Calcium-Dependent Protein Kinases as Drug Targets in Apicomplexan Parasites

Apicomplexan Parasites: Molecular Approaches toward Targeted Drug Development

Volumn , Issue , 2011, Pages 319-333

  Kugelstadt, Dominik ^a   Derrer, Bianca ^a   Kappes, Barbara ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

2,6,9 trisubstituted purines; Calcium dependent protein kinase (CDPK); CDPK inhibitors; CDPK regulation; High throughput screening; Imidazo 1,2 pyridazine; Plasmodium

Indexed keywords

EID: 84884024810     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527633883.ch17     Document Type: Chapter

References (36)

1. Billker, O., Lourido, S., and Sibley, L.D. (2009) Calcium-dependent signaling and kinases in apicomplexan parasites. Cell Host Microbe., 5, 612-622.
2. Kato, N., Sakata, T., Breton, G., Le Roch, K.G., Nagle, A., Andersen, C., Bursulaya, B., Henson, K. et al. (2008) Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat. Chem. Biol., 4, 347-356.
3. Nagamune, K., Moreno, S.N., Chini, E.N., and Sibley, L.D. (2008)Calcium regulation and signaling in apicomplexan parasites. Subcell. Biochem., 47, 70-81.
4. Hook, S.S. and Means, A.R. (2001) Ca (2p)/CaM-dependent kinases: from activation to function. Annu. Rev. Pharmacol. Toxicol., 41, 471-505.
5. Harper, J.F., and Harmon, A. (2005) Plants, symbiosis and parasites: a calcium signalling connection. Nat. Rev. Mol. Cell Biol., 6, 555-566.
6. Moskes, C., Burghaus, P.A., Wernli, B., Sauder, U., Durrenberger, M., and Kappes, B. (2004) Export of Plasmodium falciparum calcium-dependent protein kinase 1 to the parasitophorous vacuole is dependent on three N-terminal membrane anchor motifs. Mol. Microbiol., 54, 676-691.
7. Farber, P.M., Graeser, R., Franklin, R.M., and Kappes, B. (1997) Molecular cloning and characterization of a second calciumdependent protein kinase of Plasmodium falciparum. Mol. Biochem. Parasitol., 87, 211-216.
8. Garcia, C.R. (1999) Calcium homeostasis and signaling in the blood-stage malaria parasite. Parasitol. Today, 15, 488-491.
9. Coppi, A., Tewari, R., Bishop, J.R., Bennett, B.L., Lawrence, R., Esko, J.D., Billker, O., et al. (2007) Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host Microbe., 2, 316-327.
10. Green, J.L., Rees-Channer, R.R., Howell, S.A., Martin, S.R., Knuepfer, E., Taylor, H.M., Grainger, M., and Holder, A.A. (2008) The motor complex of Plasmodium falciparum: phosphorylation by a calciumdependent protein kinase. J. Biol. Chem., 283, 30980-30989.
11. Winter, D., Kugelstadt, D., Seidler, J., Kappes, B., and Lehmann, W.D. (2009) Protein phosphorylation influences proteolytic cleavage and kinase substrate properties exemplified by analysis of in vitro phosphorylated Plasmodium falciparum glideosome-associated protein 45 by nano-ultra performance liquid chromatography-tandem mass spectrometry. Anal. Biochem., 393, 41-47.
12. Garcia, G.E., Wirtz, R.A., Barr, J.R., Woolfitt, A., and Rosenberg, R. (1998) Xanthurenic acid induces gametogenesis in Plasmodium, the malaria parasite. J. Biol. Chem., 273, 12003-12005.
13. Billker, O., Dechamps, S., Tewari, R., Wenig, G., Franke-Fayard, B., and Brinkmann, V. (2004) Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite. Cell, 117, 503-514.
14. Ishino, T., Orito, Y., Chinzei, Y., and Yuda, M. (2006) A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell. Mol. Microbiol., 59, 1175-1184.
15. Siden-Kiamos, I., Ecker, A., Nyback, S., Louis, C., Sinden, R.E., and Billker, O. (2006) Plasmodium berghei calciumdependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion. Mol. Microbiol., 60, 1355-1363.
16. Christodoulou, J.,Malmendal, A.,Harper, J.F., and Chazin, W.J. (2004) Evidence for differing roles for each lobe of the calmodulin-like domain in a calciumdependent protein kinase. J. Biol. Chem., 279, 29092-29100.
17. Zhao, Y., Pokutta, S.,Maurer, P., Lindt, M., Franklin, R.M., and Kappes, B. (1994) Calcium-binding properties of a calciumdependent protein kinase from Plasmodium falciparum and the significance of individual calcium-binding sites for kinase activation. Biochemistry, 33, 3714-3721.
18. Harper, J.F., Breton, G., and Harmon, A. (2004) Decoding Ca(2{thorn}) signals through plant protein kinases. Annu. Rev. Plant. Biol., 55, 263-288.
19. Gazarini, M.L., Thomas, A.P., Pozzan, T., and Garcia, C.R. (2003) Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem. J. Cell Biol., 161, 103-110.
20. Chandran, V., Stollar, E.J., Lindorff-Larsen, K., Harper, J.F., Chazin, W.J., Dobson, C.M., Luisi, B.F., et al. (2006) Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulintarget recognition. J. Mol. Biol., 357, 400-410.
21. Ranjan, R., Ahmed, A., Gourinath, S., and Sharma, P. (2009) Dissection of mechanisms involved in the regulation of Plasmodium falciparum calciumdependent protein kinase 4. J. Biol. Chem., 284, 15267-15276.
22. Hegeman, A.D., Rodriguez, M., Han, B.W., Uno, Y., Phillips, G.N. Jr, Hrabak, E.M., Cushman, J.C., et al. (2006) A phyloproteomic characterization of in vitro autophosphorylation in calciumdependent protein kinases. Proteomics, 6, 3649-3664.
23. Witte, C.P., Keinath, N., Dubiella, U., Demouliere, R., Seal, A., and Romeis, T. (2010) Tobacco calcium-dependent protein kinases are differentially phosphorylated in vivo as part of a kinase cascade that regulates stress response. J. Biol. Chem., 285, 9740-9748.
24. Kato, K., Sudo, A., Kobayashi, K., Sugi, T., Tohya, Y., and Akashi, H. (2009) Characterization of Plasmodium falciparum calcium-dependent protein kinase 4. Parasitol. Int., 58, 394-400.
25. Zhao, Y., Franklin, R.M., and Kappes, B. (1994) Plasmodium falciparum calciumdependent protein kinase phosphorylates proteins of the host erythrocytic membrane. Mol. Biochem. Parasitol., 66, 329-343.
26. Donald, R.G., Zhong, T., Wiersma, H., Nare, B., Yao, D., Lee, A., Allocco, J., Liberator, P.A., et al. (2006) Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMPdependent protein kinase. Mol. Biochem. Parasitol., 149, 86-98.
27. Kugelstadt, D., Winter, D., Pluckhahn, K., Lehmann,W.D., and Kappes, B. (2007) Raf kinase inhibitor protein affects activity of Plasmodium falciparum calciumdependent protein kinase 1. Mol. Biochem. Parasitol., 151, 111-117.
28. Obsilova, V., Silhan, J., Boura, E., Teisinger, J., and Obsil, T. (2008) 14-3-3 proteins: a family of versatile molecular regulators. Physiol. Res., 57 (Suppl 3), S11-S21.
29. Camoni, L., Harper, J.F., and Palmgren, M.G. (1998) 14-3-3 proteins activate a plant calcium-dependent protein kinase (CDPK). FEBS Lett., 430, 381-384.
30. Cheng, S.H., Willmann, M.R., Chen, H.C., and Sheen, J. (2002) Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family. Plant Physiol., 129, 469-485.
31. McInnes, C., and Fischer, P.M. (2005) Strategies for the design of potent and selective kinase inhibitors. Curr. Pharm. Des., 11, 1845-1863.
32. Ruegg, U.T., and Burgess, G.M. (1989) Staurosporine. K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol. Sci., 10, 218-220.
33. Ding, S., Gray, N.S.,Wu, X., Ding, Q., and Schultz, P.G. (2002) A combinatorial scaffold approach toward kinase-directed heterocycle libraries. J. Am. Chem. Soc., 124, 1594-1596.
34. Lemercier, G., Fernandez-Montalvan, A., Shaw, J.P., Kugelstadt, D., Bomke, J., Domostoj, M., Schwarz, M.K., et al. (2009) Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1. Biochemistry, 48, 6379-6389.
35. Gietzen, K., Sadorf, I., and Bader, H. (1982) A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2{thorn}-transport ATPase and brain phosphodiesterase by activators and inhibitors. Biochem. J., 207, 541-548.
36. Van Belle, H. (1981) R24 571: A potent inhibitor of calmodulin-activated enzymes. Cell Calcium, 2, 483-494.