A small-molecule inhibitor, 5′-o-Tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo

Anti-Cancer Agents in Medicinal Chemistry

Volumn 13, Issue 4, 2013, Pages 532-545

  Golubovskaya, Vita M ^a   Palma, Nadia L ^b   Zheng, Min ^b   Ho, Baotran ^a   Magis, Andrew ^c   Ostrov, David ^c   Cance, William G ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c UF Shands Cancer center ^*  (United States)

Author keywords

Apoptosis; Focal adhesion kinase; Mdm 2; P53; Small molecule compound; Tumor growth

Indexed keywords

5' O TRITYLTHYMIDINE; CASPASE 8; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BREAST CANCER; CARCINOGENESIS; CELL VIABILITY; COLON CANCER; COLONY FORMATION; CONTROLLED STUDY; ENZYME ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VIVO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN INTERACTION; TUMOR GROWTH; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE; TRITYL COMPOUNDS;

EID: 84876705245     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/1871520611313040002     Document Type: Article

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