Homing frequency of human T cells inferred from peripheral blood depletion kinetics after sphingosine-1-phosphate receptor blockade

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 5, 2013, Pages 1440-1443.e7

  Mehling, Matthias ^a   Brinkmann, Volker ^b   Burgener, Anne Valerie ^a   Gubser, Patrick ^a   Luster, Andrew D ^c   Kappos, Ludwig ^a   Hess, Christoph ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; FINGOLIMOD; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; STROMAL CELL DERIVED FACTOR 1;

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CHEMOTAXIS; DRUG EFFICACY; EFFECTOR CELL; EX VIVO STUDY; HUMAN; IMMUNOSURVEILLANCE; IN VITRO STUDY; LETTER; LYMPH NODE; MULTIPLE SCLEROSIS; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84876896847     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.12.1520     Document Type: Article

References (12)

1. F. Sallusto, J. Geginat, and A. Lanzavecchia Central memory and effector memory T cell subsets: function, generation, and maintenance Annu Rev Immunol 22 2004 745 763
2. M. Miyasaka, and T. Tanaka Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Nat Rev Immunol 4 2004 360 370
3. U.H. Andrian von, and T.R. Mempel Homing and cellular traffic in lymph nodes Nat Rev Immunol 3 2003 867 878
4. M. Matloubian, C.G. Lo, G. Cinamon, M.J. Lesneski, Y. Xu, and V. Brinkmann Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Nature 427 2004 355 360
5. M. Mehling, T.A. Johnson, J. Antel, L. Kappos, and A. Bar-Or Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis Neurology 76 suppl 3 2011 S20 S27
6. M. Mehling, V. Brinkmann, J. Antel, A. Bar-Or, N. Goebels, and C. Vedrine FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis Neurology 71 2008 1261 1267
7. F. Sallusto, D. Lenig, R. Förster, M. Lipp, and A. Lanzavecchia Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 401 1999 708 712
8. B. Lee, M. Sharron, L.J. Montaner, D. Weissman, and R.W. Doms Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages Proc Natl Acad Sci U S A 96 1999 5215 5220
9. T.I. Arnon, Y. Xu, C. Lo, T. Pham, J. An, and S. Coughlin GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood Science 333 2011 1898 1903
10. A. Link, T.K. Vogt, S. Favre, M.R. Britschgi, H. Acha-Orbea, and B. Hinz Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells Nat Immunol 8 2007 1255 1265
11. R. Phillips, and A. Ager Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells Eur J Immunol 32 2002 837 847
12. J.M. Kovarik, R. Schmouder, D. Barilla, G.J. Riviere, Y. Wang, and T. Hunt Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects J Clin Pharmacol 44 2004 532 537