am J Respir Crit Care Med 170: 414-419, 2004.
47. Verbanck S, Schuermans D, Noppen M, Van Muylem A, Paiva M, Vincken W. Evidence of acinar airway involvement in asthma. Am J Respir Crit Care Med 159: 1545-1550, 1999.
48. Verbanck S, Schuermans D, Noppen M, Vincken W, Paiva M. Methacholine versus histamine: paradoxical response of spirometry and ventilation distribution. J Appl Physiol 91: 2587-2594, 2001.
49. Verbanck S, Schuermans D, Paiva M, Vincken W. The functional benefit of anti-inflammatory aerosols in the lung periphery. J Allergy Clin Immunol 118: 340-346, 2006.
50. Wagner EM, Liu MC, Weinmann GG, Permutt S, Bleecker ER. Peripheral lung resistance in normal and asthmatic subjects. Am Rev Respir Dis 141: 584-588, 1990.
51. Woolcock AJ, Vincent NJ, Macklem PT. Frequency dependence of compliance as a test for obstruction in the small airways. J Clin Invest 48: 1097-1106, 1969.
52. Yamaguchi M, Niimi A, Ueda T, Takemura M, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Takeda T, Ito I, Matsumoto H, Hirai T, Chin K, Mishima M. Effect of inhaled corticosteroids on small airways in asthma: investigation using impulse oscillometry. Pulm Pharmacol Ther 22: 326-332, 2009.
53. Yan K, Salome CM, Woolcock AJ. Rapid method for measurement of bronchial responsiveness. Thorax 38: 760-765, 1983.
54. Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J Appl Physiol 72: 1016-1023, 1992.
55. Yoo Y, Yu J, Lee SH, Kim do K, Choi SH, Kim CK, Koh YY. Comparison of delta FVC [% decrease in FVC at the PC(20)] between cough-variant asthma and classic asthma. J Asthma 44: 35-38, 2007.
56. Zeidler MR, Kleerup EC, Goldin JG, Kim HJ, Truong DA, Simmons MD, Sayre JW, Liu W, Elashoff R, Tashkin DP. Montelukast improves regional air-trapping due to small airways obstruction in asthma. Eur Respir J 27: 307-315, 2006.