Increased Bronchial Density of CD25+Foxp3+ Regulatory T Cells in Occupational Asthma: Relationship to Current Smoking

Scandinavian Journal of Immunology

Volumn 77, Issue 5, 2013, Pages 398-404

  Sjaheim T B ^a,b   Bjørtuft, Ø ^b   Drablos P A ^c   Kongerud, J ^b   Halstensen, T S ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c Health Department   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; HLA DR ANTIGEN; LYMPHOCYTE SURFACE MARKER; TRANSCRIPTION FACTOR FOXP3;

ADULT; ALUMINUM FACTORY; ARTICLE; BRONCHUS; BRONCHUS BIOPSY; CD25+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; OCCUPATIONAL ASTHMA; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SMOKING; T LYMPHOCYTE ACTIVATION;

ADULT; ASTHMA, OCCUPATIONAL; BRONCHI; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; HLA-DR ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; SMOKING; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84876811886     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12035     Document Type: Article

References (34)

1. Kongerud J, Boe J, Soyseth V, Naalsund A, Magnus P. Aluminium potroom asthma: the Norwegian experience. Eur Resp J 1994;7:165-72.
2. Mapp CE, Boschetto P, Maestrelli P, Fabbri LM. Occupational Asthma. Am J Respir Crit Care Med 2005;172:280-305.
3. Sjaheim T, Halstensen TS, Lund MB et al. Airway inflammation in aluminium potroom asthma. Occup Environ Med 2004;61:779-85.
4. Sjaheim T, Kongerud J, Bjortuft O, Drablos PA, Malterud D, Halstensen TS. Reduced bronchial CD4+ T-cell density in smokers with occupational asthma. Eur Respir J 2006;28:1138-44.
5. Azzawi M, Bradley B, Jeffery PK et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Resp Dis 1990;142:1407-13.
6. Bentley AM, Menz G, Storz C et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am Rev Resp Dis 1992;146:500-6.
7. Bentley AM, Maestrelli P, Saetta M et al. Activated T-lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma. J Allergy & Clin Immunol 1992;89:821-9.
8. Yagi H, Nomura T, Nakamura K et al. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 2004;16:1643-56.
9. Chatila TA. Role of regulatory T cells in human diseases. J Allergy Clin Immunol 2005;116:949-59.
10. Robinson DS. Regulatory T cells and asthma. Clin Exp Allergy 2009;39:1314-23.
11. Umetsu DT, DeKruyff RH. The regulation of allergy and asthma. Immunol Rev 2006;212:238-55.
12. Larche M. Regulatory T Cells in Allergy and Asthma. Chest 2007;132:1007-14.
13. Hartl D, Koller B, Mehlhorn AT et al. Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007;119:1258-66.
14. Lee JH, Yu HH, Wang LC, Yang YH, Lin YT, Chiang BL. The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma. Clin Exp Immunol 2007;148:53-63.
15. Shi HZ, Li S, Xie ZF, Qin XJ, Qin X, Zhong XN. Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma. Clin Immunol 2004;113:172-8.
16. Sullivan P, Stephens D, Ansari T, Costello J, Jeffery P. Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies. Eur Resp J 1998;12:811-5.
17. Kay AB. The role of T Lymphocytes in Asthma. Chem Immunol Allergy 2007;91:59-75.
18. Smyth LJ, Eustace A, Kolsum U, Blaikely J, Singh D. Increased airway T regulatory cells in asthmatic subjects. Chest 2010;138:905-12.
19. Nguyen KD, Vanichsarn C, Nadeau KC. TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway Allergy. Asthma Clin Immunol 2010;6:4.
20. Suto A, Nakajima H, Kagami SI, Suzuki K, Saito Y, Iwamoto I. Role of CD4+ CD25+ Regulatory T Cells in T Helper 2 Cell-mediated Allergic Inflammation in the Airways. Am J Respir Crit Care Med 2001;164:680-7.
21. Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007;445:766-70.
22. Walker LSK, Chodos A, Eggena M, Dooms H, Abbas AK. Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo. J Exp Med 2003;198:249-58.
23. Vukmanovic-Stejic M, Zhang Y, Cook JE et al. Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 2006;116:2423-33.
24. Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-β dependent but does not confer a regulatory phenotype. Blood 2007;110:2983-90.
25. Allan SE, Crome SQ, Crellin NK et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 2007;19:345-54.
26. Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C. Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunol. 2009;182:1689-95.
27. Voo KS, Wang YH, Santori FR et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009;106:4793-8.
28. Valmori D, Raffin C, Raimbaud I, Ayyoub M. Human RORγt+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors. Proc Natl Acad Sci U S A. 2010;107:19402-7.
29. Pellaton-Longaretti C, Boudousquié C, Barbier N et al. CD4+CD25-mTGF-β+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma Int Immunol 2011;1:17-27.
30. Saetta M, Turato G, Maestrelli P, Mapp CE, Fabbri LM Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Critl Care Med 2001;163:1304-9.
31. O'Sullivan S, Cormican L, Faul JL et al. Activated, cytotoxic CD8(+) T lymphocytes contribute to the pathology of asthma death. Am J Respir Critical Care Med 2001;164:560-4.
32. Lambert C, McCue J, Portas M et al. Acrolein in cigarette smoke inhibits T-cell responses. J Allergy Clin Immunol 2005;116:916-22.
33. Pyatt DW, Stillman WS, Irons RD. Hydroquinone, a reactive metabolite of benzene, inhibits NF-kappa B in primary human CD4+ T lymphocytes. Toxicol Appl Pharmacol 1998, 149: 178-84.
34. Tsoumakidou M, Elston W, Zhu J et al. Cigarette Smoking Alters Bronchial Mucosal Immunity in Asthma. Am J Respir Crit Care Med 2007;175:919-25.