A conserved region of leptospiral immunoglobulin-like A and B proteins as a DNA vaccine elicits a prophylactic immune response against leptospirosis

Clinical and Vaccine Immunology

Volumn 20, Issue 5, 2013, Pages 725-731

  Forster, Karine M ^a   Hartwig, Daiane D ^a   Seixas, Fabiana K ^a   Bacelo, Kátia L ^a   Amaral, Marta ^a   Hartleben, Cláudia P ^a   Dellagostin, Odir A ^a  

^a FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; IMMUNOGLOBULIN G; LEPTOSPIRAL IMMUNOGLOBULIN LIKE PROTEIN A VACCINE; LEPTOSPIRAL IMMUNOGLOBULIN LIKE PROTEIN B VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIAL LOAD; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SURVIVAL TIME; TREATMENT RESPONSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CRICETINAE; FEMALE; IMMUNOGLOBULIN G; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; MESOCRICETUS; MICE; MICE, INBRED BALB C; VACCINATION; VACCINES, DNA; VACCINES, SYNTHETIC;

EID: 84876882512     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00601-12     Document Type: Article

References (38)

1. Faine SB, Adler B, Bolin C, Perolat P. 1999. Leptospira and leptospirosis, 2nd ed. MediSci, Melbourne, Australia.
2. Levett PN. 2001. Leptospirosis. Clin. Microbiol. Rev. 14:296-326. (Pubitemid 32294672)
3. Reis RB, Ribeiro GS, Felzemburgh RD, Santana FS, Mohr S, Melendez AX, Queiroz A, Santos AC, Ravines RR, Tassinari WS, Carvalho MS, Reis MG, Ko AI. 2008. Impact of environment and social gradient on Leptospira infection in urban slums. PLoS Negl. Trop. Dis. 2:e228. doi:10.1371/journal.pntd.0000228.
4. Hartskeerl RA. 2006. Leptospirosis: current status and future trends. Indian J. Med. Microbiol. 24:309. (Pubitemid 46033998)
5. McBride AJ, Athanazio DA, Reis MG, Ko AI. 2005. Leptospirosis. Curr. Opin. Infect. Dis. 18:376-386. (Pubitemid 41345294)
6. Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM. 2003. Leptospirosis: a zoonotic disease of global importance. Lancet Infect. Dis. 3:757-771.
7. Lau C, Smythe L, Weinstein P. 2010. Leptospirosis: an emerging disease in travellers. Travel Med. Infect. Dis. 8:33-39.
8. Hartskeerl RA, Collares-Pereira M, Ellis WA. 2011. Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world. Clin. Microbiol. Infect. 17:494-501.
9. Guitian J, Thurmond MC, Hietala SK. 1999. Infertility and abortion among first-lactation dairy cows seropositive or seronegative for Leptospira interrogans serovar hardjo. J. Am. Vet. Med. Assoc. 215:515-518. (Pubitemid 129535904)
10. Ko AI, Goarant C, Picardeau M. 2009. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen. Nat. Rev. Microbiol. 7:736-747.
11. Sonrier C, Branger C, Michel V, Ruvoen-Clouet N, Ganiere JP, Andre-Fontaine G. 2000. Evidence of cross-protection within Leptospira interrogans in an experimental model. Vaccine 19:86-94. (Pubitemid 30618958)
12. Koizumi N, Watanabe H. 2005. Leptospirosis vaccines: past, present, and future. J. Postgrad. Med. 51:210-214. (Pubitemid 41782218)
13. Cullen PA, Haake DA, Adler B. 2004. Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol. Rev. 28:291-318. (Pubitemid 38721407)
14. Haake DA, Mazel MK, McCoy AM, Milward F, Chao G, Matsunaga J, Wagar EA. 1999. Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection. Infect. Immun. 67:6572-6582.
15. Isberg RR, Voorhis DL, Falkow S. 1987. Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell 50:769-778.
16. Jerse AE, Yu J, Tall BD, Kaper JB. 1990. A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc. Natl. Acad. Sci. U. S. A. 87:7839-7843.
17. Dellagostin OA, Grassmann AA, Hartwig DD, Felix SR, da Silva EF, McBride AJ. 2011. Recombinant vaccines against leptospirosis. Hum. Vaccin. 7:1215-1224.
18. Choy HA, Kelley MM, Chen TL, Moller AK, Matsunaga J, Haake DA. 2007. Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen. Infect. Immun. 75:2441-2450. (Pubitemid 46744335)
19. Matsunaga J, Medeiros MA, Sanchez Y, Werneid KF, Ko AI. 2007. Osmotic regulation of expression of two extracellular matrix-binding proteins and a haemolysin of Leptospira interrogans: differential effects on LigA and Sph2 extracellular release. Microbiology 153:3390-3398. (Pubitemid 47629544)
20. Matsunaga J, Sanchez Y, Xu X, Haake DA. 2005. Osmolarity, a key environmental signal controlling expression of leptospiral proteins LigA and LigB and the extracellular release of LigA. Infect. Immun. 73:70-78. (Pubitemid 40041098)
21. Castiblanco-Valencia MM, Fraga TR, Silva LB, Monaris D, Abreu PA, Strobel S, Jozsi M, Isaac L, Barbosa AS. 2012. Leptospiral immunoglobulin-like proteins interact with human complement regulators factor H, FHL-1, FHR-1, and C4BP. J. Infect. Dis. 205:995-1004.
22. Choy HA. 2012. Multiple activities of LigB potentiate virulence of Leptospira interrogans: inhibition of alternative and classical pathways of complement. PLoS One 7:e41566. doi:10.1371/journal.pone.0041566.
23. McBride AJ, Cerqueira GM, Suchard MA, Moreira AN, Zuerner RL, Reis MG, Haake DA, Ko AI, Dellagostin OA. 2009. Genetic diversity of the leptospiral immunoglobulin-like (Lig) genes in pathogenic Leptospira spp. Infect. Genet. Evol. 9:196-205.
24. Silva EF, Medeiros MA, McBride AJ, Matsunaga J, Esteves GS, Ramos JG, Santos CS, Croda J, Homma A, Dellagostin OA, Haake DA, Reis MG, Ko AI. 2007. The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis. Vaccine 25:6277-6286. (Pubitemid 47088033)
25. Branger C, Chatrenet B, Gauvrit A, Aviat F, Aubert A, Bach JM, Andre-Fontaine G. 2005. Protection against Leptospira interrogans sensu lato challenge by DNA immunization with the gene encoding hemolysin-associated protein 1. Infect. Immun. 73:4062-4069. (Pubitemid 40923146)
26. Faisal SM, Yan W, Chen CS, Palaniappan RU, McDonough SP, Chang YF. 2008. Evaluation of protective immunity of Leptospira immunoglobulin like protein A (LigA) DNA vaccine against challenge in hamsters. Vaccine 26:277-287. (Pubitemid 350266122)
27. Ramos CR, Abreu PA, Nascimento AL, Ho PL. 2004. A high-copy T7 Escherichia coli expression vector for the production of recombinant proteins with a minimal N-terminal His-tagged fusion peptide. Braz. J. Med. Biol. Res. 37:1103-1109. (Pubitemid 39172546)
28. Seixas FK, da Silva EF, Hartwig DD, Cerqueira GM, Amaral M, Fagundes MQ, Dossa RG, Dellagostin OA. 2007. Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge. Vaccine 26:88-95. (Pubitemid 350213201)
29. Palaniappan RU, McDonough SP, Divers TJ, Chen CS, Pan MJ, Matsumoto M, Chang YF. 2006. Immunoprotection of recombinant leptospiral immunoglobulin-like protein A against Leptospira interrogans serovar Pomona infection. Infect. Immun. 74:1745-1750. (Pubitemid 43346809)
30. Yan W, Faisal SM, McDonough SP, Divers TJ, Barr SC, Chang CF, Pan MJ, Chang YF. 2009. Immunogenicity and protective efficacy of recombinant Leptospira immunoglobulin-like protein B (rLigB) in a hamster challenge model. Microbes Infect. 11:230-237.
31. Cao Y, Faisal SM, Yan W, Chang YC, McDonough SP, Zhang N, Akey BL, Chang YF. 2011. Evaluation of novel fusion proteins derived from extracellular matrix binding domains of LigB as vaccine candidates against leptospirosis in a hamster model. Vaccine 29:7379-7386.
32. Coutinho ML, Choy HA, Kelley MM, Matsunaga J, Babbitt JT, Lewis MS, Aleixo JA, Haake DA. 2011. A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans. PLoS Negl. Trop. Dis. 5:e1422. doi:10.1371/journal.pntd.0001422.
33. Kwissa M, Lindblad EB, Schirmbeck R, Reimann J. 2003. Codelivery of a DNA vaccine and a protein vaccine with aluminum phosphate stimulates a potent and multivalent immune response. J. Mol. Med. (Berl.) 81:502-510. (Pubitemid 37070203)
34. Wang S, Liu X, Fisher K, Smith JG, Chen F, Tobery TW, Ulmer JB, Evans RK, Caulfield MJ. 2000. Enhanced type I immune response to a hepatitis B DNA vaccine by formulation with calcium- or aluminum phosphate. Vaccine 18:1227-1235. (Pubitemid 30001837)
35. Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
36. Matsunaga J, Barocchi MA, Croda J, Young TA, Sanchez Y, Siqueira I, Bolin CA, Reis MG, Riley LW, Haake DA, Ko AI. 2003. Pathogenic Leptospira species express surface-exposed proteins belonging to the bacterial immunoglobulin superfamily. Mol. Microbiol. 49:929-945. (Pubitemid 36981340)
37. Koizumi N, Watanabe H. 2004. Leptospiral immunoglobulin-like proteins elicit protective immunity. Vaccine 22:1545-1552. (Pubitemid 38446933)
38. Saade F, Petrovsky N. 2012. Technologies for enhanced efficacy of DNA vaccines. Expert Rev. Vaccines 11:189-209.