Carbon monoxide and the brain: Time to rethink the dogma

Current Pharmaceutical Design

Volumn 19, Issue 15, 2013, Pages 2771-2775

  Hanafy, Khalid A ^a,b   Oh, Justin ^a   Otterbein, Leo E ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Brain; Carbon monoxide; Heme oxygenase; Intracerebral hemorrhage; Protective; Stroke

Indexed keywords

ADIPIC ACID; CARBON MONOXIDE; GLUTAMATE RECEPTOR AGONIST; GUANYLATE CYCLASE; HEME OXYGENASE;

ARTICLE; BRAIN; BRAIN ISCHEMIA; CIRCADIAN RHYTHM; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL;

BLOOD VESSELS; BRAIN; CARBON MONOXIDE; HUMANS;

EID: 84876732556     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319150013     Document Type: Article

References (47)

1. Hanafy KA, Krumenacker JS, Murad F. NO, nitrotyrosine, and cyclic GMP in signal transduction. Med Sci Monit 2001; 7(4): 801-19.
2. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37: 517-54.
3. Koneru P, Leffler CW. Role of cGMP in carbon monoxide-induced cerebral vasodilation in piglets. Am J Physiol Heart Circ Physiol 2004; 286(1): H304-9.
4. Clark JE, Foresti R, Sarathchandra P, Kaur H, Green CJ, Motterlini R. Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. Am J Physiol Heart Circ Physiol 2000; 278(2): H643-51.
5. Leffler CW, Balabanova L, Fedinec AL, Parfenova H. Nitric oxide increases carbon monoxide production by piglet cerebral microvessels. Am J Physiol. Heart Circ Physiol 2005; 289(4): H1442-7.
6. Leffler CW, Balabanova L, Fedinec AL, Waters CM, Parfenova H. Mechanism of glutamate stimulation of CO production in cerebral microvessels. Am J Physiol Heart Circ Physiol 2003; 285(1): H74-80.
7. Ding Y, McCoubrey WK Jr, Maines MD. Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular "sink" for NO? Eur J Biochem 1999; 264(3): 854-61.
8. McCoubrey WK Jr, Huang TJ, Maines MD. Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis. J Biol Chem 1997; 272(19): 12568-74.
9. Wang B, Cao W, Biswal S, Doré S. Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia. Stroke 2011; 42(9): 2605-10.
10. Yabluchanskiy A, Sawle P, Homer-Vanniasinkam S, Green CJ, Foresti R, Motterlini R. CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke. Crit Care Med 2012; 40(2): 544-52.
11. Chora AA, Fontoura P, Cunha A, et al. Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. J Clin Invest 2007; 117(2): 438-47.
12. Verma A, Hirsch DJ, Glatt CE, Ronnett GV, Snyder SH. Carbon monoxide: a putative neural messenger. Science 1993; 259(5093): 381-4.
13. Vincent SR, Das S, Maines MD. Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons. Neuroscience 1994; 63(1): 223-31.
14. King DP, Zhao Y, Sangoram AM, et al. Positional Cloning of the Mouse Circadian Clock Gene. Cell 1997; 89(4): 641-53.
15. Dioum EM, Rutter J, Tuckerman JR, Gonzalez G, Gilles-Gonzalez M-A, McKnight SL. NPAS2: A Gas-Responsive Transcription Factor. Science 2002; 298(5602): 2385-7.
16. Mancuso C, Kostoglou-Athanassiou I, Forsling ML, et al. Activation of heme oxygenase and consequent carbon monoxide forma tion inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function. Brain Res Mol Brain Res 1997; 50(1-2): 267-76.
17. Parkes D, Kasckow J, Vale W. Carbon monoxide modulates secretion of corticotropin-releasing factor from rat hypothalamic cell cultures. Brain Res 1994; 646(2): 315-8.
18. Alkadhi KA, Al-Hijailan RS, Malik K, Hogan YH. Retrograde carbon monoxide is required for induction of long-term potentiation in rat superior cervical ganglion. J Neurosci 2001; 21(10): 3515-20.
19. Christodoulides N, Durante W, Kroll MH, Schafer AI. Vascular smooth muscle cell heme oxygenases generate guanylyl cyclasestimulatory carbon monoxide. Circulation 1995; 91(9): 2306-9.
20. Zhuo M, Hu Y, Schultz C, Kandel ER, Hawkins RD. Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 1994; 368(6472): 635-9.
21. Hou S, Xu R, Heinemann SH, Hoshi T. The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels. Proc Natl Acad Sci USA 2008; 105(10): 4039-43.
22. Jaggar JH, Li A, Parfenova H, et al. Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Circ Res 2005; 97(8): 805-12.
23. Kaide JI, Zhang F, Wei Y, et al. Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors. J Clin Invest 2001; 107(9): 1163-71.
24. Ingi T, Cheng J, Ronnett GV. Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide-Cyclic GMP Signaling System. Neuron 1996; 16(4): 835-42.
25. Leffler CW, Parfenova H, Fedinec AL, Basuroy S, Tcheranova D. Contributions of astrocytes and CO to pial arteriolar dilation to glutamate in newborn pigs. Am J Physiol Heart Circ Physiol 2006; 291(6): H2897-2904.
26. Decaluwé K, Pauwels B, Verpoest S, Van de Voorde J. Divergent mechanisms involved in CO and CORM-2 induced vasorelaxation. Eur J Pharmacol 2012; 674(2-3): 370-7.
27. Koehler RC, Traystman RJ. Cerebrovascular effects of carbon monoxide. Antioxid Redox Signal 2002; 4(2): 279-90.
28. Kim HP, Wang X, Nakao A, et al. Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. Proc Natl Acad Sci USA 2005; 102(32): 11319-24.
29. Bor-Seng-Shu E, Kita WS, Figueiredo EG, et al. Cerebral hemodynamics: concepts of clinical importance. Arq Neuropsiquiatr 2012; 70(5): 352-6.
30. Leffler CW, Parfenova H, Jaggar JH. Carbon monoxide as an endogenous vascular modulator. Am J Physiol Heart Circ Physiol 2011; 301(1): H1-H11.
31. Kostoglou-Athanassiou I, Forsling ML, Navarra P, Grossman AB. Oxytocin release is inhibited by the generation of carbon monoxide from the rat hypothalamus--further evidence for carbon monoxide as a neuromodulator. Brain Res Mol Brain Res 1996; 42(2): 301-6.
32. Wang R, Wu L, Wang Z. The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells. Pflugers Arch 1997; 434(3): 285-91.
33. Wu L, Cao K, Lu Y, Wang R. Different mechanisms underlying the stimulation of K(Ca) channels by nitric oxide and carbon monoxide. J Clin Invest 2002; 110(5): 691-700.
34. Lok J, Leung W, Murphy S, Butler W, Noviski N, Lo EH. Intracranial hemorrhage: mechanisms of secondary brain injury. Acta Neurochir Suppl 2011; 111: 63-9.
35. Xi Q, Tcheranova D, Parfenova H, Horowitz B, Leffler CW, Jaggar JH. Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of alpha-subunits. Am J Physiol Heart Circ Physiol 2004; 286(2): H610-618.
36. Pérez GJ, Bonev AD, Nelson MT. Micromolar Ca(2+) from sparks activates Ca(2+)-sensitive K(+) channels in rat cerebral artery smooth muscle. Am J Physiol Cell Physiol 2001; 281(6): C1769-1775.
37. Dallas ML, Boyle JP, Milligan CJ, et al. Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1. FASEB J 2011; 25(5): 1519-30.
38. Otterbein LE, Otterbein SL, Ifedigbo E, et al. MKK3 mitogenactivated protein kinase pathway mediates carbon monoxideinduced protection against oxidant-induced lung injury. Am J Pathol 2003; 163(6): 2555-63.
39. Barbagallo I, Marrazzo G, Frigiola A, Zappala A, Li Volti G. Role of carbon monoxide in vascular diseases. Curr Pharm Biotechnol 2012; 13(6): 787-96.
40. Song R, Mahidhara RS, Liu F, Ning W, Otterbein LE, Choi AMK. Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am J Respir Cell Mol Biol 2002; 27(5): 603-10.
41. Xi Q, Umstot E, Zhao G, Narayanan D, Leffler CW, Jaggar JH. Glutamate regulates Ca2+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte-and heme oxygenase-dependent mechanisms. Am J Physiol Heart Circ Physiol 2010; 298(2): H562-569.
42. Parfenova H, Basuroy S, Bhattacharya S, et al. Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection. Am. J Physiol., Cell Physiol 2006; 290(5): C1399-1410.
43. Morikawa T, Kajimura M, Nakamura T, et al. Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxidesensitive hydrogen sulfide pathway. Proc Natl Acad Sci USA 2012; 109(4): 1293-8.
44. Poss KD, Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci USA 1997; 94(20): 10925-30.
45. Yachie A, Niida Y, Wada T, et al. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 1999; 103(1): 129-35.
46. Zhang X, Shan P, Otterbein LE, et al. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem 2003; 278(2): 1248-58.
47. Hervera A, Leánez S, Negrete R, Motterlini R, Pol O. Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice. PLoS One 2012; 7(8): e43693. Epub 2012 Aug 22.