-
1
-
-
0035316574
-
Chromosome territories, nuclear architecture and gene regulation in mammalian cells
-
Cremer T., and Cremer C. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genet 2 (2001) 292-301
-
(2001)
Nat Rev Genet
, vol.2
, pp. 292-301
-
-
Cremer, T.1
Cremer, C.2
-
2
-
-
18744375181
-
Concepts in nuclear architecture
-
Misteli T. Concepts in nuclear architecture. Bioessays 27 (2005) 477-487
-
(2005)
Bioessays
, vol.27
, pp. 477-487
-
-
Misteli, T.1
-
3
-
-
30444437477
-
Subnuclear organelles: new insights into form and function
-
Handwerger K.E., and Gall J.G. Subnuclear organelles: new insights into form and function. Trends Cell Biol 16 (2006) 19-26
-
(2006)
Trends Cell Biol
, vol.16
, pp. 19-26
-
-
Handwerger, K.E.1
Gall, J.G.2
-
4
-
-
0041669439
-
Nuclear speckles: a model for nuclear organelles
-
Lamond A.I., and Spector D.L. Nuclear speckles: a model for nuclear organelles. Nat Rev Mol Cell Biol 4 (2003) 605-612
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 605-612
-
-
Lamond, A.I.1
Spector, D.L.2
-
5
-
-
0042767995
-
The dynamics of chromosome organization and gene regulation
-
Spector D.L. The dynamics of chromosome organization and gene regulation. Annu Rev Biochem 72 (2003) 573-608
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 573-608
-
-
Spector, D.L.1
-
6
-
-
0038738334
-
Pre-ribosomes on the road from the nucleolus to the cytoplasm
-
Tschochner H., and Hurt E. Pre-ribosomes on the road from the nucleolus to the cytoplasm. Trends Cell Biol 13 (2003) 255-263
-
(2003)
Trends Cell Biol
, vol.13
, pp. 255-263
-
-
Tschochner, H.1
Hurt, E.2
-
8
-
-
30544442161
-
Histone acetylation increases chromatin accessibility
-
The diffusional mobilities of dextrans of varying sizes are carefully measured and on the basis of their diffusional pore sizes in the chromatin network are estimated to be of the order of 20 nm, 40 nm and 60-100 nm.
-
Gorisch S.M., Wachsmuth M., Toth K.F., Lichter P., and Rippe K. Histone acetylation increases chromatin accessibility. J Cell Sci 118 (2005) 5825-5834. The diffusional mobilities of dextrans of varying sizes are carefully measured and on the basis of their diffusional pore sizes in the chromatin network are estimated to be of the order of 20 nm, 40 nm and 60-100 nm.
-
(2005)
J Cell Sci
, vol.118
, pp. 5825-5834
-
-
Gorisch, S.M.1
Wachsmuth, M.2
Toth, K.F.3
Lichter, P.4
Rippe, K.5
-
9
-
-
0030742748
-
Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus
-
Seksek O., Biwersi J., and Verkman A.S. Translational diffusion of macromolecule-sized solutes in cytoplasm and nucleus. J Cell Biol 138 (1997) 131-142
-
(1997)
J Cell Biol
, vol.138
, pp. 131-142
-
-
Seksek, O.1
Biwersi, J.2
Verkman, A.S.3
-
11
-
-
4644243088
-
Intracellular macromolecular mobility measured by fluorescence recovery after photobleaching with confocal laser scanning microscopes
-
Braga J., Desterro J.M., and Carmo-Fonseca M. Intracellular macromolecular mobility measured by fluorescence recovery after photobleaching with confocal laser scanning microscopes. Mol Biol Cell 15 (2004) 4749-4760
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4749-4760
-
-
Braga, J.1
Desterro, J.M.2
Carmo-Fonseca, M.3
-
12
-
-
3042760021
-
Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins
-
A comprehensive analysis of a large number of chromatin proteins demonstrates that protein-chromatin interactions are generally highly transient. A simple kinetic model for determination of residence times of proteins on chromatin is introduced.
-
Phair R.D., Scaffidi P., Elbi C., Vecerova J., Dey A., Ozato K., Brown D.T., Hager G., Bustin M., and Misteli T. Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins. Mol Cell Biol 24 (2004) 6393-6402. A comprehensive analysis of a large number of chromatin proteins demonstrates that protein-chromatin interactions are generally highly transient. A simple kinetic model for determination of residence times of proteins on chromatin is introduced.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6393-6402
-
-
Phair, R.D.1
Scaffidi, P.2
Elbi, C.3
Vecerova, J.4
Dey, A.5
Ozato, K.6
Brown, D.T.7
Hager, G.8
Bustin, M.9
Misteli, T.10
-
13
-
-
0034611785
-
High mobility of proteins in the mammalian cell nucleus
-
Phair R.D., and Misteli T. High mobility of proteins in the mammalian cell nucleus. Nature 404 (2000) 604-609
-
(2000)
Nature
, vol.404
, pp. 604-609
-
-
Phair, R.D.1
Misteli, T.2
-
14
-
-
0035106336
-
Macromolecular dynamics in living cell nuclei revealed by fluorescence redistribution after photobleaching
-
Houtsmuller A.B., and Vermeulen W. Macromolecular dynamics in living cell nuclei revealed by fluorescence redistribution after photobleaching. Histochem Cell Biol 115 (2001) 13-21
-
(2001)
Histochem Cell Biol
, vol.115
, pp. 13-21
-
-
Houtsmuller, A.B.1
Vermeulen, W.2
-
15
-
-
0036164351
-
Solute and macromolecule diffusion in cellular aqueous compartments
-
Verkman A.S. Solute and macromolecule diffusion in cellular aqueous compartments. Trends Biochem Sci 27 (2002) 27-33
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 27-33
-
-
Verkman, A.S.1
-
16
-
-
13244291467
-
FRAP analysis of binding: proper and fitting
-
Sprague B.L., and McNally J.G. FRAP analysis of binding: proper and fitting. Trends Cell Biol 15 (2005) 84-91
-
(2005)
Trends Cell Biol
, vol.15
, pp. 84-91
-
-
Sprague, B.L.1
McNally, J.G.2
-
17
-
-
0034640133
-
Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy
-
Wachsmuth M., Waldeck W., and Langowski J. Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy. J Mol Biol 298 (2000) 677-689
-
(2000)
J Mol Biol
, vol.298
, pp. 677-689
-
-
Wachsmuth, M.1
Waldeck, W.2
Langowski, J.3
-
18
-
-
0038297629
-
Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching
-
Wachsmuth M., Weidemann T., Muller G., Hoffmann-Rohrer U.W., Knoch T.A., Waldeck W., and Langowski J. Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching. Biophys J 84 (2003) 3353-3363
-
(2003)
Biophys J
, vol.84
, pp. 3353-3363
-
-
Wachsmuth, M.1
Weidemann, T.2
Muller, G.3
Hoffmann-Rohrer, U.W.4
Knoch, T.A.5
Waldeck, W.6
Langowski, J.7
-
19
-
-
0036929125
-
DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters
-
Sporbert A., Gahl A., Ankerhold R., Leonhardt H., and Cardoso M.C. DNA polymerase clamp shows little turnover at established replication sites but sequential de novo assembly at adjacent origin clusters. Mol Cell 10 (2002) 1355-1365
-
(2002)
Mol Cell
, vol.10
, pp. 1355-1365
-
-
Sporbert, A.1
Gahl, A.2
Ankerhold, R.3
Leonhardt, H.4
Cardoso, M.C.5
-
20
-
-
18744374129
-
Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo
-
Hoogstraten D., Nigg A.L., Heath H., Mullenders L.H., van Driel R., Hoeijmakers J.H., Vermeulen W., and Houtsmuller A.B. Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo. Mol Cell 10 (2002) 1163-1174
-
(2002)
Mol Cell
, vol.10
, pp. 1163-1174
-
-
Hoogstraten, D.1
Nigg, A.L.2
Heath, H.3
Mullenders, L.H.4
van Driel, R.5
Hoeijmakers, J.H.6
Vermeulen, W.7
Houtsmuller, A.B.8
-
21
-
-
0035654399
-
Kinetic modelling approaches to in vivo imaging
-
Phair R.D., and Misteli T. Kinetic modelling approaches to in vivo imaging. Nat Rev Mol Cell Biol 2 (2001) 898-907
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 898-907
-
-
Phair, R.D.1
Misteli, T.2
-
22
-
-
3042579602
-
How do site-specific DNA-binding proteins find their targets?
-
Halford S.E., and Marko J.F. How do site-specific DNA-binding proteins find their targets?. Nucleic Acids Res 32 (2004) 3040-3052
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 3040-3052
-
-
Halford, S.E.1
Marko, J.F.2
-
23
-
-
2942690158
-
Analysis of binding reactions by fluorescence recovery after photobleaching
-
Sprague B.L., Pego R.L., Stavreva D.A., and McNally J.G. Analysis of binding reactions by fluorescence recovery after photobleaching. Biophys J 86 (2004) 3473-3495
-
(2004)
Biophys J
, vol.86
, pp. 3473-3495
-
-
Sprague, B.L.1
Pego, R.L.2
Stavreva, D.A.3
McNally, J.G.4
-
24
-
-
0346525136
-
Modulation of heterochromatin protein 1 dynamics in primary mammalian cells
-
Festenstein R., Pagakis S.N., Hiragami K., Lyon D., Verreault A., Sekkali B., and Kioussis D. Modulation of heterochromatin protein 1 dynamics in primary mammalian cells. Science 299 (2003) 719-721
-
(2003)
Science
, vol.299
, pp. 719-721
-
-
Festenstein, R.1
Pagakis, S.N.2
Hiragami, K.3
Lyon, D.4
Verreault, A.5
Sekkali, B.6
Kioussis, D.7
-
25
-
-
0348150714
-
Maintenance of stable heterochromatin domains by dynamic HP1 binding
-
Cheutin T., McNairn A.J., Jenuwein T., Gilbert D.M., Singh P.B., and Misteli T. Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science 299 (2003) 721-725
-
(2003)
Science
, vol.299
, pp. 721-725
-
-
Cheutin, T.1
McNairn, A.J.2
Jenuwein, T.3
Gilbert, D.M.4
Singh, P.B.5
Misteli, T.6
-
26
-
-
0036668636
-
Competition between histone H1 and HMGN proteins for chromatin binding sites
-
Catez F., Brown D.T., Misteli T., and Bustin M. Competition between histone H1 and HMGN proteins for chromatin binding sites. EMBO Rep 3 (2002) 760-766
-
(2002)
EMBO Rep
, vol.3
, pp. 760-766
-
-
Catez, F.1
Brown, D.T.2
Misteli, T.3
Bustin, M.4
-
27
-
-
0034649663
-
Dynamic binding of histone H1 to chromatin in living cells
-
Misteli T., Gunjan A., Hock R., Bustin M., and Brown D.T. Dynamic binding of histone H1 to chromatin in living cells. Nature 408 (2000) 877-881
-
(2000)
Nature
, vol.408
, pp. 877-881
-
-
Misteli, T.1
Gunjan, A.2
Hock, R.3
Bustin, M.4
Brown, D.T.5
-
28
-
-
0034649621
-
Rapid exchange of histone H1.1 on chromatin in living cells
-
Lever M.A., Th'ng J.P.H., Sun X., and Hendzel M.J. Rapid exchange of histone H1.1 on chromatin in living cells. Nature 408 (2000) 873-876
-
(2000)
Nature
, vol.408
, pp. 873-876
-
-
Lever, M.A.1
Th'ng, J.P.H.2
Sun, X.3
Hendzel, M.J.4
-
29
-
-
2542497773
-
High- and low-mobility populations of HP1 in heterochromatin of mammalian cells
-
Schmiedeberg L., Weisshart K., Diekmann S., Meyer Zu Hoerste G., and Hemmerich P. High- and low-mobility populations of HP1 in heterochromatin of mammalian cells. Mol Biol Cell 15 (2004) 2819-2833
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2819-2833
-
-
Schmiedeberg, L.1
Weisshart, K.2
Diekmann, S.3
Meyer Zu Hoerste, G.4
Hemmerich, P.5
-
30
-
-
0035954427
-
Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B
-
Kimura H., and Cook P.R. Kinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B. J Cell Biol 153 (2001) 1341-1353
-
(2001)
J Cell Biol
, vol.153
, pp. 1341-1353
-
-
Kimura, H.1
Cook, P.R.2
-
31
-
-
0030763228
-
Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis
-
Ellenberg J., Siggia E.D., Moreira J.E., Smith C.L., Presley J.F., Worman H.J., and Lippincott-Schwartz J. Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis. J Cell Biol 138 (1997) 1193-1206
-
(1997)
J Cell Biol
, vol.138
, pp. 1193-1206
-
-
Ellenberg, J.1
Siggia, E.D.2
Moreira, J.E.3
Smith, C.L.4
Presley, J.F.5
Worman, H.J.6
Lippincott-Schwartz, J.7
-
32
-
-
7944236264
-
Mapping the dynamic organization of the nuclear pore complex inside single living cells
-
Rabut G., Doye V., and Ellenberg J. Mapping the dynamic organization of the nuclear pore complex inside single living cells. Nat Cell Biol 6 (2004) 1114-1121
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1114-1121
-
-
Rabut, G.1
Doye, V.2
Ellenberg, J.3
-
33
-
-
0035793376
-
Protein dynamics: Implications for nuclear architecture and gene expression
-
Misteli T. Protein dynamics: Implications for nuclear architecture and gene expression. Science 291 (2001) 843-847
-
(2001)
Science
, vol.291
, pp. 843-847
-
-
Misteli, T.1
-
34
-
-
27644460480
-
Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA
-
Elegantly designed in vitro experiments demonstrate that a restriction enzyme finds its binding sites largely by hopping rather than by one-dimensional sliding.
-
Gowers D.M., Wilson G.G., and Halford S.E. Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA. Proc Natl Acad Sci USA 102 (2005) 15883-15888. Elegantly designed in vitro experiments demonstrate that a restriction enzyme finds its binding sites largely by hopping rather than by one-dimensional sliding.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15883-15888
-
-
Gowers, D.M.1
Wilson, G.G.2
Halford, S.E.3
-
35
-
-
23744470858
-
Facilitated diffusion in chromatin lattices: mechanistic diversity and regulatory potential
-
Kampmann M. Facilitated diffusion in chromatin lattices: mechanistic diversity and regulatory potential. Mol Microbiol 57 (2005) 889-899
-
(2005)
Mol Microbiol
, vol.57
, pp. 889-899
-
-
Kampmann, M.1
-
36
-
-
0142155175
-
Condensed chromatin domains in the mammalian nucleus are accessible to large macromolecules
-
Verschure P.J., van der Kraan I., Manders E.M., Hoogstraten D., Houtsmuller A.B., and van Driel R. Condensed chromatin domains in the mammalian nucleus are accessible to large macromolecules. EMBO Rep 4 (2003) 861-866
-
(2003)
EMBO Rep
, vol.4
, pp. 861-866
-
-
Verschure, P.J.1
van der Kraan, I.2
Manders, E.M.3
Hoogstraten, D.4
Houtsmuller, A.B.5
van Driel, R.6
-
37
-
-
17744411075
-
Diffusion-limited compartmentalization of mammalian cell nuclei assessed by microinjected macromolecules
-
Gorisch S.M., Richter K., Scheuermann M.O., Herrmann H., and Lichter P. Diffusion-limited compartmentalization of mammalian cell nuclei assessed by microinjected macromolecules. Exp Cell Res 289 (2003) 282-294
-
(2003)
Exp Cell Res
, vol.289
, pp. 282-294
-
-
Gorisch, S.M.1
Richter, K.2
Scheuermann, M.O.3
Herrmann, H.4
Lichter, P.5
-
38
-
-
11144328968
-
Cajal bodies, nucleoli, and speckles in the Xenopus oocyte nucleus have a low-density, sponge-like structure
-
This careful interferometry analysis of the ability of dextrans of various sizes to penetrate nuclear bodies in Xenopus oocytes demonstrates their sponge-like structure and suggests that the absolute concentration of resident proteins inside nuclear bodies is only marginally higher than in the nucleoplasm.
-
Handwerger K.E., Cordero J.A., and Gall J.G. Cajal bodies, nucleoli, and speckles in the Xenopus oocyte nucleus have a low-density, sponge-like structure. Mol Biol Cell 16 (2005) 202-211. This careful interferometry analysis of the ability of dextrans of various sizes to penetrate nuclear bodies in Xenopus oocytes demonstrates their sponge-like structure and suggests that the absolute concentration of resident proteins inside nuclear bodies is only marginally higher than in the nucleoplasm.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 202-211
-
-
Handwerger, K.E.1
Cordero, J.A.2
Gall, J.G.3
-
39
-
-
0032568529
-
Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells
-
Politz J.C., Browne E.S., Wolf D.E., and Pederson T. Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells. Proc Natl Acad Sci USA 95 (1998) 6043-6048
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6043-6048
-
-
Politz, J.C.1
Browne, E.S.2
Wolf, D.E.3
Pederson, T.4
-
40
-
-
0033602460
-
Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells
-
Politz J.C., Tuft R.A., Pederson T., and Singer R.H. Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells. Curr Biol 9 (1999) 285-291
-
(1999)
Curr Biol
, vol.9
, pp. 285-291
-
-
Politz, J.C.1
Tuft, R.A.2
Pederson, T.3
Singer, R.H.4
-
41
-
-
2142662109
-
Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells
-
Molenaar C., Abdulle A., Gena A., Tanke H.J., and Dirks R.W. Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells. J Cell Biol 165 (2004) 191-202
-
(2004)
J Cell Biol
, vol.165
, pp. 191-202
-
-
Molenaar, C.1
Abdulle, A.2
Gena, A.3
Tanke, H.J.4
Dirks, R.W.5
-
42
-
-
2942733310
-
Dynamics of single mRNPs in nuclei of living cells
-
The first visualization and quantitative analysis of the movement of a single mRNA in living cells. Movement of the mRNA is shown to be energy-independent and to occur by diffusion. Energy depletion leads to trapping of molecules in collapsed chromatin regions.
-
Shav-Tal Y., Darzacq X., Shenoy S.M., Fusco D., Janicki S.M., Spector D.L., and Singer R.H. Dynamics of single mRNPs in nuclei of living cells. Science 304 (2004) 1797-1800. The first visualization and quantitative analysis of the movement of a single mRNA in living cells. Movement of the mRNA is shown to be energy-independent and to occur by diffusion. Energy depletion leads to trapping of molecules in collapsed chromatin regions.
-
(2004)
Science
, vol.304
, pp. 1797-1800
-
-
Shav-Tal, Y.1
Darzacq, X.2
Shenoy, S.M.3
Fusco, D.4
Janicki, S.M.5
Spector, D.L.6
Singer, R.H.7
-
43
-
-
28044451048
-
Mechanism of mRNA transport in the nucleus
-
Vargas D.Y., Raj A., Marras S.A., Kramer F.R., and Tyagi S. Mechanism of mRNA transport in the nucleus. Proc Natl Acad Sci USA 102 (2005) 17008-17013
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17008-17013
-
-
Vargas, D.Y.1
Raj, A.2
Marras, S.A.3
Kramer, F.R.4
Tyagi, S.5
-
44
-
-
0033909431
-
Movement of mRNA from transcription site to nuclear pores
-
Politz J.C., and Pederson T. Movement of mRNA from transcription site to nuclear pores. J Struct Biol 129 (2000) 252-257
-
(2000)
J Struct Biol
, vol.129
, pp. 252-257
-
-
Politz, J.C.1
Pederson, T.2
-
45
-
-
0344875510
-
Diffusion-based transport of nascent ribosomes in the nucleus
-
Politz J.C., Tuft R.A., and Pederson T. Diffusion-based transport of nascent ribosomes in the nucleus. Mol Biol Cell 14 (2003) 4805-4812
-
(2003)
Mol Biol Cell
, vol.14
, pp. 4805-4812
-
-
Politz, J.C.1
Tuft, R.A.2
Pederson, T.3
-
46
-
-
33646499500
-
-
Ritland-Politz JC, Tufft RA, Prasanth KV, Baudendistel N, Fogarty KE, Lifshitz LM, Langowski J, Spector DL, Pederson T: Rapid, diffusional shuttling of poly(A)-RNA between nuclear speckles and the nucleoplasm. Mol Cell Biol 2006, in press.
-
-
-
-
47
-
-
0344338368
-
Gene gating: a hypothesis
-
Blobel G. Gene gating: a hypothesis. Proc Natl Acad Sci USA 82 (1985) 8527-8529
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 8527-8529
-
-
Blobel, G.1
-
48
-
-
0037049650
-
The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive
-
Calapez A., Pereira H.M., Calado A., Braga J., Rino J., Carvalho C., Tavanez J.P., Wahle E., Rosa A.C., and Carmo-Fonseca M. The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive. J Cell Biol 159 (2002) 795-805
-
(2002)
J Cell Biol
, vol.159
, pp. 795-805
-
-
Calapez, A.1
Pereira, H.M.2
Calado, A.3
Braga, J.4
Rino, J.5
Carvalho, C.6
Tavanez, J.P.7
Wahle, E.8
Rosa, A.C.9
Carmo-Fonseca, M.10
-
49
-
-
19344378943
-
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors
-
Bentley D.L. Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors. Curr Opin Cell Biol 17 (2005) 251-256
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 251-256
-
-
Bentley, D.L.1
-
50
-
-
0041013167
-
Inefficient processing impairs release of RNA from the site of transcription
-
Custodio N., Carmo-Fonseca M., Geraghty F., Pereira H., Grosveld F., and Antoniou M. Inefficient processing impairs release of RNA from the site of transcription. EMBO J 18 (1999) 2855-2866
-
(1999)
EMBO J
, vol.18
, pp. 2855-2866
-
-
Custodio, N.1
Carmo-Fonseca, M.2
Geraghty, F.3
Pereira, H.4
Grosveld, F.5
Antoniou, M.6
-
51
-
-
26844440157
-
Regulating gene expression through RNA nuclear retention
-
Retention of a partially processed but translatable RNA in a nuclear compartment is demonstrated to act as a regulatory mechanism in gene expression.
-
Prasanth K.V., Prasanth S.G., Xuan Z., Hearn S., Freier S.M., Bennett C.F., Zhang M.Q., and Spector D.L. Regulating gene expression through RNA nuclear retention. Cell 123 (2005) 249-263. Retention of a partially processed but translatable RNA in a nuclear compartment is demonstrated to act as a regulatory mechanism in gene expression.
-
(2005)
Cell
, vol.123
, pp. 249-263
-
-
Prasanth, K.V.1
Prasanth, S.G.2
Xuan, Z.3
Hearn, S.4
Freier, S.M.5
Bennett, C.F.6
Zhang, M.Q.7
Spector, D.L.8
-
52
-
-
0035795422
-
Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells
-
Chen D., and Huang S. Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells. J Cell Biol 153 (2001) 169-176
-
(2001)
J Cell Biol
, vol.153
, pp. 169-176
-
-
Chen, D.1
Huang, S.2
-
53
-
-
0034735515
-
Mutational analysis of fibrillarin and its mobility in living human cells
-
Snaar S., Wiesmeijer K., Jochemsen A.G., Tanke H.J., and Dirks R.W. Mutational analysis of fibrillarin and its mobility in living human cells. J Cell Biol 151 (2000) 653-662
-
(2000)
J Cell Biol
, vol.151
, pp. 653-662
-
-
Snaar, S.1
Wiesmeijer, K.2
Jochemsen, A.G.3
Tanke, H.J.4
Dirks, R.W.5
-
54
-
-
0033533730
-
Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway
-
Sleeman J.E., and Lamond A.I. Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. Curr Biol 9 (1999) 1065-1074
-
(1999)
Curr Biol
, vol.9
, pp. 1065-1074
-
-
Sleeman, J.E.1
Lamond, A.I.2
-
55
-
-
12144290254
-
In vivo kinetics of cajal body components
-
A systematic analysis of the dissociation kinetics of Cajal body components demonstrates multiple kinetically distinct groups of Cajal body resident proteins.
-
Dundr M., Hebert M.D., Karpova T.S., Stanek D., Xu H., Shpargel K.B., Meier U.T., Neugebauer K.M., Matera A.G., and Misteli T. In vivo kinetics of cajal body components. J Cell Biol 164 (2004) 831-842. A systematic analysis of the dissociation kinetics of Cajal body components demonstrates multiple kinetically distinct groups of Cajal body resident proteins.
-
(2004)
J Cell Biol
, vol.164
, pp. 831-842
-
-
Dundr, M.1
Hebert, M.D.2
Karpova, T.S.3
Stanek, D.4
Xu, H.5
Shpargel, K.B.6
Meier, U.T.7
Neugebauer, K.M.8
Matera, A.G.9
Misteli, T.10
-
56
-
-
24144477311
-
Regulation of ubiquitin ligase dynamics by the nucleolus
-
Using photobleaching experiments, the dramatic accumulation of the MDM2 and VHL ubiquitin ligases in response to physiological cues are shown to be due to the retention of these proteins in the nucleolus.
-
Mekhail K., Khacho M., Carrigan A., Hache R.R., Gunaratnam L., and Lee S. Regulation of ubiquitin ligase dynamics by the nucleolus. J Cell Biol 170 (2005) 733-744. Using photobleaching experiments, the dramatic accumulation of the MDM2 and VHL ubiquitin ligases in response to physiological cues are shown to be due to the retention of these proteins in the nucleolus.
-
(2005)
J Cell Biol
, vol.170
, pp. 733-744
-
-
Mekhail, K.1
Khacho, M.2
Carrigan, A.3
Hache, R.R.4
Gunaratnam, L.5
Lee, S.6
-
57
-
-
13844294281
-
A multistep, GTP-driven mechanism controlling the dynamic coupling of nucleostemin
-
Evidence is presented that the nuclear distribution of nucleostemin and particularly its retention in the nucleolus is driven by a GTP cycle. This is a novel mechanism for controlling protein localization in the nucleus.
-
Tsai R.Y., and McKay R.D. A multistep, GTP-driven mechanism controlling the dynamic coupling of nucleostemin. J Cell Biol 168 (2005) 179-184. Evidence is presented that the nuclear distribution of nucleostemin and particularly its retention in the nucleolus is driven by a GTP cycle. This is a novel mechanism for controlling protein localization in the nucleus.
-
(2005)
J Cell Biol
, vol.168
, pp. 179-184
-
-
Tsai, R.Y.1
McKay, R.D.2
-
58
-
-
18744364184
-
The moving parts of the nucleolus
-
Olson M.O., and Dundr M. The moving parts of the nucleolus. Histochem Cell Biol 123 (2005) 203-216
-
(2005)
Histochem Cell Biol
, vol.123
, pp. 203-216
-
-
Olson, M.O.1
Dundr, M.2
-
59
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin Jr. W.G. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2 (2002) 673-682
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
60
-
-
21844453203
-
A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin
-
Politz J.C., Polena I., Trask I., Bazett-Jones D.P., and Pederson T. A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin. Mol Biol Cell 16 (2005) 3401-3410
-
(2005)
Mol Biol Cell
, vol.16
, pp. 3401-3410
-
-
Politz, J.C.1
Polena, I.2
Trask, I.3
Bazett-Jones, D.P.4
Pederson, T.5
-
61
-
-
11944274520
-
Nucleolar proteome dynamics
-
A novel mass-spectroscopy method is introduced which allows proteomic analysis of dynamic events. As proof of principle, the changes in nucleolar protein composition upon inhibition of transcription are characterized.
-
Andersen J.S., Lam Y.W., Leung A.K., Ong S.E., Lyon C.E., Lamond A.I., and Mann M. Nucleolar proteome dynamics. Nature 433 (2005) 77-83. A novel mass-spectroscopy method is introduced which allows proteomic analysis of dynamic events. As proof of principle, the changes in nucleolar protein composition upon inhibition of transcription are characterized.
-
(2005)
Nature
, vol.433
, pp. 77-83
-
-
Andersen, J.S.1
Lam, Y.W.2
Leung, A.K.3
Ong, S.E.4
Lyon, C.E.5
Lamond, A.I.6
Mann, M.7
|