Kinetics of the utilization of dietary arginine for nitric oxide and urea synthesis: Insight into the arginine-nitric oxide metabolic system in humans

American Journal of Clinical Nutrition

Volumn 97, Issue 5, 2013, Pages 972-979

  Mariotti, François ^a,b   Petzke, Klaus J ^c   Bonnet, Damien ^d   Szezepanski, Isabelle ^d   Bos, Cécile ^a,b   Huneau, Jean François ^a,b   Fouillet, Héléne ^a,b  

^a AGROPARISTECH   (France)

^b CENTRE MAURICE HALBWACHS   (France)

^c GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGEN 15; UREA;

ADULT; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; METABOLISM; NITROGEN NUCLEAR MAGNETIC RESONANCE; NORMAL HUMAN; PLASMA; POSTPRANDIAL STATE; SIGNAL TRANSDUCTION; UREA CYCLE;

ADOLESCENT; ADULT; ARGINASE; ARGININE; BODY MASS INDEX; CHROMATOGRAPHY, ION EXCHANGE; CREATININE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOTOPE LABELING; KINETICS; MALE; MODELS, THEORETICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGEN ISOTOPES; POSTPRANDIAL PERIOD; UREA; YOUNG ADULT;

EID: 84876900622     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.048025     Document Type: Article

References (49)

1. Moncada S, Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995;9:1319-30.
2. Napoli C, de Nigris F, Williams-Ignarro S, Pignalosa O, Sica V, Ignarro LJ. Nitric oxide and atherosclerosis: an update. Nitric Oxide 2006;15: 265-79.
3. Moncada S, Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 2006;147(suppl 1):S193-201.
4. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006;113:1888-904.
5. Wu G, Meininger CJ. Regulation of nitric oxide synthesis by dietary factors. Annu Rev Nutr 2002;22:61-86.
6. Luiking YC, Engelen MP, Deutz NE. Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care 2010; 13:97-104.
7. Magné J, Huneau JF, Delemasure S, Rochette L, Tome D, Mariotti F. Whole-body basal nitric oxide production is impaired in postprandial endothelial dysfunction in healthy rats. Nitric Oxide 2009;21:37-43.
8. Preli RB, Klein KP, Herrington DM. Vascular effects of dietary L-arginine supplementation. Atherosclerosis 2002;162:1-15.
9. West SG, Likos-Krick A, Brown P, Mariotti F. Oral L-arginine improves hemodynamic responses to stress and reduces plasma homocysteine in hypercholesterolemic men. J Nutr 2005;135:212-7.
10. Loscalzo J. What we know and don't know about L-arginine and NO. Circulation 2000;101:2126-9.
11. Ohta F, Takagi T, Sato H, Ignarro LJ. Low-dose L-arginine administration increases microperfusion of hindlimb muscle without affecting blood pressure in rats. Proc Natl Acad Sci USA 2007;104:1407-11.
12. Boger RH. The pharmacodynamics of L-arginine. J Nutr 2007;137: 1650S-5S.
13. Bode-Boger SM. Effect of L-arginine supplementation on NO production in man. Eur J Clin Pharmacol 2006;62(suppl 1):91S-9S. 14. Mori M, Gotoh T. Regulation of nitric oxide production by arginine metabolic enzymes. Biochem Biophys Res Commun 2000;275:715-9.
14. van Eijk HM, Luiking YC, Deutz NE. Methods using stable isotopes to measure nitric oxide (NO) synthesis in the L-arginine/NO pathway in health and disease. J Chromatogr B Analyt Technol Biomed Life Sci 2007;851:172-85.
15. Avogaro A, Toffolo G, Kiwanuka E, de Kreutzenberg SV, Tessari P, Cobelli C. L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: a stable-labelled 15N arginine approach. Diabetes 2003;52:795-802.
16. Tessari P, Coracina A, Puricelli L, Vettore M, Cosma A, Millioni R, Cecchet D, Avogaro A, Tiengo A, Kiwanuka E. Acute effect of insulin on nitric oxide synthesis in humans: a precursor-product isotopic study. Am J Physiol Endocrinol Metab 2007;293:E776-82.
17. Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J 1998;336:1-17.
18. Tangphao O, Grossmann M, Chalon S, Hoffman BB, Blaschke TF. Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. Br J Clin Pharmacol 1999;47:261-6.
19. Cynober L. Pharmacokinetics of arginine and related amino acids. J Nutr 2007;137:1646S-9S.
20. Kurz S, Harrison DG. Insulin and the arginine paradox. J Clin Invest 1997;99:369-70.
21. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 1997;100:2153-7.
22. Tsikas D, Boger RH, Sandmann J, Bode-Boger SM, Frolich JC. Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox. FEBS Lett 2000;478:1-3.
23. Flam BR, Hartmann PJ, Harrell-Booth M, Solomonson LP, Eichler DC. Caveolar localization of arginine regeneration enzymes, argininosuccinate synthase, and lyase, with endothelial nitric oxide synthase. Nitric Oxide 2001;5:187-97.
24. Lee J, Ryu H, Ferrante RJ, Morris SM Jr., Ratan RR. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci USA 2003;100:4843-8.
25. Miner SE, Al-Hesayen A, Kelly S, Benson T, Thiessen JJ, Young VR, Parker JD. L-arginine transport in the human coronary and peripheral circulation. Circulation 2004;109:1278-83.
26. Berkowitz DE, White R, Li D, Minhas KM, Cernetich A, Kim S, Burke S, Shoukas AA, Nyhan D, Champion HC, et al. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation 2003;108:2000-6.
27. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, et al. Mitochondrial arginase II constrains endothelial NOS-3 activity. Am J Physiol Heart Circ Physiol 2007;293:H3317-24.
28. Morris SM Jr. Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol 2009;157:922-30.
29. Neill MA, Aschner J, Barr F, Summar ML. Quantitative RT-PCR comparison of the urea and nitric oxide cycle gene transcripts in adult human tissues. Mol Genet Metab 2009;97:121-7.
30. Morris SM Jr. Arginine metabolism: boundaries of our knowledge. J Nutr 2007;137:1602S-9S.
31. Mariotti F, Huneau JF, Szezepanski I, Petzke KJ, Aggoun Y, Tome D, Bonnet D. Meal amino acids with varied levels of arginine do not affect postprandial vascular endothelial function in healthy young men. J Nutr 2007;137:1383-9.
32. Mariotti F, Mahe S, Luengo C, Benamouzig R, Tome D. Postprandial modulation of dietary and whole-body nitrogen utilization by carbohydrates in humans. Am J Clin Nutr 2000;72:954-62.
33. Forte P, Smith LM, Milne E, Benjamin N. Measurement of nitric oxide synthesis in humans using L-[15N2]arginine. Methods Enzymol 1999; 301:92-8.
34. Retzlaff JA, Tauxe WN, Kiely JM, Stroebel CF. Erythrocyte volume, plasma volume, and lean body mass in adult men and women. Blood 1969;33:649-61.
35. Juillet B, Saccomani MP, Bos C, Gaudichon C, Tome D, Fouillet H. Conceptual, methodological and computational issues concerning the compartmental modeling of a complex biological system: Postprandial inter-organ metabolism of dietary nitrogen in humans. Math Biosci 2006;204:282-309.
36. Castillo L, Beaumier L, Ajami AM, Young VR. Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N]citrulline labeling. Proc Natl Acad Sci USA 1996;93:11460-5.
37. Castillo L, Sanchez M, Chapman TE, Ajami A, Burke JF, Young VR. The plasma flux and oxidation rate of ornithine adaptively decline with restricted arginine intake. Proc Natl Acad Sci USA 1994;91: 6393-7.
38. Castillo L, Chapman TE, Yu YM, Ajami A, Burke JF, Young VR. Dietary arginine uptake by the splanchnic region in adult humans. Am J Physiol 1993;265:E532-9.
39. Castillo L, deRojas TC, Chapman TE, Vogt J, Burke JF, Tannenbaum SR, Young VR. Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. Proc Natl Acad Sci USA 1993;90:193-7.
40. Beaumier L, Castillo L, Ajami AM, Young VR. Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans. Am J Physiol 1995;269:E884-96.
41. Fouillet H, Juillet B, Gaudichon C, Mariotti F, Tome D, Bos C. Absorption kinetics are a key factor regulating postprandial protein metabolism in response to qualitative and quantitative variations in protein intake. Am J Physiol Regul Integr Comp Physiol 2009;297: R1691-705.
42. Bertolo RF, Burrin DG. Comparative aspects of tissue glutamine and proline metabolism. J Nutr 2008;138:2032S-9S.
43. Castillo L, Chapman TE, Sanchez M, Yu YM, Burke JF, Ajami AM, Vogt J, Young VR. Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc Natl Acad Sci USA 1993; 90:7749-53.
44. Yu YM, Young VR, Castillo L, Chapman TE, Tompkins RG, Ryan CM, Burke JF. Plasma arginine and leucine kinetics and urea production rates in burn patients. Metabolism 1995;44:659-66.
45. van de Poll MC, Siroen MP, van Leeuwen PA, Soeters PB, Melis GC, Boelens PG, Deutz NE, Dejong CH. Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. Am J Clin Nutr 2007;85:167-72.
46. Wu G. Intestinal mucosal amino acid catabolism. J Nutr 1998;128: 1249-52.
47. Berthold HK, Reeds PJ, Klein PD. Isotopic evidence for the differential regulation of arginine and proline synthesis in man. Metabolism 1995; 44:466-73.
48. Luiking YC, Deutz NE. Isotopic investigation of nitric oxide metabolism in disease. Curr Opin Clin Nutr Metab Care 2003;6:103-8.
49. Bai Y, Sun L, Yang T, Sun K, Chen J, Hui R. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a metaanalysis of randomized controlled trials. Am J Clin Nutr 2009;89: 77-84.