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Volumn 24, Issue 10, 2010, Pages 980-985

Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity

Author keywords

DNA binding site affinity; Eye development; Gene regulation; Mathematical modeling; Protein binding microarray; Transcription factor

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PREP1; UNCLASSIFIED DRUG;

EID: 77952352833     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1890410     Document Type: Article
Times cited : (89)

References (44)
  • 1
    • 0037403778 scopus 로고    scopus 로고
    • Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene
    • DOI 10.1016/S0012-1606(03)00058-7
    • Aota S, Nakajima N, Sakamoto R, Watanabe S, Ibaraki N, Okazaki K. 2003. Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene. Dev Biol 257: 1-13. (Pubitemid 36438640)
    • (2003) Developmental Biology , vol.257 , Issue.1 , pp. 1-13
    • Aota, S.-I.1    Nakajima, N.2    Sakamoto, R.3    Watanabe, S.4    Ibaraki, N.5    Okazaki, K.6
  • 2
    • 17644397256 scopus 로고    scopus 로고
    • Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards?
    • Arnosti DN, Kulkarni MM. 2005. Transcriptional enhancers: Intelligent enhanceosomes or flexible billboards? J Cell Biochem 94: 890-898.
    • (2005) J Cell Biochem , vol.94 , pp. 890-898
    • Arnosti, D.N.1    Kulkarni, M.M.2
  • 3
    • 0034312313 scopus 로고    scopus 로고
    • Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    • DOI 10.1101/gad.184000
    • Ashery-Padan R, Marquardt T, Zhou X, Gruss P. 2000. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes & Dev 14: 2701-2711. (Pubitemid 32531197)
    • (2000) Genes and Development , vol.14 , Issue.21 , pp. 2701-2711
    • Ashery-Padan, R.1    Marquardt, T.2    Zhou, X.3    Gruss, P.4
  • 6
    • 33846186034 scopus 로고    scopus 로고
    • Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage
    • Blixt A, Landgren H, Johansson BR, Carlsson P. 2007. Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev Biol 302: 218-229.
    • (2007) Dev Biol , vol.302 , pp. 218-229
    • Blixt, A.1    Landgren, H.2    Johansson, B.R.3    Carlsson, P.4
  • 7
    • 58149481232 scopus 로고    scopus 로고
    • Properties of developmental gene regulatory networks
    • Davidson EH, Levine MS. 2008. Properties of developmental gene regulatory networks. Proc Natl Acad Sci 105: 20063-20066.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 20063-20066
    • Davidson, E.H.1    Levine, M.S.2
  • 9
    • 0035195501 scopus 로고    scopus 로고
    • The upstream ectoderm enhancer in Pax6 has an important role in lens induction
    • Dimanlig PV, Faber SC, Auerbach W, Makarenkova HP, Lang RA. 2001. The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development 128: 4415-4424. (Pubitemid 33130423)
    • (2001) Development , vol.128 , Issue.22 , pp. 4415-4424
    • Dimanlig, P.V.1    Faber, S.C.2    Auerbach, W.3    Makarenkova, H.P.4    Lang, R.A.5
  • 10
    • 33847376751 scopus 로고    scopus 로고
    • Sox2 and Pou2f1 interact to control lens and olfactory placode development
    • DOI 10.1016/j.ydbio.2006.10.047, PII S0012160606013431
    • Donner AL, Episkopou V, Maas RL. 2007. Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol 303: 784-799. (Pubitemid 46341275)
    • (2007) Developmental Biology , vol.303 , Issue.2 , pp. 784-799
    • Donner, A.L.1    Episkopou, V.2    Maas, R.L.3
  • 11
    • 0024323615 scopus 로고
    • Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
    • DOI 10.1038/340363a0
    • Driever W, Thoma G, Nüsslein-Volhard C. 1989. Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen. Nature 340: 363-367. (Pubitemid 19191601)
    • (1989) Nature , vol.340 , Issue.6232 , pp. 363-367
    • Driever, W.1    Thoma, G.2    Nusslein-Volhard, C.3
  • 13
    • 0033005668 scopus 로고    scopus 로고
    • The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
    • Ferretti E, Schulz H, Talarico D, Blasi F, Berthelsen J. 1999. The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse. Mech Dev 83: 53-64.
    • (1999) Mech Dev , vol.83 , pp. 53-64
    • Ferretti, E.1    Schulz, H.2    Talarico, D.3    Blasi, F.4    Berthelsen, J.5
  • 15
    • 0036468361 scopus 로고    scopus 로고
    • Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4
    • Gaudet J, Mango SE. 2002. Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Science 295: 821-825.
    • (2002) Science , vol.295 , pp. 821-825
    • Gaudet, J.1    Mango, S.E.2
  • 16
    • 58149354385 scopus 로고    scopus 로고
    • Analysis of combinatorial cisregulation in synthetic and genomic promoters
    • Gertz J, Siggia ED, Cohen BA. 2009. Analysis of combinatorial cisregulation in synthetic and genomic promoters. Nature 457: 215-218.
    • (2009) Nature , vol.457 , pp. 215-218
    • Gertz, J.1    Siggia, E.D.2    Cohen, B.A.3
  • 17
    • 75949115944 scopus 로고    scopus 로고
    • Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs
    • Giorgetti L, Siggers T, Tiana G, Caprara G, Notarbartolo S, Corona T, Pasparakis M, Milani P, Bulyk ML, Natoli G. 2010. Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Mol Cell 37: 418-428.
    • (2010) Mol Cell , vol.37 , pp. 418-428
    • Giorgetti, L.1    Siggers, T.2    Tiana, G.3    Caprara, G.4    Notarbartolo, S.5    Corona, T.6    Pasparakis, M.7    Milani, P.8    Bulyk, M.L.9    Natoli, G.10
  • 18
    • 0028074973 scopus 로고
    • PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects
    • DOI 10.1038/ng0894-463
    • Glaser T, Jepeal L, Edwards JG, Young SR, Favor J, Maas RL. 1994. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nat Genet 7: 463-471. (Pubitemid 24308331)
    • (1994) Nature Genetics , vol.7 , Issue.4 , pp. 463-471
    • Glaser, T.1    Jepeal, L.2    Edwards, J.G.3    Young, S.R.4    Favor, J.5    Maas, R.L.6
  • 19
    • 70350731108 scopus 로고    scopus 로고
    • Distinguishing direct versus indirect transcription factor-DNA interactions
    • Gordan R, Hartemink AJ, Bulyk ML. 2009. Distinguishing direct versus indirect transcription factor-DNA interactions. Genome Res 19: 2090-2100.
    • (2009) Genome Res , vol.19 , pp. 2090-2100
    • Gordan, R.1    Hartemink, A.J.2    Bulyk, M.L.3
  • 20
    • 34447099234 scopus 로고    scopus 로고
    • Probing the limits to positional information
    • Gregor T, Tank DW, Wieschaus EF, Bialek W. 2007. Probing the limits to positional information. Cell 130: 153-164.
    • (2007) Cell , vol.130 , pp. 153-164
    • Gregor, T.1    Tank, D.W.2    Wieschaus, E.F.3    Bialek, W.4
  • 21
    • 0029002548 scopus 로고
    • The role of Pax-6 in eye and nasal development
    • Grindley JC, Davidson DR, Hill RE. 1995. The role of Pax-6 in eye and nasal development. Development 121: 1433-1442.
    • (1995) Development , vol.121 , pp. 1433-1442
    • Grindley, J.C.1    Davidson, D.R.2    Hill, R.E.3
  • 23
    • 34547641224 scopus 로고    scopus 로고
    • Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family
    • Hollenhorst PC, Shah AA, Hopkins C, Graves BJ. 2007. Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes & Dev 21: 1882-1894.
    • (2007) Genes & Dev , vol.21 , pp. 1882-1894
    • Hollenhorst, P.C.1    Shah, A.A.2    Hopkins, C.3    Graves, B.J.4
  • 24
    • 77950339177 scopus 로고    scopus 로고
    • Conservation and regulatory associations of a wide affinity range of mouse transcription factor binding sites
    • Jaeger SA, Chan ET, Berger MF, Stottmann R, Hughes TR, Bulyk ML. 2010. Conservation and regulatory associations of a wide affinity range of mouse transcription factor binding sites. Genomics 95: 185-195.
    • (2010) Genomics , vol.95 , pp. 185-195
    • Jaeger, S.A.1    Chan, E.T.2    Berger, M.F.3    Stottmann, R.4    Hughes, T.R.5    Bulyk, M.L.6
  • 25
    • 0027511507 scopus 로고
    • Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
    • Jiang J, Levine M. 1993. Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell 72: 741-752.
    • (1993) Cell , vol.72 , pp. 741-752
    • Jiang, J.1    Levine, M.2
  • 26
    • 0032895297 scopus 로고    scopus 로고
    • Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity
    • Kammandel B, Chowdhury K, Stoykova A, Aparicio S, Brenner S, Gruss P. 1999. Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol 205: 79-97.
    • (1999) Dev Biol , vol.205 , pp. 79-97
    • Kammandel, B.1    Chowdhury, K.2    Stoykova, A.3    Aparicio, S.4    Brenner, S.5    Gruss, P.6
  • 27
    • 55549113874 scopus 로고    scopus 로고
    • A quantitative model of transcription factor-activated gene expression
    • Kim H, O'Shea EK. 2008. A quantitative model of transcription factor-activated gene expression. Nat Struct Mol Biol 15: 1192-1198.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 1192-1198
    • Kim, H.1    O'Shea, E.K.2
  • 28
    • 67749113808 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits: Predicting numbers from alphabets
    • Kim HD, Shay T, O'Shea EK, Regev A. 2009. Transcriptional regulatory circuits: Predicting numbers from alphabets. Science 325: 429-432.
    • (2009) Science , vol.325 , pp. 429-432
    • Kim, H.D.1    Shay, T.2    O'Shea, E.K.3    Regev, A.4
  • 29
    • 0034782502 scopus 로고    scopus 로고
    • Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6
    • Kleinjan DA, Seawright A, Schedl A, Quinlan RA, Danes S, van Heyningen V. 2001. Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6. Hum Mol Genet 10: 2049-2059.
    • (2001) Hum Mol Genet , vol.10 , pp. 2049-2059
    • Kleinjan, D.A.1    Seawright, A.2    Schedl, A.3    Quinlan, R.A.4    Danes, S.5    Van Heyningen, V.6
  • 30
    • 0023956674 scopus 로고
    • Both basal and ontogenic promoter elements affect the timing and level of expression of a sea urchin H1 gene during early embryogenesis
    • Lai ZC, Maxson R, Childs G. 1988. Both basal and ontogenic promoter elements affect the timing and level of expression of a sea urchin H1 gene during early embryogenesis. Genes & Dev 2: 173-183.
    • (1988) Genes & Dev , vol.2 , pp. 173-183
    • Lai, Z.C.1    Maxson, R.2    Childs, G.3
  • 31
    • 34047179944 scopus 로고    scopus 로고
    • Analysis of protein-DNA interactions using surface plasmon resonance
    • Majka J, Speck C. 2007. Analysis of protein-DNA interactions using surface plasmon resonance. Adv Biochem Eng Biotechnol 104: 13-36.
    • (2007) Adv Biochem Eng Biotechnol , vol.104 , pp. 13-36
    • Majka, J.1    Speck, C.2
  • 32
    • 58149200952 scopus 로고    scopus 로고
    • UniPROBE: An online database of protein binding microarray data on protein-DNA interactions
    • doi: 10.1093/nar/gkn660
    • Newburger D, Bulyk ML. 2009. UniPROBE: An online database of protein binding microarray data on protein-DNA interactions. Nucleic Acids Res 37: D77-D82. doi: 10.1093/nar/gkn660.
    • (2009) Nucleic Acids Res , vol.37
    • Newburger, D.1    Bulyk, M.L.2
  • 33
    • 49249137030 scopus 로고    scopus 로고
    • Notch signaling regulates growth and differentiation in the mammalian lens
    • Rowan S, Conley KW, Le TT, Donner AL, Maas RL, Brown NL. 2008. Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol 321: 111-122.
    • (2008) Dev Biol , vol.321 , pp. 111-122
    • Rowan, S.1    Conley, K.W.2    Le, T.T.3    Donner, A.L.4    Maas, R.L.5    Brown, N.L.6
  • 34
    • 67651208830 scopus 로고    scopus 로고
    • The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis
    • doi: 10.1371/journal.pgen.1000511
    • Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ. 2009. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet 5: e1000511. doi: 10.1371/journal. pgen.1000511.
    • (2009) PLoS Genet , vol.5
    • Sansom, S.N.1    Griffiths, D.S.2    Faedo, A.3    Kleinjan, D.J.4    Ruan, Y.5    Smith, J.6    Van Heyningen, V.7    Rubenstein, J.L.8    Livesey, F.J.9
  • 35
    • 0038765091 scopus 로고    scopus 로고
    • Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6
    • Scardigli R, Baumer N, Gruss P, Guillemot F, Le Roux I. 2003. Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development 130: 3269-3281.
    • (2003) Development , vol.130 , pp. 3269-3281
    • Scardigli, R.1    Baumer, N.2    Gruss, P.3    Guillemot, F.4    Le Roux, I.5
  • 36
    • 0030581164 scopus 로고    scopus 로고
    • Influence of PAX6 gene dosage on development: Overexpression causes severe eye abnormalities
    • Schedl A, Ross A, Lee M, Engelkamp D, Rashbass P, van Heyningen V, Hastie ND. 1996. Influence of PAX6 gene dosage on development: Overexpression causes severe eye abnormalities. Cell 86: 71-82.
    • (1996) Cell , vol.86 , pp. 71-82
    • Schedl, A.1    Ross, A.2    Lee, M.3    Engelkamp, D.4    Rashbass, P.5    Van Heyningen, V.6    Hastie, N.D.7
  • 37
    • 38749127589 scopus 로고    scopus 로고
    • Predicting expression patterns from regulatory sequence in Drosophila segmentation
    • Segal E, Raveh-Sadka T, Schroeder M, Unnerstall U, Gaul U. 2008. Predicting expression patterns from regulatory sequence in Drosophila segmentation. Nature 451: 535-540.
    • (2008) Nature , vol.451 , pp. 535-540
    • Segal, E.1    Raveh-Sadka, T.2    Schroeder, M.3    Unnerstall, U.4    Gaul, U.5
  • 38
    • 0024380401 scopus 로고
    • The gradient morphogen bicoid is a concentration-dependent transcriptional activator
    • Struhl G, Struhl K, Macdonald PM. 1989. The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell 57: 1259-1273.
    • (1989) Cell , vol.57 , pp. 1259-1273
    • Struhl, G.1    Struhl, K.2    Macdonald, P.M.3
  • 39
    • 0034526271 scopus 로고    scopus 로고
    • Dosage requirement and allelic expression of PAX6 during lens placode formation
    • van Raamsdonk CD, Tilghman SM. 2000. Dosage requirement and allelic expression of PAX6 during lens placode formation. Development 127: 5439-5448.
    • (2000) Development , vol.127 , pp. 5439-5448
    • Van Raamsdonk, C.D.1    Tilghman, S.M.2
  • 40
    • 0033582718 scopus 로고    scopus 로고
    • A mathematical model for synergistic eukaryotic gene activation
    • Wang J, Ellwood K, Lehman A, Carey MF, She ZS. 1999. A mathematical model for synergistic eukaryotic gene activation. J Mol Biol 286: 315-325.
    • (1999) J Mol Biol , vol.286 , pp. 315-325
    • Wang, J.1    Ellwood, K.2    Lehman, A.3    Carey, M.F.4    She, Z.S.5
  • 42
    • 0032549745 scopus 로고    scopus 로고
    • Genomic cis-regulatory logic: Experimental and computational analysis of a sea urchin gene
    • DOI 10.1126/science.279.5358.1896
    • Yuh CH, Bolouri H, Davidson EH. 1998. Genomic cis-regulatory logic: Experimental and computational analysis of a sea urchin gene. Science 279: 1896-1902. (Pubitemid 28168638)
    • (1998) Science , vol.279 , Issue.5358 , pp. 1896-1902
    • Yuh, C.-H.1    Bolouri, H.2    Davidson, E.H.3
  • 43
    • 0037102552 scopus 로고    scopus 로고
    • Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis
    • Zhang X, Friedman A, Heaney S, Purcell P, Maas RL. 2002. Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes & Dev 16: 2097-2107.
    • (2002) Genes & Dev , vol.16 , pp. 2097-2107
    • Zhang, X.1    Friedman, A.2    Heaney, S.3    Purcell, P.4    Maas, R.L.5
  • 44
    • 33845456870 scopus 로고    scopus 로고
    • Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development
    • DOI 10.1016/j.ydbio.2006.06.030, PII S0012160606009420
    • Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL. 2006. Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Dev Biol 300: 748-757. (Pubitemid 44909095)
    • (2006) Developmental Biology , vol.300 , Issue.2 , pp. 748-757
    • Zhang, X.1    Rowan, S.2    Yue, Y.3    Heaney, S.4    Pan, Y.5    Brendolan, A.6    Selleri, L.7    Maas, R.L.8


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