Associations between urinary excretion of cadmium and proteins in a nonsmoking population: Renal toxicity or normal physiology?

Environmental Health Perspectives

Volumn 121, Issue 2, 2013, Pages 187-191

  Akerstrom, Magnus ^a   Sallsten, Gerd ^a   Lundh, Thomas ^b   Barregard, Lars ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Albumin; Alpha 1 microglobulin; Cadmium; Cadmium toxicity; Kidney effect; Renal function; Urinary excretion

Indexed keywords

ALBUMIN; ALPHA 1 MICROGLOBULIN; CADMIUM; CREATININE; PROTEIN;

ADULT; CHEMICAL ANALYSIS; ELISA KIT; FEMALE; HUMAN; KIDNEY FUNCTION; MALE; MASS SPECTROMETRY; NEPHROTOXICITY; NORMAL HUMAN; NOTE; PRIORITY JOURNAL; RELATIVE DENSITY; URINALYSIS; URINARY EXCRETION; URINE FLOW RATE;

CADMIUM; FEMALE; HUMANS; MALE; PROTEINURIA; REFERENCE VALUES;

EID: 84873363059     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1205418     Document Type: Note

References (22)

1. Åkesson A, Lundh T, Vahter M, Bjellerup P, Lidfeldt J, Nerbrand C, et al. 2005. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ Health Perspect 113:1627-1631.
2. Andersson L, Haraldsson B, Johansson C, Barregard L. 2008. Methodological issues on the use of urinary alpha-1-microglobuline in epidemiological studies. Nephrol Dial Transplant 23(4):1252-1256.
3. Bakoush O, Grubb A, Rippe B, Tencer J. 2001. Urine excretion of protein HC in proteinuric glomerular diseases correlates to urine IgG but not to albuminuria. Kidney Int 60(5):1904-1909.
4. Barany E, Bergdahl I, Schütz A, Skerfving S, Oskarsson A. 1997. Inductively coupled plasma mass spectrometry for direct multi-element analysis of diluted human blood and serum. J Anal At Spectrom 12:1005-1009.
5. Berlin A, Alessio L, Sesana G, Dellórto A, Ghezzi I. 1985. Problems concerning the usefulness of adjustment of urinary cadmium for creatine and specific gravity. Int Arch Occup Environ Health 55(2):107-111.
6. Bernard A. 2008. Biomarkers of metal toxicity in population studies: research potential and interpretation issues. J Toxicol Environ Health A 71(18):1259-1265.
7. Bernard AM, Ouled Amor A, Lauwerys RR. 1987. The effects of low doses of cadmium-metallo thionein on the renal uptake of beta 2-microglobulin in rats. Toxicol Appl Pharmacol 87(3):440-445.
8. Chaumont A, De Winter F, Dumont X, Haufroid V, Bernard A. 2010. The threshold level of urinary cadmium associated with increased urinary excretion of retinol-binding protein and beta 2-microglobulin: a re-assessment in a large cohort of nickel-cadmium battery workers. Occup Environ Med 68(4):257-264.
9. Chaumont A, Nickmilder M, Dumont X, Lundh T, Skerfving S, Bernard A. 2012. Associations between proteins and heavy metals in urine at low environmental exposures: Evidence of reverse causality. Toxicol Lett 210(3):345-352.
10. Christensen EI, Verroust PJ, Nielsen R. 2009. Receptor-mediated endocytosis in renal proximal tubule. Pfugers Arch 458:1039-1048.
11. EFSA (European Food Safety Authority). 2009. Scientifc Opinion of the Panel on Contaminants in the Food Chain on a request from the European Commission on cadmium in food. EFSA J 980:1-139.
12. Friberg L. 1950. Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning; a clinical and experimental study. Acta Med Scand Suppl 240:1-124.
13. Haddam N, Samira S, Dumont X, Taleb A, Lison D, Haufroid V, et al. 2011. Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers. Environ Health 10:37; doi:10.1186/1476-069X-10-37 [Online 14 May 2011].
14. Hornung RW, Reed LD. 1990. Estimation of Average Concentration in the Presence of Nondetectable Values. Appl Occup Environ Hyg 5:46-51.
15. Järup L, Åkesson A. 2009. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238(3):201-208.
16. Järup L, Berglund M, Elinder CG, Nordberg G, Vahter M. 1998. Health effects of cadmium exposure-a review of the literature and a risk estimate. Scand J Work Environ Health 24(suppl 1):1-51.
17. Nordberg GF, Fowler BA, Nordberg M, Friberg LT, eds. 2007. Handbook on the Toxicology of Metals. London: Elsevier.
18. Nordberg GF, Jin T, Wu X, Lu J, Chen L, Lei L, et al. 2009. Prevalence of kidney dysfunction in humans-relationship to cadmium dose, metallo thionein, immunological and metabolic factors. Biochimie 91(10):1282-1285.
19. Nordberg M. 1984. General aspects of cadmium: transport, uptake and metabolism by the kidney. Environ Health Perspect 54:13-20.
20. Penders J, Delanghe JR. 2004. Alpha 1-microglobulin: clinical laboratory aspects and applications. Clin Chim Acta 346(2):107-118.
21. Suwazono Y, Åkesson A, Alfvén T, Järup L, Vahter M. 2005. Creatinine versus specifc gravity-adjusted urinary cadmium concentrations. Biomarkers 10(2-3):117-126.
22. Trevisan A, Nicoletto G, Maso S, Grandesso G, Odynets A, Secondin L. 1994. Biological monitoring of cadmium exposure: reliability of spot urine samples. Int Arch Occup Environ Health 65(6):373-375.