Recent developments and challenges in mouse models of Chikungunya virus infection

Future Virology

Volumn 8, Issue 5, 2013, Pages 423-426

  Yeo, Li Sze ^a   Chu, Justin Jang Hann ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Chikungunya virus; humanized mouse models; infection; mouse models; muscle weakness; pathogenesis; tropism

Indexed keywords

ANTIVIRUS AGENT;

ARTHRITIS; CHIKUNGUNYA; CHIKUNGUNYA ALPHAVIRUS; DISEASE COURSE; HAIR LOSS; HOST PATHOGEN INTERACTION; INOCULATION; LETHARGY; MORTALITY; MOUSE; MUSCLE WEAKNESS; MYOSITIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; TENOSYNOVITIS; WEIGHT REDUCTION;

CHIKUNGUNYA VIRUS;

EID: 84876898965     PISSN: 17460794     EISSN: 17460808     Source Type: Journal    
DOI: 10.2217/fvl.13.14     Document Type: Review

References (20)

1. Robinson MC. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features. Trans. R. Soc. Trop. Med. Hyg. 49(1), 28-32 (1955).
2. De Lamballerie X, Leroy E, Charrel RN, Ttsetsarkin K, Higgs S, Gould EA. Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? Virol. J. 5, 33 (2008).
3. Powers AM, Logue CH. Changing patterns of Chikungunya virus: re-emergence of a zoonotic arbovirus. J. Gen. Virol. 88(Pt 9), 2363-2377 (2007).
4. Her Z, Kam YW, Lin RT, Ng LF. Chikungunya: a bending reality. Microbes Infect. Inst. Pasteur 11(14-15), 1165-1176 (2009).
5. Hapuarachchi HC, Bandara KB, Sumanadasa SD et al. Re-emergence of Chikungunya virus in south-east Asia: virological evidence from Sri Lanka and Singapore. J. Gen. Virol. 91(Pt 4), 1067-1076 (2010).
6. Robin S, Ramful D, Le Seach F, Jaffar- Bandjee MC, Rigou G, Alessandri JL. Neurologic manifestations of pediatric Chikungunya infection. J. Child Neurol. 23(9), 1028-1035 (2008).
7. Arpino C, Curatolo P, Rezza G. Chikungunya and the nervous system: what we do and do not know. Rev. Med. Virol. 19(3), 121-129 (2009).
8. Hochedez P, Hausfater P, Jaureguiberry S et al. Cases of Chikungunya fever imported from the islands of the south west Indian Ocean to Paris, France. Euro Surveill. 12(1), 679 (2007).
9. Lim PL, Oh HM, Ooi EE. Chikungunya in Singapore: imported cases among travelers visiting friends and relatives. J. Travel. Med. 16(4), 289-291 (2009).
10. De Lamballerie X, Ninove L, Charrel RN. Antiviral treatment of Chikungunya virus infection. Infect. Dis. Drug Targets 9(2), 101-104 (2009).
11. Couderc T, Chretien F, Schilte C et al. A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog. 4(2), e29 (2008).
12. Werneke SW, Schilte C, Rohatgi A et al. ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation. PLoS Pathog. 7(10), e1002322 (2011).
13. Ziegler SA, Lu L, Da Rosa AP, Xiao SY, Tesh RB. An animal model for studying the pathogenesis of Chikungunya virus infection. Am. J. Trop. Med. Hyg. 79(1), 133-139 (2008).
14. Gardner J, Anraku I, Le TT et al. Chikungunya virus arthritis in adult wild-type mice. J. Virol. 84(16), 8021-8032 (2010).
15. Morrison TE, Oko L, Montgomery SA et al. A mouse model of Chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence. Am. J. Pathol. 178(1), 32-40 (2011).
16. Wang E, Volkova E, Adams AP et al. Chimeric alphavirus vaccine candidates for Chikungunya. Vaccine 26(39), 5030-5039 (2008).
17. Mallilankaraman K, Shedlock DJ, Bao H et al. A DNA vaccine against Chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates. PLoS Neglect. Trop. Dis. 5(1), e928 (2011).
18. Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3(8), 711-715 (2004).
19. Hiramatsu H, Nishikomori R, Heike T et al. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102(3), 873-880 (2003).
20. Chen Q, Khoury M, Chen J. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc. Natl Acad. Sci. USA 106(51), 21783-21788 (2009).