메뉴 건너뛰기




Volumn 44, Issue 2, 2013, Pages 519-528

Dietary l-leucine and l-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity

Author keywords

Diet induced fatty liver; Energy intake; High protein diet; l Alanine supplementation; l Leucine supplementation; Metabolic syndrome; Satiety; Water intake

Indexed keywords

ALANINE; CHOLESTEROL; FATTY ACID SYNTHASE; GLUCOSE; HORMONE SENSITIVE LIPASE; INSULIN; LEUCINE; NITROGEN; PYRUVATE KINASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

EID: 84876791382     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1363-2     Document Type: Article
Times cited : (70)

References (42)
  • 1
    • 84862282554 scopus 로고    scopus 로고
    • Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state
    • 22332087 1:CAS:528:DC%2BC3MXhs1CrtrnF
    • Adams SH (2011) Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv Nutr 2(6):445-456
    • (2011) Adv Nutr , vol.2 , Issue.6 , pp. 445-456
    • Adams, S.H.1
  • 2
    • 77649180245 scopus 로고    scopus 로고
    • Lipolysis in adipocytes
    • 20025992 10.1016/j.biocel.2009.12.009 1:CAS:528:DC%2BC3cXivFGrur8%3D
    • Ahmadian M, Wang Y, Sul HS (2010) Lipolysis in adipocytes. Int J Biochem Cell Biol 42(5):555-559
    • (2010) Int J Biochem Cell Biol , vol.42 , Issue.5 , pp. 555-559
    • Ahmadian, M.1    Wang, Y.2    Sul, H.S.3
  • 3
    • 79953313457 scopus 로고    scopus 로고
    • The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice
    • 21372430 10.1507/endocrj.K10E-221 1:CAS:528:DC%2BC3MXpsVGks7Y%3D
    • Arakawa M, Masaki T, Nishimura J, Seike M, Yoshimatsu H (2011) The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice. Endocr J 58(3):161-170
    • (2011) Endocr J , vol.58 , Issue.3 , pp. 161-170
    • Arakawa, M.1    Masaki, T.2    Nishimura, J.3    Seike, M.4    Yoshimatsu, H.5
  • 5
    • 68949128765 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity
    • 19296907 10.1016/j.physbeh.2009.03.006 1:CAS:528:DC%2BD1MXmvF2it7s%3D
    • Cota D (2009) Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity. Physiol Behav 97(5):520-524
    • (2009) Physiol Behav , vol.97 , Issue.5 , pp. 520-524
    • Cota, D.1
  • 6
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • 16690869 10.1126/science.1124147 1:CAS:528:DC%2BD28Xktlyhs7Y%3D
    • Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ (2006) Hypothalamic mTOR signaling regulates food intake. Science 312(5775):927-930
    • (2006) Science , vol.312 , Issue.5775 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Smith, K.A.3    Kozma, S.C.4    Thomas, G.5    Woods, S.C.6    Seeley, R.J.7
  • 7
    • 45449100939 scopus 로고    scopus 로고
    • Water consumption reduces energy intake at a breakfast meal in obese older adults
    • 18589036 10.1016/j.jada.2008.04.013
    • Davy BM, Dennis EA, Dengo AL, Wilson KL, Davy KP (2008) Water consumption reduces energy intake at a breakfast meal in obese older adults. J Am Diet Assoc 108(7):1236-1239
    • (2008) J Am Diet Assoc , vol.108 , Issue.7 , pp. 1236-1239
    • Davy, B.M.1    Dennis, E.A.2    Dengo, A.L.3    Wilson, K.L.4    Davy, K.P.5
  • 8
    • 70349389758 scopus 로고    scopus 로고
    • Beverage consumption and adult weight management: A review
    • 19778754 10.1016/j.eatbeh.2009.07.006
    • Dennis EA, Flack KD, Davy BM (2009) Beverage consumption and adult weight management: a review. Eat Behav 10(4):237-246
    • (2009) Eat Behav , vol.10 , Issue.4 , pp. 237-246
    • Dennis, E.A.1    Flack, K.D.2    Davy, B.M.3
  • 9
    • 42149157213 scopus 로고    scopus 로고
    • Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis
    • 18403916 10.1097/MCO.0b013e3282fa17fb 1:CAS:528:DC%2BD1cXlslGgs7k%3D
    • Drummond MJ, Rasmussen BB (2008) Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis. Curr Opin Clin Nutr Metab Care 11(3):222-226
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , Issue.3 , pp. 222-226
    • Drummond, M.J.1    Rasmussen, B.B.2
  • 10
    • 0015578098 scopus 로고
    • The glucose-alanine cycle
    • 4567003 10.1016/0026-0495(73)90269-2 1:CAS:528:DyaE3sXktVyhsA%3D%3D
    • Felig P (1973) The glucose-alanine cycle. Metabolism 22(2):179-207
    • (1973) Metabolism , vol.22 , Issue.2 , pp. 179-207
    • Felig, P.1
  • 11
    • 0031820994 scopus 로고    scopus 로고
    • The 24-h whole body leucine and urea kinetics at normal and high protein intakes with exercise in healthy adults
    • 9688634 1:CAS:528:DyaK1cXlsVCktrc%3D
    • Forslund AH, Hambraeus L, Olsson RM, El-Khoury AE, Yu YM, Young VR (1998) The 24-h whole body leucine and urea kinetics at normal and high protein intakes with exercise in healthy adults. Am J Physiol 275(2 Pt 1):E310-E320
    • (1998) Am J Physiol , vol.275 , Issue.2 PART 1
    • Forslund, A.H.1    Hambraeus, L.2    Olsson, R.M.3    El-Khoury, A.E.4    Yu, Y.M.5    Young, V.R.6
  • 12
    • 84867720919 scopus 로고    scopus 로고
    • Comparison of high-protein diets and leucine supplementation on metabolic syndrome and related disorders in mice
    • doi: 10.1016/j.jnutbio.2011.10.005
    • Freudenberg A, Petzke KJ, Klaus S (2012) Comparison of high-protein diets and leucine supplementation on metabolic syndrome and related disorders in mice. J Nutr Biochem. doi: 10.1016/j.jnutbio.2011.10.005
    • (2012) J Nutr Biochem
    • Freudenberg, A.1    Petzke, K.J.2    Klaus, S.3
  • 13
    • 77954395002 scopus 로고    scopus 로고
    • Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus
    • 10.1186/1743-7075-7-57
    • Guo K, Yu YH, Hou J, Zhang Y (2010) Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus. Nutr Metab (Lond) 7:57
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 57
    • Guo, K.1    Yu, Y.H.2    Hou, J.3    Zhang, Y.4
  • 14
    • 14644413174 scopus 로고    scopus 로고
    • The effects of high protein diets on thermogenesis, satiety and weight loss: A critical review
    • 15466943
    • Halton TL, Hu FB (2004) The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review. J Am Coll Nutr 23(5):373-385
    • (2004) J Am Coll Nutr , vol.23 , Issue.5 , pp. 373-385
    • Halton, T.L.1    Hu, F.B.2
  • 15
    • 61449132407 scopus 로고    scopus 로고
    • Comparison of 2 diets with either 25 % or 10 % of energy as casein on energy expenditure, substrate balance, and appetite profile
    • 19176726 10.3945/ajcn.2008.26917 1:CAS:528:DC%2BD1MXjtFGltbs%3D
    • Hochstenbach-Waelen A, Veldhorst MA, Nieuwenhuizen AG, Westerterp-Plantenga MS, Westerterp KR (2009) Comparison of 2 diets with either 25 % or 10 % of energy as casein on energy expenditure, substrate balance, and appetite profile. Am J Clin Nutr 89(3):831-838
    • (2009) Am J Clin Nutr , vol.89 , Issue.3 , pp. 831-838
    • Hochstenbach-Waelen, A.1    Veldhorst, M.A.2    Nieuwenhuizen, A.G.3    Westerterp-Plantenga, M.S.4    Westerterp, K.R.5
  • 16
    • 80054959391 scopus 로고    scopus 로고
    • Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet - Effect of starvation
    • 21963952 10.1016/j.fct.2011.09.016 1:CAS:528:DC%2BC3MXhsFSjt7bL
    • Holecek M, Kovarik M (2011) Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet - effect of starvation. Food Chem Toxicol 49(12):3336-3342
    • (2011) Food Chem Toxicol , vol.49 , Issue.12 , pp. 3336-3342
    • Holecek, M.1    Kovarik, M.2
  • 17
    • 0031746136 scopus 로고    scopus 로고
    • Salvage of urea-nitrogen in the large bowel: Functional significance in metabolic control and adaptation
    • 9649753 1:CAS:528:DyaK1cXjvVakurs%3D
    • Jackson AA (1998) Salvage of urea-nitrogen in the large bowel: functional significance in metabolic control and adaptation. Biochem Soc Trans 26(2):231-236
    • (1998) Biochem Soc Trans , vol.26 , Issue.2 , pp. 231-236
    • Jackson, A.A.1
  • 19
    • 40149106348 scopus 로고    scopus 로고
    • Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1
    • 18042832 1:CAS:528:DC%2BD1cXmt1Wju74%3D
    • Katterle Y, Keipert S, Hof J, Klaus S (2008) Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1. Physiol Genomics 32(3):352-359
    • (2008) Physiol Genomics , vol.32 , Issue.3 , pp. 352-359
    • Katterle, Y.1    Keipert, S.2    Hof, J.3    Klaus, S.4
  • 20
    • 23244437927 scopus 로고    scopus 로고
    • Increasing the protein:carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice
    • 16046708 1:CAS:528:DC%2BD2MXnvVSmtb4%3D
    • Klaus S (2005) Increasing the protein:carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice. J Nutr 135(8):1854-1858
    • (2005) J Nutr , vol.135 , Issue.8 , pp. 1854-1858
    • Klaus, S.1
  • 21
    • 21244480070 scopus 로고    scopus 로고
    • Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    • 15687481 10.1152/physiolgenomics.00299.2004 1:CAS:528: DC%2BD2MXktVCjs7k%3D
    • Klaus S, Rudolph B, Dohrmann C, Wehr R (2005) Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation. Physiol Genomics 21(2):193-200
    • (2005) Physiol Genomics , vol.21 , Issue.2 , pp. 193-200
    • Klaus, S.1    Rudolph, B.2    Dohrmann, C.3    Wehr, R.4
  • 22
    • 79959453305 scopus 로고    scopus 로고
    • Dietary leucine - An environmental modifier of insulin resistance acting on multiple levels of metabolism
    • 21731668 10.1371/journal.pone.0021187 1:CAS:528:DC%2BC3MXotF2gurg%3D
    • Macotela Y, Emanuelli B, Bang AM, Espinoza DO, Boucher J et al (2011) Dietary leucine - an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One 6(6):e21187
    • (2011) PLoS One , vol.6 , Issue.6 , pp. 21187
    • Macotela, Y.1    Emanuelli, B.2    Bang, A.M.3    Espinoza, D.O.4    Boucher, J.5
  • 23
    • 78649544447 scopus 로고    scopus 로고
    • Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation
    • 20962152 10.3945/jn.110.128421
    • Murgas Torrazza R, Suryawan A, Gazzaneo MC, Orellana RA, Frank JW, Nguyen HV, Fiorotto ML, El-Kadi S, Davis TA (2010) Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr 140(12):2145-2152
    • (2010) J Nutr , vol.140 , Issue.12 , pp. 2145-2152
    • Murgas Torrazza, R.1    Suryawan, A.2    Gazzaneo, M.C.3    Orellana, R.A.4    Frank, J.W.5    Nguyen, H.V.6    Fiorotto, M.L.7    El-Kadi, S.8    Davis, T.A.9
  • 24
    • 0020597395 scopus 로고
    • Thermic response to isoenergetic protein, carbohydrate or fat meals in lean and obese subjects
    • 1:STN:280:DyaL3s3mtVamtw%3D%3D
    • Nair KS, Halliday D, Garrow JS (1983) Thermic response to isoenergetic protein, carbohydrate or fat meals in lean and obese subjects. Clin Sci (Lond) 65(3):307-312
    • (1983) Clin Sci (Lond) , vol.65 , Issue.3 , pp. 307-312
    • Nair, K.S.1    Halliday, D.2    Garrow, J.S.3
  • 25
    • 80053918222 scopus 로고    scopus 로고
    • Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets
    • 21170537 10.1007/s00394-010-0155-2 1:CAS:528:DC%2BC3MXhtVKlu7nF
    • Noatsch A, Petzke KJ, Millrose MK, Klaus S (2011) Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets. Eur J Nutr 50(6):479-488
    • (2011) Eur J Nutr , vol.50 , Issue.6 , pp. 479-488
    • Noatsch, A.1    Petzke, K.J.2    Millrose, M.K.3    Klaus, S.4
  • 26
    • 0034529471 scopus 로고    scopus 로고
    • Long-term high protein intake does not increase oxidative stress in rats
    • 11110842 1:CAS:528:DC%2BD3cXptVKmtLo%3D
    • Petzke KJ, Elsner A, Proll J, Thielecke F, Metges CC (2000) Long-term high protein intake does not increase oxidative stress in rats. J Nutr 130(12):2889-2896
    • (2000) J Nutr , vol.130 , Issue.12 , pp. 2889-2896
    • Petzke, K.J.1    Elsner, A.2    Proll, J.3    Thielecke, F.4    Metges, C.C.5
  • 27
    • 19944398463 scopus 로고    scopus 로고
    • Chlorogenic acid moderately decreases the quality of whey proteins in rats
    • 15853425 10.1021/jf048186z 1:CAS:528:DC%2BD2MXisl2jtb8%3D
    • Petzke KJ, Schuppe S, Rohn S, Rawel HM, Kroll J (2005) Chlorogenic acid moderately decreases the quality of whey proteins in rats. J Agric Food Chem 53(9):3714-3720
    • (2005) J Agric Food Chem , vol.53 , Issue.9 , pp. 3714-3720
    • Petzke, K.J.1    Schuppe, S.2    Rohn, S.3    Rawel, H.M.4    Kroll, J.5
  • 28
    • 84878346358 scopus 로고    scopus 로고
    • Dietary leucine and alanine supplementation have similar effects in the prevention of high fat diet induced obesity
    • Petzke KJ, Freudenberg A, Klaus S (2012) Dietary leucine and alanine supplementation have similar effects in the prevention of high fat diet induced obesity. FASEB J 26(820):7
    • (2012) FASEB J , vol.26 , Issue.820 , pp. 7
    • Petzke, K.J.1    Freudenberg, A.2    Klaus, S.3
  • 29
    • 0001015930 scopus 로고
    • The influence of protein intake on water balance, flow rate and apparent digestibility of nutrients at the distal ileum in growing pigs
    • 10.1016/0301-6226(95)00070-4
    • Pfeiffer A, Henkel H, Verstegen MWA, Philipczyk I (1995) The influence of protein intake on water balance, flow rate and apparent digestibility of nutrients at the distal ileum in growing pigs. Livestock Prod Sci 44(2):179-187
    • (1995) Livestock Prod Sci , vol.44 , Issue.2 , pp. 179-187
    • Pfeiffer, A.1    Henkel, H.2    Verstegen, M.W.A.3    Philipczyk, I.4
  • 30
    • 33645639207 scopus 로고    scopus 로고
    • A new proposed guidance system for beverage consumption in the United States
    • 16522898 1:CAS:528:DC%2BD28XislSku7s%3D
    • Popkin BM, Armstrong LE, Bray GM, Caballero B, Frei B, Willett WC (2006) A new proposed guidance system for beverage consumption in the United States. Am J Clin Nutr 83(3):529-542
    • (2006) Am J Clin Nutr , vol.83 , Issue.3 , pp. 529-542
    • Popkin, B.M.1    Armstrong, L.E.2    Bray, G.M.3    Caballero, B.4    Frei, B.5    Willett, W.C.6
  • 31
    • 58149141517 scopus 로고    scopus 로고
    • Protein, amino acids and the control of food intake
    • 19057188 10.1097/MCO.0b013e32831b9e01 1:CAS:528:DC%2BD1cXhsVKntLjF
    • Potier M, Darcel N, Tomé D (2009) Protein, amino acids and the control of food intake. Curr Opin Clin Nutr Metab Care 12(1):54-58
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , Issue.1 , pp. 54-58
    • Potier, M.1    Darcel, N.2    Tomé, D.3
  • 32
    • 0017893712 scopus 로고
    • Inter-organ relationships between glucose, lactate and amino acids in rats fed on high-carbohydrate or high-protein diets
    • Rémésy C, Demigné C, Aufrère J (1978) Inter-organ relationships between glucose, lactate and amino acids in rats fed on high-carbohydrate or high-protein diets. Biochem J 170(2):321-329
    • (1978) Biochem J , vol.170 , Issue.2 , pp. 321-329
    • Rémésy, C.1    Demigné, C.2    Aufrère, J.3
  • 33
    • 0023183933 scopus 로고
    • Modification of tubuloglomerular feedback signal by dietary protein
    • 3812704
    • Seney F, Persson EG, Wright FS (1987) Modification of tubuloglomerular feedback signal by dietary protein. Am J Physiol 252(1 Pt 2):F83-F90
    • (1987) Am J Physiol , vol.252 , Issue.1 PART 2
    • Seney, F.1    Persson, E.G.2    Wright, F.S.3
  • 34
    • 55249100211 scopus 로고    scopus 로고
    • Drinking water is associated with weight loss in overweight dieting women independent of diet and activity
    • 10.1038/oby.2008.409
    • Stookey JD, Constant F, Popkin BM, Gardner CD (2008) Drinking water is associated with weight loss in overweight dieting women independent of diet and activity. Obesity (Silver Spring) 16(11):2481-2488
    • (2008) Obesity (Silver Spring) , vol.16 , Issue.11 , pp. 2481-2488
    • Stookey, J.D.1    Constant, F.2    Popkin, B.M.3    Gardner, C.D.4
  • 35
    • 0029065480 scopus 로고
    • Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6 and A/J mice
    • 7752914 10.1016/0026-0495(95)90123-X 1:CAS:528:DyaK2MXlsFSlt70%3D
    • Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn CM, Rebuffe-Scrive M (1995) Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6 and A/J mice. Metabolism 44(5):645-651
    • (1995) Metabolism , vol.44 , Issue.5 , pp. 645-651
    • Surwit, R.S.1    Feinglos, M.N.2    Rodin, J.3    Sutherland, A.4    Petro, A.E.5    Opara, E.C.6    Kuhn, C.M.7    Rebuffe-Scrive, M.8
  • 36
    • 80052559088 scopus 로고    scopus 로고
    • Triennial growth symposium: Leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs
    • 20935141 10.2527/jas.2010-3400 1:CAS:528:DC%2BC3MXoslCisrk%3D
    • Suryawan A, Orellana RA, Fiorotto ML, Davis TA (2011) Triennial growth symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs. J Anim Sci 89(7):2004-2016
    • (2011) J Anim Sci , vol.89 , Issue.7 , pp. 2004-2016
    • Suryawan, A.1    Orellana, R.A.2    Fiorotto, M.L.3    Davis, T.A.4
  • 38
    • 78751591613 scopus 로고    scopus 로고
    • Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs
    • 20505962 10.1007/s00726-010-0629-9 1:CAS:528:DC%2BC3MXntVWg
    • Wilson FA, Suryawan A, Orellana RA, Gazzaneo MC, Nguyen HV, Davis TA (2011) Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs. Amino Acids 40(1):157-165
    • (2011) Amino Acids , vol.40 , Issue.1 , pp. 157-165
    • Wilson, F.A.1    Suryawan, A.2    Orellana, R.A.3    Gazzaneo, M.C.4    Nguyen, H.V.5    Davis, T.A.6
  • 39
    • 63649111659 scopus 로고    scopus 로고
    • Amino acids: Metabolism, functions, and nutrition
    • 19301095 10.1007/s00726-009-0269-0
    • Wu G (2009) Amino acids: metabolism, functions, and nutrition. Amino Acids 37(1):1-17
    • (2009) Amino Acids , vol.37 , Issue.1 , pp. 1-17
    • Wu, G.1
  • 40
    • 0034069490 scopus 로고    scopus 로고
    • Rates of urea production and hydrolysis and leucine oxidation change linearly over widely varying protein intakes in healthy adults
    • 10736327 1:CAS:528:DC%2BD3cXit1Kntbg%3D
    • Young VR, El-Khoury AE, Raguso CA, Forslund AH, Hambraeus L (2000) Rates of urea production and hydrolysis and leucine oxidation change linearly over widely varying protein intakes in healthy adults. J Nutr 130(4):761-766
    • (2000) J Nutr , vol.130 , Issue.4 , pp. 761-766
    • Young, V.R.1    El-Khoury, A.E.2    Raguso, C.A.3    Forslund, A.H.4    Hambraeus, L.5
  • 41
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • 17360978 10.2337/db07-0123 1:CAS:528:DC%2BD2sXmtlKhs70%3D
    • Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH (2007) Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56(6):1647-1654
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    Leblanc, R.E.3    Loh, D.4    Schwartz, G.J.5    Yu, Y.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.