Total synthesis of daptomycin by cyclization via a chemoselective serine ligation

Journal of the American Chemical Society

Volumn 135, Issue 16, 2013, Pages 6272-6279

  Lam, Hiu Yung ^a   Zhang, Yinfeng ^a   Liu, Han ^a   Xu, Jianchao ^a   Wong, Clarence T T ^a   Xu, Ci ^a   Li, Xuechen ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOSELECTIVE; CONVERGENT SYNTHESIS; CYCLIC DEPSIPEPTIDES; MACRO-CYCLIZATION; NATURAL PRODUCTS; STRUCTURE-ACTIVITY; THREONINE RESIDUES; TOTAL SYNTHESIS;

ESTERIFICATION; ESTERS; OZONE; SYNTHESIS (CHEMICAL);

AMINO ACIDS;

CYCLOPEPTIDE; DAPTOMYCIN; KYNURENINE; SERINE; THREONINE; TRYPTOPHAN;

ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG SYNTHESIS; ESTERIFICATION; LIGATION; OZONOLYSIS; PROTEIN ASSEMBLY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANTI-BACTERIAL AGENTS; CYCLIZATION; DAPTOMYCIN; INDICATORS AND REAGENTS; KYNURENINE; LACTAMS; LIGANDS; OZONE; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE;

EID: 84876726616     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4012468     Document Type: Article

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