Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Zhu, Lei ^a   Li, Yuhuan ^c   Li, Shaohua ^b   Li, Haodong ^b   Qiu, Zongxing ^a   Lee, Chichang ^b   Lu, Henry ^b   Lin, Xianfeng ^a   Zhao, Rong ^a   Chen, Li ^a   Wu, Jim Z ^a   Tang, Guozhi ^a   Yang, Wengang ^a  

^a Roche Pharma Research and Early Development   (China)

^b WUXI APPTEC   (China)

^c INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(5 HYDROXY 1,3,3 TRIMETHYL CYCLOHEXYLMETHYL)AMINO]BENZENESULFONAMIDE; ANTIVIRUS AGENT; BENZENESULFONAMIDE DERIVATIVE; INFLUENZA VIRUS HEMAGGLUTININ; OSELTAMIVIR; RIBAVIRIN; RO 5464466; RO 5487624; TRYPSIN; UNCLASSIFIED DRUG; BENZENESULFONAMIDE; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL ASSAY; CELL STRAIN; CHICKEN; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG STRUCTURE; DRUG TARGETING; FEMALE; HEMAGGLUTINATION INHIBITION TEST; HEMOLYSIS; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A (H1N1); LD 50; MALE; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POST EXPOSURE PROPHYLAXIS; PROTECTION; TREATMENT DURATION; TRYPSIN SENSITIVITY ASSAY; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS REPLICATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DOG; DRUG EFFECT; ERYTHROCYTE; INFLUENZA VIRUS A H1N1; MEMBRANE FUSION; METABOLISM; ORTHOMYXOVIRUS INFECTION; PATHOLOGY; PH; TIME; TREATMENT OUTCOME; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CHICKENS; DOGS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ERYTHROCYTES; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HEMOLYSIS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS, H1N1 SUBTYPE; MEMBRANE FUSION; MICE; ORTHOMYXOVIRIDAE INFECTIONS; SULFONAMIDES; TIME FACTORS; TREATMENT OUTCOME; TRYPSIN; VIRUS REPLICATION;

EID: 83455162535     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029120     Document Type: Article

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