Synthesis and anti-influenza virus activities of a novel class of gastrodin derivatives

Molecules

Volumn 18, Issue 4, 2013, Pages 3789-3805

  Xue, Si Tu ^a   He, Wei Ying ^a   Ma, Lin Lin ^a   Wang, Hui Qiang ^a   Wang, Bo ^a   Zheng, Guang Hui ^a   Ji, Xing Yue ^a   Zhang, Tian ^a   Li, Yu Huan ^a   Jiang, Jian Dong ^a   Li, Zhuo Rong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Aryl glycoside; Gastrodin; Influenza virus inhibitors; Synthesis

Indexed keywords

ANTIVIRUS AGENT; BENZYL ALCOHOL DERIVATIVE; GASTRODIN; GLUCOSIDE; M2 PROTEIN, INFLUENZA A VIRUS; MATRIX PROTEIN; OSELTAMIVIR; SIALIDASE;

ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GROWTH, DEVELOPMENT AND AGING; HEMAGGLUTINATION; IC 50; INFLUENZA VIRUS A H1N1; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIVIRAL AGENTS; BENZYL ALCOHOLS; FEMALE; GLUCOSIDES; HEMAGGLUTINATION; INFLUENZA A VIRUS, H1N1 SUBTYPE; INHIBITORY CONCENTRATION 50; MICE; NEURAMINIDASE; OSELTAMIVIR; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL MATRIX PROTEINS;

EID: 84876758398     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18043789     Document Type: Article

References (13)

1. Calatayud, L.; Lackenby, A.; Reynolds, A.; McMenamin, J.; Phin, N.F.; Zambon, M.C.; Pebody, R. Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus Infection inEngland and Scotland, 2009-2010. Emerg. Infect. Dis. 2011, 17, 1807-1815.
2. Bright, R.A.; Medina, M.J.; Xu, X. Incidence of adamantine resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: A cause for concern. Lancet 2005, 366, 1175-1181.
3. Deyde, V.M.; Xu, X.; Bright, R.A. Surveillance of resistance to adamantanes among influenza A (H3N2) and A (H1N1) viruses isolated worldwide. J. Infect. Dis. 2007, 196, 249-257.
4. Deogaonkar, M.; Wilson, K.; Vitek, J. Amantadine induced reversible corneal edema. J. Clin. Neurosci. 2011, 18, 298-299.
5. Hurt, A.C.; Lee, R.T.; Leang, S.K.; Cui, L.; Deng, Y.M.; Phuah, S.P.; Caldwell, N.; Freeman, K.; Komadina, N.; Smith, D.; et al. Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N. Eurosurveillance 2011, 16, Available online: http://www.eurosurveillance.org/ ViewArticle.aspx? ArticleId=19884 (accessed on 9 June 2011).
6. Hurt, A.C.; Holien, J.K.; Parker, M.; Kelso, A.; Barr, I.G. Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation. J. Virol. 2009, 83, 10366-10373.
7. Relman, D.A.; Choffnes, E.R.; Mack, A. The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic: Global Challenges, Global Solutions; Workshop Summary, Forum on Microbial Threats, Institute of Medicine; National Academies Press: Washington, DC, USA, 2010.
8. Tao, Y.-H. Recent progress on pharmacological effects of Gastrodia elata. Zhongguo Zhong Yao Za Zhi 2008, 33, 108-110.
9. Huang, H.W.; Qian, Z.H. The Synthesis of Fluorinated Gastrodin. Acta Chim. Sin. 1987, 45, 1175-1179.
10. Zhou, J.; Yang, H.B.; Yang, C.R. Chemical study on Gastrodin ELATA BL. Acta Chim. Sin. 1980, 38, 162-166.
11. Zhu, L.; Li, Y.; Li, S.; Li, H.; Qiu, Z.; Lee, C.; Lu, H.; Lin, X.; Zhao, R.; Chen, L.; et al. Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin. PLoS One 2011, 6, e29120.
12. Yu, M.; Liu, A.; Du, G.; Naesens, L.; Vanderlinden, E.; de Clercq, E.; Liu, X. Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents. Chem. Biol. Drug Des. 2011, 78, 596-602.
13. Zhang, J.; Liu, T.; Tong, X.; Li, G.; Yan, J.; Ye, X. Identification of novel virus inhibitors by influenza A virus specific reporter cell based screening. Antiviral Res. 2012, 93, 48-54.