Lead, mercury, and cadmium in blood and their relation to diet among swedish adults

Food and Chemical Toxicology

Volumn 57, Issue , 2013, Pages 161-169

  Bjermo, Helena ^a   Sand, Salomon ^a   Nälsén, Cecilia ^a   Lundh, Thomas ^b   Enghardt Barbieri, Heléne ^a   Pearson, Monika ^a   Lindroos, Anna Karin ^a   Jönsson, Bo A G ^b   Barregård, Lars ^c   Darnerud, Per Ola ^a  

^a National Food Agency   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Blood; Cadmium; Diet; Heavy metals; Lead; Mercury

Indexed keywords

BIOLOGICAL MARKER; CADMIUM; LEAD; MERCURY;

ADULT; AGE DISTRIBUTION; AGED; ALCOHOL CONSUMPTION; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; BODY BURDEN; CADMIUM BLOOD LEVEL; DIETARY INTAKE; EATING HABIT; ETHNIC GROUP; FEMALE; FISH MEAT; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; LEAD BLOOD LEVEL; LIFESTYLE; MALE; MASS SPECTROMETRY; MERCURY BLOOD LEVEL; NUTRITIONAL ASSESSMENT; SEX DIFFERENCE; SMOKING HABIT; SPECTROFLUOROMETRY; SWEDEN; URINALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BODY BURDEN; CADMIUM; DIET; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD HABITS; HUMANS; LEAD; LIFE STYLE; MALE; MERCURY; MIDDLE AGED; NUTRITION SURVEYS; SMOKING; SWEDEN; YOUNG ADULT;

EID: 84876697610     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.03.024     Document Type: Article

References (51)

1. Aitio A., Bernard A., Fowler B.A., Nordberg G. Biological monitoring and biomarkers. Handbook on the Toxicology of Metals 2007, Elsevier, London.
2. Akerstrom M., Sallsten G., Lundh T., Barregard L. Associations between Urinary Excretion of Cadmium and Proteins in a Nonsmoking Population: Renal Toxicity or Normal Physiology? Environ. Health Perspect 2013, 121:187-191.
3. Akesson A., Lundh T., Vahter M., Bjellerup P., Lidfeldt J., Nerbrand C., Samsioe G., Stromberg U., Skerfving S. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ. Health Perspect. 2005, 113:1627-1631.
4. Amcoff, E., Edberg, A., Enghardt Barbieri, H., Lindroos, A.K., Nälsén, C., Pearson, M., Warensjö Lemmin, E., Riksmaten, 2010-2011. Intake of Food and Nutrients among Adults in Sweden. The National Food Agency, Uppsala, Sweden, 2012.
5. Andersen O., Nielsen J.B., Nordberg G.F. Nutritional interactions in intestinal cadmium uptake - possibilities for risk reduction. Biometals 2004, 17:543-547.
6. Barany E., Bergdahl I., Schütz A., Skerfving S., Oskarsson A. Inductively coupled plasma mass spectrometry for direct multi-element analysis of diluted human blood and serum. J. Anal. At. Spectrom. 1997, 12:1005.
7. Barany E., Bergdahl I.A., Bratteby L.E., Lundh T., Samuelson G., Schutz A., Skerfving S., Oskarsson A. Trace elements in blood and serum of Swedish adolescents: relation to gender, age, residential area, and socioeconomic status. Environ. Res. 2002, 89:72-84.
8. Barany E., Bergdahl I.A., Bratteby L.E., Lundh T., Samuelson G., Skerfving S., Oskarsson A. Iron status influences trace element levels in human blood and serum. Environ. Res. 2005, 98:215-223.
9. Barregard L., Fabricius-Lagging E., Lundh T., Molne J., Wallin M., Olausson M., Modigh C., Sallsten G. Cadmium, mercury, and lead in kidney cortex of living kidney donors: impact of different exposure sources. Environ. Res. 2010, 110:47-54.
10. Bellinger D.C. Very low lead exposures and children's neurodevelopment. Curr. Opin. Pediatr. 2008, 20:172-177.
11. Berglund M., Akesson A., Nermell B., Vahter M. Intestinal absorption of dietary cadmium in women depends on body iron stores and fiber intake. Environ. Health Perspect. 1994, 102:1058-1066.
12. Bjornberg K.A., Vahter M., Grawe K.P., Berglund M. Methyl mercury exposure in Swedish women with high fish consumption. Sci. Total Environ. 2005, 341:45-52.
13. Cerna M., Krskova A., Cejchanova M., Spevackova V. Human biomonitoring in the Czech Republic: an overview. Int. J. Hyg. Environ. Health 2012, 215:109-119.
14. Chaumont A., Nickmilder M., Dumont X., Lundh T., Skerfving S., Bernard A. Associations between proteins and heavy metals in urine at low environmental exposures: evidence of reverse causality. Toxicol. Lett. 2012, 210:345-352.
15. Chen A., Kim S.S., Chung E., Dietrich K.N. Thyroid hormones in relation to lead, mercury and cadmium exposure in the National Health and Nutrition Examination Survey, 2007-2008. Environ. Health Perspect. 2013, 121:181-186.
16. Clark N.A., Teschke K., Rideout K., Copes R. Trace element levels in adults from the west coast of Canada and associations with age, gender, diet, activities, and levels of other trace elements. Chemosphere 2007, 70:155-164.
17. EFSA Scientific opinion of the panel on contaminants in the food chain on a request from the European commission on cadmium in food. EFSA J. 2009, 980:1-139.
18. EFSA EFSA panel on contaminants in the food chain (CONTAM); scientific opinion on lead in food. EFSA J. 2010, 8:1570.
19. Engstrom A., Hakansson H., Skerfving S., Bjellerup P., Lidfeldt J., Lundh T., Samsioe G., Vahter M., Akesson A. Retinol may counteract the negative effect of cadmium on bone. J. Nutr. 2011, 141:2198-2203.
20. Ferraro P.M., Costanzi S., Naticchia A., Sturniolo A., Gambaro G. Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999-2006. BMC Public Health 2010, 10:304.
21. Florea A.M., Busselberg D. Occurrence, use and potential toxic effects of metals and metal compounds. Biometals 2006, 19:419-427.
22. Garcia-Esquinas E., Perez-Gomez B., Fernandez M.A., Perez-Meixeira A.M., Gil E., de Paz C., Iriso A., Sanz J.C., Astray J., Cisneros M., de Santos A., Asensio A., Garcia-Sagredo J.M., Garcia J.F., Vioque J., Pollan M., Lopez-Abente G., Gonzalez M.J., Martinez M., Bohigas P.A., Pastor R., Aragones N. Mercury, lead and cadmium in human milk in relation to diet, lifestyle habits and sociodemographic variables in Madrid (Spain). Chemosphere 2011, 85:268-276.
23. Gerhardsson L., Lundh T. Metal concentrations in blood and hair in pregnant females in southern Sweden. J. Environ. Health 2010, 72:37-41.
24. Haines D.A., Murray J. Human biomonitoring of environmental chemicals - early results of the 2007-2009 Canadian Health Measures Survey for males and females. Int. J. Hyg. Environ. Health 2012, 215:133-137.
25. Heitland P., Köster H.D. Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS. J. Trace Elem. Med. Biol. 2006, 20:253-262.
26. Hunt W.G., Watson R.T., Oaks J.L., Parish C.N., Burnham K.K., Tucker R.L., Belthoff J.R., Hart G. Lead bullet fragments in venison from rifle-killed deer: potential for human dietary exposure. PLoS ONE 2009, 4:e5330.
27. Johnsson C., Sällsten G., Schütz A., Sjörs A., Barregård L. Hair mercury levels versus freshwater fish consumption in household members of Swedish angling societies. Environ. Res. 2004, 96(3):257-263.
28. Johnsson C., Schütz A., Sällsten G. Impact of consumption of freshwater fish on mercury levels in hair, blood, urine, and alveolar air. J. Toxicol. Environ. Health A 2005, 68(2):129-140.
29. Kim Y., Lee B.-K. Associations of blood lead, cadmium, and mercury with estimated glomerrular filtration rate in Korean general population: Analysis of 2008-2010 Korean National Health and Nutrition Examination Survey data. Environ. Res. 2012, 118:124-129.
30. Kim H., Lee H.J., Hwang J.Y., Ha E.H., Park H., Ha M., Kim J.H., Hong Y.C., Chang N. Blood cadmium concentrations of male cigarette smokers are inversely associated with fruit consumption. J. Nutr. 2010, 140:1133-1138.
31. Kippler M., Tofail F., Hamadani J.D., Gardner R.M., Grantham-McGregor S.M., Bottai M., Vahter M. Early-life cadmium exposure and child development in 5-year-old girls and boys: a cohort study in rural Bangladesh. Environ. Health Perspect. 2012, 120:1462-1468.
32. Martorell I., Perelló G., Martí-Cid R., Llobet J.M., Castell V., Domingo J.L. Human exposure to arsenic, cadmium, mercury, and lead from foods in Catalonia, Spain: temporal trend. Biol. Trace Elem. Res. 2011, 2011(142):309-322.
33. Mazzachi B.C., Peake M.J., Ehrhardt V. Reference range and method comparison studies for enzymatic and Jaffé creatinine assays in plasma and serum and early morning urine. Clin. Lab. 2000, 46:53-55.
34. Mendola P., Selevan S.G., Gutter S., Rice D. Environmental factors associated with a spectrum of neurodevelopmental deficits. Ment. Retard. Dev. Disabil. Res. Rev. 2002, 8:188-197.
35. NFA, 2007. Risk Assessment of Methylmercury in Fish. Report no. 10-2007. The National Food Agency, Uppsala, Sweden (in Swedish).
36. NFA, 2012a. Market Basket 2010 - chemical analysis, exposure estimation and health-related assessment of nutrients and toxic compounds in Swedish food baskets. The National Food Agency, Uppsala, Sweden, ( (English version); reports/risk assessments-risk benefits/report no. 7-2012). http://www.livsmedelsverket.se.
37. NFA Lead in Game Meat - Risk Management Report 2012, The National Food Agency, Uppsala, Sweden, (in Swedish).
38. Nordberg M., Winblad B., Fratiglioni L., Basun H. Lead concentrations in elderly urban people related to blood pressure and mental performance: results from a population-based study. Am. J. Ind. Med. 2000, 38:290-294.
39. Handbook on The Toxicology of Metals 2007, Academic Press, Elsevier, London, UK. G.F. Nordberg, B.A. Fowler, M. Nordberg, L.T. Friberg (Eds.).
40. NRC, Toxicological effects of methylmercury. N.A. Press, 2000. National Research Council, Washington, DC, p. 344.
41. Olsson I.M., Bensryd I., Lundh T., Ottosson H., Skerfving S., Oskarsson A. Cadmium in blood and urine-impact of sex, age, dietary intake, iron status, and former smoking-association of renal effects. Environ. Health Perspect. 2002, 110:1185-1190.
42. Sandborgh-Englund G., Elinder C.G., Langworth S., Schutz A., Ekstrand J. Mercury in biological fluids after amalgam removal. J. Dent. Res. 1998, 77:615-624.
43. Satarug S., Moore M.R. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect. 2004, 112:1099-1103.
44. Skerfving S., Bencko V., Vahter M., Schutz A., Gerhardsson L. Environmental health in the Baltic region-toxic metals. Scand. J. Work Environ. Health 1999, 25(Suppl 3):40-64.
45. Soharan T., Pang D., Esmen N., Sadra S. Urinary concentration of toxic substances: an assessment of alternative approaches to adjusting for specific gravity. J. Occup. Environ. Hyg. 2008, 5:721-723.
46. Stromberg U., Lundh T., Skerfving S. Yearly measurements of blood lead in Swedish children since 1978: the declining trend continues in the petrol-lead-free period 1995-2007. Environ. Res. 2008, 107:332-335.
47. Vahter M., Berglund M., Lind B., Jorhem L., Slorach S., Friberg L. Personal monitoring of lead and cadmium exposure - a Swedish study with special reference to methodological aspects. Scand. J. Work Environ. Health 1991, 17:65-74.
48. Vahter M., Akesson A., Lind B., Bjors U., Schutz A., Berglund M. Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ. Res. 2000, 84:186-194.
49. Vahter M., Akesson A., Liden C., Ceccatelli S., Berglund M. Gender differences in the disposition and toxicity of metals. Environ. Res. 2007, 104:85-95.
50. Wennberg M., Lundh T., Bergdahl I.A., Hallmans G., Jansson J.H., Stegmayr B., Custodio H.M., Skerfving S. Time trends in burdens of cadmium, lead, and mercury in the population of northern Sweden. Environ. Res. 2006, 100:330-338.
51. WHO, Methylmercury. Sixty-first meeting of Joint FAO/WHO Expert Committee on Food Additives and Contaminants. Safety evaluation of certain Food Additives and Contaminants. Food Additives Series, 52. World Health Organization, Geneva, 2004.