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Volumn 13, Issue 5, 2013, Pages 513-522

Vemurafenib in melanoma

Author keywords

BRAF; melanoma; vemurafenib; Zelboraf

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; DABRAFENIB; DACARBAZINE; TEMOZOLOMIDE; VEMURAFENIB;

EID: 84876858957     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.13.24     Document Type: Review
Times cited : (10)

References (90)
  • 1
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to BRAF (V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H, Wang Q et al. Melanomas acquire resistance to BRAF (V600E) inhibition by RTK or N-RAS upregulation. Nature 468(7326), 973-977 (2010).
    • (2010) Nature , vol.468 , Issue.7326 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3
  • 2
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • Balch CM, Gershenwald JE, Soong SJ et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol. 27(36), 6199-6206 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.36 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 3
    • 0347503603 scopus 로고    scopus 로고
    • Palliative therapy of disseminated malignant melanoma: A systematic review of 41 randomised clinical trials
    • Eigentler TK, Caroli UM, Radny P, Garbe C. Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials. Lancet Oncol. 4(12), 748-759 (2003).
    • (2003) Lancet Oncol. , vol.4 , Issue.12 , pp. 748-759
    • Eigentler, T.K.1    Caroli, U.M.2    Radny, P.3    Garbe, C.4
  • 5
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 6
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364(26), 2517-2526 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 7
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 417(6892), 949-954 (2002).
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 8
    • 1942506706 scopus 로고    scopus 로고
    • V599EB-RAF is an oncogene in melanocytes
    • Wellbrock C, Ogilvie L, Hedley D et al. V599EB-RAF is an oncogene in melanocytes. Cancer Res. 64(7), 2338-2342 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.7 , pp. 2338-2342
    • Wellbrock, C.1    Ogilvie, L.2    Hedley, D.3
  • 9
    • 84864042630 scopus 로고    scopus 로고
    • BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma
    • Colombino M, Capone M, Lissia A et al. BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J. Clin. Oncol. 30(20), 2522-2529 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.20 , pp. 2522-2529
    • Colombino, M.1    Capone, M.2    Lissia, A.3
  • 10
    • 60849112820 scopus 로고    scopus 로고
    • Tumour cell survival signalling by the ERK1/2 pathway
    • Balmanno K, Cook SJ. Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ. 16(3), 368-377 (2009).
    • (2009) Cell Death Differ. , vol.16 , Issue.3 , pp. 368-377
    • Balmanno, K.1    Cook, S.J.2
  • 11
    • 77954761299 scopus 로고    scopus 로고
    • Oncogenic B-RAF(V600E) promotes anchorage-independent survival of human melanocytes
    • Becker TM, Philipsz S, Scurr LL et al. Oncogenic B-RAF(V600E) promotes anchorage-independent survival of human melanocytes. J. Invest. Dermatol. 130(8), 2144-2147 (2010).
    • (2010) J. Invest. Dermatol. , vol.130 , Issue.8 , pp. 2144-2147
    • Becker, T.M.1    Philipsz, S.2    Scurr, L.L.3
  • 12
    • 52149107116 scopus 로고    scopus 로고
    • Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival
    • Cartlidge RA, Thomas GR, Cagnol S et al. Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival. Pigment Cell Melanoma Res. 21(5), 534-544 (2008).
    • (2008) Pigment Cell Melanoma Res. , vol.21 , Issue.5 , pp. 534-544
    • Cartlidge, R.A.1    Thomas, G.R.2    Cagnol, S.3
  • 14
  • 15
    • 0037442752 scopus 로고    scopus 로고
    • Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation
    • Satyamoorthy K, Li G, Gerrero MR et al. Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res. 63(4), 756-759 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.4 , pp. 756-759
    • Satyamoorthy, K.1    Li, G.2    Gerrero, M.R.3
  • 16
    • 84857131874 scopus 로고    scopus 로고
    • Targeting oncogenic serine/ threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia
    • Bottos A, Martini M, Di Nicolantonio F et al. Targeting oncogenic serine/ threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia. Proc. Natl Acad. Sci. USA 109(6), E353-E359 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.6
    • Bottos, A.1    Martini, M.2    Di Nicolantonio, F.3
  • 18
    • 78651457445 scopus 로고    scopus 로고
    • Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMPspecific phosphodiesterase PDE5A
    • Arozarena I, Sanchez-Laorden B, Packer L et al. Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMPspecific phosphodiesterase PDE5A. Cancer Cell 19(1), 45-57 (2011).
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 45-57
    • Arozarena, I.1    Sanchez-Laorden, B.2    Packer, L.3
  • 19
    • 33846220276 scopus 로고    scopus 로고
    • Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway
    • Gaggioli C, Robert G, Bertolotto C et al. Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway. J. Invest. Dermatol. 127(2), 400-410 (2007).
    • (2007) J. Invest. Dermatol. , vol.127 , Issue.2 , pp. 400-410
    • Gaggioli, C.1    Robert, G.2    Bertolotto, C.3
  • 20
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Cancer Genome Project.
    • Wan PT, Garnett MJ, Roe SM et al.; Cancer Genome Project. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116(6), 855-867 (2004).
    • (2004) Cell , vol.116 , Issue.6 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3
  • 21
    • 0038408488 scopus 로고    scopus 로고
    • BRAF as a melanoma susceptibility candidate gene?
    • French Herediatary Melanoma Study Group
    • Laud K, Kannengiesser C, Avril MF et al.; French Herediatary Melanoma Study Group. BRAF as a melanoma susceptibility candidate gene? Cancer Res. 63(12), 3061-3065 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.12 , pp. 3061-3065
    • Laud, K.1    Kannengiesser, C.2    Avril, M.F.3
  • 22
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer EA, Therasse P, Bogaerts J et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009).
    • (2009) Eur. J. Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 23
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • BRIM-3 Study Group
    • Chapman PB, Hauschild A, Robert C et al.; BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N. Engl. J. Med. 364(26), 2507-2516 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 24
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim KB, Schuchter L et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N. Engl. J. Med. 366(8), 707-714 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.8 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 25
    • 0343492260 scopus 로고
    • Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus
    • Rapp UR, Goldsborough MD, Mark GE et al. Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc. Natl Acad. Sci. USA 80(14), 4218-4222 (1983).
    • (1983) Proc. Natl Acad. Sci. USA , vol.80 , Issue.14 , pp. 4218-4222
    • Rapp, U.R.1    Goldsborough, M.D.2    Mark, G.E.3
  • 26
    • 0025604178 scopus 로고
    • Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies
    • Sithanandam G, Kolch W, Duh FM, Rapp UR. Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. Oncogene 5(12), 1775-1780 (1990).
    • (1990) Oncogene , vol.5 , Issue.12 , pp. 1775-1780
    • Sithanandam, G.1    Kolch, W.2    Duh, F.M.3    Rapp, U.R.4
  • 28
    • 27544453376 scopus 로고    scopus 로고
    • Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF
    • Emuss V, Garnett M, Mason C, Marais R. Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF. Cancer Res. 65(21), 9719-9726 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.21 , pp. 9719-9726
    • Emuss, V.1    Garnett, M.2    Mason, C.3    Marais, R.4
  • 30
    • 67149101027 scopus 로고    scopus 로고
    • C-KIT signaling as the driving oncogenic event in sub-groups of melanomas
    • Smalley KS, Sondak VK, Weber JS. c-KIT signaling as the driving oncogenic event in sub-groups of melanomas. Histol. Histopathol. 24(5), 643-650 (2009).
    • (2009) Histol. Histopathol. , vol.24 , Issue.5 , pp. 643-650
    • Smalley, K.S.1    Sondak, V.K.2    Weber, J.S.3
  • 31
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin JA, Fridlyand J, Kageshita T et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353(20), 2135-2147 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.20 , pp. 2135-2147
    • Curtin, J.A.1    Fridlyand, J.2    Kageshita, T.3
  • 33
    • 31544442670 scopus 로고    scopus 로고
    • Oncogenic BRAF is required for tumor growth and maintenance in melanoma models
    • Hoeflich KP, Gray DC, Eby MT et al. Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Cancer Res. 66(2), 999-1006 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.2 , pp. 999-1006
    • Hoeflich, K.P.1    Gray, D.C.2    Eby, M.T.3
  • 34
    • 0038697566 scopus 로고    scopus 로고
    • Raf proteins and cancer: B-Raf is identified as a mutational target
    • Mercer KE, Pritchard CA. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim. Biophys. Acta 1653(1), 25-40 (2003).
    • (2003) Biochim. Biophys. Acta , vol.1653 , Issue.1 , pp. 25-40
    • Mercer, K.E.1    Pritchard, C.A.2
  • 35
    • 0042885906 scopus 로고    scopus 로고
    • BRAF as a potential therapeutic target in melanoma and other malignancies
    • Tuveson DA, Weber BL, Herlyn M. BRAF as a potential therapeutic target in melanoma and other malignancies. Cancer Cell 4(2), 95-98 (2003).
    • (2003) Cancer Cell , vol.4 , Issue.2 , pp. 95-98
    • Tuveson, D.A.1    Weber, B.L.2    Herlyn, M.3
  • 36
    • 2942607408 scopus 로고    scopus 로고
    • Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis
    • Houben R, Becker JC, Kappel A et al. Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J. Carcinog. 3(1), 6 (2004).
    • (2004) J. Carcinog. , vol.3 , Issue.1 , pp. 6
    • Houben, R.1    Becker, J.C.2    Kappel, A.3
  • 37
    • 0348223934 scopus 로고    scopus 로고
    • NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression
    • Omholt K, Platz A, Kanter L, Ringborg U, Hansson J. NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin. Cancer Res. 9(17), 6483-6488 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.17 , pp. 6483-6488
    • Omholt, K.1    Platz, A.2    Kanter, L.3    Ringborg, U.4    Hansson, J.5
  • 38
    • 84978034236 scopus 로고    scopus 로고
    • Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    • Long GV, Menzies AM, Nagrial AM et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J. Clin. Oncol. 29(10), 1239-1246 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.10 , pp. 1239-1246
    • Long, G.V.1    Menzies, A.M.2    Nagrial, A.M.3
  • 40
    • 79960848073 scopus 로고    scopus 로고
    • Sorafenib and dacarbazine as first-line therapy for advanced melanoma: Phase i and open-label Phase II studies
    • Eisen T, Marais R, Affolter A et al. Sorafenib and dacarbazine as first-line therapy for advanced melanoma: Phase I and open-label Phase II studies. Br. J. Cancer 105(3), 353-359 (2011).
    • (2011) Br. J. Cancer , vol.105 , Issue.3 , pp. 353-359
    • Eisen, T.1    Marais, R.2    Affolter, A.3
  • 41
    • 51049095131 scopus 로고    scopus 로고
    • A Phase i trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel
    • Flaherty KT, Schiller J, Schuchter LM et al. A Phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel. Clin. Cancer Res. 14(15), 4836-4842 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.15 , pp. 4836-4842
    • Flaherty, K.T.1    Schiller, J.2    Schuchter, L.M.3
  • 42
    • 67649909568 scopus 로고    scopus 로고
    • Results of a Phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U et al. Results of a Phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J. Clin. Oncol. 27(17), 2823-2830 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.17 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3
  • 43
    • 78650633021 scopus 로고    scopus 로고
    • Computational medicinal chemistry in fragment-based drug discovery: What, how and when
    • Rabal O, Urbano-Cuadrado M, Oyarzabal J. Computational medicinal chemistry in fragment-based drug discovery: what, how and when. Future Med. Chem. 3(1), 95-134 (2011).
    • (2011) Future Med. Chem. , vol.3 , Issue.1 , pp. 95-134
    • Rabal, O.1    Urbano-Cuadrado, M.2    Oyarzabal, J.3
  • 44
    • 84856389159 scopus 로고    scopus 로고
    • Structural biology and drug discovery of difficult targets: The limits of ligandability
    • Surade S, Blundell TL. Structural biology and drug discovery of difficult targets: the limits of ligandability. Chem. Biol. 19(1), 42-50 (2012).
    • (2012) Chem. Biol. , vol.19 , Issue.1 , pp. 42-50
    • Surade, S.1    Blundell, T.L.2
  • 45
    • 79961000327 scopus 로고    scopus 로고
    • Ligand specificity, privileged substructures and protein druggability from fragment-based screening
    • Barelier S, Krimm I. Ligand specificity, privileged substructures and protein druggability from fragment-based screening. Curr. Opin. Chem. Biol. 15(4), 469-474 (2011).
    • (2011) Curr. Opin. Chem. Biol. , vol.15 , Issue.4 , pp. 469-474
    • Barelier, S.1    Krimm, I.2
  • 46
    • 75849142553 scopus 로고    scopus 로고
    • Scaffold-based design of kinase inhibitors for cancer therapy
    • Zhang C, Bollag G. Scaffold-based design of kinase inhibitors for cancer therapy. Curr. Opin. Genet. Dev. 20(1), 79-86 (2010).
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , Issue.1 , pp. 79-86
    • Zhang, C.1    Bollag, G.2
  • 47
    • 67049154293 scopus 로고    scopus 로고
    • The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase
    • Xie P, Streu C, Qin J et al. The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. Biochemistry 48(23), 5187-5198 (2009).
    • (2009) Biochemistry , vol.48 , Issue.23 , pp. 5187-5198
    • Xie, P.1    Streu, C.2    Qin, J.3
  • 48
    • 42949149240 scopus 로고    scopus 로고
    • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
    • Tsai J, Lee JT, Wang W et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc. Natl Acad. Sci. USA 105(8), 3041-3046 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.8 , pp. 3041-3046
    • Tsai, J.1    Lee, J.T.2    Wang, W.3
  • 49
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G, Hirth P, Tsai J et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467(7315), 596-599 (2010).
    • (2010) Nature , vol.467 , Issue.7315 , pp. 596-599
    • Bollag, G.1    Hirth, P.2    Tsai, J.3
  • 50
    • 77957089182 scopus 로고    scopus 로고
    • The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
    • Joseph EW, Pratilas CA, Poulikakos PI et al. The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner. Proc. Natl Acad. Sci. USA 107(33), 14903-14908 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.33 , pp. 14903-14908
    • Joseph, E.W.1    Pratilas, C.A.2    Poulikakos, P.I.3
  • 51
    • 77954376912 scopus 로고    scopus 로고
    • RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models
    • Yang H, Higgins B, Kolinsky K et al. RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res. 70(13), 5518-5527 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.13 , pp. 5518-5527
    • Yang, H.1    Higgins, B.2    Kolinsky, K.3
  • 52
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464(7287), 427-430 (2010).
    • (2010) Nature , vol.464 , Issue.7287 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 53
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou G, Song K, Yen I et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 464(7287), 431-435 (2010).
    • (2010) Nature , vol.464 , Issue.7287 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3
  • 54
    • 77956029013 scopus 로고    scopus 로고
    • Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma
    • Tap WD, Gong KW, Dering J et al. Pharmacodynamic characterization of the efficacy signals due to selective BRAF inhibition with PLX4032 in malignant melanoma. Neoplasia 12(8), 637-649 (2010).
    • (2010) Neoplasia , vol.12 , Issue.8 , pp. 637-649
    • Tap, W.D.1    Gong, K.W.2    Dering, J.3
  • 55
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363(9), 809-819 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 56
    • 79959776574 scopus 로고    scopus 로고
    • BRIM-2: An open-label, multicenter Phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma
    • Ribas A, Kim KB, Schuchter LM et al. BRIM-2: An open-label, multicenter Phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma. ASCO Meeting Abstracts 29(15 Suppl.), 8509 (2011).
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.15 SUPPL. , pp. 8509
    • Ribas, A.1    Kim, K.B.2    Schuchter, L.M.3
  • 57
    • 84863590891 scopus 로고    scopus 로고
    • Co-development of a companion diagnostic for targeted cancer therapy
    • Cheng S, Koch WH, Wu L. Co-development of a companion diagnostic for targeted cancer therapy. N. Biotechnol. 29(6), 682-688 (2012).
    • (2012) N. Biotechnol. , vol.29 , Issue.6 , pp. 682-688
    • Cheng, S.1    Koch, W.H.2    Wu, L.3
  • 58
    • 84862584008 scopus 로고    scopus 로고
    • Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma
    • Menzies AM, Haydu LE, Visintin L et al. Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma. Clin. Cancer Res. 18(12), 3242-3249 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.12 , pp. 3242-3249
    • Menzies, A.M.1    Haydu, L.E.2    Visintin, L.3
  • 59
    • 84862732834 scopus 로고    scopus 로고
    • Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations
    • Greger JG, Eastman SD, Zhang V et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol. Cancer Ther. 11(4), 909-920 (2012).
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.4 , pp. 909-920
    • Greger, J.G.1    Eastman, S.D.2    Zhang, V.3
  • 60
    • 79953781233 scopus 로고    scopus 로고
    • Prognostic factors for survival in melanoma patients with brain metastases
    • Davies MA, Liu P, McIntyre S et al. Prognostic factors for survival in melanoma patients with brain metastases. Cancer 117(8), 1687-1696 (2011).
    • (2011) Cancer , vol.117 , Issue.8 , pp. 1687-1696
    • Davies, M.A.1    Liu, P.2    McIntyre, S.3
  • 61
    • 84861083983 scopus 로고    scopus 로고
    • Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A Phase 1 dose-escalation trial
    • Falchook GS, Long GV, Kurzrock R et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a Phase 1 dose-escalation trial. Lancet 379(9829), 1893-1901 (2012).
    • (2012) Lancet , vol.379 , Issue.9829 , pp. 1893-1901
    • Falchook, G.S.1    Long, G.V.2    Kurzrock, R.3
  • 62
    • 84855179546 scopus 로고    scopus 로고
    • Vemurafenib for melanoma metastases to the brain
    • Rochet NM, Kottschade LA, Markovic SN. Vemurafenib for melanoma metastases to the brain. N. Engl. J. Med. 365(25), 2439-2441 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , Issue.25 , pp. 2439-2441
    • Rochet, N.M.1    Kottschade, L.A.2    Markovic, S.N.3
  • 63
    • 84868120907 scopus 로고    scopus 로고
    • Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, Phase 2 trial
    • Long GV, Trefzer U, Davies MA et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, Phase 2 trial. Lancet Oncol. 13(11), 1087-1095 (2012).
    • (2012) Lancet Oncol. , vol.13 , Issue.11 , pp. 1087-1095
    • Long, G.V.1    Trefzer, U.2    Davies, M.A.3
  • 64
    • 84859183431 scopus 로고    scopus 로고
    • Melanoma whole-exome sequencing identifies (V600E)B-RAF amplificationmediated acquired B-RAF inhibitor resistance
    • Shi H, Moriceau G, Kong X et al. Melanoma whole-exome sequencing identifies (V600E)B-RAF amplificationmediated acquired B-RAF inhibitor resistance. Nat. Commun. 3, 724 (2012).
    • (2012) Nat. Commun. , vol.3 , Issue.724
    • Shi, H.1    Moriceau, G.2    Kong, X.3
  • 65
    • 83455254767 scopus 로고    scopus 로고
    • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
    • Poulikakos PI, Persaud Y, Janakiraman M et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480(7377), 387-390 (2011).
    • (2011) Nature , vol.480 , Issue.7377 , pp. 387-390
    • Poulikakos, P.I.1    Persaud, Y.2    Janakiraman, M.3
  • 66
    • 84863115580 scopus 로고    scopus 로고
    • Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation
    • Su F, Bradley WD, Wang Q et al. Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation. Cancer Res. 72(4), 969-978 (2012).
    • (2012) Cancer Res. , vol.72 , Issue.4 , pp. 969-978
    • Su, F.1    Bradley, W.D.2    Wang, Q.3
  • 67
    • 84861381332 scopus 로고    scopus 로고
    • Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells
    • Basile KJ, Abel EV, Aplin AE. Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells. Oncogene 31(19), 2471-2479 (2012).
    • (2012) Oncogene , vol.31 , Issue.19 , pp. 2471-2479
    • Basile, K.J.1    Abel, E.V.2    Aplin, A.E.3
  • 68
    • 79960946383 scopus 로고    scopus 로고
    • Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition
    • Shi H, Kong X, Ribas A, Lo RS. Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition. Cancer Res. 71(15), 5067-5074 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.15 , pp. 5067-5074
    • Shi, H.1    Kong, X.2    Ribas, A.3    Lo, R.S.4
  • 69
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva J, Vultur A, Lee JT et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18(6), 683-695 (2010).
    • (2010) Cancer Cell , vol.18 , Issue.6 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3
  • 70
    • 79953325104 scopus 로고    scopus 로고
    • PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
    • Paraiso KH, Xiang Y, Rebecca VW et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res. 71(7), 2750-2760 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.7 , pp. 2750-2760
    • Paraiso, K.H.1    Xiang, Y.2    Rebecca, V.W.3
  • 71
    • 83355170673 scopus 로고    scopus 로고
    • Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway
    • Atefi M, von Euw E, Attar N et al. Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway. PLoS ONE 6(12), e28973 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.12
    • Atefi, M.1    Von Euw, E.2    Attar, N.3
  • 72
    • 84860533156 scopus 로고    scopus 로고
    • The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms
    • Paraiso KH, Haarberg HE, Wood E et al. The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms. Clin. Cancer Res. 18(9), 2502-2514 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.9 , pp. 2502-2514
    • Paraiso, K.H.1    Haarberg, H.E.2    Wood, E.3
  • 73
    • 84862908097 scopus 로고    scopus 로고
    • RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
    • Su F, Viros A, Milagre C et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N. Engl. J. Med. 366(3), 207-215 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.3 , pp. 207-215
    • Su, F.1    Viros, A.2    Milagre, C.3
  • 74
    • 84862908526 scopus 로고    scopus 로고
    • RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors
    • Oberholzer PA, Kee D, Dziunycz P et al. RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors. J. Clin. Oncol. 30(3), 316-321 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.3 , pp. 316-321
    • Oberholzer, P.A.1    Kee, D.2    Dziunycz, P.3
  • 76
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N. Engl. J. Med. 367(18), 1694-1703 (2012).
    • (2012) N. Engl. J. Med. , vol.367 , Issue.18 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 77
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • Boni A, Cogdill AP, Dang P et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 70(13), 5213-5219 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.13 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3
  • 78
    • 79959206459 scopus 로고    scopus 로고
    • CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans
    • Huang RR, Jalil J, Economou JS et al. CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans. Clin. Cancer Res. 17(12), 4101-4109 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.12 , pp. 4101-4109
    • Huang, R.R.1    Jalil, J.2    Economou, J.S.3
  • 79
    • 84864059240 scopus 로고    scopus 로고
    • Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A
    • Martin MJ, Hayward R, Viros A, Marais R. Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. Cancer Discov. 2(4), 344-355 (2012).
    • (2012) Cancer Discov. , vol.2 , Issue.4 , pp. 344-355
    • Martin, M.J.1    Hayward, R.2    Viros, A.3    Marais, R.4
  • 80
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366(10), 883-892 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 81
    • 79551591312 scopus 로고    scopus 로고
    • Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression
    • Lin J, Goto Y, Murata H et al. Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression. Br. J. Cancer 104(3), 464-468 (2011).
    • (2011) Br. J. Cancer 104 , vol.3 , pp. 464-468
    • Lin, J.1    Goto, Y.2    Murata, H.3
  • 82
    • 84864042630 scopus 로고    scopus 로고
    • BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma
    • Colombino M, Capone M, Lissia A et al. BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J. Clin. Oncol. 30(20), 2522-2529 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.20 , pp. 2522-2529
    • Colombino, M.1    Capone, M.2    Lissia, A.3
  • 83
    • 84876843564 scopus 로고    scopus 로고
    • Cancer Research UK: Accessed 10 May 2012
    • Cancer Research UK: Cancer Statistics. http://info.cancerresearchuk.org/ cancerstats/types/skin/ incidence/#Malignant (Accessed 10 May 2012)
    • Cancer Statistics.
  • 85
    • 84876835660 scopus 로고    scopus 로고
    • Catalogue of Somatic Mutations in Cancer (COSMIC). Accessed 10 May 2012
    • Catalogue of Somatic Mutations in Cancer (COSMIC). www.sanger.ac.uk/ genetics/CGP/cosmic (Accessed 10 May 2012)
  • 87
    • 84876880630 scopus 로고    scopus 로고
    • Accessed 12 May 2012
    • BRAF Mutations Other than V600E. http://clinicaltrials.gov/ct2/show/ NCT015 86195?term=vemurafenib&rank=12 (Accessed 12 May 2012)
    • BRAF Mutations Other Than V600E
  • 89
    • 84876882593 scopus 로고    scopus 로고
    • ClincalTrials.gov. Studies Involving Vemurafenib. Accessed 13 May 2012
    • ClincalTrials.gov. Studies involving vemurafenib. http://clinicaltrials. gov/ct2/ results?term=vemurafenib (Accessed 13 May 2012)
  • 90
    • 84876842480 scopus 로고    scopus 로고
    • ClincalTrials.gov. Ph III Ipilimumab Vemurafenib Combo. Accessed 13 May 2012
    • ClincalTrials.gov. Ph I/II Ipilimumab Vemurafenib Combo. http://clinicaltrials.gov/ct2/show/NCT014 00451?term=vemurafenib&rank=7 (Accessed 13 May 2012)


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