Chaperonopathies and chaperonotherapy. Hsp60 as therapeutic target in cancer: Potential benefits and risks

Current Pharmaceutical Design

Volumn 19, Issue 3, 2013, Pages 452-457

  Cappello, Francesco ^a,b   Angileri, Francesca ^a,b   de Macario, Everly Conway ^c,d   Macario, Alberto J L ^b,c,d  

^a UNIVERSITY OF PALERMO   (Italy)

^b Istituto Euro Mediterraneo di Scienza e Tecnologia IEMEST   (Italy)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d Maryland Sea Grant Exten Program   (United States)

Author keywords

Antibodies; Antitumor immunotherapy; Autoantibodies; Cpn60; Hsp60; HSPD1; Plasma membrane

Indexed keywords

CASPASE 3; CHAPERONIN 60; IMMUNOGLOBULIN;

ADAPTIVE IMMUNITY; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; APOPTOSIS; AUTOIMMUNE DISEASE; CANCER IMMUNOTHERAPY; CANCER THERAPY; CARCINOGENESIS; CELL DEATH; CELL MEMBRANE; CELL PROLIFERATION; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CHAPERONOTHERAPY; CYTOSOL; CYTOTOXICITY; DRUG EFFICACY; GLOMERULONEPHRITIS; GLYCOGEN SYNTHESIS; HUMAN; INNATE IMMUNITY; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REVIEW; RISK BENEFIT ANALYSIS; STEM CELL TRANSPLANTATION;

EID: 84876707367     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161213804143653     Document Type: Review

References (50)

1. Hartl FU, Bracher A, Hayer-Hartl M. Molecular chaperones in protein folding and proteostasis. Nature 2011; 475: 324-32.
2. Krøll J. The molecular chaperones and the phenomena of cellular immortalization and apoptosis in vitro. Ann N Y Acad Sci 2004; 1019: 568-71.
3. Nakamoto H, Vígh L. The small heat shock proteins and their clients. Cell Mol Life Sci 2007; 64: 294-306.
4. Haak J, Kregel KC. 1962-2007: a cell stress odyssey. Novartis Found Symp 2008; 291:3-15; discussion 15-22, 137-40.
5. Asea A. Hsp70: a chaperokine. Novartis Found Symp 2008; 291:173-9; discussion 179-83, 221-4.
6. Csermely P, Korcsmáros T, Kovács IA, et al. System biology of molecular chaperone networks. Novartis Found Symp 2008; 291:45-54; discussion 54-8, 137-40.
7. Pockley AG, Multhoff G. Cell stress proteins in extracellular fluids: friend or foe? Novartis Found Symp 2008; 291: 86-95; discussion 96-100, 137-40.
8. Quintana FJ, Cohen IR. HSP60 speaks to the immune system in many voices. Novartis Found Symp 2008; 291:101-11; discussion 111-4, 137-40.
9. Macario AJL, Conway de Macario E. Sick chaperones, cellular stress, and disease. N Engl J Med 2005; 353: 1489-501.
10. Macario AJL, Conway de Macario E. Chaperonopathies by defect, excess, or mistake. Ann N Y Acad Sci 2007; 1113: 178-91.
11. Macario AJL, Conway de Macario E. Chaperonopathies and chaperonotherapy. FEBS Lett 2007; 581: 3681-8.
12. Almeida MB, do Nascimento JL, Herculano AM, et al. Molecular chaperones: toward new therapeutic tools. Biomed Pharmacother 2011; 65: 239-43.
13. Kampinga HH, Hageman J, Vos MJ, et al. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones 2009; 14: 105-11.
14. Gomez-Monterrey I, Sala M, Musella S, et al. Heat Shock Protein 90 Inhibitors as Therapeutic Agents. Recent Pat Anticancer Drug Discov. 2012 [Epub ahead of print] Feb 9.
15. Rothbard JB, Kurnellas MP, Brownell S, et al. Therapeutic effects of systemic administration of the chaperone alpha B crystallin associated with binding proinflammatory plasma proteins. J Biol Chem 2012 [Epub ahead of print] Feb 3.
16. Kang BH. TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors. BMB Rep 2012; 45: 1-6.
17. da Silva VC, Ramos CH. The network interaction of the human cytosolic 90kDa heat shock protein Hsp90: A target for cancer therapeutics. J Proteomics 2012 [Epub ahead of print] Jan 2.
18. Guttmann DM, Koumenis C. Source The heat shock proteins as targets for radiosensitization and chemosensitization in cancer. Cancer Biol Ther 2011; 12(12).
19. Ebrahimi-Fakhari D, Wahlster L, McLean PJ. Molecular chaperones in Parkinson's Disease-present and future. J Parkinsons Dis 2011; 1: 299-320.
20. Kalia SK, Kalia LV, McLean PJ. Molecular chaperones as rational drug targets for Parkinson's disease therapeutics. CNS Neurol Disord Drug Targets 2010; 9: 741-53.
21. Tan MH, Smith AJ, Pawlyk B, et al. Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors. Hum Mol Genet 2009; 18: 2099-114.
22. Sigler PB, Xu Z, Rye HS, et al. Structure and function in GroELmediated protein folding. Annu Rev Biochem 1998; 67: 581-608.
23. Török Z, Horváth I, Goloubinoff P, et al. Evidence for a lipochaperonin: association of active protein-folding GroESL oligomers with lipids can stabilize membranes under heat shock conditions. Proc Natl Acad Sci USA 1997 94: 2192-7.
24. Macario AJL, Lange M, Ahring BK, et al. Stress genes and proteins in the archaea. Microbiol Mol Biol Rev 1999; 63: 923-67.
25. Mukherjee K, Conway de Macario E, Macario AJL, et al. Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes. BMC Evol Biol 2010, 10:64.
26. Corrao S, Campanella C, Anzalone R, et al. Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: current knowledge and perspectives. Life Sci 2010; 86: 145-52.
27. Dencher NA, Frenzel M, Reifschneider NH, et al. Proteome alterations in rat mitochondria caused by aging. Ann N Y Acad Sci 2007; 1100:291-8.
28. Folli F, Guzzi V, Perego L, et al. Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation. PLoS One 2010;5:e9923.
29. Cappello F, Conway de Macario E, Marasa L, et al. Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy. Cancer Biol Ther 2008; 7:801-9.
30. Kaufman BA, Kolesar JE, Perlman PS, et al. A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae. J Cell Biol 2003;163: 457-61.
31. Chandra D, Choy G, Tang DG. Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J Biol Chem 2007; 282: 31289-301.
32. Campanella C, Bucchieri F, Ardizzone NM, et al. Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. Eur J Histochem 2008; 52: 221-8.
33. Merendino AM, Bucchieri F, Campanella C, et al. Hsp60 is actively secreted by human tumor cells. PLoS One 2010;5:e9247.
34. Bobrie A, Colombo M, Raposo G, et al. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 2011; 12: 1659-68.
35. Cappello F, Conway de Macario E, Di Felice V, et al. Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin. PLoS Pathog 2009;5:e1000552.
36. Macario AJL, Cappello F, Zummo G, et al. Chaperonopathies of senescence and the scrambling of interactions between the chaperoning and the immune systems. Ann N Y Acad Sci 2010; 1197: 85-93.
37. Rizzo M, Macario AJL, Conway de Macario E, et al. Heat shock protein-60 and risk for cardiovascular disease. Curr Pharm Des 2011; 17: 3662-8.
38. Pockley AG, Bulmer J, Hanks BM, et al. Identification of human heat shock protein 60 (Hsp60) and anti-Hsp60 antibodies in the peripheral circulation of normal individuals. Cell Stress Chaperones 1999; 4: 29-35.
39. Alard JE, Dueymes M, Youinou P, et al. Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases. Autoimmun Rev 2007; 6: 438-43.
40. Cappello F, Czarnecka AM, La Rocca G, et al. Hsp60 and Hsp10 as antitumor molecular agents. Cancer Biol Ther 2007;6: 487-9.
41. Rahlff J, Trusch M, Haag F, et al. Antigen-specificity of oligoclonal abnormal protein bands in multiple myeloma after allogeneic stem cell transplantation. Cancer Immunol Immunother 2012 [Epub ahead of print] Feb 21.
42. Cappello F, David S, Peri G, et al. Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment. Front Biosci (Schol Ed) 2011; 3: 341-51.
43. Stangl S, Gehrmann M, Riegger J, et al. Targeting membrane heatshock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci USA 2011; 108: 733-8.
44. Cappello F, Conway de Macario E, Zummo G, et al. Immunohistochemistry of human Hsp60 in health and disease: from autoimmunity to cancer. Methods Mol Biol 2011; 787: 245-54.
45. Zhong H, Yang Y, Ma S, et al. Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients. Int J Hyperthermia 2011; 27: 604-11.
46. Victora GD, Socorro-Silva A, Volsi EC, et al. Immune response to vaccination with DNA-Hsp65 in a phase I clinical trial with head and neck cancer patients. Cancer Gene Ther 2009; 16: 598-608.
47. Pfister G, Stroh CM, Perschinka H, et al. Detection of HSP60 on the membrane surface of stressed human endothelial cells by atomic force and confocal microscopy. J Cell Sci 2005; 118: 1587-94.
48. Lin L, Kim SC, Wang Y, et al. HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol 2007; 293: H2238-47.
49. Goh YC, Yap CT, Huang BH, et al. Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis. Cell Mol Life Sci 2011; 68: 1581-92.
50. Soltys BJ, Gupta RS. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Exp Cell Res 1996; 222:16-27.