Why detailed model gene studies in higher eukaryotes are still necessary

Immunology

Volumn 139, Issue 2, 2013, Pages 158-160

  Bonifer, Constanze ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Gene regulation; Gene regulatory networks; Genomics; Transcription factors

Indexed keywords

DNA BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MICRORNA; PIWI INTERACTING RNA; RNA; RNA POLYMERASE; TINYRNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ARTICLE; BINDING SITE; CELL CYCLE; CELL TYPE; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; EUKARYOTE; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE REGULATORY NETWORK; GENETIC MODEL; HUMAN; MOLECULAR DYNAMICS; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; SINGLE NUCLEOTIDE POLYMORPHISM; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; EUKARYOTA; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC ASSOCIATION STUDIES; GENOMICS; HUMANS; PROTEOMICS;

EID: 84876784243     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12066     Document Type: Article

References (18)

1. Higgs DR, Engel JD, Stamatoyannopoulos G. Thalassaemia. Lancet 2012; 379:373-83.
2. Wozniak RJ, Bresnick EH. Epigenetic control of complex loci during erythropoiesis. Curr Top Dev Biol 2008; 82:55-83.
3. Bolland DJ, Wood AL, Corcoran AE. Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation. Adv Exp Med Biol 2009; 650:59-72.
4. Dougherty DC, Sanders MM. Estrogen action: revitalization of the chick oviduct model. Trends Endocrinol Metab 2005; 16:414-9.
5. Vicent GP, Nacht AS, Zaurin R, Ballare C, Clausell J, Beato M. Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin. Mol Endocrinol 2010; 24:2088-98.
6. Angel A, Song J, Dean C, Howard M. A Polycomb-based switch underlying quantitative epigenetic memory. Nature 2011; 476:105-8.
7. Spitz F, Furlong EE. Transcription factors: from enhancer binding to developmental control. Nat Rev Genet 2012; 13:613-26.
8. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 1993; 90:4304-8.
9. Maurano MT, Wang H, Kutyavin T, Stamatoyannopoulos JA. Widespread site-dependent buffering of human regulatory polymorphism. PLoS Genet 2012; 8:e1002599.
10. Lichtinger M, Ingram R, Hannah R et al. RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis. EMBO J 2012; 31:4318-33.
11. Steidl U, Steidl C, Ebralidze A et al. A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. J Clin Invest 2007; 117:2611-20.
12. Kowalczyk MS, Hughes JR, Garrick D et al. Intragenic enhancers act as alternative promoters. Mol Cell 2012; 45:447-58.
13. Leddin M, Perrod C, Hoogenkamp M et al. Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells. Blood 2011; 117:2827-38.
14. Davidson EH. Emerging properties of animal gene regulatory networks. Nature 2010; 468:911-20.
15. Rowan S, Siggers T, Lachke SA, Yue Y, Bulyk ML, Maas RL. Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev 2010; 24:980-5.
16. Mattick JS. RNA driving the epigenetic bus. EMBO J 2012; 31:515-6.
17. Spitale RC, Tsai MC, Chang HY. RNA templating the epigenome: long noncoding RNAs as molecular scaffolds. Epigenetics 2011; 6:539-43.
18. Lefevre P, Witham J, Lacroix CE, Cockerill PN, Bonifer C. The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. Mol Cell 2008; 32:129-39.