Nuclear pores and perinuclear expression sites of var and ribosomal DNA genes correspond to physically distinct regions in Plasmodium falciparum

Eukaryotic Cell

Volumn 12, Issue 5, 2013, Pages 697-702

  Guizetti, Julien ^a,b   Martins, Rafael Miyazawa ^a,b   Guadagnini, Stéphanie ^a   Claes, Aurélie ^a,b   Scherfa, Artur ^b  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTE MEMBRANE PROTEIN 1, PLASMODIUM FALCIPARUM; NUCLEOPORIN; PROTOZOAL PROTEIN; RIBOSOME DNA;

ARTICLE; CELL CULTURE; ECHOGRAPHY; ERYTHROCYTE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NUCLEAR PORE; PARASITOLOGY; PLASMODIUM FALCIPARUM; PROTEIN TRANSPORT; TROPHOZOITE; ULTRASTRUCTURE;

CELLS, CULTURED; DNA, RIBOSOMAL; ERYTHROCYTES; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, PROTOZOAN; HUMANS; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; PLASMODIUM FALCIPARUM; PROTEIN TRANSPORT; PROTOZOAN PROTEINS; TROPHOZOITES;

PLASMODIUM FALCIPARUM;

EID: 84876859139     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00023-13     Document Type: Article

References (33)

1. Arib G, Akhtar A. 2011. Multiple facets of nuclear periphery in gene expression control. Curr. Opin. Cell Biol. 23:346-353.
2. Dieppois G, Stutz F. 2010. Connecting the transcription site to the nuclear pore: a multi-tether process that regulates gene expression. J. Cell Sci. 123:1989-1999.
3. Brickner DG, Brickner JH. 2012. Interchromosomal clustering of active genes at the nuclear pore complex. Nucleus 3:487-492.
4. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI. 2005. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434:214-217.
5. Murray CJ, Rosenfeld LC, Lim SS, Andrews KG, Foreman KJ, Haring D, Fullman N, Naghavi M, Lozano R, Lopez AD. 2012. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 379:413-431.
6. Maier AG, Cooke BM, Cowman AF, Tilley L. 2009. Malaria parasite proteins that remodel the host erythrocyte. Nat. Rev. Microbiol. 7:341-354.
7. Scherf A, Lopez-Rubio JJ, Riviere L. 2008. Antigenic variation in Plasmodium falciparum. Annu. Rev. Microbiol. 62:445-470.
8. Scherf A, Hernandez-Rivas R, Buffet P, Bottius E, Benatar C, Pouvelle B, Gysin J, Lanzer M. 1998. Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO J. 17: 5418-5426.
9. Schieck E, Pfahler JM, Sanchez CP, Lanzer M. 2007. Nuclear run-on analysis of var gene expression in Plasmodium falciparum. Mol. Biochem. Parasitol. 153:207-212.
10. Lopez-Rubio JJ, Gontijo AM, Nunes MC, Issar N, Hernandez Rivas R, Scherf A. 2007. 5= Flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites. Mol. Microbiol. 66:1296-1305.
11. Volz JC, Bartfai R, Petter M, Langer C, Josling GA, Tsuboi T, Schwach F, Baum J, Rayner JC, Stunnenberg HG, Duffy MF, Cowman AF. 2012. PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division. Cell Host Microbe 11:7-18.
12. Scherf A, Riviere L, Lopez-Rubio JJ. 2008. SnapShot: var gene expression in the malaria parasite. Cell 134:190.
13. Ralph SA, Scheidig-Benatar C, Scherf A. 2005. Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations. Proc. Natl. Acad. Sci. U. S. A. 102:5414-5419.
14. Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, Rojas-Meza AP, Mancio-Silva L, Leal-Silvestre RJ, Gontijo AM, Shorte S, Scherf A. 2005. Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites. Cell 121:25-36.
15. Navarro M, Gull K. 2001. A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei. Nature 414:759-763.
16. Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A. 2010. Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites. Proc. Natl. Acad. Sci. U. S. A. 107:15117-15122.
17. Akhtar A, Gasser SM. 2007. The nuclear envelope and transcriptional control. Nat. Rev. Genet. 8:507-517.
18. Weiner A, Dahan-Pasternak N, Shimoni E, Shinder VP, von Huth Elbaum M, Dzikowski R. 2011. 3D nuclear architecture reveals coupled cell cycle dynamics of chromatin and nuclear pores in the malaria parasite Plasmodium falciparum. Cell Microbiol. 13:967-977.
19. Lopez-Rubio JJ, Mancio-Silva L, Scherf A. 2009. Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites. Cell Host Microbe 5:179-190.
20. Chene A, Vembar SS, Riviere L, Lopez-Rubio JJ, Claes A, Siegel TN, Sakamoto H, Scheidig-Benatar C, Hernandez-Rivas R, Scherf A. 2012. PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites. Nucleic Acids Res. 40:3066-3077.
21. Dastidar EG, Dzeyk K, Krijgsveld J, Malmquist NA, Doerig C, Scherf A, Lopez-Rubio JJ. 2013. Comprehensive histone phosphorylation analysis and identification of pf14-3-3 protein as a histone h3 phosphorylation reader in malaria parasites. PLoS One 8:e53179. doi:10.1371/journal.pone.0053179.
22. Mancio-Silva L, Scherf A. 2013. In situ fluorescence visualization of transcription sites and genomic loci in blood stages of Plasmodium falciparum. Methods Mol. Biol. 923:335-351.
23. Oehring SC, Woodcroft BJ, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Maeser P, Flueck C, Witmer K, Brancucci NM, Niederwieser I, Jenoe P, Ralph SA, Voss TS. 2012. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome Biol. 13:R108. doi:10.1186/gb-2012-13-11-r108.
24. Volz J, Carvalho TG, Ralph SA, Gilson P, Thompson J, Tonkin CJ, Langer C, Crabb BS, Cowman AF. 2010. Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum. Int. J. Parasitol. 40:109-121.
25. Zhang Q, Huang Y, Zhang Y, Fang X, Claes A, Duchateau M, Namane A, Lopez-Rubio JJ, Pan W, Scherf A. 2011. A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites. Cell Host Microbe 10:451-463.
26. Ho HC. 2010. Redistribution of nuclear pores during formation of the redundant nuclear envelope in mouse spermatids. J. Anat. 216:525-532.
27. + RNA transport and nuclear pore distribution. EMBO J. 13:6062-6075.
28. Steinberg G, Schuster M, Theisen U, Kilaru S, Forge A, Martin-Urdiroz M. 2012. Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport. J. Cell Biol. 198:343-355.
29. Gorski SA, Dundr M, Misteli T. 2006. The road much traveled: trafficking in the cell nucleus. Curr. Opin. Cell Biol. 18:284-290.
30. Blobel G. 1985. Gene gating: a hypothesis. Proc. Natl. Acad. Sci. U. S. A. 82:8527-8529.
31. Freitas-Junior LH, Bottius E, Pirrit LA, Deitsch KW, Scheidig C, Guinet F, Nehrbass U, Wellems TE, Scherf A. 2000. Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum. Nature 407:1018-1022.
32. Figueiredo LM, Freitas-Junior LH, Bottius E, Olivo-Marin JC, Scherf A. 2002. A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation. EMBO J. 21:815-824.
33. Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. 2012. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe. 12:739-750.