Effect of Withania somnifera on 20-methylcholanthrene induced fibrosarcoma

Journal of Experimental and Clinical Cancer Research

Volumn 19, Issue 2, 2000, Pages 165-167

  Davis, L ^a   Kuttan, G ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

GSH; GST; Methyl cholanthrene; Sarcoma; Withania somnifera

Indexed keywords

3 METHYLCHOLANTHRENE; OXYGEN RADICAL; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; EXTRACTION; FIBROSARCOMA; LIPID PEROXIDATION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; SURVIVAL RATE; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; FIBROSARCOMA; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INJECTIONS, SUBCUTANEOUS; LIPID PEROXIDES; LIVER; METHYLCHOLANTHRENE; MICE; PLANT EXTRACTS; PLANT ROOTS; SOLANACEAE; SURVIVAL RATE;

EID: 0033928424     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Halliwal B. and Gutteridge J. M. C. : Free radicals in Biology and medicine (1 eds). Darden Press, Oxford 279-313, 1985.
2. Wattenberg L.W.: Chemoprevention of Cancer. Cancer Res. 45, 1-8, 1985.
3. Cerutti P.A. : Pro-oxidant states of tumour promotion. Science 227: 375-381, 1985.
4. Sun Y.: Free radicals, antioxidant enzymes and carcinogenesis. Free radical Biology and Medicine 8: 583-599, 1991.
5. Budhiraja R.D. and Sudhir S.: J. of Scientific and Industrial Research 46:488, 1988.
6. Agarwal R. and Mukhtar H.: Cutaneous Chemical Carcinogenesis. In Mukhtar. H. (ed) Pharmacology of the skin. C.R.C. Press, Boca Raton, FL. 371-387, 1991.
7. Grandis J.R. and Tweardy D.J. : Elevated levels of TGF- and EGF- receptor, m RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res. 53: 3579-3584, 1993.
8. Budhiraja R.D. and Sudhir S.: J. of Scientific and Industrial Research 46: 488, 1988.
9. Sethi P.D., Thiacarajan A.R., Subramanian S.S. : Ind. J. of Pharmacol. 2: 165, 1970.
10. Sbohat B., Gitter S., Abraham A., Lavie D.: Cancer Chemotherapy 51, 5: 271, 1961.
11. Ziauddin M., Phansalkar N., Patki P., Diwanay S., Patwardhan B.: J. of Ethanopharmacology 50 (2): 69, 1996.
12. Sbohat B., Gitter S., and Lavie D.: Effect of Withaferin A on Ehlrich ascites tumour cells. Cytological Observations. Int. J.Cancer 5: 244-252, 1961.
13. Das H., Dutta S.K., Battacharya B., Chakraborti S.K.: Indian J. Cancer Chemotherapy 7: 59-65, 1985.
14. Davis L., Kuttan G.: Suppressive effect of cyclophoshamide induced toxicity by withania somnifera extract in normal mice. J. of Ethnopharmacology 2: 69-72, 1998.
15. Kuttan G. :Use of withania somnifera as adjuvant during radiation therapy. Indian J. of Experimental Biology 34: 854 -856, 1996.
16. Ohkawa H., Ohishi N., Yagi K.: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358, 1979.
17. Moron M. A., Depierre J.W., Mannervick B. : Levels of glutathione reductase and glutathione -S - transferase activities in liver. Biochem. Biophys. Acta 582 : 67-68, 1979.
18. Habig H., Pabit M. J., Jakoby W.R.: Glutathione - S- transferase. The first enzymatic step in mercapturic acid form. J. Biol. Chem. 249: 7130-7139, 1974.