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Volumn 3, Issue 1, 2013, Pages 1-11

[11C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors

Author keywords

Agonist; G protein coupled receptor; M1 muscarinic acetylcholine receptor; PET imaging; Rat brain

Indexed keywords

AF 150S; AF 150S C 11; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; TRACER; UNCLASSIFIED DRUG;

EID: 84876900769     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/2191-219X-3-19     Document Type: Article
Times cited : (19)

References (58)
  • 1
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus RT: On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 2000, 163:495-529.
    • (2000) Exp Neurol , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 2
    • 0027208248 scopus 로고
    • Muscarinic receptors - characterization, coupling and function
    • Caulfield MP: Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 1993, 58:319-379.
    • (1993) Pharmacol Ther , vol.58 , pp. 319-379
    • Caulfield, M.P.1
  • 3
    • 0026722913 scopus 로고
    • Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1
    • Berstein G, Blank JL, Smrcka AV, Higashijima T, Sternweis PC, Exton JH, Ross EM: Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1. J Biol Chem 1992, 267:8081-8088.
    • (1992) J Biol Chem , vol.267 , pp. 8081-8088
    • Berstein, G.1    Blank, J.L.2    Smrcka, A.V.3    Higashijima, T.4    Sternweis, P.C.5    Exton, J.H.6    Ross, E.M.7
  • 4
    • 0022869345 scopus 로고
    • Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain
    • Mash DC, Potter LT: Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain. Neuroscience 1986, 19:551-564.
    • (1986) Neuroscience , vol.19 , pp. 551-564
    • Mash, D.C.1    Potter, L.T.2
  • 7
    • 0041866256 scopus 로고    scopus 로고
    • Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists
    • Mirza NR, Peters D, Sparks RG: Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists. CNS Drug Rev 2003, 9:159-186.
    • (2003) CNS Drug Rev , vol.9 , pp. 159-186
    • Mirza, N.R.1    Peters, D.2    Sparks, R.G.3
  • 13
    • 0035869742 scopus 로고    scopus 로고
    • Assessment of muscarinic receptor concentrations in affinity and Alzheimer disease with [C-11]NMPB and PET
    • Zubieta JK, Koeppe AR, Frey KA, Kilbourn MR, Mangner TJ, Foster NL, Kuhl DE: Assessment of muscarinic receptor concentrations in affinity and Alzheimer disease with [C-11]NMPB and PET. Synapse 2001, 39:275-287.
    • (2001) Synapse , vol.39 , pp. 275-287
    • Zubieta, J.K.1    Koeppe, A.R.2    Frey, K.A.3    Kilbourn, M.R.4    Mangner, T.J.5    Foster, N.L.6    Kuhl, D.E.7
  • 14
    • 84876922590 scopus 로고    scopus 로고
    • Targeting cerebral muscarinic acetylcholine receptors with radioligands for diagnostic nuclear medicine studies
    • Edited by Lopatin AN, Nichols CG. Totowa (New York): Humana
    • McPherson W: Targeting cerebral muscarinic acetylcholine receptors with radioligands for diagnostic nuclear medicine studies. In Ion Channel Localization: Methods and Protocols. Edited by Lopatin AN, Nichols CG. Totowa (New York): Humana; 2001:17-38.
    • (2001) Ion Channel Localization: Methods and Protocols , pp. 17-38
    • McPherson, W.1
  • 15
    • 0036258990 scopus 로고    scopus 로고
    • G protein-coupled receptor allosterism and complexing
    • Christopoulos A, Kenakin T: G protein-coupled receptor allosterism and complexing. Pharmacol Rev 2002, 54:323-374.
    • (2002) Pharmacol Rev , vol.54 , pp. 323-374
    • Christopoulos, A.1    Kenakin, T.2
  • 16
    • 0027296870 scopus 로고
    • Distinct kinetic binding-properties of N-[H-3]-methylscopolamine afford differential labeling and localization of M1, M2, and M3-muscarinic receptor subtypes in primate brain
    • Flynn DD, Mash DC: Distinct kinetic binding-properties of N-[H-3]-methylscopolamine afford differential labeling and localization of M1, M2, and M3-muscarinic receptor subtypes in primate brain. Synapse 1993, 14:283-296.
    • (1993) Synapse , vol.14 , pp. 283-296
    • Flynn, D.D.1    Mash, D.C.2
  • 18
    • 33646078787 scopus 로고    scopus 로고
    • Binding characteristics and sensitivity to endogenous dopamine of [C-11]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D-2 receptors in vivo using positron emission tomography
    • Ginovart N, Galineau L, Willeit M, Mizrahi R, Bloomfield PM, Seeman P, Houle S, Kapur S, Wilson AA: Binding characteristics and sensitivity to endogenous dopamine of [C-11]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D-2 receptors in vivo using positron emission tomography. J Neurochem 2006, 97:1089-1103.
    • (2006) J Neurochem , vol.97 , pp. 1089-1103
    • Ginovart, N.1    Galineau, L.2    Willeit, M.3    Mizrahi, R.4    Bloomfield, P.M.5    Seeman, P.6    Houle, S.7    Kapur, S.8    Wilson, A.A.9
  • 20
    • 4744348428 scopus 로고    scopus 로고
    • Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, C-11 -PPHT and C-11-ZYY-339 in rodents and imaging in non-human primates by PET
    • Mukherjee J, Narayanan TK, Christian BT, Shi BZ, Yang ZY: Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, C-11 -PPHT and C-11-ZYY-339 in rodents and imaging in non-human primates by PET. Synapse 2004, 54:83-91.
    • (2004) Synapse , vol.54 , pp. 83-91
    • Mukherjee, J.1    Narayanan, T.K.2    Christian, B.T.3    Shi, B.Z.4    Yang, Z.Y.5
  • 21
    • 1542498592 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R, S)-5-hydroxy-2-(N-propyl-N-(5'-18F-fluoropentyl)aminotetralin (18F-5-OH-FPPAT) in rodents and nonhuman primates
    • Shi B, Narayanan TK, Christian BT, Chattopadhyay S, Mukherjee J: Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R, S)-5-hydroxy-2-(N-propyl-N-(5'-18F-fluoropentyl)aminotetralin (18F-5-OH-FPPAT) in rodents and nonhuman primates. Nuc Med Biol 2004, 31:303-311.
    • (2004) Nuc Med Biol , vol.31 , pp. 303-311
    • Shi, B.1    Narayanan, T.K.2    Christian, B.T.3    Chattopadhyay, S.4    Mukherjee, J.5
  • 22
    • 20444379220 scopus 로고    scopus 로고
    • 11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography
    • 11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography. J Med Chem 2005, 48:4153-4160.
    • (2005) J Med Chem , vol.48 , pp. 4153-4160
    • Wilson, A.A.1    McCormick, P.2    Kapur, S.3    Willeit, M.4    Garcia, A.5    Hussey, D.6    Houle, S.7    Seeman, P.8    Ginovart, N.9
  • 26
    • 78651247846 scopus 로고    scopus 로고
    • Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefore
    • (patent: WO 03/092580 A2)
    • Fisher A, Bar-Ner N, Karton Y: Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefore. 2003 (patent: WO 03/092580 A2).
    • (2003)
    • Fisher, A.1    Bar-Ner, N.2    Karton, Y.3
  • 28
    • 0035968057 scopus 로고    scopus 로고
    • Reduction of cerebrospinal fluid amyloid β after systemic administration of M1 muscarinic agonists
    • Beach TG, Walker DG, Potter PE, Sue LI, Fisher A: Reduction of cerebrospinal fluid amyloid β after systemic administration of M1 muscarinic agonists. Brain Res 2001, 905:220-223.
    • (2001) Brain Res , vol.905 , pp. 220-223
    • Beach, T.G.1    Walker, D.G.2    Potter, P.E.3    Sue, L.I.4    Fisher, A.5
  • 30
    • 84655164275 scopus 로고    scopus 로고
    • Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: Perspectives and challenges in treatment of Alzheimer's disease
    • Fisher A: Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease. J Neurochem 2012, 120:22-33.
    • (2012) J Neurochem , vol.120 , pp. 22-33
    • Fisher, A.1
  • 36
    • 0020631201 scopus 로고
    • 3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes
    • 3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes. Life Sci 1983, 32:3001-3011.
    • (1983) Life Sci , vol.32 , pp. 3001-3011
    • Watson, M.1    Yamamura, H.I.2    Roeske, W.R.3
  • 37
    • 0025923421 scopus 로고
    • M1 muscarinic antagonists interact with sigma recognition sites
    • Life Sci 1992, 50:245. Erratum
    • Hudkins RL, DeHaven-Hudkins DL: M1 muscarinic antagonists interact with sigma recognition sites. Life Sci 1991, 49:1229-1235. Life Sci 1992, 50:245. Erratum.
    • (1991) Life Sci , vol.49 , pp. 1229-1235
    • Hudkins, R.L.1    Dehaven-Hudkins, D.L.2
  • 38
    • 44249115580 scopus 로고    scopus 로고
    • In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment
    • Maruyama S, Tsukada H, Nishiyama S, Kakiuchi T, Fukumoto D, Oku N, Yamada S: In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment. J Pharmacol Exp Ther 2008, 325:774-781.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 774-781
    • Maruyama, S.1    Tsukada, H.2    Nishiyama, S.3    Kakiuchi, T.4    Fukumoto, D.5    Oku, N.6    Yamada, S.7
  • 39
    • 0019935002 scopus 로고
    • 3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain
    • 3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain. J Pharmacol Exp Ther 1982, 223:284-290.
    • (1982) J Pharmacol Exp Ther , vol.223 , pp. 284-290
    • Su, T.P.1
  • 40
    • 0030751274 scopus 로고    scopus 로고
    • Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats
    • Vannucchi MG, Scali C, Kopf SR, Pepeu G, Casamenti F: Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience 1997, 79:837-846.
    • (1997) Neuroscience , vol.79 , pp. 837-846
    • Vannucchi, M.G.1    Scali, C.2    Kopf, S.R.3    Pepeu, G.4    Casamenti, F.5
  • 41
    • 0033955001 scopus 로고    scopus 로고
    • Gender differences in the effect of rivastigmine on brain cholinesterase activity and cognitive function in rats
    • Wang RH, Bejar C, Weinstock M: Gender differences in the effect of rivastigmine on brain cholinesterase activity and cognitive function in rats. Neuropharmacology 2000, 39:497-506.
    • (2000) Neuropharmacology , vol.39 , pp. 497-506
    • Wang, R.H.1    Bejar, C.2    Weinstock, M.3
  • 43
    • 0141706482 scopus 로고    scopus 로고
    • Positron emission tomography microdosing: A new concept with application in tracer and early clinical drug development
    • Bergstrom M, Grahnen A, Langstrom B: Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development. Eur J Clin Pharmacol 2003, 59:357-366.
    • (2003) Eur J Clin Pharmacol , vol.59 , pp. 357-366
    • Bergstrom, M.1    Grahnen, A.2    Langstrom, B.3
  • 44
    • 0030468875 scopus 로고    scopus 로고
    • Simplified reference tissue model for PET receptor studies
    • Lammertsma AA, Hume SP: Simplified reference tissue model for PET receptor studies. Neuroimage 1996, 4:153-158.
    • (1996) Neuroimage , vol.4 , pp. 153-158
    • Lammertsma, A.A.1    Hume, S.P.2
  • 45
    • 62149119608 scopus 로고    scopus 로고
    • Importance and prospects for design of selective muscarinic agonists
    • Jakubik J, Michal P, Machova E, Dolezal V: Importance and prospects for design of selective muscarinic agonists. Physiol Res 2008, 57:S39-S47.
    • (2008) Physiol Res , vol.57
    • Jakubik, J.1    Michal, P.2    Machova, E.3    Dolezal, V.4
  • 46
    • 84876889926 scopus 로고    scopus 로고
    • Xanomeline quasi-irreversibly bound to an ectopic site can stimulate presynaptic M2 receptors via the orthosteric binding site
    • Machova E, El-Fakahany EE, Dolezal V: Xanomeline quasi-irreversibly bound to an ectopic site can stimulate presynaptic M2 receptors via the orthosteric binding site. J Neurochem 2005, 94:90.
    • (2005) J Neurochem , vol.94 , pp. 90
    • Machova, E.1    El-Fakahany, E.E.2    Dolezal, V.3
  • 47
    • 12344300380 scopus 로고    scopus 로고
    • Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice
    • Oki T, Takagi Y, Inagaki S, Taketo MM, Manabe T, Matsui M, Yamada S: Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice. Mol Brain Res 2005, 133:6-11.
    • (2005) Mol Brain Res , vol.133 , pp. 6-11
    • Oki, T.1    Takagi, Y.2    Inagaki, S.3    Taketo, M.M.4    Manabe, T.5    Matsui, M.6    Yamada, S.7
  • 48
    • 0042575347 scopus 로고    scopus 로고
    • Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2//M4 muscarinic receptor knockout mice
    • Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, Nomikos GG: Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2//M4 muscarinic receptor knockout mice. Mol Psychiatry 2003, 8:673-679.
    • (2003) Mol Psychiatry , vol.8 , pp. 673-679
    • Tzavara, E.T.1    Bymaster, F.P.2    Felder, C.C.3    Wade, M.4    Gomeza, J.5    Wess, J.6    McKinzie, D.L.7    Nomikos, G.G.8
  • 49
    • 0030990069 scopus 로고    scopus 로고
    • Pharmacological strategies to selectively label and localize muscarinic receptor subtypes
    • Flynn DD, Reever CM, FerrariDiLeo G: Pharmacological strategies to selectively label and localize muscarinic receptor subtypes. Drug Dev Res 1997, 40:104-116.
    • (1997) Drug Dev Res , vol.40 , pp. 104-116
    • Flynn, D.D.1    Reever, C.M.2    Ferraridileo, G.3
  • 50
    • 0025193914 scopus 로고
    • 5-Ht2 receptor blockade by Ici-169,369 and other 5-Ht2 antagonists modulates the effects of D-2 dopamine receptor blockade
    • Saller CF, Czupryna MJ, Salama AI: 5-Ht2 receptor blockade by Ici-169,369 and other 5-Ht2 antagonists modulates the effects of D-2 dopamine receptor blockade. J Pharmacol Exp Ther 1990, 253:1162-1170.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 1162-1170
    • Saller, C.F.1    Czupryna, M.J.2    Salama, A.I.3
  • 52
    • 0030423708 scopus 로고    scopus 로고
    • Physiological release of striatal acetylcholine in vivo: Modulation by D1 and D2 dopamine receptor subtypes
    • DeBoer P, Abercrombie ED: Physiological release of striatal acetylcholine in vivo: modulation by D1 and D2 dopamine receptor subtypes. J Pharmacol Exp Ther 1996, 277:775-783.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 775-783
    • Deboer, P.1    Abercrombie, E.D.2
  • 53
    • 0028933521 scopus 로고
    • Identification of the primary muscarinic autoreceptor subtype in rat striatum as M2 through a correlation of in vivo microdialysis and in vitro receptor binding data
    • Billard W, Binch H, Crosby G, McQuade RD: Identification of the primary muscarinic autoreceptor subtype in rat striatum as M2 through a correlation of in vivo microdialysis and in vitro receptor binding data. J Pharmacol Exp Ther 1995, 273:273-279.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 273-279
    • Billard, W.1    Binch, H.2    Crosby, G.3    McQuade, R.D.4
  • 55
    • 12344274279 scopus 로고    scopus 로고
    • Positron-labeled dopamine agonists for probing the high affinity states of dopamine subtype 2 receptors
    • Hwang DR, Narendran R, Laruelle M: Positron-labeled dopamine agonists for probing the high affinity states of dopamine subtype 2 receptors. Bioconj Chem 2005, 16:27-31.
    • (2005) Bioconj Chem , vol.16 , pp. 27-31
    • Hwang, D.R.1    Narendran, R.2    Laruelle, M.3
  • 58


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