Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas

Anticancer Research

Volumn 33, Issue 4, 2013, Pages 1519-1524

  Khazal, Kamel F ^a   Samuel, Temesgen ^a   Hill, Donald L ^b   Grubbs, Clinton J ^c  

^a TUSKEGEE UNIVERSITY   (United States)

^b University of Alabama at Birmingham   (United States)

^c Kentucky   (United States)

Author keywords

Chemoprevention; Ki67; Mammary cancer; PCNA; Rats; Withania somnifera

Indexed keywords

CYCLINE; KI 67 ANTIGEN; METHYLNITROSOUREA; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER PREVENTION; CANCER SIZE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FEMALE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; RAT; TREATMENT DURATION; WITHANIA SOMNIFERA;

ALKYLATING AGENTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IMMUNOENZYME TECHNIQUES; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; WITHANIA;

EID: 84876764334     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Coleman MP, Quaresma M, Berrino F, Lutz JM, DeAngelis R, Capocaccia R, Baili P, Rachet B, Gatta G et al: Cancer survival in five continents: a worldwide population-based study (CONCORD). Lancet Oncol 9: 730-756, 2008.
2. Siegel R, Naishadham D and Jemal A: Cancer Statistics, 2012. CA Cancer J Clinicians 62: 10-29, 2012.
3. Shulman LN, Willett W, Sievers A and Knaul FM: Breast cancer in developing counties, opportunities for improved survival. J Oncol 2010: 1-6, 2010.
4. Singh RB, Manoharan S and Balakrishnan S: Chemopreventative mechanisms of natural products in oral, mammary and skin carcinogenesis: An overview. Open Nutraceutical J 2: 52-63, 2009.
5. Aggarwal BB, Ichikawa H, Garodia P, Weerasinghe P, Sethi G, Bhatt ID, Pandey MK, Shishodia S and Nair MG: From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opin Ther Targets 10: 87-118, 2006. (Pubitemid 43263269)
6. Verma P, Singh N, Pandey BR and Gilca M: Role of Withania somnifera in prevention and treatment of cancer: An overview. Int J Pharmaceut Sci Drug Res 3: 274-279, 2011.
7. Newman DJ and Cragg GM: Natural products as sources of new drugs over the last 25 years J Nat Prod Mar 70: 461-477, 2007. (Pubitemid 46595760)
8. Jayaprakasam B, Zhang Y, Seeram NP and Nair MG: Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. Life Sci 74: 125-132, 2003. (Pubitemid 37324225)
9. Davis L and Kuttan G: Effect of Withania somnifera on 20-methylcholanthrene induced fibrosarcoma. J Exp Clin Cancer Res 19: 165-167, 2000. (Pubitemid 30490155)
10. Mirjalili MH, Moyano E, Bonfill M, Cusido RM and Palazon J: Steroidal lactones from Withania somnifera, an ancient plant for novel medicine. Molecules 14: 2373-2393, 2009.
11. Grubbs CJ, Peckham JC and McDonnough KD: Effect of ovarian hormones on the induction of 1-methyl-nitrosourea induced mammary cancer. Carcinogenesis 4: 495-497, 1983. (Pubitemid 13105332)
12. Russo J, Gusterson BA, Rogers AE, Russo IH, Weilings SR and van Zwieten MJ: Comparative study of human and rat mammary tumorigenesis. Lab Invest 62: 244-278, 1990. (Pubitemid 20124262)
13. Chan MM, Lu X, Merchant FM, Inglehart JD and Miron PL: Gene expression profiling of MNU-induced rat mammary tumors; cross species comparison with human breast cancer. Carcinogenesis 26: 1343-1353, 2005. (Pubitemid 41417876)
14. Gottardis M and Jordon C: Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Res 47: 4020-4024, 1987. (Pubitemid 17108463)
15. Lubet RA, Steele VE, Casebolt TL, Eto I, Kelloff GJ and Grubbs CJ: Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats Carcinogenesis 15: 2775-2780, 1994.
16. Gottardis MM, Bischoff ED, Shirley MA, Wagoner MA, Lamph WW and Heyman RA: Chemoprevention of mamamry carcinoma by LGD1069 (Targretin): An RXR selective ligand. Cancer Res 56: 5566-5570, 1996. (Pubitemid 26422151)
17. Lubet RA, Christov K, You M, Yao R, Steele VE, End DW, Juliana MM and Grubbs CJ: Effects of the farnesyltransferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis; prevention, therapy, and role of HaRas mutations. Mol Cancer Ther 5: 1073-1078, 2006. (Pubitemid 43724608)
18. Senthilnathan P, Padmavathi R, Magesh V and Sakthisekaran D: Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer Life Sci 78: 1010-1014, 2006. (Pubitemid 43112540)
19. Winters M: Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern Med Rev 11: 269-277, 2006. (Pubitemid 46037128)
20. Yu Y, Hamza A, Zhang T, Gu M, Zou P, Newman B, Li Y, Gunatilaka AA, Zhan CG and Sun D: Withaferin A targets heat-shock protein 90 in pancreatic cancer cells. Biochem Pharmacol 79: 542-551, 2010.